Opportunity Information: Apply for PA 11 320
Apply for PA 11 320
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Single Cell Studies in Aging Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research 93.866 Aging Research.
- This funding opportunity was created on Aug 24, 2011 and posted on Aug 24, 2011.
- Applicants must submit their applications by Sep 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments County governments Special district governments Private institutions of higher education Native American tribal governments (Federally recognized) City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity titled "Single Cell Studies in Aging Research (R01)" (Funding Opportunity Number PA 11 320) is a discretionary grant program issued by the National Institutes of Health, specifically the National Institute on Aging (NIA). Its main purpose is to support research that uses single-cell biology approaches to deepen scientific understanding of both normal aging processes and the biological mechanisms behind age-related diseases. The underlying idea is that studying tissues at the level of individual cells can reveal important differences between cell types and cell states that are often hidden in traditional bulk tissue experiments, where signals from many cells are averaged together. By resolving that heterogeneity, single-cell work can clarify which specific cell populations drive functional decline with age, which ones remain resilient, and how interactions among cells change over time in different organs.
This announcement emphasizes the use of advanced, cutting-edge tools that can measure biological features in single cells with high precision. It explicitly encourages applications that use omics technologies at the single-cell level (such as transcriptomics, epigenomics, proteomics, and related approaches), along with imaging-based methods, optofluidic platforms, mass spectrometry, whole-genome sequencing, and other emerging technologies capable of analyzing individual cells. The program frames these technologies not as ends in themselves, but as ways to identify unique and biologically meaningful properties of tissues and organs as they age. In practical terms, projects responsive to this FOA would typically aim to map age-associated cellular changes, discover rare or previously unrecognized cell subpopulations, connect cellular phenotypes to functional outcomes, or define how molecular pathways shift within and between cell types during aging and disease progression.
The mechanism of support is the NIH R01, meaning it is designed for hypothesis-driven, investigator-initiated research projects that can support a substantial and sustained research effort. The activity category is Health, and the listing aligns with CFDA numbers 93.866 (Aging Research) and 93.838 (Lung Diseases Research), signaling that the research scope can include aging broadly as well as organ- or disease-relevant studies where aging biology is a central factor. The announcement states there is no cost sharing or matching requirement, so applicants are not expected to provide mandatory matching funds as part of the award conditions.
Eligibility is broad and includes a wide range of domestic and international entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (including those other than small businesses), small businesses, and multiple levels of government (state, county, city/township, special district governments, and independent school districts). The FOA also lists public housing authorities/Indian housing authorities and a number of mission-specific or community-based categories such as faith-based and community-based organizations. In addition, it explicitly includes institutions and organizations that serve specific populations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and Native American tribal organizations, including both federally recognized tribal governments and other tribal entities. International participation is also permitted: non-U.S. (foreign) institutions can apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined under NIH policy are allowed, which can be important for projects requiring specialized cohorts, technologies, or collaborative resources.
Key administrative details reflect that this was a time-limited announcement. It was posted and created on August 24, 2011, with an original and current closing date of September 7, 2014, and it was archived on October 8, 2014. The full announcement was made available through the NIH Grants Guide at the provided link (http://grants.nih.gov/grants/guide/pa-files/PA-11-320.html). For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, this FOA can be viewed as an NIH/NIA effort to push aging research toward higher-resolution biology, where the unit of analysis is the single cell rather than the whole tissue. It is geared toward projects that can use single-cell technologies to reveal mechanisms, cell-specific pathways, and tissue architecture changes that shape aging and age-related disease, with the expectation that these insights will improve how the field characterizes aging phenotypes and identifies meaningful targets for future interventions.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Single Cell Studies in Aging Research (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-11-320.
Which agency and institute are offering this grant?
This is a discretionary grant program issued by the National Institutes of Health (NIH), specifically through the National Institute on Aging (NIA).
What is the main purpose of this FOA?
The purpose is to support research that uses single-cell biology approaches to improve scientific understanding of normal aging processes and the biological mechanisms that drive age-related diseases.
Why does the FOA emphasize single-cell approaches instead of bulk tissue studies?
The FOA is based on the idea that tissues contain diverse cell types and cell states that can be obscured in traditional bulk experiments, where measurements average signals across many cells. Single-cell analysis can reveal cellular heterogeneity, identify rare or previously unrecognized cell populations, and clarify which specific cells contribute to age-related functional decline or resilience.
What types of research projects are considered responsive to this FOA?
Projects responsive to this FOA would typically aim to map age-associated cellular changes, discover rare or unrecognized cell subpopulations, connect cellular phenotypes to functional outcomes, or define how molecular pathways shift within and between cell types during aging and age-related disease progression.
What grant mechanism is used for this program?
The mechanism of support is the NIH R01, which is intended for hypothesis-driven, investigator-initiated research projects supporting a substantial and sustained research effort.
What is the activity category for this opportunity?
The activity category is Health.
Which CFDA numbers are associated with this FOA?
This opportunity aligns with CFDA 93.866 (Aging Research) and CFDA 93.838 (Lung Diseases Research).
Does this FOA require cost sharing or matching funds?
No. The announcement states there is no cost sharing or matching requirement.
What types of single-cell technologies does the FOA encourage?
The FOA emphasizes advanced tools that measure biological features in single cells with high precision, including single-cell omics approaches (such as transcriptomics, epigenomics, and proteomics), as well as imaging-based methods, optofluidic platforms, mass spectrometry, whole-genome sequencing, and other emerging technologies capable of analyzing individual cells.
Does the FOA treat advanced technology development as the main goal?
No. The FOA frames these tools as a means to identify unique and biologically meaningful properties of tissues and organs as they age, rather than as ends in themselves.
Is the eligibility limited to universities?
No. Eligibility is broad and includes many types of domestic and international entities, including higher education institutions, nonprofits, for-profits, small businesses, and multiple levels of government.
Which higher education institutions are eligible?
Eligible higher education applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible to apply?
Yes. Nonprofit organizations with or without 501(c)(3) status are eligible.
Are for-profit organizations eligible to apply?
Yes. For-profit organizations are eligible, including those other than small businesses.
Are small businesses eligible to apply?
Yes. Small businesses are listed as eligible applicants.
Which government entities are eligible to apply?
Multiple levels of government are eligible, including state governments, county governments, city or township governments, special district governments, and independent school districts.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are included in the eligibility list.
Are faith-based or community-based organizations eligible?
Yes. The FOA includes categories such as faith-based and community-based organizations.
Does the FOA encourage or permit applications from institutions serving specific populations?
Yes. The FOA explicitly includes institutions and organizations that serve specific populations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and Native American tribal organizations (including federally recognized tribal governments and other tribal entities).
Are international (non-U.S.) organizations eligible to apply?
Yes. Non-U.S. (foreign) institutions may apply. The FOA also allows non-U.S. components of U.S. organizations and foreign components (as defined under NIH policy).
When was this FOA posted and created?
The FOA was posted and created on August 24, 2011.
What was the closing date for this opportunity?
The original and current closing date was September 7, 2014.
Is this FOA still active?
No. The announcement was archived on October 8, 2014.
Where can the full announcement be found?
The full announcement was made available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-11-320.html
Who is listed as the contact for technical issues accessing or linking to the announcement?
The contact listed for technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
How does this FOA describe the scientific value of single-cell studies in aging?
The FOA positions single-cell studies as a way to reveal which cell populations drive age-related decline, which remain resilient, and how cell-to-cell interactions and tissue architecture change over time in different organs, improving how aging phenotypes are characterized and how future intervention targets might be identified.
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