Opportunity Information: Apply for RFA RM 13 022
Apply for RFA RM 13 022
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Revisions to Add Single Cell Analysis to Active Research Projects (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Dec 19, 2013 and posted on Dec 19, 2013.
- Applicants must submit their applications by Apr 4, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,200,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: State governments City or township governments Independent school districts Private institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Revisions to Add Single Cell Analysis to Active Research Projects (R01) (Funding Opportunity Number RFA-RM-13-022) is a National Institutes of Health (NIH) discretionary grant opportunity designed to help investigators already running active R01 projects add single cell analysis (SCA) capabilities through a new collaboration. The core idea is not to start a brand-new R01, but to revise an existing, currently funded R01 so it can incorporate and validate emerging single cell methods that allow researchers to interrogate biology at the level of individual cells, ideally in the native tissue context (in situ). NIH is aiming to speed up how quickly cutting-edge SCA approaches move from being specialized technologies to becoming broadly usable, well-tested tools that materially improve ongoing biomedical research projects.
A central requirement is that the collaboration must be new and must pair an active R01 investigator with a developer of a novel, powerful single cell analysis approach. The expectation is that the partnership will do more than simply provide a fee-for-service measurement. Instead, it should meaningfully advance the scientific aims of the parent R01 by enabling measurements, spatially resolved observations, or mechanistic insights that are only possible (or far more informative) when you can examine single cells rather than bulk tissue averages. At the same time, the user side of the collaboration (the R01-funded research team) is expected to provide iterative, informed feedback to the technology developer so the method can be refined, validated, and made more robust in real-world biological settings. NIH is explicitly trying to strengthen the interface between tool builders and tool users, because that loop is often what determines whether an innovation becomes a dependable research platform.
Programmatically, the opportunity is positioned as a catalyst for discovery and translation. By promoting adoption and validation of SCA approaches within active disease- and mechanism-focused R01 projects, NIH is aiming to accelerate fundamental biological insights, while also laying groundwork for clinical applications such as improved diagnostics and therapeutic strategies. Single cell measurements can reveal rare cell populations, transient cell states, cell-to-cell variability, and microenvironment effects that are masked in traditional bulk assays, and this opportunity is structured to push those advantages into ongoing mainstream research efforts.
The announcement strongly encourages collaborations with investigators funded through the NIH Common Fund Single Cell Analysis Program, signaling that NIH wants the methods emerging from that Common Fund investment to be tested, stress-tested, and improved through use in diverse biological systems. While such partnerships are not stated as mandatory in the provided text, the encouragement indicates alignment with broader NIH priorities and may strengthen the relevance of an application if the proposed technology comes from that ecosystem of SCA developers.
From an administrative and funding standpoint, this is a grant mechanism under the NIH umbrella with a Health-related funding activity category (CFDA 93.310, Trans-NIH Research Support). The opportunity does not require cost sharing or matching. NIH estimated total funding at $2.2 million, with an award ceiling of $250,000. The funding instrument type is listed as a grant, and the intent is to support R01 revisions that add SCA components to active projects, rather than to fund entirely new standalone projects.
Eligibility is broad and includes many organization types typically eligible for NIH funding. Eligible applicants include state, county, city/township, and special district governments; public and private institutions of higher education; nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits other than universities); small businesses and other for-profit organizations; public housing authorities and Indian housing authorities; and tribal organizations and tribal governments. The eligibility language also explicitly includes a wide range of mission-driven and capacity-building institutions such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, as well as faith-based and community-based organizations where applicable. Importantly, foreign organizations and foreign components are allowed: non-U.S. entities (foreign organizations) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined in the NIH Grants Policy Statement are permitted. This means collaborations can be structured to include international expertise when scientifically justified and compliant with NIH policy.
Key dates included a posted and creation date of December 19, 2013, with an original and current closing date of April 4, 2014, and an archive date of May 5, 2014. Even though it is archived, the description captures a common NIH pattern for technology-infused administrative supplements or revisions: leverage ongoing funded science, add a targeted capability, and require genuine partnership between domain scientists and method developers so both the biology and the technology improve.
For applicants looking at the full requirements, NIH provided an official announcement link (http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-13-022.html). For access or technical issues with the electronic announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the funding opportunity RFA-RM-13-022?
RFA-RM-13-022, titled "Revisions to Add Single Cell Analysis to Active Research Projects (R01)," is a National Institutes of Health (NIH) discretionary grant opportunity that supports revisions to already-active, currently funded NIH R01 research projects so they can add single cell analysis (SCA) capabilities through a new collaboration.
What is the main purpose of this opportunity?
The purpose is to accelerate the adoption, validation, and refinement of emerging single cell analysis methods by integrating them into ongoing R01 projects. NIH aims to move cutting-edge SCA approaches from specialized, early-stage technologies into broadly usable, well-tested tools that measurably improve real biomedical research.
Is this for a brand-new R01 application?
No. The opportunity is designed to revise an existing, currently funded R01 project. The intent is not to start a new standalone R01, but to add SCA capabilities to an active R01 through a revision.
What kind of work is NIH trying to support with these R01 revisions?
