Opportunity Information: Apply for RFA FD 10 016

The FDA's Office of Critical Path Programs is inviting grant proposals aimed at advancing the diagnosis, treatment, and prevention of tuberculosis and other tropical diseases. The funding is specifically for collaborative partnerships that identify and address scientific and infrastructural gaps in these areas. Proposals should focus on two main goals: enhancing the development process for treatments and creating sustainable funding models for ongoing collaboration.

Eligible applicants include higher education institutions and certain nonprofit organizations. Proposals must detail the structure of the partnership, the roles of collaborators, and plans for future funding mechanisms. Here are key areas of focus for the proposals:

1. **Bridging Discovery to Testing**: Support is sought for programs that advance new compounds from laboratory discovery into human clinical trials. This includes generating necessary data and facilitating collaborations among stakeholders in drug development.

2. **Alternative Uses of Existing Products**: Applicants are encouraged to explore the repurposing of existing FDA-approved drugs for TB and tropical disease treatments, including conducting reviews and developing strategies for clinical studies.

3. **Biomarkers for Vaccines**: The program aims to identify immunological biomarkers for vaccine efficacy. Proposals should evaluate existing biomarkers and establish partnerships to fund further research.

4. **Capacity Building for Clinical Trials**: Given the lack of infrastructure in developing countries, proposals can involve creating resources like open-source electronic case report forms and training programs to enhance local research capabilities.

5. **Development of Diagnostics**: The FDA seeks proposals for developing reliable diagnostic tools for TB, including biomarkers for treatment outcomes and rapid tests suitable for low-resource settings.

6. **Combination Therapy**: Proposals should investigate effective drug combinations for treating TB, specifying project milestones and public health outcomes.

Lastly, the FDA plans to assist in program design and will oversee the funded initiatives to ensure alignment with health goals.

  • The Food Drug Administration in the agriculture consumer protection environment food and nutrition health information and statistics natural resources science and technology and other research and development sector is offering a public funding opportunity titled "Scientific Priorities to Improve the Diagnosis, Treatment and Prevention of Tuberculosis and other Tropical Diseases." and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.103 Food and Drug AdministrationResearch.
  • This funding opportunity was created on Jul 12, 2010 and posted on Jul 12, 2010.
  • Applicants must submit their applications by Aug 11, 2010 NOTE On time submission requires that applications be successfully submitted to Grants.gov no later than 500 p.m. local time (of the applicant institution/organization). Application Due Date(s) August 11, 2010 Peer Review Date(s) August 2010 Council Review Date(s) September 7 9, 2010 Earliest Anticipated Start Date(s) September, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2025.)
  • The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Independent school districts State governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Public and State controlled institutions of higher education County governments Native American tribal governments (Federally recognized).
  • Eligible Agencies of the Federal Government Faith based or Community based Organizations
Apply for RFA FD 10 016

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