Opportunity Information: Apply for RFA AI 16 039

  • The HHS-NIH11 in the education, health, income security and social services sector is offering a public funding opportunity titled "Revision Applications for U.S-South Africa Program for Collaborative Biomedical Research (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.396, 93.399, 93.855, 93.856, 93.865,.
  • This funding opportunity was created on May 11, 2016 and posted on May 11, 2016.
  • Applicants must submit their applications by Aug 02, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:

Revision Applications for U.S-South Africa Program for Collaborative Biomedical Research (R01) is a National Institutes of Health (NIH) funding opportunity issued by the U.S. Department of Health and Human Services (HHS) under the U.S.-South Africa Program for Collaborative Biomedical Research. It is structured as a discretionary grant using the R01 mechanism, and it specifically supports revision applications, meaning it is aimed at expanding or enhancing already-funded or already-established collaborative research activities rather than launching entirely new, unrelated projects. The overarching intent is to strengthen and broaden the scope of existing U.S.-South Africa biomedical research collaborations by adding targeted components that align with the program goals.

A central focus of this FOA is workforce development and equity in research participation within South Africa. The revisions are meant to increase the number and meaningful engagement of underrepresented scientists, defined in this announcement as Black South African investigators based at historically disadvantaged institutions (HDIs) and other Universities of Technology. In practice, the funding is meant to help these researchers take on deeper roles in collaborative projects, build research capacity, and expand their participation in high-impact international research partnerships. While the mechanism is an R01 research grant, the revision emphasis signals that applicants are expected to propose concrete expansion activities that integrate underrepresented scientists into collaborative research in sustained and substantive ways.

The scientific areas supported by the opportunity are centered on major infectious disease and related health burdens affecting South Africa and global public health. Priority topics include tuberculosis (TB), HIV/AIDS biomedical research, HIV/AIDS behavioral science, and HIV-related co-morbidities. The FOA also explicitly includes malignancies as part of HIV-associated co-morbidity research, reflecting the clinical reality that immunosuppression and long-term HIV infection can elevate cancer risks and complicate care. Overall, the supported research domains span both biological mechanisms and behavioral or implementation-related dimensions of disease prevention, treatment, and outcomes, as long as they fit within the TB and HIV/AIDS landscape and strengthen collaborative U.S.-South Africa research efforts.

Administratively, the opportunity was posted May 11, 2016, with an application due date of August 2, 2016. The award ceiling listed is $200,000, indicating the maximum additional funding anticipated per award under the revision, and it is positioned as a limited, targeted supplement to expand specific activities rather than a full-scale, multi-million-dollar R01 budget. The number of expected awards is not specified in the provided source data. Eligibility is described broadly as "Others (see text field entitled Additional Information on Eligibility for clarification)," which signals that applicants needed to consult the full FOA text for precise eligibility rules, such as which organizations and partnerships qualify and what conditions apply to revision submissions under the U.S.-South Africa collaboration framework.

This FOA is associated with multiple CFDA numbers (93.242, 93.396, 93.399, 93.855, 93.856, 93.865), which typically indicates involvement of several NIH Institutes or program authorities that can support research in the covered disease and health areas. Taken together, the opportunity is best understood as a targeted NIH effort to extend and deepen existing U.S.-South Africa collaborative R01 research by adding components that directly expand participation, training, and leadership opportunities for Black South African scientists at HDIs and Universities of Technology, within priority research areas of TB, HIV/AIDS (biomedical and behavioral), and HIV-associated co-morbidities including cancers.

Frequently Asked Questions (FAQs)

What is the name of this grant opportunity?

The opportunity is titled "Revision Applications for U.S-South Africa Program for Collaborative Biomedical Research (R01)."

Which agency is offering this funding opportunity?

This is a National Institutes of Health (NIH) funding opportunity issued by the U.S. Department of Health and Human Services (HHS) under the U.S.-South Africa Program for Collaborative Biomedical Research.

What type of funding mechanism is being used?

The program uses the NIH R01 research grant mechanism and is structured as a discretionary grant.

