Opportunity Information: Apply for PA 08 256
Apply for PA 08 256
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Research to Advance Vaccine Safety (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.061 Innovations in Applied Public Health Research 93.113 Environmental Health 93.242 Mental Health Research Grants 93.361 Nursing Research 93.855 Allergy, Immunology and Transplantation Research 93.856 Microbiology and Infectious Diseases Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 28, 2011 and posted on Aug 28, 2008.
- Applicants must submit their applications by Jan 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) County governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Private institutions of higher education State governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Small businesses Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity PA-08-256, titled Research to Advance Vaccine Safety (R01), supports research projects that strengthen the scientific understanding of vaccine safety. It uses the NIH Research Project Grant (R01) mechanism, meaning it is intended for well-developed, hypothesis-driven research programs that can produce solid, publishable findings and advance the field in a meaningful way. The overarching goal is to build clearer biological and mechanistic knowledge around how vaccines and vaccine components interact with the body, and to improve the evidence base used to evaluate and monitor safety.
The research scope is centered on several broad scientific areas that NIH considers especially relevant to vaccine safety. One major area is studying physiological and immunological responses to vaccines and specific vaccine components, which can include how the immune system is activated, what inflammatory pathways are engaged, and what normal versus atypical response patterns look like across populations. Another emphasis is on how genetic variation may influence immune or physiological responses in ways that could affect safety outcomes, reflecting interest in host factors that may help explain why rare adverse events occur in some individuals but not others. The FOA also encourages research aimed at identifying risk factors and biological markers that could help assess whether certain diseases or disorders have any relationship to licensed vaccines, which can include developing or validating measurable indicators that improve safety evaluations. A fourth highlighted area is the application of genomic and molecular technologies to expand vaccine safety knowledge, which can involve modern tools and platforms that sharpen mechanistic understanding or improve detection and interpretation of biological signals related to safety.
This R01 announcement runs in parallel with a companion funding opportunity that covers the same scientific scope but uses a different grant mechanism: PA-08-257, which supports Exploratory/Developmental Research Grants (R21). In practical terms, PA-08-256 is positioned for more mature research plans suitable for the R01 format, while the parallel R21 mechanism is typically used for earlier-stage, higher-risk exploratory work. Applicants choosing between them would generally align the mechanism with the readiness of their preliminary data, the scale of the proposed aims, and the expected timeline to produce robust outcomes.
In terms of funding expectations, NIH does not commit in this notice to a fixed total budget or a set number of awards. Instead, the agency notes that award size and project duration will vary depending on the nature and scope of each application. The total amount awarded and the number of funded projects are expected to depend on how many applications are submitted, how strong they are scientifically, and what their requested budgets and project periods look like. The opportunity does not require cost sharing or matching.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants listed include public and private institutions of higher education, nonprofit organizations (both with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profit entities), and a wide range of government entities such as state, county, city/township, special district governments, and independent school districts, as well as public housing authorities/Indian housing authorities. Tribal eligibility is also extensive, covering federally recognized tribal governments and other tribal organizations. The FOA also explicitly includes several categories often called out in federal grantmaking, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, U.S. territories or possessions, regional organizations, and foreign (non-U.S.) entities.
Key administrative details show this is a discretionary grant opportunity offered by NIH. The opportunity was posted on August 28, 2008, with later record dates indicating the entry was created July 28, 2011. It lists an original closing date of September 7, 2011, a current closing date of January 7, 2012, and an archive date of February 7, 2012. The CFDA program numbers associated with this announcement span multiple NIH and public health research areas, including allergy/immunology, infectious diseases, child health, nursing research, environmental health, mental health, and applied public health research, reflecting how vaccine safety research can intersect with several biomedical and population health domains.
For the full announcement and official requirements, NIH points applicants to the detailed notice at http://grants.nih.gov/grants/guide/pa-files/PA-08-256.html. For access or technical issues related to the online posting, the listed contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: NIH PA-08-256 - Research to Advance Vaccine Safety (R01)
What is NIH funding opportunity PA-08-256?
PA-08-256 is a National Institutes of Health (NIH) funding opportunity titled Research to Advance Vaccine Safety (R01). It supports research projects intended to strengthen the scientific understanding of vaccine safety and to improve the evidence base used to evaluate and monitor vaccine safety.
What grant mechanism does PA-08-256 use?
This opportunity uses the NIH Research Project Grant (R01) mechanism, which is typically intended for well-developed, hypothesis-driven research programs designed to generate solid, publishable findings and advance the field in a meaningful way.
What is the overall goal of this R01 opportunity?
The overarching goal is to build clearer biological and mechanistic knowledge of how vaccines and vaccine components interact with the body, and to strengthen the scientific foundation used to assess, evaluate, and monitor vaccine safety.
What research topics or scientific areas are considered within scope?
The FOA highlights several broad scientific areas considered especially relevant to vaccine safety, including:
- Physiological and immunological responses to vaccines and specific vaccine components (including immune activation, inflammatory pathways, and patterns of normal vs. atypical responses across populations).
- How genetic variation may influence immune or physiological responses that could affect safety outcomes (host factors that may help explain rare adverse events in some individuals).
- Identifying risk factors and biological markers that could help assess whether certain diseases or disorders have any relationship to licensed vaccines (including development or validation of measurable indicators to improve evaluations).
- Applying genomic and molecular technologies to expand vaccine safety knowledge, using modern tools and platforms to sharpen mechanistic understanding or improve detection and interpretation of biological signals related to safety.
