Opportunity Information: Apply for PA 12 125
Apply for PA 12 125
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Apr 1, 2015 and posted on Mar 19, 2012.
- Applicants must submit their applications by Apr 1, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Special district governments City or township governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Private institutions of higher education Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply.Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21)" (Funding Opportunity Number PA 12-125) is a National Institutes of Health (NIH) discretionary grant announcement designed to support exploratory research projects that rely on secondary analysis of already-existing datasets. It is sponsored primarily by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), with participation from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the Office of Dietary Supplements (ODS). The central purpose of the program is to help researchers test new, innovative, and sometimes higher-risk hypotheses without needing to launch expensive or time-consuming new data collection efforts. In practice, the FOA is meant to unlock additional scientific value from data that have already been collected, whether from prior clinical studies, cohort studies, epidemiologic surveillance, administrative or health system data, registries, or other established resources.
Scientifically, the scope is broad but anchored in diseases and conditions that fall within NIDDK and partner missions. Projects must be relevant to diabetes and related endocrine, metabolic, and obesity-focused research; digestive diseases and nutrition (explicitly including obesity and eating disorders); and kidney, urologic, and hematologic diseases. Because NIAAA is involved, the announcement also leaves room for secondary analyses that intersect with alcohol use and alcohol-related factors when those relationships matter for the targeted conditions. ODS participation signals that nutrition and dietary supplement-related questions are also within scope, as long as they tie back to the program areas. The emphasis is not simply on re-running basic statistics on an old dataset, but on using existing data to ask sharper, more original questions, examine understudied subgroups, apply new analytic approaches, or generate findings that can set up larger future studies.
The activity mechanism is the NIH R21, which is typically used for early-stage, exploratory, or developmental research. In this FOA, the award ceiling is listed as $200,000, reflecting the smaller, hypothesis-generating nature of R21 projects. The announcement does not require cost sharing or matching, which generally lowers barriers for applicants because they are not expected to provide institutional funds to supplement the federal award. The funding activity category is listed under Food and Nutrition and Health, and the associated CFDA numbers include 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) and 93.273 (Alcohol Research Programs), reflecting the joint institute participation.
Eligibility is intentionally expansive and includes most major applicant types that commonly apply for NIH grants. Eligible applicants include state and local governments (such as county governments, city or township governments, and special district governments), public housing authorities/Indian housing authorities, and independent school districts. A wide range of academic institutions can apply, including public and state-controlled institutions of higher education and private institutions of higher education. Nonprofit eligibility includes organizations with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education). For-profit entities are also eligible, including small businesses and other for-profit organizations. Tribal entities are explicitly included, such as federally recognized Native American tribal governments, tribal organizations that are not federally recognized, and tribally controlled colleges and universities (TCCUs). The FOA also highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and other regionally focused organizations, reinforcing that the program is open to a diverse set of institutional applicants.
A notable feature is the allowance for international participation. Non-domestic (non-U.S.) entities, foreign institutions, and non-domestic components of U.S. organizations are eligible to apply. In addition, foreign components, as defined in the NIH Grants Policy Statement, are allowed. This matters because many high-value datasets and unique populations are located outside the United States, and secondary analysis can be particularly efficient when leveraging well-established international cohorts, national registries, or multi-country studies. That said, applicants still need to ensure the proposed work aligns with NIH policies and that the dataset access, ethical considerations, and any human subjects requirements are addressed appropriately for the secondary-use context.
Operationally, the FOA was posted on March 19, 2012. The record shows an original closing date of May 7, 2015, with a current closing date listed as April 1, 2015, and an archive date of May 1, 2015, indicating that this particular announcement is no longer active as a live competition. Even so, it remains a useful reference point because NIH often releases similar opportunities over time, and the program concept (secondary analyses using existing datasets in these disease areas) is a recurring priority across NIH institutes.
For applicants looking for the authoritative details, the FOA points to the full announcement on the NIH grants site at http://grants.nih.gov/grants/guide/pa-files/PA-12-125.html. The provided contact route for technical access problems is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, which is specifically intended for issues accessing or linking to the announcement rather than for scientific or programmatic questions.
FAQs: Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21) - PA-12-125
What is the title and funding opportunity number for this grant?
