Opportunity Information: Apply for RFA RM 13 023
Apply for RFA RM 13 023
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Revisions to Add Single Cell Analysis to Active Research Projects (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Dec 19, 2013 and posted on Dec 19, 2013.
- Applicants must submit their applications by Apr 4, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,200,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Independent school districts For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses County governments Special district governments Private institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity RFA-RM-13-023, titled "Revisions to Add Single Cell Analysis to Active Research Projects (U01)," is a discretionary NIH grant mechanism designed to add new single cell analysis (SCA) capabilities to research projects that are already supported under active U01 cooperative agreements. The core intent is not to start brand-new standalone projects, but to provide revision support that helps existing U01 teams adopt, test, and validate emerging single-cell methods in ways that meaningfully extend or strengthen the scientific aims of their ongoing U01 work. Because single-cell technologies can reveal biological variation that is hidden in bulk measurements, the program is framed as a way to speed up both fundamental discovery and the downstream translation of insights into diagnostics or therapies.
A central requirement is that applications must be built around new collaborations between currently funded U01 investigators and developers of novel SCA approaches. These partnerships are expected to be genuinely new relationships rather than extensions of long-standing collaborations, and they must have a clear rationale for how the single-cell component will substantially advance the U01 project's goals. In addition to enabling the U01 research team to incorporate cutting-edge methods, the collaboration is also meant to function as a two-way exchange: U01 investigators provide iterative, real-world feedback to the technology developers so the tools can be refined, improved, and better validated for broader use. In practice, NIH is emphasizing the "user-developer" interface, aiming to close the gap between technology creation and biological application so that promising single-cell tools mature faster and become more robust and informative.
The announcement strongly encourages collaborations with investigators funded through the NIH Common Fund Single Cell Analysis Program (referenced in the opportunity text), signaling NIH's interest in connecting tool builders from that program with active U01 projects that can provide high-value testbeds and compelling biological questions. While collaborations with Common Fund awardees are not described as mandatory, the explicit encouragement indicates those partnerships may align especially well with the program's goals of accelerating validation, usability, and scientific impact of novel single-cell approaches.
From an administrative and funding standpoint, this opportunity uses the cooperative agreement model (U01), which typically means NIH expects an active stewardship role and substantial programmatic involvement compared to standard research grants. The total estimated program funding is listed as $2.2 million, with an award ceiling of $250,000. The opportunity does not require cost sharing or matching funds. The activity is categorized under health research, with CFDA number 93.310 (Trans-NIH Research Support), and the sponsoring agency is the National Institutes of Health.
Eligibility is broad and includes a wide range of domestic and non-domestic entities. Eligible applicants encompass public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), small businesses, for-profit organizations other than small businesses, and numerous governmental entities (state, county, city/township, special district). The announcement also highlights eligibility for a variety of mission- or population-focused institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs). Importantly, foreign organizations and foreign institutions are eligible to apply, and non-U.S. components of U.S. organizations are also eligible, with foreign components allowed as defined under NIH policy.
Key dates indicate the opportunity was posted and created on December 19, 2013, with an application closing date of April 4, 2014, and an archive date of May 5, 2014. The full announcement and official instructions were provided through the NIH Grants Guide via the linked RFA page. Contact details in the provided source emphasize technical support through the NIH Office of Extramural Research webmaster for applicants who encounter access or linking issues with the electronic announcement.
Overall, this funding opportunity is best understood as a targeted NIH push to rapidly integrate next-generation single-cell technologies into ongoing, high-value U01 research programs through new, structured collaborations that simultaneously advance biology and strengthen the underlying analytical tools. The expected payoff is both near-term improvement in the rigor and reach of single-cell methods through iterative validation, and longer-term acceleration of biological discovery and clinical translation enabled by measuring and interpreting biology at the resolution of individual cells.
FAQs: NIH RFA-RM-13-023 (U01 Revision) - Add Single Cell Analysis to Active Research Projects
What is RFA-RM-13-023?
RFA-RM-13-023 is an NIH funding opportunity titled "Revisions to Add Single Cell Analysis to Active Research Projects (U01)." It supports discretionary NIH grant revisions that add new single cell analysis (SCA) capabilities to research projects that are already funded under active U01 cooperative agreements.