Does the FOA focus only on vaccines themselves, or also on components?
Based on the description provided, the scope includes research on vaccines as well as specific vaccine components, particularly in the context of physiological and immunological responses and mechanistic understanding relevant to safety.
Is there a companion funding opportunity related to PA-08-256?
Yes. PA-08-256 runs in parallel with a companion FOA, PA-08-257, which covers the same scientific scope but uses a different grant mechanism: the Exploratory/Developmental Research Grant (R21).
How is PA-08-256 (R01) different from PA-08-257 (R21)?
PA-08-256 is positioned for more mature research plans suitable for the R01 format. The parallel R21 mechanism is typically used for earlier-stage, higher-risk exploratory work. Selecting between them generally depends on the readiness of preliminary data, the scale of proposed aims, and the timeline needed to produce robust outcomes.
Does NIH specify a fixed total funding amount or a set number of awards?
No. NIH does not commit in this notice to a fixed total budget or a set number of awards. Award size and project duration are expected to vary depending on the nature and scope of individual applications.
What factors influence how many awards are made and how much funding is provided?
The total amount awarded and the number of funded projects are expected to depend on how many applications are submitted, their scientific strength, and their requested budgets and project periods.
Is cost sharing or matching required for this opportunity?
No. The opportunity does not require cost sharing or matching.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations. The FOA lists eligible applicants across academia, nonprofit, for-profit, and government entities, including tribal and foreign entities.
Are institutions of higher education eligible?
Yes. Eligible applicants include public and private institutions of higher education.
Are nonprofit organizations eligible to apply?
Yes. Eligible applicants include nonprofit organizations with and without 501(c)(3) status.
Are for-profit organizations eligible?
Yes. The FOA includes for-profit organizations, including small businesses and other for-profit entities.
Are government entities eligible?
Yes. The FOA lists a wide range of eligible government entities, including state, county, city/township, special district governments, and independent school districts, as well as public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. Tribal eligibility is extensive and includes federally recognized tribal governments and other tribal organizations.
Are specific institution types (like HBCUs or Hispanic-serving Institutions) explicitly included?
Yes. The FOA explicitly includes categories commonly referenced in federal grantmaking, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian-serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based and community-based organizations eligible?
Yes. The FOA explicitly includes faith-based and community-based organizations.
Are U.S. territories or possessions and regional organizations eligible?
Yes. The FOA explicitly includes U.S. territories or possessions and regional organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. The FOA explicitly includes foreign (non-U.S.) entities.
Is this a discretionary grant opportunity?
Yes. The listing indicates this is a discretionary grant opportunity offered by NIH.
When was this funding opportunity posted and when did it close?
The opportunity was posted on August 28, 2008. It lists an original closing date of September 7, 2011, a current closing date of January 7, 2012, and an archive date of February 7, 2012. The entry also indicates later record dates, including that the entry was created on July 28, 2011.
Which CFDA program numbers are associated with this announcement?
The CFDA program numbers associated with the announcement span multiple NIH and public health research areas, including allergy/immunology, infectious diseases, child health, nursing research, environmental health, mental health, and applied public health research. This reflects that vaccine safety research can intersect with several biomedical and population health domains.
Where can applicants find the full official announcement and requirements?
NIH directs applicants to the full announcement at: http://grants.nih.gov/grants/guide/pa-files/PA-08-256.html
Who should be contacted for access or technical issues related to the online posting?
For access or technical issues related to the online posting, the listed contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 08 256) also looked into and applied for these:
| Funding Opportunity |
|---|
| Research to Advance Vaccine Safety (R21) Apply for PA 08 257 Funding Number: PA 08 257 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Mentored Research Scientist Development Award (K01) Apply for PA 06 001 Funding Number: PA 06 001 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Independent Scientist Award (K02) Apply for PA 06 527 Funding Number: PA 06 527 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Independent Scientist Award (K02) Apply for PA 09 038 Funding Number: PA 09 038 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21) Apply for PA 09 164 Funding Number: PA 09 164 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (F33) Apply for PA 09 211 Funding Number: PA 09 211 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| The Human Connectome Project (U54) Apply for RFA MH 10 020 Funding Number: RFA MH 10 020 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Bioengineering Nanotechnology Initiative (STTR R41/R42 Apply for PA 09 266 Funding Number: PA 09 266 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Bioengineering Research Grants (BRG)(R01) Apply for PA 10 009 Funding Number: PA 10 009 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Exploratory/Developmental Bioengineering Research Grants (EBRG) R21 Apply for PA 10 010 Funding Number: PA 10 010 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32) Apply for PA 10 036 Funding Number: PA 10 036 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award Short Term Institutional Research Training Grants (T35) Apply for PA 10 037 Funding Number: PA 10 037 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Blueprint Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (R25) Apply for RFA MH 10 070 Funding Number: RFA MH 10 070 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02) Apply for PA 10 057 Funding Number: PA 10 057 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| NIH Exploratory Developmental Research Grant Program (Parent R21) Apply for PA 10 069 Funding Number: PA 10 069 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (Parent F33) Apply for PA 10 111 Funding Number: PA 10 111 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Promoting Health Literacy (R03) Apply for PAR 10 134 Funding Number: PAR 10 134 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Promoting Health Literacy (R21) Apply for PAR 10 135 Funding Number: PAR 10 135 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21) Apply for PAR 10 137 Funding Number: PAR 10 137 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Innovative Neuroscience K 12 Education (SBIR R43/R44) Apply for PAR 10 154 Funding Number: PAR 10 154 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
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