Opportunity Information: Apply for PAR 13 172
Apply for PAR 13 172
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Revision Applications to R01 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394 Cancer Detection and Diagnosis Research.
- This funding opportunity was created on Apr 11, 2013 and posted on Apr 11, 2013.
- Applicants must submit their applications by Dec 11, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: Private institutions of higher education Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Small businesses County governments Public housing authorities/Indian housing authorities State governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity PAR-13-172, titled "Revision Applications to R01 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (R01)," was a discretionary grant program designed specifically for investigators who already held an active NIH R01 award and wanted to expand that existing project in a targeted way. Rather than supporting entirely new, stand-alone projects, this announcement focused on revision applications (previously known as competing revisions). In practical terms, that meant applicants needed to propose clearly defined, additional work that fit as new specific aims under the umbrella of the currently funded parent R01, thereby expanding the scientific scope of the ongoing grant.
The central scientific emphasis of the FOA was on improving detection and risk assessment for cancers that arise from carcinogenic pathogens, with a strong push toward understanding the biological interplay among three elements: the pathogen itself, the human host, and the human microbiome. The program sought research that could clarify how pathogen-driven processes interact with microbial communities and host responses in ways that either initiate cancer or promote the transition from chronic infection and inflammation to invasive disease. A key theme running through the announcement was the idea that pathogen-induced carcinogenesis often involves a long pre-cancer phase, and that measurable molecular signals during that window might be used to identify risk earlier, improve early detection strategies, and better understand mechanisms of progression.
Within that scope, the FOA explicitly encouraged studies aimed at identifying and validating molecular signatures linked to (1) risk of developing pathogen-induced cancers and (2) early detection of those cancers. It also emphasized chronic inflammation as a biological bridge between infection and invasive malignancy, encouraging applicants to investigate inflammatory signatures or related markers that track with progression. The overall goal was to support incremental, strategically chosen expansions of existing R01 projects that could yield new knowledge or tools relevant to detection of pathogen-induced cancer, especially where microbiome-pathogen-host interactions might produce diagnostic or prognostic markers.
From an administrative and programmatic standpoint, the opportunity fell under the NIH activity code R01 and was categorized under the CFDA number 93.394, Cancer Detection and Diagnosis Research. There was no cost sharing or matching requirement. The award ceiling listed for the revision component was $150,000, signaling that the add-on work was intended to be substantial enough to add meaningful new aims, but still bounded as a supplement-like expansion rather than a full new grant of typical R01 scale.
Eligibility was broad in terms of institution types, spanning public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels of government entities (state, county, city/township, special district, and certain housing authorities). The FOA also made clear that a wide range of mission-driven and community-oriented organizations could be eligible, including faith-based and community-based organizations, and it explicitly included many institution categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI institutions. Notably, foreign organizations and foreign institutions were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were allowed, which opened the door for international collaborations or research programs where pathogen-associated cancers may be highly prevalent.
In terms of timing, the FOA was posted on April 11, 2013, with an original and final closing date of December 11, 2015, and it was archived on January 11, 2016. The sponsoring agency was the NIH, and the full announcement was made available through the NIH grants guide at the link provided in the source material. For access or technical issues, the contact point listed was the NIH Office of Extramural Research (OER) webmaster.
FAQs: NIH PAR-13-172 (Revision Applications to R01 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (R01))
What is PAR-13-172?
PAR-13-172 is an NIH funding opportunity announcement titled "Revision Applications to R01 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (R01)." It supported revision applications (previously called competing revisions) to expand the scientific scope of an existing, active NIH R01 award with clearly defined new work.
Is this opportunity for new, stand-alone research projects?
No. This FOA was designed for revision applications to an already-funded parent R01. Applicants were expected to propose additional work framed as new specific aims that fit under the umbrella of the active R01, rather than proposing an entirely separate project.
Who was the intended applicant?
The intended applicant was an investigator who already held an active NIH R01 award and wanted to add a targeted, well-justified expansion to that existing project focused on detection and risk assessment in pathogen-induced cancers.
What type of application did this FOA request?
This FOA focused on revision applications (competing revisions) to existing R01 awards. The proposed work needed to be incremental and strategically chosen, adding meaningful new aims while remaining part of the parent R01 project.
What is the main scientific focus of the FOA?
The central focus was improving detection and risk assessment for cancers caused by carcinogenic pathogens. A strong emphasis was placed on understanding interactions among the pathogen, the human host, and the human microbiome, especially as they relate to cancer initiation and progression.
What kinds of biological interactions were emphasized?
The FOA highlighted the biological interplay among three elements: the pathogen itself, the human host, and the human microbiome. It encouraged work that clarifies how pathogen-driven processes interact with microbial communities and host responses in ways that can initiate cancer or promote progression from chronic infection and inflammation to invasive disease.
Why did the FOA emphasize a "pre-cancer phase"?
The FOA noted that pathogen-induced carcinogenesis often includes a long pre-cancer window. It emphasized that measurable molecular signals during this period could help identify risk earlier, improve early detection strategies, and illuminate mechanisms of progression toward invasive cancer.
What kinds of research were explicitly encouraged?
The FOA explicitly encouraged studies that identify and validate molecular signatures associated with (1) risk of developing pathogen-induced cancers and (2) early detection of those cancers.
Did the FOA mention inflammation-related research?
