Opportunity Information: Apply for PA 08 257
Apply for PA 08 257
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Research to Advance Vaccine Safety (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.061 Innovations in Applied Public Health Research 93.113 Environmental Health 93.242 Mental Health Research Grants 93.361 Nursing Research 93.855 Allergy, Immunology and Transplantation Research 93.856 Microbiology and Infectious Diseases Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 28, 2011 and posted on Aug 28, 2008.
- Applicants must submit their applications by Jan 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education County governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments For profit organizations other than small businesses Private institutions of higher education Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments City or township governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Research to Advance Vaccine Safety (R21) is a National Institutes of Health (NIH) funding opportunity designed to support early-stage, exploratory research that can strengthen the scientific understanding of vaccine safety. The focus is on studies that can generate new leads, pilot data, or proof-of-concept findings that help explain how vaccines and vaccine components interact with the body, and why responses may differ across individuals. The program uses the NIH Exploratory/Developmental Grant mechanism (R21), which is typically used for innovative or high-impact ideas that are not yet ready for a larger, fully developed R01 project. NIH also notes that this announcement runs in parallel with a companion opportunity of the same scientific scope that uses the R01 mechanism (PA 08 256), meaning applicants with more mature projects may consider the R01 route while earlier concepts fit the R21.
The scientific areas encouraged under this announcement center on several broad themes tied directly to vaccine safety. One theme is studying physiological and immunological responses to vaccines and specific vaccine components, which can include how the immune system is activated, what inflammatory pathways are engaged, and what short- or longer-term biological changes may follow vaccination. A second theme is the role of genetics in shaping immune or physiological responses, emphasizing that genetic variation may help explain why rare adverse events occur in some individuals but not others. A third theme is the identification of risk factors and biological markers that could help assess whether there is a relationship between certain diseases or disorders and licensed vaccines; this points toward research aimed at improving methods for evaluating safety signals and distinguishing coincidence from causality. A fourth theme encourages the use of genomic and molecular technologies to deepen vaccine safety knowledge, which can include modern laboratory and analytic approaches that clarify mechanisms and improve assessment tools.
In terms of funding structure, NIH indicates that award size and project duration may vary depending on the nature and scope of the proposed work, and that the total number of awards and total dollars awarded are not fixed in advance. Instead, they depend on the volume of applications received and, importantly, their scientific quality, proposed budgets, and timelines. The listing includes an award ceiling of $200,000, which signals an upper limit for the award amount under this opportunity as presented in the source data. There is no cost sharing or matching requirement, so applicants are not required to commit institutional funds as a condition of eligibility.
Eligibility is broad and includes many types of organizations that commonly apply to NIH, spanning public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special district, independent school districts, and public housing authorities/Indian housing authorities). It also explicitly includes Native American tribal governments (federally recognized and other than federally recognized), tribal organizations, and tribally controlled colleges and universities. Additional eligible applicant categories listed include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), faith-based or community-based organizations, eligible agencies of the federal government, U.S. territories or possessions, regional organizations, and non-U.S. (foreign) entities. Practically, that means NIH is open to proposals from a wide range of research-capable organizations, including international partners where appropriate.
Key administrative details in the source data identify the opportunity as Funding Opportunity Number PA 08 257, categorized as a discretionary grant. The opportunity is associated with multiple CFDA program areas (including allergy/immunology, microbiology and infectious diseases, child health, nursing research, environmental health, mental health research grants, and applied public health research), reflecting how vaccine safety research can cut across many biomedical and public health domains. The posting date is listed as August 28, 2008, with later administrative dates shown in the record, and the latest closing date provided in the source data is January 7, 2012, with an archive date of February 7, 2012. The sponsoring agency is NIH, and the full announcement is linked through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-08-257.html. For access or technical issues with the announcement link, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs): Research to Advance Vaccine Safety (R21) - NIH (PA-08-257)
What is the "Research to Advance Vaccine Safety (R21)" opportunity?
This is a National Institutes of Health (NIH) funding opportunity that supports early-stage, exploratory research intended to advance scientific understanding of vaccine safety. It uses the NIH Exploratory/Developmental Grant mechanism (R21), which is generally used to help generate new leads, pilot data, or proof-of-concept findings for innovative ideas that are not yet ready for a larger R01 project.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number listed is PA 08 257 (often written as PA-08-257).
Which federal agency sponsors this grant opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of funding opportunity is this?
The opportunity is categorized as a discretionary grant.
What is the main purpose of the R21 mechanism in this announcement?
The R21 mechanism is intended to support exploratory/developmental projects, especially innovative or potentially high-impact ideas that need early evidence (such as pilot data or proof-of-concept results) before they can be developed into a larger, fully developed project.
How does this R21 opportunity relate to the companion R01 opportunity?
NIH notes that this announcement runs in parallel with a companion opportunity of the same scientific scope that uses the R01 mechanism (PA 08 256). In practical terms, earlier-stage concepts may fit the R21 route, while more mature projects may be better suited to the R01 route.
What kinds of research topics are encouraged under this vaccine safety announcement?
The announcement encourages research aligned with broad themes tied to vaccine safety, including:
- Physiological and immunological responses to vaccines and specific vaccine components (for example, immune activation, inflammatory pathways, and short- or longer-term biological changes following vaccination).
- Genetic influences on immune or physiological responses, including how genetic variation might help explain rare adverse events in some individuals.
- Identification of risk factors and biological markers to help assess whether relationships exist between certain diseases/disorders and licensed vaccines, and to improve evaluation of safety signals (including distinguishing coincidence from causality).
- Use of genomic and molecular technologies to deepen vaccine safety knowledge, clarify mechanisms, and improve assessment tools.
