Opportunity Information: Apply for RFA RM 08 029
Apply for RFA RM 08 029
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Roadmap Transformative R01 Program (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Oct 3, 2008 and posted on Oct 3, 2008.
- Applicants must submit their applications by Jan 29, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Independent school districts Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education City or township governments State governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Roadmap Transformative R01 Program (R01) is a National Institutes of Health (NIH) funding opportunity under the NIH Roadmap for Biomedical Research that is designed to support research that is genuinely bold and paradigm-shifting. The central aim is to attract Research Project Grant (R01) applications that propose exceptionally innovative, high-risk work that is original, unconventional, or otherwise outside the usual paths of incremental science. The expectation is that proposed projects will not just add another piece to an existing puzzle, but instead have a clear line of sight to creating an entirely new scientific direction or meaningfully challenging current scientific assumptions. To be competitive, an application needs to convincingly argue for the potential to deliver a major impact across a broad area of biomedical or behavioral research, rather than a narrow or highly specialized niche.
This opportunity uses the standard NIH Research Project Grant (R01) mechanism, meaning it is structured as a traditional R01 award but with an explicit emphasis on transformative science. In practice, that emphasis signals that novelty, originality, and the ability to change thinking in a field are central to the program’s intent, even when the work carries substantial technical or conceptual risk. The program is housed within the NIH Common Fund (listed under CFDA 93.310, Trans-NIH Research Support), which is typically used to support cross-cutting initiatives intended to catalyze progress across multiple NIH Institutes and Centers.
From a funding standpoint, NIH indicated it intended to commit $25 million in fiscal year 2009 to support awards made through this announcement, with an anticipated total of up to 60 funded applications. This framing suggests the program sought to fund a sizable cohort of projects, likely to seed multiple high-risk ideas simultaneously and increase the odds that several would lead to outsized scientific returns. There is no cost sharing or matching requirement, which is consistent with most NIH research grant programs and means applicants are not required to provide non-federal matching funds as a condition of eligibility.
The announcement is identified as discretionary funding and is issued as a grant funding instrument. The Funding Opportunity Number is RFA-RM-08-029, and the title is Roadmap Transformative R01 Program (R01). It was posted on October 3, 2008, with an original and current closing date of January 29, 2009, and an archive date of March 1, 2009. The sponsoring agency is the National Institutes of Health.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (including those other than institutions of higher education), for-profit organizations (other than small businesses), small businesses, independent school districts, and a range of governmental entities such as city or township governments, county governments, state governments, special district governments, and public housing authorities/Indian housing authorities. The eligibility list also explicitly includes Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments). In addition, the opportunity notes other eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), tribally controlled colleges and universities (TCCUs), regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities/foreign organizations. This wide eligibility range aligns with the program’s goal of surfacing unconventional ideas from many corners of the research ecosystem, rather than limiting participation to a narrow band of institutions.
For those seeking the full official text, NIH provided an announcement link through the NIH Grants Guide (http://grants.nih.gov/grants/guide/rfa_files/RFA-RM-08-029.html). For access issues or technical problems with the announcement link, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs): Roadmap Transformative R01 Program (R01)
What is the Roadmap Transformative R01 Program (R01)?
The Roadmap Transformative R01 Program (R01) is a National Institutes of Health (NIH) funding opportunity under the NIH Roadmap for Biomedical Research. It is designed to support research that is genuinely bold and paradigm-shifting, with the goal of attracting R01 applications that propose exceptionally innovative, high-risk work.
What is the main purpose of this funding opportunity?
The central aim is to support research projects that are original, unconventional, or outside the usual paths of incremental science. Proposed projects are expected to have a clear line of sight to creating an entirely new scientific direction or meaningfully challenging current scientific assumptions, rather than simply adding another piece to an existing research puzzle.
What kind of research is NIH looking for under this program?
NIH is looking for exceptionally innovative and transformative research in biomedical or behavioral science. The opportunity emphasizes novelty and originality, including projects with substantial technical or conceptual risk, as long as the proposed work has strong potential to change thinking in a field and deliver major impact across a broad area.
How is this different from a typical NIH R01?
This opportunity uses the standard NIH Research Project Grant (R01) mechanism, meaning it is structured as a traditional R01 award. The difference is the explicit emphasis on transformative science: applicants are expected to prioritize bold, paradigm-shifting ideas and clearly articulate how the work could redirect a field or challenge established assumptions.
Does the program favor incremental advances or transformative ideas?
The program is specifically intended to fund transformative ideas rather than incremental advances. Competitive applications are expected to propose work that goes beyond incremental science and instead has potential to create a new direction or meaningfully challenge current scientific assumptions.
How should applicants describe impact to be competitive?
Based on the program description, an application should convincingly argue that the project could deliver a major impact across a broad area of biomedical or behavioral research, rather than focusing on a narrow or highly specialized niche.
What funding mechanism is used?
The funding mechanism is the NIH Research Project Grant (R01).
Which NIH program or office houses this opportunity?
The program is housed within the NIH Common Fund and is listed under CFDA 93.310 (Trans-NIH Research Support). The Common Fund is typically used to support cross-cutting initiatives intended to catalyze progress across multiple NIH Institutes and Centers.
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-RM-08-029.
What is the official title of the announcement?
The official title is Roadmap Transformative R01 Program (R01).
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
Is this a grant or a contract?
This opportunity is issued as a grant funding instrument.
Is this discretionary funding?
Yes. The announcement is identified as discretionary funding.
How much funding did NIH intend to commit?
NIH indicated it intended to commit $25 million in fiscal year 2009 to support awards made through this announcement.
How many awards or applications were anticipated to be funded?
The announcement anticipated a total of up to 60 funded applications.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of eligibility.
When was the opportunity posted?
The opportunity was posted on October 3, 2008.
What was the application deadline?
The original and current closing date listed for this opportunity was January 29, 2009.
Is this opportunity archived?
Yes. The archive date is March 1, 2009.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include (as listed in the announcement) institutions of higher education (public/state-controlled and private), nonprofits (with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, independent school districts, and multiple categories of government entities.
Are non-U.S. (foreign) organizations eligible?
Yes. The eligibility list explicitly includes non-domestic (non-U.S.) entities/foreign organizations.
Are U.S. territories or possessions eligible?
Yes. The opportunity notes U.S. territories or possessions among other eligible applicants.
Are small businesses eligible to apply?
Yes. Small businesses are included in the eligibility list.
Are for-profit organizations eligible to apply?
Yes. For-profit organizations (other than small businesses) are included, and small businesses are also listed separately as eligible.
Are nonprofits without 501(c)(3) status eligible?
Yes. The eligibility list includes nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status.
Are governmental entities eligible to apply?
Yes. The eligibility list includes a range of governmental entities such as city or township governments, county governments, state governments, special district governments, and public housing authorities/Indian housing authorities.
Are Native American tribal governments or tribal organizations eligible?
Yes. The eligibility list explicitly includes Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments).
Are minority-serving institutions mentioned as eligible applicants?
Yes. The announcement notes additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and tribally controlled colleges and universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The opportunity notes faith-based or community-based organizations among other eligible applicants.
Where can applicants find the full official announcement text?
NIH provided the announcement link through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa_files/RFA-RM-08-029.html.
Who should be contacted for access issues or technical problems with the announcement link?
For access issues or technical problems with the announcement link, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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