Opportunity Information: Apply for PA 08 060
Apply for PA 08 060
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Role of Adipose Tissue as an Endocrine Organ in Reproduction and Infertility (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Dec 19, 2007.
- Applicants must submit their applications by Jan 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education State governments Independent school districts Special district governments Public and State controlled institutions of higher education City or township governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The funding opportunity PA 08 060, titled "Role of Adipose Tissue as an Endocrine Organ in Reproduction and Infertility (R21)," is a discretionary NIH grant announcement from the National Institute of Child Health and Human Development (NICHD). Its main goal is to support early stage, exploratory research that clarifies how adipose tissue functions as an endocrine organ in the context of reproduction. In practical terms, the program is looking for projects that investigate how signals originating from fat tissue help regulate normal reproductive physiology, and how disruptions in those signals might contribute to diseases and disorders that reduce or impair human fertility. The emphasis is on improving biological understanding, including potential mechanisms that connect metabolic status, adipose derived hormones or signaling molecules, and reproductive function across the lifespan.
This opportunity uses the NIH Exploratory/Developmental Research Grant (R21) mechanism. An R21 is designed for innovative, higher risk concepts where investigators may be testing new hypotheses, developing tools or models, generating preliminary data, or exploring emerging mechanistic links that are not yet ready for a full scale R01. The announcement explicitly notes that it runs in parallel with a companion funding opportunity (PA 08 059) with the same scientific scope but using the R01 mechanism, which is generally intended for more mature, hypothesis driven projects with a stronger preliminary evidence base and a larger, longer term research plan. Applicants should therefore view PA 08 060 as the entry point for novel ideas and early proof of concept studies focused on adipose reproductive biology.
Funding levels and the number of awards are not fixed in the announcement. Instead, awards depend on the availability of NIH funds and on whether a sufficient number of high quality, meritorious applications are submitted. Because the science may range from small, focused mechanistic experiments to broader exploratory studies, the agency anticipates that both the size and duration of awards will vary by project. The total amount awarded and the total number of funded projects will ultimately be determined by the mix of applications received, including their scientific merit, proposed budgets, and proposed project periods.
Eligibility is broad and includes many types of domestic applicants across government, higher education, nonprofit, and private sectors. Eligible applicants listed include public and state controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with 501(c)(3) status and those without it), for profit organizations (other than small businesses) as well as small businesses, and a variety of governmental entities such as state governments, county governments, city or township governments, special district governments, and independent school districts. The announcement also includes Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments), plus public housing authorities and Indian housing authorities. Beyond these categories, the FOA states that foreign institutions are eligible to apply, eligible federal agencies may apply, and faith based or community based organizations may apply as well, which further widens the pool of potential research performers.
From an administrative standpoint, the opportunity is identified under CFDA 93.865 (Child Health and Human Development Extramural Research). There is no cost sharing or matching requirement, meaning applicants are not required to contribute non federal funds to be eligible. The opportunity was posted on December 19, 2007, and it had an original and current closing date of January 7, 2011, with an archive date of February 7, 2011, indicating it is no longer active but remains important as a reference point for the kinds of research NICHD has sought in this area. The full announcement was hosted through the NIH Grants Guide (link provided in the source), and the NIH Office of Extramural Research (OER) webmaster contact is provided for technical access or linking issues.
Overall, PA 08 060 reflects NICHD interest in the intersection of metabolism and fertility, treating adipose tissue not just as energy storage but as an active endocrine organ that can influence reproductive hormones, ovulation, spermatogenesis, pregnancy related physiology, and broader fertility outcomes. The FOA is structured to encourage creative, developmental projects that can open new lines of inquiry or generate the preliminary evidence needed for later stage, larger NIH studies.
FAQs: PA 08 060 - Role of Adipose Tissue as an Endocrine Organ in Reproduction and Infertility (R21)
What is the official title and number of this funding opportunity?
The opportunity is NIH Funding Opportunity Announcement (FOA) PA 08 060, titled "Role of Adipose Tissue as an Endocrine Organ in Reproduction and Infertility (R21)."
Which agency and institute offer this grant opportunity?
This is a discretionary NIH grant announcement from the National Institutes of Health (NIH), offered through the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
What is the main purpose of PA 08 060?