Does this opportunity focus on licensed vaccines?
One of the encouraged themes explicitly includes research to help assess whether there is a relationship between certain diseases or disorders and licensed vaccines, including work that improves methods for evaluating safety signals.
Is the program interested in studying vaccine components, not just whole vaccines?
Yes. The scientific scope includes studies of responses to vaccines and specific vaccine components, including how they interact with the body and trigger immune or inflammatory pathways.
Is genetics-based vaccine safety research within scope?
Yes. A stated theme is the role of genetics in shaping immune or physiological responses, including research aimed at understanding why rare adverse events may occur in some individuals but not others.
Are biomarker or risk-factor studies relevant to this announcement?
Yes. The announcement encourages identification of risk factors and biological markers that can support better assessment of potential relationships between diseases/disorders and licensed vaccines and improve evaluation of safety signals.
Are genomic and molecular technology approaches encouraged?
Yes. The announcement explicitly encourages the use of genomic and molecular technologies as a way to deepen vaccine safety knowledge, clarify mechanisms, and improve tools used for safety assessment.
How much funding is available per award?
The source data lists an award ceiling of $200,000, indicating an upper limit for the award amount under this opportunity as presented in the listing.
Are the number of awards and total dollars fixed?
No. NIH indicates the total number of awards and total dollars awarded are not fixed in advance and will depend on factors such as the number of applications received, scientific quality, and the proposed budgets and timelines.
How long can projects last under this opportunity?
NIH indicates that project duration may vary depending on the nature and scope of the proposed work, and on the proposed timelines in applications.
Is cost sharing or matching required?
No. The listing states there is no cost sharing or matching requirement, meaning applicants are not required to commit institutional funds as a condition of eligibility.
What types of organizations are eligible to apply?
Eligibility is broad and includes many organization types, including:
- Public and private institutions of higher education
- Nonprofit organizations (both 501(c)(3) and non-501(c)(3))
- For-profit organizations (including small businesses and other for-profits)
- State, county, city/township governments
- Special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Native American tribal governments (federally recognized and other than federally recognized)
- Tribal organizations and tribally controlled colleges and universities
- Alaska Native and Native Hawaiian Serving Institutions
- Hispanic-serving institutions
- Historically Black Colleges and Universities (HBCUs)
- Faith-based or community-based organizations
- Eligible agencies of the federal government
- U.S. territories or possessions
- Regional organizations
- Non-U.S. (foreign) entities
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility list explicitly includes non-U.S. (foreign) entities.
Does the opportunity include tribal governments and tribal organizations?
Yes. The eligibility list includes Native American tribal governments (federally recognized and other than federally recognized), tribal organizations, and tribally controlled colleges and universities.
Which research program areas or fields does this opportunity connect to?
The opportunity is associated with multiple CFDA program areas, reflecting that vaccine safety research can span many fields. The listing includes areas such as allergy/immunology, microbiology and infectious diseases, child health, nursing research, environmental health, mental health research grants, and applied public health research.
When was this opportunity posted, and what are the key dates shown in the listing?
The posting date in the source data is August 28, 2008. The latest closing date provided is January 7, 2012, and the archive date is February 7, 2012. The record also shows later administrative dates.
Where can applicants find the full announcement?
The full announcement is linked through the NIH grants guide at: http://grants.nih.gov/grants/guide/pa-files/PA-08-257.html
Who should be contacted for access or technical issues with the announcement link?
The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) webmaster: FBOWebmaster@OD.NIH.GOV
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 08 257) also looked into and applied for these:
| Funding Opportunity |
|---|
| Mentored Research Scientist Development Award (K01) Apply for PA 06 001 Funding Number: PA 06 001 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Independent Scientist Award (K02) Apply for PA 06 527 Funding Number: PA 06 527 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Independent Scientist Award (K02) Apply for PA 09 038 Funding Number: PA 09 038 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21) Apply for PA 09 164 Funding Number: PA 09 164 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (F33) Apply for PA 09 211 Funding Number: PA 09 211 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| The Human Connectome Project (U54) Apply for RFA MH 10 020 Funding Number: RFA MH 10 020 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Bioengineering Nanotechnology Initiative (STTR R41/R42 Apply for PA 09 266 Funding Number: PA 09 266 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Bioengineering Research Grants (BRG)(R01) Apply for PA 10 009 Funding Number: PA 10 009 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Exploratory/Developmental Bioengineering Research Grants (EBRG) R21 Apply for PA 10 010 Funding Number: PA 10 010 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32) Apply for PA 10 036 Funding Number: PA 10 036 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award Short Term Institutional Research Training Grants (T35) Apply for PA 10 037 Funding Number: PA 10 037 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Blueprint Program for Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences (R25) Apply for RFA MH 10 070 Funding Number: RFA MH 10 070 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02) Apply for PA 10 057 Funding Number: PA 10 057 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| NIH Exploratory Developmental Research Grant Program (Parent R21) Apply for PA 10 069 Funding Number: PA 10 069 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellows (Parent F33) Apply for PA 10 111 Funding Number: PA 10 111 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Promoting Health Literacy (R03) Apply for PAR 10 134 Funding Number: PAR 10 134 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Understanding and Promoting Health Literacy (R21) Apply for PAR 10 135 Funding Number: PAR 10 135 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21) Apply for PAR 10 137 Funding Number: PAR 10 137 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Innovative Neuroscience K 12 Education (SBIR R43/R44) Apply for PAR 10 154 Funding Number: PAR 10 154 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Research on Autism and Autism Spectrum Disorders (R01) Apply for PA 10 158 Funding Number: PA 10 158 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
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