Opportunity Information: Apply for PA 07 454
Apply for PA 07 454
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Research on Malignancies in the Context of HIV/AIDS (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Sep 13, 2007.
- Applicants must submit their applications by Sep 7, 2010 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Independent school districts Special district governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments For profit organizations other than small businesses City or township governments Private institutions of higher education Small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification).
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The NIH funding opportunity titled "Research on Malignancies in the Context of HIV/AIDS (R21)" (Funding Opportunity Number PA-07-454) is a discretionary grant program designed to support exploratory, early-stage research that improves what is known about cancers that occur in people living with HIV infection or AIDS. The central aim is to push forward understanding of how these malignancies start, how they develop and progress over time, how they can be diagnosed more effectively, and how they can be treated in ways that make sense for HIV-infected populations. The announcement is led by the National Cancer Institute (NCI) and the National Institute of Dental and Craniofacial Research (NIDCR), reflecting an interest that spans both general oncology and conditions relevant to oral and craniofacial health as they relate to cancer risk and outcomes in HIV.
A major focus of the opportunity is research that clarifies why malignancies are more likely, different in behavior, or more challenging to manage when HIV is part of the clinical picture. The FOA highlights studies on etiologic factors and cofactors (the underlying causes and contributing exposures or conditions), pathogenesis (the biological mechanisms driving disease), and the consequences of HIV-associated cancers in diverse populations. That emphasis on diversity is important because HIV burden, access to care, co-infections, environmental exposures, and cancer screening and treatment patterns can vary widely across communities, and those differences can shape both risk and outcomes. The program is also interested in research that links biology to real-world clinical impacts, such as how immune suppression, chronic inflammation, viral co-infections, or antiretroviral therapy might influence tumor initiation, progression, response to treatment, or survivorship issues.
In addition to cancers that have historically been considered AIDS-defining, the FOA explicitly encourages work on non-AIDS-defining malignancies in the setting of HIV. It notes that in the era of Highly Active Antiretroviral Therapy (HAART), the incidence of several non-AIDS-defining cancers appears to be increasing, with examples including anal cancer, skin cancers, lung cancer, and Hodgkin disease. This shift reflects the reality that many people with HIV are living longer due to effective antiviral treatment, which changes the long-term cancer risk landscape and raises new questions about screening, early detection, and tailored therapies. The announcement therefore encourages studies that can do two practical things: first, generate clearer information about clinical outcomes for these cancers specifically in HIV-infected populations; and second, isolate and describe the specific contributions of HIV infection to the development and biological behavior of these cancers. The long-range goal is to produce evidence that can guide screening strategies and treatment approaches designed specifically for people living with HIV, rather than relying solely on data from the general population.
This is an R21 mechanism, which typically supports exploratory and developmental research projects that may be higher risk but potentially high payoff, often used to establish feasibility, generate preliminary data, or test novel hypotheses. The grant’s listed award ceiling is $200,000, and there is no cost sharing or matching requirement. The opportunity falls under NIH activity areas connected to health and education and is associated with CFDA numbers that include oral diseases and disorders research (93.121) and several cancer research categories (93.393 cancer cause and prevention research; 93.396 cancer biology research), signaling that proposed projects can range from mechanistic biology to prevention, clinical outcomes research, or translational directions, so long as they are centered on malignancies in the context of HIV/AIDS.
Eligibility is broad and includes many types of domestic applicants such as public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), state and local governments, tribal governments and tribal organizations, public housing authorities, school districts, and for-profit organizations other than small businesses, as well as small businesses. The FOA also states that foreign institutions are eligible to apply, and that eligible federal agencies can apply. Faith-based and community-based organizations are also eligible, which opens the door to projects rooted in community-engaged research, implementation questions, or population-focused studies where those groups have strong access and trust with affected communities.
The opportunity was posted on September 13, 2007, with multiple receipt dates indicated in the full announcement. The current closing date listed in the source data is September 7, 2010, with an archive date of October 8, 2010, meaning it is no longer active as a current competition, but it remains useful as a reference point for the NIH’s priorities and the kinds of research questions that were being explicitly encouraged during that period. The full announcement was provided through the NIH grants website at the link included in the source data (http://grants.nih.gov/grants/guide/pa-files/PA-07-454.html), and the NIH Office of Extramural Research webmaster contact is listed for technical access issues.
