Opportunity Information: Apply for PA 08 059
Apply for PA 08 059
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Role of Adipose Tissue as an Endocrine Organ in Reproduction and Infertility (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Dec 19, 2007.
- Applicants must submit their applications by Jan 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: City or township governments Native American tribal governments (Federally recognized) Small businesses For profit organizations other than small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) State governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Private institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
This funding opportunity, PA 08 059, is an NIH National Institute of Child Health and Human Development (NICHD) Research Project Grant (R01) announcement focused on adipose (fat) tissue as an endocrine organ and how its hormone-like signaling influences reproduction and infertility. The central idea behind the program is that adipose tissue is not just an energy storage depot; it actively secretes biologically active factors (often referred to as adipokines and other signaling molecules) that can interact with the brain, pituitary, ovaries, testes, uterus, placenta, and other parts of the reproductive axis. NICHD is seeking R01 research projects that clarify how adipose-derived signals contribute to normal reproductive physiology, how disruptions in adipose signaling might contribute to reproductive diseases and fertility problems, and whether differences in these pathways could help explain why certain reproductive disorders show different prevalence rates across racial and ethnic groups.
The scientific scope is broad and is meant to support hypothesis-driven, mechanistic research that deepens understanding of the connection between metabolic status and reproductive function. Proposed studies can address normal regulation (for example, how adipose-derived factors modulate puberty timing, ovulation, sperm production, implantation, pregnancy maintenance, or lactation-related physiology), as well as disease etiology (for example, how altered adipose signaling in obesity, lipodystrophy, insulin resistance, chronic inflammation, or other metabolic states may contribute to conditions that impair fertility). A key emphasis is on discerning causal roles and biological mechanisms, not simply reporting associations, and on probing potential contributions to disparities in reproductive health outcomes among different populations.
The award mechanism is the NIH R01, which typically supports substantial, multi-year research projects with a defined set of aims and a clear plan for generating rigorous, generalizable knowledge. This FOA is described as running in parallel with a companion announcement of identical scientific scope that uses the R21 mechanism (PA 08 060), which is generally intended for earlier-stage, exploratory, or high-risk/high-reward projects. Applicants should therefore align their proposal with the expectations of an R01 in terms of depth, feasibility, and scope, while recognizing that NICHD is also supporting smaller, more exploratory efforts through the companion R21 pathway.
Funding levels and the number of awards are not preset. The announcement states that awards depend on the availability of funds and the submission of a sufficient number of meritorious applications. Because proposed projects can differ widely in approach, complexity, and resource needs, the size and duration of individual awards may vary. In practical terms, this means there is no guaranteed number of funded projects, and budgets will be evaluated in relation to the scientific rationale, the work proposed, and the justification of costs.
Eligibility is expansive and includes a wide range of domestic and foreign institutions and organizations. Eligible applicants listed include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, small businesses and other for-profit organizations, state and local governmental entities (including city/township, county, special district governments, and independent school districts), public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations. The announcement also specifies that foreign institutions may apply, eligible federal agencies may apply, and faith-based or community-based organizations are eligible as well. Cost sharing or matching is not required, which is consistent with many NIH research grant programs.
Administratively, the opportunity is categorized as a discretionary grant under the Health activity category, with CFDA number 93.865 (Child Health and Human Development Extramural Research). The posting date is December 19, 2007, with an original closing date of January 7, 2011 (and the current closing date also listed as January 7, 2011), after which the opportunity was archived on February 7, 2011. The full announcement and detailed NIH requirements, including application instructions and contacts, were provided through the NIH Grants Guide link associated with PA 08 059. For access or technical issues related to the online announcement, the notice directs applicants to the NIH Office of Extramural Research (OER) webmaster contact.
FAQs: NIH NICHD Research Project Grant (R01) - PA 08 059
What is PA 08 059?
PA 08 059 is a funding opportunity announcement from the NIH National Institute of Child Health and Human Development (NICHD) using the Research Project Grant (R01) mechanism. It focuses on research about adipose (fat) tissue as an endocrine organ and how adipose-derived, hormone-like signaling affects reproduction and infertility.
What is the main scientific focus of this opportunity?
The opportunity centers on the idea that adipose tissue is not only an energy storage depot, but also an active endocrine tissue that secretes biologically active factors (including adipokines and other signaling molecules). NICHD is seeking R01 projects that clarify how these adipose-derived signals influence the reproductive axis and contribute to normal reproductive physiology, reproductive disease, and fertility problems.
