Research on Malignancies in the Context of HIV/AIDS (R01) | Apply Online

Opportunity Summary:

The NIH funding opportunity PA-07-455, titled "Research on Malignancies in the Context of HIV/AIDS (R01)," is a discretionary grant program designed to support research that deepens scientific and clinical understanding of cancers occurring in people living with HIV or AIDS. Led by the National Cancer Institute (NCI) with participation from the National Institute of Dental and Craniofacial Research (NIDCR), the FOA focuses on how HIV infection influences cancer risk, cancer biology, clinical course, diagnosis, and treatment outcomes. The overall aim is to generate knowledge that can translate into better prevention strategies, improved screening and diagnostic approaches, and more effective, tailored therapies for HIV-infected populations.

A central emphasis of this opportunity is understanding the full range of malignancies seen in the setting of HIV, including both AIDS-defining cancers and non-AIDS-defining malignancies. The announcement specifically highlights that, in the era of Highly Active Antiretroviral Therapy (HAART), there has been an apparent increase in certain non-AIDS-defining cancers such as anal cancer, skin cancers, lung cancer, and Hodgkin's disease. Because HAART has extended life expectancy and changed immune dynamics, the FOA encourages research that clarifies whether rising incidence reflects longer survival, persistent immune dysfunction, viral coinfections, chronic inflammation, lifestyle and environmental exposures, treatment-related effects, or other interacting factors. Projects are expected to investigate etiologic factors and cofactors, mechanisms of pathogenesis, and the consequences of malignancy in the context of HIV, with attention to diverse populations to ensure findings are relevant across different demographic and risk groups.

The FOA also calls for studies that generate practical clinical insights. In particular, it encourages research that (i) provides information on clinical outcomes for cancers occurring in HIV-infected individuals and (ii) identifies HIV-specific contributions to the development and biological behavior of these cancers. That can include work examining how HIV-related immune suppression or immune activation affects tumor initiation and progression, how coinfections (for example, oncogenic viruses) shape cancer risk, and how HIV status influences response to standard cancer therapies. The announcement is framed around building an evidence base that could ultimately refine cancer screening practices and guide development or optimization of treatments specifically targeted to the needs and constraints of people living with HIV.

From an administrative standpoint, this is an R01 research project grant, meaning it is intended to fund hypothesis-driven, investigator-initiated research programs that can vary in scope and approach, including basic, translational, clinical, and population-based studies as aligned with NIH R01 expectations. The FOA is categorized under education and health, and it aligns with CFDA program areas including Oral Diseases and Disorders Research (93.121) and multiple cancer research categories such as Cancer Cause and Prevention Research (93.393) and Cancer Biology Research (93.396). Cost sharing or matching is not required, which reduces barriers for applicants and is consistent with many NIH research project grants.

Eligibility is broad and includes a wide range of domestic and international organizations. Eligible applicants include state and local governments (including county and city or township governments), special district governments, public housing authorities/Indian housing authorities, federally recognized tribal governments and other tribal organizations, public and private institutions of higher education, independent school districts, nonprofits with or without 501(c)(3) status (other than higher education institutions), for-profit organizations (including small businesses and other for-profit entities), and other applicants as clarified in the full announcement. Importantly, foreign institutions are explicitly eligible, eligible federal agencies may apply, and both faith-based and community-based organizations are also eligible, reflecting NIH's interest in supporting research capacity across many institutional settings where HIV and cancer burdens may be studied effectively.

Key dates indicate the opportunity was posted on September 13, 2007, with multiple receipt dates referenced in the full announcement, and a current closing date listed as September 7, 2010, with an archive date of October 8, 2010. While archived opportunities are no longer open for new submissions, the content still provides a useful template for the types of research priorities NIH has historically supported at the intersection of HIV and oncology. The full announcement was available via the NIH Grants Guide, and the NIH Office of Extramural Research provided webmaster contact information for access or technical issues related to the posting.

In practical terms, this FOA is aimed at advancing cancer research that specifically accounts for the biological and clinical realities of HIV infection, including evolving cancer patterns in the HAART era. It encourages investigators to move beyond documenting incidence by also explaining mechanisms, identifying modifiable risk factors, clarifying outcomes and treatment responses, and producing findings that can directly improve screening and therapeutic strategies for people living with HIV.

Browse more business programs for HIV and AIDS support

Browse more opportunities from the same agency: National Institutes of Health

Browse more opportunities from the same category: Education Health

Next opportunity: NINDS Diversity Research Education Grants in Neuroscience (R25)

Previous opportunity: Research on Malignancies in the Context of HIV/AIDS (R21)

USGrants.org Applicant Portal:

Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.

Apply for PA 07 455

 

[Watch] how do funding administrators access proposals?

Applicants also applied for:

Applicants who have applied for this opportunity (PA 07 455) also looked into and applied for these:

 

Grant application guides and resources

It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!

Apply for Grants

 

 

Premium leads for funding administrators, grant writers, and loan issuers

Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.

If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.

Subscribe to Leads

 

Request more information:

Would you like to learn more about this funding opportunity, similar opportunities to "PA 07 455", eligibility, application service, and/or application tips? Submit an inquiry below:

Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.