What is the main purpose of this funding opportunity?
The main purpose is to help currently funded U01 project teams adopt, test, and validate emerging single-cell methods in a way that meaningfully extends or strengthens the scientific aims of their ongoing U01 work. It is designed to accelerate both fundamental discovery and translation to diagnostics or therapies by enabling measurement and interpretation at the resolution of individual cells.
Is this opportunity meant for brand-new, standalone projects?
No. The core intent is not to start brand-new standalone projects. This opportunity is specifically for revision support to active U01 cooperative agreements to add a single-cell analysis component that advances the existing project.
Who is this opportunity designed for?
It is designed for teams working on active U01 cooperative agreements who want to integrate new single-cell analysis approaches into their ongoing research, along with developers of novel SCA approaches who can partner with those U01 investigators.
What is required in terms of collaboration?
Applications must be built around new collaborations between currently funded U01 investigators and developers of novel single-cell analysis approaches. The partnership must be a genuinely new relationship rather than an extension of a long-standing collaboration, and it must include a clear rationale showing how the single-cell component will substantially advance the U01 project's goals.
Why does NIH emphasize a "user-developer" partnership?
NIH emphasizes the "user-developer" interface to close the gap between technology creation and biological application. The goal is a two-way exchange: U01 investigators apply the tools in real research settings and provide iterative feedback, helping technology developers refine, improve, and validate methods for broader use.
Are collaborations with NIH Common Fund Single Cell Analysis Program awardees required?
No. Collaborations with investigators funded through the NIH Common Fund Single Cell Analysis Program are strongly encouraged, but not described as mandatory. The encouragement signals that these partnerships may align especially well with NIH's goals for faster validation, usability, and scientific impact of novel single-cell approaches.
What types of advances are expected from adding single-cell analysis?
Single-cell technologies can reveal biological variation that is hidden in bulk measurements. The expected advances include faster fundamental discovery and improved downstream translation of insights into diagnostics or therapies, along with more rigorous and broadly validated single-cell methods through iterative testing in real-world research projects.
What funding mechanism is used?
This opportunity uses the U01 cooperative agreement model. Under a cooperative agreement, NIH typically has substantial programmatic involvement and active stewardship compared to standard research grants.
How much funding is available under this opportunity?
The total estimated program funding is $2.2 million, and the award ceiling is $250,000.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching funds.
What is the CFDA number and program category?
The CFDA number is 93.310 (Trans-NIH Research Support). The activity is categorized under health research.
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What organizations are eligible to apply?
Eligibility is broad and includes domestic and non-domestic entities. Eligible applicants include public and private institutions of higher education; nonprofits (both 501(c)(3) and non-501(c)(3)); small businesses; for-profit organizations other than small businesses; and governmental entities such as state, county, city/township, and special district governments.
Are minority-serving and mission-focused institutions eligible?
Yes. The opportunity explicitly highlights eligibility for institutions and organizations including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Are foreign organizations eligible?
Yes. Foreign organizations and foreign institutions are eligible to apply. In addition, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined under NIH policy.
What were the key dates for this opportunity?
- Posted/Created: December 19, 2013
- Application closing date: April 4, 2014
- Archive date: May 5, 2014
Where were the official instructions and full announcement posted?
The full announcement and official instructions were provided through the NIH Grants Guide via the linked RFA page referenced in the opportunity information.
Who should be contacted for technical issues accessing the announcement?
For access or linking issues with the electronic announcement, the provided source emphasizes technical support through the NIH Office of Extramural Research webmaster.
What makes a proposed single-cell component fit this opportunity?
Based on the provided description, a good fit is a single-cell analysis addition that (1) meaningfully extends or strengthens the scientific aims of an already active U01 project, (2) is carried out through a new collaboration with developers of novel SCA approaches, and (3) includes iterative real-world testing and feedback that improves both the biology outcomes and the underlying single-cell tools.
What is the intended longer-term impact of the program?
The longer-term impact is to accelerate biological discovery and clinical translation by enabling robust measurement and interpretation at the level of individual cells, while also maturing single-cell technologies faster through structured validation and refinement in active, high-value U01 research environments.
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