Opportunity Information: Apply for PA 07 043
Apply for PA 07 043
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Right Heart Function in Health and Chronic Lung Diseases (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.838 Lung Diseases Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Nov 20, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) County governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts State governments Private institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Public housing authorities/Indian housing authorities City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The funding opportunity titled "Right Heart Function in Health and Chronic Lung Diseases (R01)" (Funding Opportunity Number PA-07-043) is a National Institutes of Health (NIH) program announcement that supports research aimed at clarifying how the right ventricle and the lungs interact in both normal physiology and in disease states. The central goal is to push the field toward a more complete, mechanistic understanding of how chronic lung diseases contribute to right heart dysfunction and, ultimately, right heart failure. The announcement emphasizes that right heart failure in the setting of lung disease remains an area where the biology is not fully mapped, and it encourages projects that can fill foundational knowledge gaps rather than only describing clinical correlations.
A major focus of the announcement is strengthening the basic science framework around right ventricular physiology, including the cellular, molecular, and biomechanical drivers of right ventricular dysfunction that occur alongside pulmonary disease. In practical terms, NIH is looking for studies that explain the "why" and "how" behind right ventricular changes when the lung environment is altered by chronic disease, such as changes in pulmonary vascular load, hypoxia, inflammation, remodeling, or other stressors that can reshape right ventricular structure and performance. The opportunity is intentionally broad in scientific approach, inviting work that ranges from fundamental mechanistic studies to translational efforts that connect those mechanisms to human disease and potential clinical implications.
The FOA explicitly supports both basic and translational research, and it allows applicants to use many different study systems and data sources depending on what best fits the scientific question. Proposed research can be built around animal models, animal tissues, human tissues, and human plasma samples, as well as analyses tied to clinical outcomes. This flexibility signals that NIH is open to diverse experimental strategies, including laboratory-based mechanistic work, biomarker-driven studies, integrative physiology, and studies that link biological measures to patient trajectories, provided the central theme remains the right ventricle-lung relationship in health and chronic lung disease.
In terms of funding mechanism, the announcement uses the NIH R01 grant mechanism, which is the standard research project grant designed for discrete, investigator-initiated projects. The opportunity is categorized as discretionary and uses a grant funding instrument within the health activity category. There is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of award.
Eligibility is broad and includes a wide range of domestic organizations such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), for-profit organizations (other than small businesses), small businesses, state and local governments (including counties, cities or townships, special districts, and independent school districts), public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The announcement also states that foreign institutions are eligible to apply, eligible federal agencies may apply, and faith-based or community-based organizations may apply, which further expands the pool of potential applicants beyond the typical academic medical center audience.
Key administrative details include the posted date (November 20, 2006), creation date (December 5, 2008), and that the announcement used multiple receipt dates rather than a single deadline, with applicants directed to the full announcement for the specific schedule. The archive date is listed as December 6, 2009, indicating it was eventually closed and archived, though it remains a useful reference for the NIH priorities and framing around right ventricular dysfunction in chronic lung disease during that period. The CFDA numbers associated with the opportunity are 93.233 (National Center on Sleep Disorders Research) and 93.838 (Lung Diseases Research), which reflects NIH programmatic alignment with sleep-related and lung disease research portfolios where right heart-pulmonary interactions are clinically significant.
For applicants seeking the original full text, NIH provided an additional information link to the archived program announcement page (http://grants.nih.gov/grants/guide/pa-files/PA-07-043.html). For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV, which is intended for problems accessing or linking to the announcement rather than for scientific questions about project fit.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Right Heart Function in Health and Chronic Lung Diseases (R01)" and the Funding Opportunity Number is PA-07-043.
Which agency is offering this funding opportunity?
This is a National Institutes of Health (NIH) program announcement.
What is the main purpose of this program announcement?
The central purpose is to support research that clarifies how the right ventricle and the lungs interact in normal physiology and in disease, with an emphasis on building a more complete mechanistic understanding of how chronic lung diseases contribute to right heart dysfunction and right heart failure.
What kind of research questions does NIH want to see addressed?