Yes. Chronic inflammation was described as a biological bridge between infection and invasive malignancy. The FOA encouraged investigating inflammatory signatures or related markers that track with progression.
What was the overall goal of the FOA?
The overall goal was to support incremental expansions of existing R01 projects that could produce new knowledge or tools relevant to detection of pathogen-induced cancer, particularly where microbiome-pathogen-host interactions might yield diagnostic or prognostic markers.
What NIH activity code applied to this opportunity?
The opportunity used the NIH activity code R01.
What CFDA number was associated with this FOA?
The FOA was categorized under CFDA 93.394, Cancer Detection and Diagnosis Research.
Was there a cost sharing or matching requirement?
No. The FOA stated there was no cost sharing or matching requirement.
What was the funding limit for the revision component?
The listed award ceiling for the revision component was $150,000. This indicated an add-on scope intended to be substantial enough to support meaningful new aims, but still bounded as an expansion rather than a full new R01-scale project.
What types of organizations were eligible to apply?
Eligibility included a wide range of organization types: public and private institutions of higher education; nonprofits (including 501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses and other for-profits); and multiple levels of government entities (state, county, city/township, special district, and certain housing authorities). Faith-based and community-based organizations were also included among eligible applicants.
Were minority-serving and specialized institutions included in eligibility?
Yes. The FOA explicitly included categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI institutions.
Were foreign organizations eligible?
Yes. Foreign organizations and foreign institutions were eligible to apply. The FOA also allowed non-U.S. components of U.S. organizations and permitted foreign components (as defined by NIH policy), supporting international collaborations or research in regions where pathogen-associated cancers may be prevalent.
When was the FOA posted, and when did it close?
The FOA was posted on April 11, 2013. The original and final closing date was December 11, 2015.
Is this FOA still active?
No. It was archived on January 11, 2016.
Which agency sponsored this funding opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
Where was the full announcement made available?
The full announcement was made available through the NIH grants guide at the link provided in the source material.
Who was listed as the contact for access or technical issues?
For access or technical issues, the listed contact point was the NIH Office of Extramural Research (OER) webmaster.
Browse more opportunities from the same category: Education Health
Next opportunity: Revision Applications to U01 Awards on Detection of Pathogen Induced Cancer (DPIC) (U01)
Previous opportunity: Revision Applications to P50 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P50)
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 13 172) also looked into and applied for these:
| Funding Opportunity |
|---|
| Revision Applications to U01 Awards on Detection of Pathogen Induced Cancer (DPIC) (U01) Apply for PAR 13 173 Funding Number: PAR 13 173 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Revision Applications to P01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P01) Apply for PAR 13 175 Funding Number: PAR 13 175 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Revisions to P50 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (P50) Apply for PAR 13 170 Funding Number: PAR 13 170 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Revisions to P01 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (P01) Apply for PAR 13 171 Funding Number: PAR 13 171 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Paul Calabresi Career Development Award for Clinical Oncology (K12) Apply for PAR 13 201 Funding Number: PAR 13 201 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Symptom Management in HIV Infected Individuals with Comorbid Conditions (R01) Apply for PA 13 210 Funding Number: PA 13 210 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Symptom Management in HIV Infected Individuals with Comorbid Conditions (R21) Apply for PA 13 211 Funding Number: PA 13 211 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Innovative Measurement Tools for Community Engaged Research Efforts (R01) Apply for PA 13 209 Funding Number: PA 13 209 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Innovative Measurement Tools for Community Engaged Research Efforts (R21) Apply for PA 13 212 Funding Number: PA 13 212 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Limited Competition Fogarty HIV Research Training Program for Low and Middle Income Country Institutions (D43) Apply for PAR 13 126 Funding Number: PAR 13 126 Agency: National Institutes of Health Category: Education Health Funding Amount: $282,000 |
| Medications Development Centers of Excellence Cooperative Program (U54) Apply for RFA DA 14 004 Funding Number: RFA DA 14 004 Agency: National Institutes of Health Category: Education Health Funding Amount: $1,000,000 |
| Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R01) Apply for RFA DA 14 005 Funding Number: RFA DA 14 005 Agency: National Institutes of Health Category: Education Health Funding Amount: $350,000 |
| Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R21) Apply for RFA DA 14 006 Funding Number: RFA DA 14 006 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Integration and Analysis of Diverse HIV Associated Data (R03) Apply for RFA MH 14 200 Funding Number: RFA MH 14 200 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NIDA Research Center of Excellence Grant Program (P50) Apply for PAR 13 222 Funding Number: PAR 13 222 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| FY14 NIDA Avant Garde Award Program for HIV/AIDS Research (DP1) Apply for RFA DA 14 008 Funding Number: RFA DA 14 008 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Integrating Substance Abuse Prevention and Treatment within HIV/AIDS Service Delivery Settings (R01) Apply for RFA DA 14 011 Funding Number: RFA DA 14 011 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| HIV/AIDS and Substance Use among Black/African American Women and Young MSM (R01) Apply for RFA DA 14 010 Funding Number: RFA DA 14 010 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| HIV/AIDS and Substance Use Among the Homeless and Unstably Housed (R01) Apply for RFA DA 14 009 Funding Number: RFA DA 14 009 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Comorbid HIV, Chronic Pain, and Substance Use among Older Adults (R21) Apply for RFA DA 14 012 Funding Number: RFA DA 14 012 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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