Opportunity Information: Apply for PA 11 321
Apply for PA 11 321
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Single Cell Studies in Aging Research (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research 93.866 Aging Research.
- This funding opportunity was created on Aug 24, 2011 and posted on Aug 24, 2011.
- Applicants must submit their applications by Sep 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities City or township governments Small businesses State governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Independent school districts For profit organizations other than small businesses Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity titled "Single Cell Studies in Aging Research (R21)" (Funding Opportunity Number PA-11-321) is a discretionary NIH grant program led by the National Institute on Aging (NIA). Its core purpose is to support exploratory, early-stage research that uses single-cell biology approaches to deepen understanding of both normal aging processes and the biological mechanisms that drive age-related diseases. The central idea behind the announcement is that studying tissues in bulk can hide important differences between cells, while single-cell methods can reveal rare cell populations, distinct cellular states, and subtle molecular changes that may be critical for explaining how aging unfolds in organs and how disease risk increases over time.
This FOA emphasizes technology-enabled projects that interrogate biology at the resolution of individual cells. Applicants are encouraged to use cutting-edge tools such as omics technologies (for example, transcriptomics, epigenomics, proteomics, and metabolomics at single-cell scale), advanced imaging approaches, optofluidic platforms, mass spectrometry-based methods, and whole genome sequencing, along with other emerging single-cell techniques. The program rationale is that single-cell measurements can improve the identification of biologically meaningful properties within tissues and organs during aging, including heterogeneity among cell types, shifts in cell function, lineage relationships, stress responses, senescence-related features, and microenvironmental interactions that may be missed by averaged measurements.
The award mechanism is an R21, which is typically used by NIH to support innovative, high-impact ideas that may still be at an earlier proof-of-concept stage. The listed award ceiling is $200,000, and the opportunity does not require cost sharing or matching. The activity category is Health, and it is associated with CFDA numbers 93.866 (Aging Research) and 93.838 (Lung Diseases Research), signaling that proposals may span broad aging biology and potentially include organ-specific aging questions, including but not limited to pulmonary aging and related conditions, as long as the work aligns with NIA interests in aging and age-associated disease mechanisms.
Eligibility is broad and inclusive, allowing applications from many types of U.S. organizations and governments, including public and private institutions of higher education, nonprofits (including 501(c)(3) and other nonprofit structures), for-profit organizations (including small businesses and other for-profits), and a wide range of governmental entities (state, county, city/township, special district, and certain housing authorities). The FOA also explicitly includes eligibility for organizations that serve specific communities and missions, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal governments and organizations (including federally recognized tribes and other tribal entities), faith-based and community-based organizations, and regional organizations. Importantly, foreign institutions (non-U.S. entities) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy, which opens the door to international collaborations or studies requiring specialized expertise or cohorts outside the United States.
In terms of timing and status, the FOA was posted and created on August 24, 2011, with an original and current closing date of September 7, 2014, and an archive date of October 8, 2014, meaning the opportunity is no longer active as written and is provided for historical reference. The official announcement link is listed as http://grants.nih.gov/grants/guide/pa-files/PA-11-321.html. For technical issues accessing the announcement or linking problems, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, this R21 announcement is aimed at catalyzing innovative single-cell research that can map and explain aging-related cellular diversity and change, with the expectation that finer-resolution biology will lead to clearer mechanistic insights into how aging affects tissues and how age-related diseases emerge.
Frequently Asked Questions (FAQs): Single Cell Studies in Aging Research (R21) - PA-11-321
What is the title and funding opportunity number for this program?
The opportunity is titled "Single Cell Studies in Aging Research (R21)" and the Funding Opportunity Number is PA-11-321.
Which federal agency and NIH institute lead this funding opportunity?
This is an NIH discretionary grant program led by the National Institute on Aging (NIA).
What is the main purpose of this funding opportunity?