Is this opportunity for new projects or for changes to existing projects?

This FOA specifically supports revision applications. That means it is intended to expand or enhance already-funded or already-established U.S.-South Africa collaborative research activities, rather than starting entirely new, unrelated projects.

What is the main purpose of the revision applications under this FOA?

The overarching intent is to strengthen and broaden the scope of existing U.S.-South Africa biomedical research collaborations by adding targeted components that align with the program goals.

What does the FOA emphasize in terms of workforce development and equity?

A central focus is workforce development and equity in research participation within South Africa. The revisions are meant to increase the number and meaningful engagement of underrepresented scientists in South Africa within these collaborations.

Who is considered an underrepresented scientist in this announcement?

In this announcement, underrepresented scientists are defined as Black South African investigators based at historically disadvantaged institutions (HDIs) and other Universities of Technology.

What kinds of activities should a revision propose to match the FOA intent?

Applicants are expected to propose concrete expansion activities that integrate underrepresented scientists into collaborative research in sustained and substantive ways, including deeper roles in collaborative projects, research capacity building, and expanded participation in high-impact international research partnerships.

What research topics are supported by this opportunity?

The supported scientific areas focus on major infectious disease and related health burdens affecting South Africa and global public health, especially tuberculosis (TB) and HIV/AIDS.

Does the FOA include both biomedical and behavioral research for HIV/AIDS?

Yes. Priority topics explicitly include HIV/AIDS biomedical research and HIV/AIDS behavioral science.

Are HIV-related co-morbidities included, and what does that cover?

Yes. The FOA includes HIV-related co-morbidities. It also explicitly includes malignancies as part of HIV-associated co-morbidity research.

Why are malignancies mentioned in this FOA?

Malignancies are included to reflect the clinical reality that immunosuppression and long-term HIV infection can elevate cancer risks and complicate care, making them relevant to HIV-associated co-morbidity research.

Is the research scope limited to biological studies only?

No. The opportunity spans both biological mechanisms and behavioral or implementation-related dimensions of disease prevention, treatment, and outcomes, as long as the work fits within the TB and HIV/AIDS landscape and strengthens U.S.-South Africa collaborations.

When was this funding opportunity posted?

The opportunity was posted on May 11, 2016.

What was the application due date?

The application due date listed is August 2, 2016.

What is the maximum award amount mentioned for this revision opportunity?

The award ceiling listed is $200,000, indicating the maximum additional funding anticipated per award under the revision.

Does the $200,000 ceiling represent a full R01 budget?

No. Based on the description provided, it is positioned as a limited, targeted amount to expand specific activities under a revision, rather than a full-scale multi-million-dollar R01 budget.

How many awards were expected to be made?

The number of expected awards is not specified in the provided information.

Who is eligible to apply?

Eligibility is described broadly as "Others (see text field entitled Additional Information on Eligibility for clarification)." This indicates applicants would need to consult the full FOA text for precise eligibility rules and conditions related to revision submissions under the U.S.-South Africa collaboration framework.

Why does the eligibility section say "Others" instead of listing specific organization types?

Based on the provided information, "Others" signals that the FOA likely contains additional eligibility details and requirements in a separate section (the "Additional Information on Eligibility" text field) rather than summarizing them in a short category list.

What CFDA numbers are associated with this FOA?

This FOA is associated with multiple CFDA numbers: 93.242, 93.396, 93.399, 93.855, 93.856, and 93.865.

What does it mean that multiple CFDA numbers are listed?

Multiple CFDA numbers typically indicate involvement of several NIH Institutes or program authorities that can support research in the covered disease and health areas described in the opportunity.

What is the overall takeaway for applicants considering this FOA?

This opportunity is best understood as a targeted NIH effort to extend and deepen existing U.S.-South Africa collaborative R01 research by adding components that directly expand participation, training, capacity, and leadership opportunities for Black South African scientists at HDIs and Universities of Technology within priority areas of TB, HIV/AIDS (biomedical and behavioral), and HIV-associated co-morbidities including cancers.

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