Revision Applications to U01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (U01) | Apply Online

Opportunity Summary:

This grant opportunity, PAR 13-176, is an NIH Funding Opportunity Announcement for revision applications to existing NIH U01 cooperative agreement awards that are already supporting research on imaging and biomarkers for early cancer detection. It is not a stand-alone U01 for new projects. Instead, it is meant for investigators who already hold an active, funded NIH U01 in this scientific area and who want to expand that ongoing project by adding new work through a formal “revision” (often called a competing supplement in other contexts, but here specifically framed as a revision to the parent award). The main expectation is that the proposed revision adds clear, additional specific aims that broaden the scope of the parent U01 rather than simply continuing or extending what is already funded.

The scientific focus is tightly defined around combining imaging and biomarker approaches to improve cancer screening, early detection, and diagnostic decision-making. The FOA emphasizes integration, meaning applicants are expected to link multi-modality imaging strategies with multiplexed biomarker methodologies in a coordinated way, rather than proposing imaging-only work or biomarker-only work. In practical terms, this points toward studies that intentionally connect different types of imaging (for example, pairing anatomic and functional methods, or combining radiologic imaging with optical or molecular imaging) with biomarker panels (for example, proteomic, genomic, epigenomic, metabolomic, or other multiplex assays) to improve the ability to detect cancer earlier, characterize suspicious findings, and better distinguish malignant from benign disease. The goal is to push beyond single-tool approaches and move toward integrated detection pipelines that can perform better in real-world screening and diagnostic settings.

Because this is a cooperative agreement (U01), the program structure implies substantial NIH involvement compared with a standard research project grant. While the FOA text provided here does not spell out the exact cooperative terms, U01 mechanisms generally include an active partnership between the awardee and NIH staff in areas such as project coordination, milestone monitoring, data and resource sharing expectations, and alignment with broader program goals. Applicants should therefore expect that the revised aims need to fit not only the scientific objectives of the parent award but also the collaborative framework and oversight style that comes with U01 funding.

From an administrative standpoint, the opportunity sits within the NIH’s cancer detection and diagnosis research space (CFDA 93.394). It is categorized as discretionary funding and uses the cooperative agreement funding instrument. The listed award ceiling is $150,000, indicating that revisions under this announcement are capped at that level (typically per year or per project period depending on the FOA specifics, but the ceiling provided here is $150,000 as the maximum). There is no cost sharing or matching requirement, which is consistent with most NIH research funding.

Eligibility is broad in terms of institution type, but it is layered on top of the core requirement that the applicant must already have an active NIH U01 award that is appropriate for this revision. Beyond that, eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (other than small businesses are explicitly included, and small businesses are also listed), and multiple levels of government such as state, county, city/township, special district governments, and eligible federal agencies. The FOA also explicitly includes a wide range of mission-driven and underserved-serving institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations. Importantly, foreign organizations and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed under NIH policy, which signals that international collaboration or internationally based work can be supported when justified and compliant with NIH grants policy.

Key dates show the FOA was posted and created on April 11, 2013, with an original and current closing date of December 11, 2015, and an archive date of January 11, 2016. That means the opportunity is now archived and no longer open for applications, but the summary remains useful as a reference for the type of work NIH was seeking in that period and for understanding how NIH structured revisions to cooperative agreements in early cancer detection research.

In essence, PAR 13-176 was designed to let existing NIH U01 teams meaningfully expand their funded early cancer detection projects by adding new, well-justified aims that integrate complementary imaging and multiplex biomarker strategies. The intent was to accelerate progress toward better screening and earlier, more accurate detection and diagnosis by encouraging coordinated, multi-technology approaches within the structure of an NIH-managed cooperative agreement.

For the full archived announcement, NIH provided the link: http://grants.nih.gov/grants/guide/pa-files/PAR-13-176.html. For technical access or linking issues, the contact listed is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

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