The opportunity is titled "Secondary Analyses in Obesity, Diabetes and Digestive and Kidney Diseases (R21)" and the Funding Opportunity Number is PA-12-125.
What kind of research does this opportunity support?
This NIH announcement supports exploratory research projects that rely on secondary analysis of already-existing datasets. The aim is to test new, innovative, and sometimes higher-risk hypotheses without launching new data collection efforts.
What is meant by "secondary analysis" in this program?
In this context, secondary analysis means using data that have already been collected (for example, from prior clinical studies, cohorts, surveillance systems, administrative/health system sources, or registries) to answer new research questions, apply new methods, examine understudied subgroups, or generate findings that can support larger future studies.
Which NIH institutes and offices sponsor or participate in this FOA?
The FOA is sponsored primarily by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), with participation from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the Office of Dietary Supplements (ODS).
What scientific areas are within scope?
The scope is broad but anchored in diseases and conditions aligned with NIDDK and partner missions, including:
- Diabetes and related endocrine/metabolic research
- Obesity-focused research
- Digestive diseases and nutrition (explicitly including obesity and eating disorders)
- Kidney, urologic, and hematologic diseases
How does NIAAA participation affect what topics can be proposed?
Because NIAAA participates, the FOA allows room for secondary analyses that intersect with alcohol use and alcohol-related factors when those relationships are relevant to the targeted conditions within the announcement's disease areas.
How does ODS participation affect what topics can be proposed?
ODS participation signals that nutrition and dietary supplement-related questions can be within scope, as long as they connect back to the program areas described in the FOA (such as obesity, diabetes, digestive diseases, kidney diseases, etc.).
Is the FOA looking for simple re-analysis of an old dataset?
No. The emphasis is not on re-running basic statistics. The FOA prioritizes work that uses existing data to ask sharper, more original questions, explore understudied subgroups, apply new analytic approaches, and/or generate results that can set up larger future studies.
What NIH activity mechanism is used for this opportunity?
The activity mechanism is the NIH R21, which is typically used for early-stage, exploratory, or developmental research.
What is the award ceiling mentioned in the announcement?
The FOA lists an award ceiling of $200,000, reflecting the smaller, hypothesis-generating nature of R21 projects described in this opportunity.
Is cost sharing or matching required?
No. The announcement states that cost sharing or matching is not required, meaning applicants are generally not expected to contribute institutional funds to supplement the federal award.
What kinds of data sources does NIH expect applicants to use?
The FOA describes using already-existing datasets such as those from:
- Prior clinical studies
- Cohort studies
- Epidemiologic surveillance systems
- Administrative or health system datasets
- Registries
- Other established data resources
What is the funding activity category and CFDA numbers listed?
The funding activity category is listed under Food and Nutrition and Health. The associated CFDA numbers include 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) and 93.273 (Alcohol Research Programs).
Who is eligible to apply?
Eligibility is broad and includes many common NIH applicant types across government, education, nonprofit, and private sectors, as well as tribal and international entities (as described in the FOA summary provided).
Are U.S. state and local government organizations eligible?
Yes. Eligible applicants include state governments and local governments, including county governments, city or township governments, and special district governments.
Are public housing authorities and independent school districts eligible?
Yes. The eligible applicant list includes public housing authorities/Indian housing authorities and independent school districts.
Are colleges and universities eligible?
Yes. Eligible academic institutions include public/state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. Eligibility includes nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education).
Are for-profit organizations eligible?
Yes. The FOA indicates that for-profit entities are eligible, including small businesses and other for-profit organizations.
Are tribal entities eligible?
Yes. Tribal entities are explicitly included, including federally recognized Native American tribal governments, tribal organizations that are not federally recognized, and tribally controlled colleges and universities (TCCUs).
Does the FOA encourage participation from institutions serving specific communities?
The FOA highlights eligibility for organizations such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and other regionally focused organizations, indicating an open and diverse applicant pool.
Are international applicants allowed?
Yes. The FOA allows international participation, including non-domestic (non-U.S.) entities, foreign institutions, and non-domestic components of U.S. organizations.
Are foreign components allowed as part of an application?
Yes. Foreign components, as defined in the NIH Grants Policy Statement, are allowed under this opportunity (per the summary provided).
