Opportunity Information: Apply for RFA AA 13 004
Apply for RFA AA 13 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research on Comparative Effectiveness and Implementation of HIV/AIDS and Alcohol Interventions (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Apr 3, 2013 and posted on Mar 27, 2013.
- Applicants must submit their applications by May 29, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) County governments Small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Native American tribal governments (Federally recognized) City or township governments For profit organizations other than small businesses Public and State controlled institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH grant opportunity "Research on Comparative Effectiveness and Implementation of HIV/AIDS and Alcohol Interventions (R21)" (Funding Opportunity Number RFA-AA-13-004) supports short, exploratory research projects aimed at improving how alcohol-related interventions are delivered to people living with HIV and how well different intervention approaches perform in real-world settings. The opportunity is grounded in the public health reality that HIV-positive individuals who use alcohol are often underserved and face elevated risks that directly undermine HIV treatment success, including poor medication adherence, faster disease progression, heightened medication toxicities, organ damage or failure, poor viral suppression, increased likelihood of transmission, and premature mortality. The announcement also highlights an estimated potential impact of getting alcohol interventions effectively implemented in HIV care: reductions in new HIV infections on the order of nearly 20 percent and substantial survival benefits (up to about 15 additional years in some at-risk or patient populations), underscoring why the topic is positioned as both a clinical priority and a prevention strategy.
The core purpose of the solicitation is to advance knowledge in two tightly connected areas: comparative effectiveness research and implementation research. On the comparative effectiveness side, the intent is to determine which alcohol-focused intervention strategies work best for which HIV populations and under what conditions, especially with respect to engaging patients in appropriate alcohol and HIV care and keeping them retained in treatment over time. This includes examining patient-centered outcomes and practical decision points clinicians face, such as matching intervention intensity or modality to a patient’s level of alcohol use disorder, readiness for change, comorbidities, social determinants, or treatment history. On the implementation side, the initiative seeks to develop, model, and test different ways of putting proven interventions into practice so they actually reach patients and have measurable effects on HIV transmission and disease progression. In other words, it is not only about whether an intervention can work under ideal conditions, but also about how to deliver it consistently, efficiently, and equitably in the clinical and community environments where HIV care happens.
A major theme throughout the announcement is that successful care for HIV patients with alcohol use disorders depends on more than the intervention itself. Applicants are encouraged to investigate multiple layers of influence, including patient characteristics (for example, severity of alcohol use, co-occurring mental health or substance use issues, stigma, housing instability, or other barriers), provider characteristics (such as training, attitudes, screening practices, and willingness to adopt evidence-based approaches), and the organizational, financial, and structural factors that either support or block delivery of evidence-based services. This can include clinic workflow, staffing models, reimbursement and incentive structures, integration between HIV care and behavioral health, referral networks, data systems for tracking outcomes, and broader structural constraints that affect access and continuity of care. The overall goal is to generate actionable evidence that improves clinical decision-making, enhances treatment outcomes, and reduces harms associated with both HIV disease and alcohol-related complications.
The solicitation is explicitly divided into two parts, and applicants may address either one or both. The first part focuses on comparative effectiveness research that improves understanding of patient engagement and retention in both alcohol-related and HIV-related care. The second part emphasizes modeling and testing alternative implementation approaches for effective interventions, with the explicit aim of reducing HIV transmission and slowing HIV progression. Across both parts, the announcement points to a larger objective aligned with patient-centered outcomes and health services research: improving the evidence base for informed healthcare decisions and strengthening research on healthcare delivery and outcomes in real-world systems.
From an administrative standpoint, this is an NIH discretionary grant using the R21 mechanism, which typically supports early-stage, high-impact, or proof-of-concept projects rather than large definitive clinical trials. The total estimated funding listed is $500,000, with an award ceiling of $200,000, and there is no cost-sharing or matching requirement. The opportunity was posted March 27, 2013, with an original and current closing date of May 29, 2013, and an archive date of June 29, 2013. The activity falls under health-related research and is associated with CFDA numbers 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs).
Eligibility is broad and includes many types of domestic and non-domestic entities. Eligible applicants include federal, state, county, city or township governments; public and private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations (including small businesses and other for-profit entities); public housing authorities; independent school districts; special district governments; and tribal governments and tribal organizations, including federally recognized tribal governments and other tribal entities. The eligibility list also specifically notes a wide range of institution types and community-based applicants, including faith-based or community-based organizations, HBCUs, Hispanic-serving institutions, AANAPISIS institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, U.S. territories or possessions, and regional organizations. Foreign organizations and foreign institutions are eligible to apply, and non-U.S. components of U.S. organizations are also eligible; foreign components as defined by NIH policy are allowed.
Overall, the opportunity is designed to push the field beyond simply knowing that alcohol interventions can help and toward answering practical, decision-relevant questions about what works best for specific HIV populations, how to sustain engagement and retention, and how to implement effective alcohol-related care strategies in the settings and systems where people with HIV actually receive services. The intended payoff is measurable improvement in viral control, reduced transmission risk, better long-term health outcomes, and more patient-centered, workable models of care for a population that has historically been difficult to reach and retain.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "Research on Comparative Effectiveness and Implementation of HIV/AIDS and Alcohol Interventions (R21)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-AA-13-004.
What type of grant mechanism is being used?
This opportunity uses the NIH R21 mechanism, which is intended for short, exploratory projects that can generate high-impact, proof-of-concept, or early-stage findings rather than large definitive trials.
What is the main purpose of this grant opportunity?
