Opportunity Information: Apply for RFA CA 16 012

  • The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Revisions Applications to P50 Awards for Research on NCI's Provocative Questions (P50)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
  • This funding opportunity was created on Mar 29, 2016 and posted on Mar 29, 2016.
  • Applicants must submit their applications by Oct 28, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $150,000.00 in funding.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: State governments, County governments, Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for RFA CA 16 012

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Opportunity Summary:

The funding opportunity titled "Revisions Applications to P50 Awards for Research on NCI's Provocative Questions (P50)" (Funding Opportunity Number RFA-CA-16-012) is a discretionary NIH grant announcement from the National Cancer Institute (listed under HHS-NIH11). It is designed specifically for institutions that already hold an active, currently funded NCI P50 Center award and want to submit a revision application. In other words, it is not meant for brand-new P50 center proposals; it is meant to add or expand work within an existing NCI-designated P50 center through a formal revision mechanism.

The main purpose of the announcement is to stimulate focused cancer research that addresses one of the NCI "Provocative Questions" (PQs). The FOA points applicants to 12 specific PQs that were previously published under the NCI PQ initiatives referenced in RFA-CA-15-008 and RFA-CA-15-009 (which originally targeted new R01 and R21 applications). Under this revision FOA, a P50 center is expected to propose research that clearly aligns with and responds to one of those 12 questions. The intent is to push investigators toward challenging, high-impact scientific problems that the NCI has highlighted as gaps or bottlenecks in cancer research and cancer care.

A key requirement is that the revision must include a new research project that expands the overall scope of the parent P50 award while still remaining integrated with the center's overarching theme. The proposed work cannot be a minor tweak to an existing project; it needs to be a substantive addition that fits within the scientific identity and coordinated structure of the funded P50 center. The FOA also encourages projects that do more than just ask a provocative question in principle. It explicitly welcomes studies that help validate outcomes from PQ-related research and studies that help adopt, translate, disseminate, or otherwise move PQ-driven results into broader cancer research use and potentially into clinical care impact. That emphasis signals an interest in both discovery and practical follow-through, as long as the work remains anchored to one of the designated PQs.

From an administrative and funding standpoint, this is a grant mechanism with an award ceiling of $150,000 and an expectation of about three awards. The announcement was posted and created on March 29, 2016, with an original and current closing date of October 28, 2016. It falls under multiple CFDA numbers associated with NCI research and cancer center-related activities (93.393, 93.394, 93.395, 93.396, 93.399), reflecting the broad NCI funding umbrella under which P50 centers and related research may sit.

Eligibility is broad in terms of organizational type, though the practical eligibility is narrowed by the requirement that applicants must be currently funded NCI P50 Centers. Within that constraint, the FOA lists many categories of organizations that may apply, including state and county governments, public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (excluding IHE in those nonprofit categories), for-profit organizations other than small businesses, small businesses, and other entities as allowed under the additional eligibility guidance. The overall takeaway is that the FOA is a targeted supplement/revision-style opportunity: it aims to leverage the infrastructure and collaborative environment of existing NCI P50 centers to quickly add a new, tightly aligned research project that tackles one of NCI's identified provocative questions and helps generate, validate, or disseminate results with potential to move the field forward.

Frequently Asked Questions (FAQs)

What is the name of this funding opportunity?

The opportunity is titled "Revisions Applications to P50 Awards for Research on NCI's Provocative Questions (P50)."

What is the funding opportunity number (FOA number)?

The Funding Opportunity Number is RFA-CA-16-012.

Which agency is offering this opportunity?

This is an NIH grant announcement from the National Cancer Institute (NCI), listed under HHS-NIH11.

What type of application is this meant to support?

This FOA is specifically for revision applications to an existing, active, currently funded NCI P50 Center award. It is not intended for brand-new P50 center applications.

Who is eligible to apply?

Applicants must be institutions that already hold an active, currently funded NCI P50 Center award and are submitting a formal revision application to that parent award.

Does the FOA limit eligible organization types?

Yes and no. The FOA lists many eligible organization categories (such as governments, higher education institutions, nonprofits, for-profits, small businesses, and other eligible entities), but practical eligibility is narrowed by the requirement that the applicant must already be a currently funded NCI P50 Center.

What is the main purpose of this FOA?

The purpose is to stimulate focused cancer research that addresses one of NCI's "Provocative Questions" (PQs), targeting high-impact scientific challenges that NCI has identified as gaps or bottlenecks in cancer research and cancer care.

How many Provocative Questions can applicants choose from under this FOA?

The FOA points applicants to 12 specific Provocative Questions.

Where do the referenced Provocative Questions come from?

The 12 Provocative Questions referenced here were previously published under the NCI PQ initiatives referenced in RFA-CA-15-008 and RFA-CA-15-009 (which originally targeted new R01 and R21 applications).

Does the proposed revision need to align with a Provocative Question?

Yes. The revision application is expected to propose research that clearly aligns with and responds to one of the designated 12 Provocative Questions.

What is a key scientific requirement for the revision?

A key requirement is that the revision must include a new research project that expands the overall scope of the parent P50 award while still remaining integrated with the center's overarching theme.

Can the revision be a minor change to an existing project?

No. The FOA indicates the proposed work cannot be a minor tweak to an existing project; it needs to be a substantive addition that fits within the scientific identity and coordinated structure of the funded P50 center.

Does the FOA encourage research beyond basic discovery?

Yes. In addition to addressing a Provocative Question, the FOA explicitly welcomes studies that help validate outcomes from PQ-related research and studies that help adopt, translate, disseminate, or otherwise move PQ-driven results into broader cancer research use and potentially into clinical care impact.

Does the new project need to fit within the P50 center's theme?

Yes. The new project must expand the scope of the parent P50 while remaining integrated with the center's overarching theme and coordinated structure.

What is the maximum award amount (award ceiling)?

The award ceiling is $150,000.

How many awards are expected?

The FOA indicates an expectation of about three awards.

When was the announcement posted and created?

The announcement was posted and created on March 29, 2016.

What is the closing date for applications?

The original and current closing date listed is October 28, 2016.

Is this opportunity considered discretionary funding?

Yes. The opportunity is described as a discretionary NIH grant announcement.

Which CFDA numbers are associated with this FOA?

The FOA is associated with multiple CFDA numbers: 93.393, 93.394, 93.395, 93.396, and 93.399.

What is the overall intent of using P50 revisions for the Provocative Questions initiative?

The intent is to leverage the infrastructure and collaborative environment of existing NCI P50 centers to add a new, tightly aligned research project that tackles one of NCI's identified Provocative Questions and helps generate, validate, or disseminate results with potential to move the field forward.

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