NIH is looking for studies that explain the "why" and "how" behind right ventricular changes when the lung environment is altered by chronic disease. The announcement highlights knowledge gaps in the biology of right heart failure in the setting of lung disease and encourages projects that fill foundational mechanistic gaps rather than focusing only on clinical correlations.
What scientific focus areas are emphasized in the announcement?
A major emphasis is strengthening the basic science framework around right ventricular physiology, including cellular, molecular, and biomechanical drivers of right ventricular dysfunction that occur alongside pulmonary disease.
What lung-disease-related stressors or contributors are mentioned as relevant to right ventricular changes?
The announcement points to factors such as changes in pulmonary vascular load, hypoxia, inflammation, remodeling, and other stressors that can reshape right ventricular structure and performance.
Is the opportunity limited to basic science, or are translational studies allowed?
Both basic and translational research are explicitly supported. The opportunity is described as broad in scientific approach, including work ranging from fundamental mechanistic studies to translational efforts that connect mechanisms to human disease and potential clinical implications.
What study systems and sample types are allowed under this FOA?
The FOA allows flexibility in study systems and data sources. Proposed research may use animal models, animal tissues, human tissues, and human plasma samples, and may include analyses tied to clinical outcomes, as long as the central theme remains the right ventricle-lung relationship in health and chronic lung disease.
Can studies link biological measures to patient outcomes?
Yes. The opportunity allows analyses tied to clinical outcomes and explicitly welcomes work that links biological measures (for example, biomarkers or physiologic measures) to patient trajectories, provided the core focus remains the right ventricle-lung relationship.
What funding mechanism is used for this opportunity?
The announcement uses the NIH R01 mechanism, which is the standard research project grant mechanism intended for discrete, investigator-initiated projects.
What type of funding instrument and activity category does it use?
It is listed as a discretionary opportunity using a grant funding instrument within the health activity category.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of award.
Who is eligible to apply?
Eligibility is broad and includes many domestic organization types, such as public and private institutions of higher education; nonprofits (including 501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses); small businesses; state and local governments (including counties, cities or townships, special districts, and independent school districts); public housing authorities/Indian housing authorities; tribal governments and tribal organizations. The announcement also states that foreign institutions are eligible to apply, eligible federal agencies may apply, and faith-based or community-based organizations may apply.
Are foreign institutions allowed to apply?
Yes. The announcement specifically states that foreign institutions are eligible to apply.
Can small businesses apply?
Yes. Small businesses are listed among eligible applicant organizations.
Can for-profit organizations apply?
Yes. For-profit organizations are eligible, and the eligibility list includes for-profit organizations (other than small businesses) as well as small businesses.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations are explicitly included in the eligibility list.
Are faith-based or community-based organizations eligible?
Yes. The announcement states that faith-based or community-based organizations may apply.
Can federal agencies apply?
Yes. The announcement notes that eligible federal agencies may apply.
When was this opportunity posted and when was it created?
The posted date is November 20, 2006, and the creation date is December 5, 2008.
Was there a single deadline, or were there multiple receipt dates?
The announcement used multiple receipt dates rather than a single deadline, and applicants were directed to the full announcement for the specific schedule.
Is this funding opportunity still open?
The archive date is December 6, 2009, indicating the announcement was eventually closed and archived.
What are the CFDA numbers associated with this opportunity?
The CFDA numbers listed are 93.233 (National Center on Sleep Disorders Research) and 93.838 (Lung Diseases Research).
What do the CFDA listings suggest about NIH program alignment?
The CFDA numbers indicate alignment with NIH program areas connected to sleep disorders research and lung diseases research, where right heart-pulmonary interactions can be clinically significant.
Where can applicants find the original full text of the announcement?
NIH provided an archived link to the program announcement page: http://grants.nih.gov/grants/guide/pa-files/PA-07-043.html
Who is the listed contact for access or technical issues with the announcement?
The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What is the webmaster contact intended for?
The listed contact is intended for problems accessing or linking to the announcement, rather than for scientific questions about whether a specific project is a good fit.
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