The purpose is to support exploratory research that improves how alcohol-related interventions are delivered to people living with HIV and to understand how different intervention approaches perform in real-world settings.
What public health problem is this opportunity trying to address?
The announcement focuses on the reality that HIV-positive individuals who use alcohol are often underserved and face elevated risks that can undermine HIV treatment success, including poor medication adherence, faster disease progression, heightened medication toxicities, organ damage or failure, poor viral suppression, increased likelihood of HIV transmission, and premature mortality.
Why does NIH emphasize alcohol interventions in HIV care?
The opportunity frames effective alcohol intervention delivery as both a clinical priority and an HIV prevention strategy, highlighting estimated potential impacts such as reductions in new HIV infections on the order of nearly 20 percent and substantial survival benefits (up to about 15 additional years in some at-risk or patient populations) when alcohol interventions are effectively implemented in HIV care.
What research areas does the solicitation aim to advance?
It aims to advance knowledge in two connected areas: (1) comparative effectiveness research and (2) implementation research, specifically as they relate to alcohol interventions for people living with HIV.
What does "comparative effectiveness" mean in the context of this announcement?
In this solicitation, comparative effectiveness research is focused on determining which alcohol-focused intervention strategies work best for which HIV populations and under what conditions, particularly in terms of engaging patients in appropriate alcohol and HIV care and retaining them in treatment over time.
What kinds of outcomes are emphasized for comparative effectiveness research?
The announcement emphasizes patient-centered outcomes and practical clinical decision points, such as how to match an intervention's intensity or modality to a patient’s level of alcohol use disorder, readiness for change, comorbidities, social determinants, or treatment history.
What does "implementation research" mean in the context of this announcement?
Implementation research here is focused on developing, modeling, and testing ways to put proven interventions into routine practice so they reach patients and have measurable effects on HIV transmission and disease progression, including delivery that is consistent, efficient, and equitable in real-world clinical and community environments.
Does this opportunity support research on both effectiveness and implementation?
Yes. The solicitation is explicitly divided into two parts, and applicants may address either part or both parts.
What are the two parts of the solicitation?
Part 1 focuses on comparative effectiveness research aimed at improving understanding of patient engagement and retention in both alcohol-related and HIV-related care. Part 2 emphasizes modeling and testing alternative implementation approaches for effective interventions, with the explicit aim of reducing HIV transmission and slowing HIV progression.
Is the focus only on whether an intervention works under ideal conditions?
No. A central theme is moving beyond "can it work" toward "how can it be delivered in real-world settings," including how to deliver interventions consistently, efficiently, and equitably where HIV care actually occurs.
What levels of influence are applicants encouraged to study?
Applicants are encouraged to examine multiple layers that affect successful care, including patient characteristics, provider characteristics, and organizational/financial/structural factors that either support or block delivery of evidence-based services.
What patient-level factors are specifically mentioned as relevant to study?
Examples include severity of alcohol use, co-occurring mental health or substance use issues, stigma, housing instability, and other barriers that can affect engagement and continuity of care.
What provider-level factors are specifically mentioned as relevant to study?
Examples include training, attitudes, screening practices, and willingness to adopt evidence-based approaches.
What organizational or system-level factors are specifically mentioned as relevant to study?
Examples include clinic workflow, staffing models, reimbursement and incentive structures, integration between HIV care and behavioral health, referral networks, data systems for tracking outcomes, and broader structural constraints that affect access and continuity of care.
What is the overall goal of the research supported by this opportunity?
The overall goal is to generate actionable evidence that improves clinical decision-making, enhances treatment outcomes, and reduces harms associated with both HIV disease and alcohol-related complications, with measurable improvements such as better viral control and reduced transmission risk.
How much total funding is estimated for this opportunity?
The total estimated funding listed is $500,000.
What is the award ceiling?
The award ceiling listed is $200,000.
Is cost-sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
When was this funding opportunity posted?
The opportunity was posted on March 27, 2013.
What is the application closing date?
The original and current closing date listed is May 29, 2013.
When is (or was) the archive date?
The archive date listed is June 29, 2013.
What broad activity area does this opportunity fall under?
It falls under health-related research.
What CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA 93.273 (Alcohol Research Programs) and CFDA 93.279 (Drug Abuse and Addiction Research Programs).
Who is eligible to apply?
Eligibility is broad and includes domestic and non-domestic entities such as federal, state, county, city or township governments; public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); for-profit organizations (including small businesses); public housing authorities; independent school districts; special district governments; and tribal governments and tribal organizations, including federally recognized tribal governments and other tribal entities.
Are community-based and faith-based organizations eligible?
Yes. The eligibility list specifically notes faith-based or community-based organizations among eligible applicants.
Are minority-serving institutions included in eligibility?
Yes. The eligibility list specifically mentions HBCUs, Hispanic-serving institutions, AANAPISIS institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and related institution types.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included in the eligibility list.
Can foreign organizations apply?
Yes. Foreign organizations and foreign institutions are eligible to apply, and non-U.S. components of U.S. organizations are also eligible. Foreign components (as defined by NIH policy) are allowed.
What kinds of real-world settings does the opportunity emphasize?
It emphasizes the clinical and community environments where HIV care happens, with attention to systems and workflows that influence whether evidence-based alcohol interventions actually reach patients and are sustained over time.
What is the intended long-term payoff described in the announcement?
The intended payoff is improved viral control, reduced HIV transmission risk, better long-term health outcomes, and more patient-centered and workable models of care for people living with HIV who use alcohol and are often difficult to reach and retain.
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