FAQs: NIH Funding Opportunity PA-07-454 - Research on Malignancies in the Context of HIV/AIDS (R21)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Research on Malignancies in the Context of HIV/AIDS (R21)" and the Funding Opportunity Number is PA-07-454.
What is the main purpose of this funding opportunity?
This discretionary NIH grant program supports exploratory, early-stage research to improve understanding of cancers that occur in people living with HIV infection or AIDS. The goal is to advance knowledge about how these malignancies begin, how they develop and progress, how they can be diagnosed more effectively, and how they can be treated in ways that are appropriate for HIV-infected populations.
Which NIH institutes lead this announcement?
The announcement is led by the National Cancer Institute (NCI) and the National Institute of Dental and Craniofacial Research (NIDCR), reflecting interests that span general oncology and oral/craniofacial health as they relate to cancer risk and outcomes in HIV.
What types of research topics does the FOA emphasize?
The FOA emphasizes research that clarifies why malignancies are more likely, behave differently, or are more challenging to manage in the context of HIV. It highlights studies on etiologic factors and cofactors, pathogenesis and biological mechanisms, and the consequences of HIV-associated cancers in diverse populations.
Does the FOA encourage research that connects biology to clinical outcomes?
Yes. The program is interested in studies linking biology to real-world clinical impacts, including how immune suppression, chronic inflammation, viral co-infections, or antiretroviral therapy may influence tumor initiation, progression, response to treatment, and survivorship issues.
Are both AIDS-defining and non-AIDS-defining cancers included?
Yes. In addition to historically AIDS-defining cancers, the FOA explicitly encourages research on non-AIDS-defining malignancies in the setting of HIV.
Why does the FOA highlight non-AIDS-defining malignancies in the HAART era?
The FOA notes that in the era of Highly Active Antiretroviral Therapy (HAART), the incidence of several non-AIDS-defining cancers appears to be increasing. As people with HIV live longer due to effective antiviral therapy, long-term cancer risks and related research questions about screening, early detection, and tailored therapies become more important.
What examples of non-AIDS-defining cancers are mentioned in the FOA?
The FOA provides examples including anal cancer, skin cancers, lung cancer, and Hodgkin disease.
What practical outputs or impacts does the FOA aim to support?
The FOA encourages studies that (1) generate clearer information about clinical outcomes for cancers specifically in HIV-infected populations, and (2) isolate and describe the specific contributions of HIV infection to the development and biological behavior of these cancers. The long-range goal is evidence that can guide screening strategies and treatment approaches designed specifically for people living with HIV.
What grant mechanism is used (and what does it generally support)?
This opportunity uses the NIH R21 mechanism, which typically supports exploratory and developmental research projects. R21 projects are often higher risk but potentially high payoff and are commonly used to establish feasibility, generate preliminary data, or test novel hypotheses.
What is the award ceiling listed for this grant?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What activity areas and CFDA numbers are associated with this opportunity?
The opportunity falls under NIH activity areas connected to health and education and is associated with CFDA numbers including 93.121 (oral diseases and disorders research), 93.393 (cancer cause and prevention research), and 93.396 (cancer biology research). This signals projects may range from mechanistic biology to prevention, clinical outcomes research, or translational directions, as long as they focus on malignancies in the context of HIV/AIDS.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic applicants such as public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), state and local governments, tribal governments and tribal organizations, public housing authorities, school districts, for-profit organizations other than small businesses, and small businesses.
Are faith-based and community-based organizations eligible?
Yes. The FOA states that faith-based and community-based organizations are eligible, supporting the possibility of community-engaged, implementation-oriented, or population-focused projects.
Are foreign institutions eligible to apply?
Yes. The FOA states that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The FOA indicates that eligible federal agencies can apply.
When was this opportunity posted?
The opportunity was posted on September 13, 2007.
Is this funding opportunity still active?
No. The closing date listed is September 7, 2010, and the archive date is October 8, 2010, indicating it is no longer active as a current competition.
Does the FOA mention multiple application receipt dates?
Yes. It notes that multiple receipt dates are indicated in the full announcement.
Where can the full announcement be found?
The full announcement is available through the NIH grants website at: http://grants.nih.gov/grants/guide/pa-files/PA-07-454.html
Who is listed as a contact for technical access issues?
The NIH Office of Extramural Research webmaster contact is listed for technical access issues.
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