Opportunity Information: Apply for PAR 13 297

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Revisions to P01 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (P01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394 Cancer Detection and Diagnosis Research.
  • This funding opportunity was created on Aug 6, 2013 and posted on Aug 6, 2013.
  • Applicants must submit their applications by Dec 11, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $150,000.00 in funding.
  • Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Private institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Independent school districts.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:

PAR-13-297 is an NIH discretionary grant opportunity that supports revision applications to existing, currently funded P01 Program Project grants. In practical terms, it is not an open call for brand-new P01s; it is aimed at teams that already hold an NIH P01 award and want to submit a competing revision (now referred to simply as a revision) that adds a substantive, new research project and expands the scientific scope of the parent program.

The scientific focus is on improving detection of pathogen-induced cancer (DPIC) by studying how carcinogenic pathogens interact with both the human microbiome and the human host. The FOA is especially interested in work that can identify and validate molecular signatures linked to cancer risk and early detection in pathogen-associated settings. It also encourages research on chronic inflammation and how inflammatory processes related to infection may contribute to progression from earlier disease states to invasive cancer, with an emphasis on measurable signatures that could help predict or detect that transition sooner.

Applications under this announcement are expected to propose a new research project that fits within and broadens the existing P01 program. The intent is to leverage the infrastructure, collaborations, and overall theme of the parent P01 while adding a distinct project that addresses DPIC detection through pathogen-microbiome-host interactions, biomarker or signature discovery, and mechanisms connecting infection-driven inflammation to cancer development.

From an administrative standpoint, the opportunity is issued by the National Institutes of Health and is listed under CFDA 93.394 (Cancer Detection and Diagnosis Research). The funding instrument is a grant, and the activity category is Health (the listing also tags Education/Health, consistent with how some NIH opportunities are categorized). Cost sharing or matching is not required. The posted and creation date is August 6, 2013, with a closing date of December 11, 2015, and an archive date of January 11, 2016. The opportunity lists an award ceiling of $150,000.

Eligibility is broad across many U.S.-based organization types, including public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), for-profit organizations (including small businesses), state and local governments, tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, and special district governments. The eligibility notes also explicitly include a range of institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and faith-based or community-based organizations, among others. However, non-U.S. entities (foreign institutions) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible. The FOA also does not allow foreign components as defined in the NIH Grants Policy Statement.

For reference and official details, the full announcement is linked at http://grants.nih.gov/grants/guide/pa-files/PAR-13-297.html, and the NIH Office of Extramural Research (OER) webmaster contact is provided for access or linking issues (FBOWebmaster@OD.NIH.GOV).

FAQs: NIH PAR-13-297 (Revision to Existing P01 Program Project Grants)

1) What is PAR-13-297?

PAR-13-297 is an NIH discretionary funding opportunity that supports revision applications to existing, currently funded P01 Program Project grants. The purpose is to allow an active P01 team to add a substantive new research project and expand the overall scientific scope of the parent P01.

2) Is this an open call for brand-new P01 applications?

No. This opportunity is not intended for brand-new P01 Program Project applications. It is specifically for teams that already have a currently funded NIH P01 and want to submit a competing revision (referred to as a revision) to that existing award.

3) What type of application is expected under this FOA?

Applications are expected to be revisions to an existing, active P01 and must propose a new research project that both fits within and broadens the scope of the parent program.

4) What does NIH mean here by a "revision"?

In this context, a revision is a competing revision application to a currently funded P01 that adds a substantive new research project and expands the scientific scope of the parent program.

5) What is the scientific focus of PAR-13-297?

The scientific focus is on improving detection of pathogen-induced cancer (DPIC) by studying interactions among carcinogenic pathogens, the human microbiome, and the human host.

6) What research topics are especially encouraged?

The FOA is especially interested in research that can identify and validate molecular signatures linked to cancer risk and early detection in pathogen-associated settings. It also encourages work on chronic inflammation and infection-related inflammatory processes that may contribute to progression from earlier disease states to invasive cancer, particularly where measurable signatures could help predict or detect that transition earlier.

7) Does the new project have to connect pathogen, microbiome, and host?

The FOA emphasizes pathogen-microbiome-host interactions as a key theme for improving detection of pathogen-induced cancer, so proposed work is expected to address DPIC detection through those interactions and related biomarker or signature discovery and validation.

8) What is meant by "molecular signatures" in this opportunity?

Based on the FOA description, molecular signatures refer to measurable biological signals linked to cancer risk or early detection in pathogen-associated contexts, with an emphasis on identifying and validating signatures that could be used to improve prediction or detection.

9) Is inflammation research within scope?

Yes. The FOA encourages research on chronic inflammation and mechanisms by which infection-driven inflammatory processes may contribute to progression toward invasive cancer, particularly when the work includes measurable signatures relevant to prediction or early detection.

10) How should the proposed new project relate to the parent P01?

The intent is to leverage the existing infrastructure, collaborations, and overall theme of the parent P01 while adding a distinct new project that expands the program's scientific scope in the DPIC detection area described in the FOA.

11) Who is the issuing agency?

The issuing agency is the National Institutes of Health (NIH).

12) What CFDA number is associated with this opportunity?

The opportunity is listed under CFDA 93.394, Cancer Detection and Diagnosis Research.

13) What is the funding instrument and activity category?

The funding instrument is a grant. The activity category is listed as Health, and it is also tagged Education/Health as part of NIH opportunity categorization.

14) Is cost sharing or matching required?

No. Cost sharing or matching is not required under this opportunity.

15) What is the award ceiling listed for PAR-13-297?

The opportunity lists an award ceiling of $150,000.

16) When was this opportunity posted and when does it close?

The posted/creation date is August 6, 2013. The closing date is December 11, 2015.

17) When was the opportunity archived?

The archive date is January 11, 2016.

18) What types of U.S. organizations are eligible to apply?

Eligibility is broad across many U.S.-based organization types, including public and private institutions of higher education; nonprofits with and without 501(c)(3) status; for-profit organizations (including small businesses); state and local governments; tribal governments and tribal organizations; public housing authorities/Indian housing authorities; independent school districts; and special district governments.

19) Are minority-serving institutions and community-based organizations included in the eligibility notes?

Yes. The eligibility notes explicitly include institution types such as HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and faith-based or community-based organizations, among others.

20) Are foreign institutions eligible to apply?

No. Non-U.S. entities (foreign institutions) are not eligible to apply under this FOA.

21) Can a U.S. organization include a non-U.S. component?

No. Non-domestic components of U.S. organizations are not eligible, and the FOA does not allow foreign components as defined in the NIH Grants Policy Statement.

22) Where can applicants find the official announcement text?

The full announcement is available at http://grants.nih.gov/grants/guide/pa-files/PAR-13-297.html.

23) Who should be contacted for access or linking issues with the NIH posting?

The NIH Office of Extramural Research (OER) webmaster contact listed is FBOWebmaster@OD.NIH.GOV, specifically for access or linking issues.

Browse more opportunities from the same agency: National Institutes of Health

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Next opportunity: Revisions to P50 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (P50)

Previous opportunity: Advanced Development of Informatics Technology (U24)

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