Opportunity Information: Apply for PAR 13 173
Apply for PAR 13 173
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Revision Applications to U01 Awards on Detection of Pathogen Induced Cancer (DPIC) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394 Cancer Detection and Diagnosis Research.
- This funding opportunity was created on Apr 11, 2013 and posted on Apr 11, 2013.
- Applicants must submit their applications by Dec 11, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments County governments Public and State controlled institutions of higher education Private institutions of higher education Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) For profit organizations other than small businesses Public housing authorities/Indian housing authorities City or township governments Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Revision Applications to U01 Awards on Detection of Pathogen Induced Cancer (DPIC) (U01) is an NIH funding opportunity (PAR-13-173) that supports add-on, expanded work through revision applications to already-active NIH U01 cooperative agreement awards. In practical terms, it is not meant for brand-new standalone projects; it is specifically for investigators who already hold an active U01 and want to propose new, additional specific aims that broaden and extend the scientific scope of their parent U01 project. The overall purpose is to accelerate research that improves the detection of cancers driven by infectious agents, with a strong emphasis on how carcinogenic pathogens interact with the human microbiome and the human host in ways that can be measured and used for risk assessment or earlier diagnosis.
The scientific focus centers on pathogen-induced cancer (DPIC) and the biological events that lead from infection to chronic inflammation and, ultimately, invasive malignancy. The FOA encourages studies that identify and evaluate molecular signatures linked to risk and early detection, including signatures that reflect pathogen presence, host response, microbiome changes, and inflammatory pathways associated with progression. A key theme is the interplay among three elements: the cancer-causing pathogen, the surrounding microbial community (the microbiome), and the host environment. Revision applications are expected to leverage the foundation of the existing U01 project and add targeted aims that can deepen mechanistic understanding and/or yield practical detection approaches, such as biomarkers or other molecular indicators that signal early disease or elevated risk before clinically apparent cancer develops.
The mechanism is a cooperative agreement (U01), which typically implies a more active partnership with NIH staff compared to a standard research project grant. While the announcement text provided here does not detail the cooperative terms, the U01 structure generally indicates that NIH program staff may have substantial involvement in coordinating or guiding aspects of the supported research, especially when projects are part of a broader program area.
From an administrative standpoint, the opportunity is categorized as discretionary funding and falls under the health and education-related activity area, with CFDA number 93.394 (Cancer Detection and Diagnosis Research). The award ceiling is listed as $150,000, and there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of the award. The FOA was posted on April 11, 2013, and the application window extended through a closing date of December 11, 2015, with the opportunity archived on January 11, 2016.
Eligibility is broad across many organization types, but it is still constrained by the central requirement that applicants must have an active NIH U01 award to submit a revision under this FOA. Eligible applicant organizations include a wide range of public and private entities such as state, county, city or township governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; small businesses and other for-profit organizations; independent school districts; public housing authorities/Indian housing authorities; special district governments; Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments). The FOA also explicitly notes additional eligible applicants and organizational categories including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
International participation is also allowed. Non-U.S. entities (foreign organizations and foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by the NIH Grants Policy Statement) are permitted. This international openness matters because pathogen-associated cancers and microbiome-pathogen-host interactions can vary geographically, and some of the most informative cohorts, pathogen exposures, or strain diversity may exist outside the United States.
The bottom-line intent of the FOA is to use revision funding to rapidly build on existing U01 projects in ways that strengthen the field’s ability to detect pathogen-driven cancers earlier and more accurately, using measurable molecular and inflammatory signatures that reflect real biological interactions among pathogens, microbiota, and host responses. For applicants, the central fit question is whether the proposed new work clearly constitutes additional aims that extend the parent U01 and directly addresses detection-relevant science for pathogen-induced cancers, especially through the lens of microbiome-host-pathogen dynamics and the molecular signals tied to risk, early disease, and inflammation-related progression.
For full details and the official announcement language, NIH provided an additional information link: http://grants.nih.gov/grants/guide/pa-files/PAR-13-173.html. For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
1) What is this funding opportunity?
This opportunity is NIH PAR-13-173, titled "Revision Applications to U01 Awards on Detection of Pathogen Induced Cancer (DPIC) (U01)." It supports revision applications that add on to an already-active NIH U01 cooperative agreement award in the DPIC area.
2) Is this meant for brand-new projects?
No. It is not intended for brand-new, standalone projects. It is specifically for investigators who already hold an active NIH U01 award and want to propose additional work as a revision to expand the scope of their existing (parent) U01.
3) What does "revision application" mean in this context?
In this FOA, a revision is an add-on to an existing active U01 that proposes new, additional specific aims that broaden and extend the scientific scope of the parent U01 project, rather than replacing it or starting a separate project.
4) What is the overall purpose of the FOA?