The revisions are intended to incorporate and validate emerging single cell methods that enable researchers to interrogate biology at the level of individual cells, ideally in the native tissue context (in situ). The supported work should help advance the scientific aims of the parent R01 while also strengthening and validating the single cell technology itself.
What is single cell analysis (SCA) in the context of this opportunity?
In this announcement, SCA refers to methods that can measure, observe, or characterize biological features at the level of individual cells rather than bulk tissue averages. NIH highlights that SCA can reveal rare cell populations, transient cell states, cell-to-cell variability, and microenvironment effects that may be hidden in traditional bulk assays.
What collaboration structure does NIH require?
A central requirement is a new collaboration that pairs (1) an investigator with an active R01 and (2) a developer of a novel, powerful single cell analysis approach. The collaboration is expected to be more than transactional and should create a feedback loop between tool builders and tool users.
Does the collaboration have to be new?
Yes. The opportunity explicitly requires that the collaboration must be new.
Who are the two key roles in the collaboration?
The two roles are the active R01 investigator (the research team running the funded project) and the developer of a novel single cell analysis approach (the tool builder/technology developer).
Can the collaboration be fee-for-service (for example, paying for measurements)?
The expectation is that it should be more than a fee-for-service measurement arrangement. NIH is looking for a partnership that meaningfully advances the parent R01 aims and also improves the single cell method through iterative feedback and real-world validation.
How should the SCA work relate to the parent R01 aims?
The SCA addition should materially advance the scientific aims of the parent R01 by enabling measurements, spatially resolved observations, or mechanistic insights that are only possible (or substantially more informative) at single cell resolution compared to bulk measurements.
What is NIH expecting from the R01-funded (user) side of the collaboration?
The R01-funded research team is expected to provide iterative, informed feedback to the technology developer so the method can be refined, validated, and made more robust in real biological settings. NIH is intentionally trying to strengthen the interface between tool builders and tool users.
What is NIH expecting from the technology developer side of the collaboration?
The technology developer is expected to contribute a novel and powerful single cell analysis approach and work collaboratively with the R01 team so the method can be implemented, validated, and improved in the context of the parent R01 biology and research environment.
Why is NIH emphasizing the tool builder / tool user feedback loop?
NIH notes that the interface between developers and users often determines whether a new innovation becomes a dependable research platform. This opportunity is structured to promote iterative refinement so the technology becomes robust and broadly usable.
How does NIH describe the broader impact or program goal?
Programmatically, NIH positions this opportunity as a catalyst for discovery and translation. By promoting adoption and validation of SCA approaches within active disease- and mechanism-focused R01 projects, NIH aims to accelerate fundamental biological insights and lay groundwork for clinical applications such as improved diagnostics and therapeutic strategies.
Are collaborations with the NIH Common Fund Single Cell Analysis Program required?
The announcement strongly encourages collaborations with investigators funded through the NIH Common Fund Single Cell Analysis Program, but based on the provided information, such partnerships are encouraged rather than stated as mandatory.
Why does NIH encourage collaborations with Common Fund Single Cell Analysis investigators?
NIH signals an interest in having methods emerging from the Common Fund investment tested, stress-tested, validated, and improved through use in diverse biological systems, helping transition those technologies into dependable, broadly applicable tools.
What is the funding instrument type?
The funding instrument type is a grant under the NIH umbrella.
What is the activity category and CFDA number listed?
The activity category is Health-related, and the CFDA program is listed as 93.310 (Trans-NIH Research Support).
How much total funding did NIH estimate for this opportunity?
NIH estimated total funding at $2.2 million.
What is the award ceiling?
The award ceiling is $250,000.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
What types of organizations are eligible to apply?
Eligibility is broad and includes many organization types typically eligible for NIH funding. Eligible applicants include state, county, city/township, and special district governments; public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits other than universities); small businesses; other for-profit organizations; public housing authorities and Indian housing authorities; and tribal organizations and tribal governments.
Are mission-driven or capacity-building institutions explicitly included?
Yes. The eligibility language explicitly includes institutions such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions. It also notes faith-based and community-based organizations where applicable.
Are foreign organizations or foreign components allowed?
Yes. Foreign organizations are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined in the NIH Grants Policy Statement) are permitted, allowing international expertise when scientifically justified and compliant with NIH policy.
What are the key dates mentioned for this opportunity?
The posted and creation date is December 19, 2013. The original and current closing date is April 4, 2014. The archive date is May 5, 2014.
Is this opportunity still open?
No. Based on the dates provided, the opportunity is archived (archive date May 5, 2014) and had a closing date of April 4, 2014.
Where is the official announcement posted?
The official NIH announcement link provided is: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-13-022.html
Who should be contacted for access or technical issues with the electronic announcement?
For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall theme of this NIH funding approach, as described?
The description reflects a common NIH pattern for technology-infused revisions: leverage ongoing funded science, add a targeted new capability (here, single cell analysis), and require a genuine partnership between domain scientists and method developers so both the biology and the technology improve.
Browse more opportunities from the same category: Health
Next opportunity: Revisions to Add Single Cell Analysis to Active Research Projects (U01)
Previous opportunity: Exceptionally Innovative Tools and Technologies for Single Cell Analysis (R21)
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