Why might international participation matter for a secondary analysis program?
The FOA notes that many high-value datasets and unique populations exist outside the U.S., and secondary analysis can efficiently leverage established international cohorts, national registries, or multi-country studies.
Does this FOA appear to still be active?
No. The record indicates it is no longer active as a live competition. It was posted on March 19, 2012, shows closing dates in 2015 (including an original closing date of May 7, 2015 and a current closing date listed as April 1, 2015), and an archive date of May 1, 2015.
Where can applicants find the official full announcement?
The FOA points to the NIH grants site here: http://grants.nih.gov/grants/guide/pa-files/PA-12-125.html
Who should be contacted for technical access problems with the announcement link?
For technical access issues (such as problems accessing or linking to the FOA), the contact route provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Is the listed email intended for scientific or programmatic questions?
No. The provided contact is specifically intended for technical access problems related to accessing or linking to the announcement, not for scientific or programmatic inquiries.
Why might this archived FOA still be useful?
The summary notes it remains a useful reference because NIH often releases similar opportunities over time, and the overall program concept (secondary analyses using existing datasets in these disease areas) is a recurring priority across NIH institutes.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 12 125) also looked into and applied for these:
| Funding Opportunity |
|---|
| Pilot and Feasibility Clinical Research Grants in Diabetes, and Endocrine and Metabolic Diseases (R21) Apply for PA 12 157 Funding Number: PA 12 157 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
| Translational Research to Improve Obesity and Diabetes Outcomes (R18) Apply for PAR 12 172 Funding Number: PAR 12 172 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Planning Grants for Translational Research to Improve Obesity and Diabetes Outcomes (R34) Apply for PAR 12 173 Funding Number: PAR 12 173 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Promoting Organ and Tissue Donation Among Diverse Populations (R01) Apply for RFA DK 12 006 Funding Number: RFA DK 12 006 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Limited Competition for the Continuation of the Halt Polycystic Kidney Disease Trials Data Coordinating Center (DCC) (U01) Apply for RFA DK 12 505 Funding Number: RFA DK 12 505 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of Look AHEAD (Action for Health in Diabetes) Consortium (U01) Apply for RFA DK 12 502 Funding Number: RFA DK 12 502 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Renal Function and Chronic Kidney Disease in Aging (R01) Apply for PA 12 211 Funding Number: PA 12 211 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| George M. OBrien Kidney Research Core Centers (P30) Apply for RFA DK 12 008 Funding Number: RFA DK 12 008 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $750,000 |
| Research Enhancement for NIDDK Hematology Grantees (Admin Supp) Apply for PA 12 242 Funding Number: PA 12 242 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| New Technologies for the Study of Lymphatics in the Digestive and Urinary Systems (R43/R44) Apply for PA 12 258 Funding Number: PA 12 258 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01) Apply for PAR 12 259 Funding Number: PAR 12 259 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $250,000 |
| Lymphatics in Health and Disease in the Digestive, Cardiovascular and Pulmonary Systems (R21) Apply for PAR 12 260 Funding Number: PAR 12 260 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $125,000 |
| Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) Apply for PAR 12 265 Funding Number: PAR 12 265 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Assessment, Serial Evaluation and Subsequent Sequelae of Acute Kidney Injury (ASSESS AKI) Study (U01) Apply for RFA DK 12 509 Funding Number: RFA DK 12 509 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Pilot Studies of Candidate Therapies for Chronic Kidney Disease (CKD) (U01) Apply for RFA DK 12 016 Funding Number: RFA DK 12 016 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) (U01) Apply for RFA DK 12 017 Funding Number: RFA DK 12 017 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01) Apply for RFA DK 12 508 Funding Number: RFA DK 12 508 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Advancing Clinical Research in Primary Glomerular Diseases (UM1) Apply for RFA DK 12 014 Funding Number: RFA DK 12 014 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Novel Interventions to Reduce Morbidity and Mortality of Hemodialysis Patients Safety and Other Early Phase Studies (U01) Apply for RFA DK 12 010 Funding Number: RFA DK 12 010 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Multidisciplinary K12 Urologic Research (KURe) Career Development Program Apply for RFA DK 12 013 Funding Number: RFA DK 12 013 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $600,000 |
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