The purpose is to support exploratory, early-stage research using single-cell biology approaches to improve understanding of normal aging and the biological mechanisms that drive age-related diseases.
Why does the FOA emphasize single-cell approaches instead of bulk tissue studies?
The FOA is based on the idea that bulk measurements can mask important cell-to-cell differences. Single-cell methods can reveal rare cell populations, distinct cellular states, and subtle molecular changes that may be critical for explaining how aging unfolds in organs and how disease risk increases over time.
What kinds of studies are especially encouraged under this FOA?
Projects that interrogate aging biology at the resolution of individual cells are emphasized, particularly technology-enabled and cutting-edge single-cell studies aimed at uncovering biologically meaningful properties within tissues and organs during aging.
What types of technologies and methods does the FOA encourage?
The FOA encourages use of advanced single-cell tools, including omics technologies (such as single-cell transcriptomics, epigenomics, proteomics, and metabolomics), advanced imaging approaches, optofluidic platforms, mass spectrometry-based methods, whole genome sequencing, and other emerging single-cell techniques.
What kinds of biological questions in aging does this FOA highlight?
The FOA highlights questions related to aging-associated cellular heterogeneity and change, including differences among cell types, shifts in cell function, lineage relationships, stress responses, senescence-related features, and microenvironmental interactions that may be missed by averaged (bulk) measurements.
What NIH award mechanism is used for this opportunity?
This opportunity uses the NIH R21 mechanism.
What does it mean that this is an R21 opportunity?
R21 awards are typically used by NIH to support innovative, potentially high-impact ideas that are still at an early or proof-of-concept stage.
What is the maximum award amount listed for this FOA?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching.
What is the activity category associated with this FOA?
The activity category is Health.
Which CFDA numbers are associated with this opportunity?
This opportunity is associated with CFDA 93.866 (Aging Research) and 93.838 (Lung Diseases Research).
Does the FOA allow organ-specific aging research, such as lung/pulmonary aging?
Yes. The inclusion of CFDA 93.838 (Lung Diseases Research) signals that proposals may include organ-specific aging questions, including (but not limited to) pulmonary aging and related conditions, as long as the work aligns with NIA interests in aging and age-associated disease mechanisms.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations and governments, including public and private institutions of higher education, nonprofits (including 501(c)(3) and other nonprofit structures), for-profit organizations (including small businesses and other for-profits), and multiple governmental entities (state, county, city/township, special district, and certain housing authorities).
Are community-serving or mission-focused institutions explicitly included?
Yes. The FOA explicitly includes organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal governments and organizations, faith-based and community-based organizations, and regional organizations.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes tribal governments and organizations, including federally recognized tribes and other tribal entities.
Can for-profit organizations apply?
Yes. The FOA includes for-profit organizations, including small businesses and other for-profits, among eligible applicants.
Are foreign institutions eligible to apply?
Yes. The FOA states that foreign institutions (non-U.S. entities) are eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
Yes. The FOA states that non-U.S. components of U.S. organizations are eligible.
Are foreign components allowed?
Yes. Foreign components are allowed as defined by NIH policy, which supports international collaborations or work requiring specialized expertise or cohorts outside the United States.
When was this funding opportunity posted?
The FOA was posted (and created) on August 24, 2011.
What was the closing date for applications?
The original and current closing date listed is September 7, 2014.
Is this funding opportunity still active?
No. The FOA has an archive date of October 8, 2014, indicating the opportunity is no longer active as written and is provided for historical reference.
Where can I find the official announcement?
The official announcement link is: http://grants.nih.gov/grants/guide/pa-files/PA-11-321.html
Who should be contacted for technical issues with accessing the announcement link?
For technical issues accessing the announcement or linking problems, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overarching goal of this FOA in the context of aging research?
The overarching goal is to catalyze innovative single-cell research that maps and explains aging-related cellular diversity and change, with the expectation that higher-resolution biology will yield clearer mechanistic insights into how aging affects tissues and how age-related diseases emerge.
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