Which parts of the reproductive system are relevant to the research scope?
The announcement describes adipose-derived signals as interacting with multiple components of the reproductive axis, including the brain, pituitary, ovaries, testes, uterus, placenta, and other related systems.
What types of research questions are encouraged?
Projects are encouraged to deepen mechanistic understanding of the connection between metabolic status and reproductive function. Studies may examine normal regulation (how adipose-derived factors modulate reproductive processes) and disease etiology (how altered adipose signaling contributes to reproductive disorders and infertility).
Does the FOA support research on normal reproductive physiology?
Yes. The scope includes studies of normal regulation such as how adipose-derived factors may influence puberty timing, ovulation, sperm production, implantation, pregnancy maintenance, or lactation-related physiology.
Does the FOA support research on reproductive disease and infertility?
Yes. The FOA includes disease etiology, such as investigating how altered adipose signaling in obesity, lipodystrophy, insulin resistance, chronic inflammation, or other metabolic states may contribute to conditions that impair fertility.
Is the emphasis on correlation studies or causal mechanisms?
The FOA emphasizes discerning causal roles and biological mechanisms, rather than simply reporting associations. In other words, the goal is hypothesis-driven, mechanistic research intended to explain how adipose-derived signals affect reproductive outcomes.
Does the opportunity address reproductive health disparities?
Yes. The announcement highlights interest in whether differences in adipose signaling pathways could help explain why certain reproductive disorders show different prevalence rates across racial and ethnic groups.
What grant mechanism is used?
This opportunity uses the NIH Research Project Grant (R01) mechanism, which typically supports substantial, multi-year projects with defined aims and a plan for generating rigorous, generalizable knowledge.
Is there a related or companion funding opportunity?
Yes. The FOA is described as running in parallel with a companion announcement of identical scientific scope that uses the R21 mechanism: PA 08 060. The R21 is generally aimed at earlier-stage, exploratory, or high-risk/high-reward projects.
How should applicants decide between submitting to the R01 versus the companion R21?
Based on the information provided, applicants should align with R01 expectations for depth, feasibility, and overall scope for a substantial research project. NICHD is also supporting smaller, more exploratory efforts through the companion R21 pathway (PA 08 060) with the same scientific scope.
Are the funding amount, project duration, or number of awards specified?
No. Funding levels and the number of awards are not preset. Awards depend on the availability of funds and the submission of a sufficient number of meritorious applications. The size and duration of individual awards may vary because projects can differ in approach, complexity, and resource needs.
How are budgets expected to be evaluated?
The announcement indicates budgets will be evaluated in relation to the scientific rationale, the work proposed, and the justification of costs, rather than being tied to a fixed award amount.
Who is eligible to apply?
Eligibility is described as expansive, including a wide range of domestic and foreign institutions and organizations. Eligible applicants listed include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, small businesses and other for-profit organizations, and various governmental entities.
Are foreign institutions allowed to apply?
Yes. The announcement explicitly states that foreign institutions may apply.
Can for-profit organizations apply?
Yes. The eligible applicant types include small businesses and other for-profit organizations.
Can nonprofits without 501(c)(3) status apply?
Yes. The eligibility list includes nonprofits with and without 501(c)(3) status.
What types of government entities are eligible?
The FOA lists state and local governmental entities, including city/township governments, county governments, special district governments, and independent school districts. It also lists public housing authorities/Indian housing authorities.
Are Native American tribal governments and tribal organizations eligible?
Yes. The eligibility list includes Native American tribal governments and tribal organizations.
Are faith-based or community-based organizations eligible?
Yes. The announcement specifies that faith-based or community-based organizations are eligible.
Are federal agencies eligible to apply?
Yes. The announcement states that eligible federal agencies may apply.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
What is the activity category and CFDA number associated with this opportunity?
The opportunity is categorized as a discretionary grant under the Health activity category, with CFDA number 93.865 (Child Health and Human Development Extramural Research).
When was the opportunity posted, and when did it close?
The posting date is December 19, 2007. The original closing date is January 7, 2011, and the current closing date is also listed as January 7, 2011.
Is this opportunity still open?
No. The opportunity was archived on February 7, 2011, following the listed closing date.
Where were the full announcement details and application instructions provided?
The full announcement, NIH requirements, application instructions, and contacts were provided through the NIH Grants Guide link associated with PA 08 059.
Who should be contacted for access or technical issues related to the online announcement?
For access or technical issues related to the online announcement, the notice directs applicants to the NIH Office of Extramural Research (OER) webmaster contact.
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