The purpose is to accelerate research that improves detection of cancers driven by infectious agents, with a strong emphasis on measurable interactions among carcinogenic pathogens, the human microbiome, and the human host that can be used for risk assessment or earlier diagnosis.
5) What scientific area does this focus on?
The scientific focus is pathogen-induced cancer (DPIC) and the biological events that lead from infection to chronic inflammation and, ultimately, invasive malignancy.
6) What kinds of research topics are encouraged?
The FOA encourages studies that identify and evaluate molecular signatures linked to risk and early detection. Examples of signature categories mentioned include those reflecting pathogen presence, host response, microbiome changes, and inflammatory pathways associated with progression.
7) What is the emphasis regarding microbiome and host-pathogen interactions?
A key theme is the interplay among three elements: the cancer-causing pathogen, the surrounding microbial community (the microbiome), and the host environment. Proposed revision aims are expected to engage with this dynamic and produce detection-relevant insights (for example, signatures that can be measured for risk or early disease).
8) What is meant by "detection" in this FOA?
Based on the description provided, "detection" is centered on improving the ability to identify pathogen-driven cancers earlier and more accurately, including identifying measurable molecular and inflammatory signatures that signal early disease or elevated risk before clinically apparent cancer develops.
9) Are biomarker or molecular indicator approaches within scope?
Yes. The FOA explicitly highlights the goal of yielding practical detection approaches such as biomarkers or other molecular indicators tied to early disease or elevated risk.
10) What award mechanism is used?
The mechanism is a cooperative agreement (U01).
11) What does a U01 cooperative agreement imply?
The provided text notes that U01s typically involve a more active partnership with NIH staff than a standard research project grant. While cooperative terms are not detailed in the summary provided, the U01 structure generally indicates NIH program staff may have substantial involvement in coordinating or guiding aspects of the supported research, especially within broader program areas.
12) Who is eligible to apply?
Eligibility includes many organization types, but it is constrained by a central requirement: applicants must have an active NIH U01 award to submit a revision under this FOA.
13) What types of U.S. organizations are listed as eligible?
The FOA description includes (among others): state, county, city or township governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; small businesses and other for-profit organizations; independent school districts; public housing authorities/Indian housing authorities; special district governments; Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments).
14) Are specific institution categories like HBCUs or HSIs mentioned as eligible?
Yes. The FOA explicitly notes eligibility for categories including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
15) Are faith-based or community-based organizations eligible?
Yes. The FOA description explicitly includes faith-based or community-based organizations as eligible organizational categories (subject to the overarching requirement of having an active NIH U01 for a revision submission).
16) Are federal agencies and U.S. territories included?
Yes. The FOA description includes eligible federal agencies and U.S. territories or possessions among eligible applicant categories (again, within the constraint that the applicant must be submitting a revision to an active NIH U01 award).
17) Are international (non-U.S.) applicants allowed?
Yes. The FOA description states that non-U.S. entities (foreign organizations and foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by the NIH Grants Policy Statement) are permitted.
18) Why might international participation matter for this FOA?
The description notes that pathogen-associated cancers and microbiome-pathogen-host interactions can vary geographically, and some informative cohorts, pathogen exposures, or strain diversity may exist outside the United States.
19) What is the activity area and CFDA number?
The opportunity is described as discretionary funding under the health and education-related activity area, with CFDA number 93.394 (Cancer Detection and Diagnosis Research).
20) What is the maximum award amount listed?
The award ceiling is listed as $150,000.
21) Is cost sharing or matching required?
No. The description states there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of the award.
22) When was the FOA posted and what were the key dates?
The FOA was posted April 11, 2013. The application window extended through a closing date of December 11, 2015. The opportunity was archived on January 11, 2016.
23) How should applicants judge whether their proposed revision is a good fit?
The central fit question described is whether the proposed new work clearly constitutes additional aims that extend the parent U01 and directly addresses detection-relevant science for pathogen-induced cancers, especially through microbiome-host-pathogen dynamics and molecular signals tied to risk, early disease, and inflammation-related progression.
24) Where is the official NIH announcement and full details?
NIH provided an information link to the official announcement language: http://grants.nih.gov/grants/guide/pa-files/PAR-13-173.html.
25) Who is listed for technical issues accessing the announcement?
For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Browse more opportunities from the same category: Education Health
Next opportunity: Revision Applications to P01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P01)
Previous opportunity: Revision Applications to R01 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (R01)
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| Revision Applications to P01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P01) Apply for PAR 13 175 Funding Number: PAR 13 175 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
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| Comorbid HIV, Chronic Pain, and Substance Use among Older Adults (R21) Apply for RFA DA 14 012 Funding Number: RFA DA 14 012 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research to Characterize and Reduce Stigma to Improve Health (R21) Apply for PA 13 246 Funding Number: PA 13 246 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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