The main goal is to support early stage, exploratory research that clarifies how adipose tissue functions as an endocrine organ in reproduction, including how signals from adipose tissue regulate normal reproductive physiology and how disruptions in those signals may contribute to diseases or disorders that reduce or impair human fertility.
What types of scientific questions is this FOA trying to address?
The FOA emphasizes improving biological understanding of mechanisms linking metabolic status, adipose-derived hormones or signaling molecules, and reproductive function across the lifespan, including how adipose signaling may influence fertility-related processes and outcomes.
What grant mechanism does PA 08 060 use?
PA 08 060 uses the NIH Exploratory/Developmental Research Grant (R21) mechanism.
What is an R21 intended to support in the context of this FOA?
An R21 is intended for innovative, higher-risk concepts. Under this FOA, it is positioned for projects such as testing new hypotheses, developing tools or models, generating preliminary data, or exploring emerging mechanistic links related to adipose-reproductive biology that are not yet ready for a full-scale R01.
Is there a related R01 opportunity with the same scientific scope?
Yes. The FOA states it runs in parallel with a companion opportunity, PA 08 059, which has the same scientific scope but uses the R01 mechanism.
How does PA 08 060 (R21) differ from the companion PA 08 059 (R01)?
PA 08 060 (R21) is framed as an entry point for novel ideas and early proof-of-concept studies, while PA 08 059 (R01) is described as more appropriate for mature, hypothesis-driven projects with stronger preliminary evidence and a larger, longer-term research plan.
Are funding levels and the number of awards fixed?
No. The FOA indicates that funding levels and the number of awards are not fixed and will depend on NIH funds availability and the number of high-quality, meritorious applications received.
Will award size and project duration be the same for all funded projects?
No. The FOA anticipates that both the size and duration of awards may vary by project, reflecting a range from small, focused mechanistic experiments to broader exploratory studies.
What factors determine the total amount awarded and how many projects are funded?
The FOA states decisions will be driven by the mix of applications received, including scientific merit, proposed budgets, and proposed project periods, along with availability of NIH funds.
Who is eligible to apply for PA 08 060?
Eligibility is broad and includes many domestic applicant types across higher education, nonprofit, private sector, and government entities, as described in the FOA.
Are public or state-controlled institutions of higher education eligible?
Yes. Public and state-controlled institutions of higher education are listed as eligible applicants.
Are private institutions of higher education eligible?
Yes. Private institutions of higher education are listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations are eligible, including those with 501(c)(3) status and those without 501(c)(3) status.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are eligible, and small businesses are also listed as eligible applicants.
Which government entities are eligible to apply?
The FOA lists several governmental entities as eligible, including state governments, county governments, city or township governments, special district governments, and independent school districts.
Are Native American tribal governments or organizations eligible?
Yes. The FOA includes Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments) as eligible applicants.
Are public housing authorities or Indian housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are foreign institutions eligible to apply?
Yes. The FOA explicitly states that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The FOA indicates that eligible federal agencies may apply.
Are faith-based or community-based organizations eligible?
Yes. The FOA states that faith-based or community-based organizations may apply.
Is there a cost sharing or matching requirement?
No. The FOA states there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds to be eligible.
What is the CFDA number associated with this opportunity?
The opportunity is identified under CFDA 93.865, "Child Health and Human Development Extramural Research."
When was this FOA posted?
The FOA was posted on December 19, 2007.
What was the closing date for applications?
The FOA lists an original and current closing date of January 7, 2011.
Is this opportunity still active?
No. Based on the listed closing date (January 7, 2011) and archive date (February 7, 2011), the FOA is no longer active and is provided as an archived reference.
What is the archive date for this FOA?
The archive date is February 7, 2011.
Where was the full announcement hosted?
The FOA indicates the full announcement was hosted through the NIH Grants Guide (with a link provided in the original source).
Who is listed as the contact for technical access or linking issues?
The NIH Office of Extramural Research (OER) webmaster contact is provided for technical access or linking issues.
What broader research theme does PA 08 060 reflect?
The FOA reflects NICHD interest in the intersection of metabolism and fertility, treating adipose tissue as an active endocrine organ that can influence reproductive hormones, ovulation, spermatogenesis, pregnancy-related physiology, and broader fertility outcomes.
What kind of projects is this FOA designed to encourage?
It is structured to encourage creative, developmental projects that can open new lines of inquiry or generate preliminary evidence needed for later-stage, larger NIH studies.
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