Opportunity Information: Apply for PA 13 030
Apply for PA 13 030
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Solid Organ Transplantation Older Donors and Recipients (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.866 Aging Research.
- This funding opportunity was created on Jan 4, 2013 and posted on Dec 6, 2012.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses City or township governments Independent school districts Small businesses Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Solid Organ Transplantation Older Donors and Recipients (R01) funding opportunity (PA-13-030) is a National Institutes of Health grant announcement led by the National Institute on Aging (NIA) that supports research focused on solid organ transplantation in older adults. The intent is to fund a broad range of studies, including basic science, clinical research, translational work, epidemiology, and outcomes research, as long as the central goal is to improve understanding and real-world practice of transplantation involving older donors and/or older recipients. At its core, the announcement reflects the growing importance of transplantation in an aging population and the need for better evidence to guide decisions about who should receive transplants, how older recipients should be managed, and how organs from older donors can be used safely and effectively.
The scientific scope is intentionally wide, but the FOA highlights several priority areas. One major theme is improving how older donors and recipients are selected, meaning projects can address risk stratification, frailty and comorbidity assessment, donor organ quality metrics, and decision tools that better predict transplant suitability and outcomes in later life. Another emphasis is the improved management of older transplant recipients, which can include perioperative care, long-term monitoring, rehabilitation, medication management, and strategies to reduce complications that may be more common or more severe in older people. A third focal area is immunology and immunosuppression in aging, encouraging work that examines how immune aging (immunosenescence) influences rejection risk, infection susceptibility, cancer risk, and drug responses, and how immunosuppressive regimens might be tailored for older recipients to balance graft protection with safety. The FOA also calls attention to healthcare disparities, utilization, and costs, supporting studies that look at unequal access to transplant evaluation or listing, variation in organ allocation or acceptance practices, differential outcomes by demographic or socioeconomic factors, and the economic impact of transplant care in older populations.
The expected impact is both scientific and practical. On the science side, NIA is aiming to strengthen knowledge about the immunobiology of aging in the context of transplantation, which could lead to more age-appropriate approaches to immune monitoring and therapy. On the clinical and policy side, the FOA is meant to produce evidence-based guidance that can improve access to transplantation for older adults, inform organ allocation and utilization decisions (including organs from older donors), and ultimately improve graft survival and patient outcomes in both the short and long term. In other words, successful projects should help clinicians and health systems make better decisions and reduce avoidable harms while improving the likelihood that older patients benefit from transplantation.
Administratively, this opportunity uses the NIH R01 mechanism, which typically supports discrete, hypothesis-driven projects of significant scope under a traditional research grant structure. It falls under the health research activity category, with CFDA listings that include Aging Research (93.866) and Nursing Research (93.361), reflecting the multidisciplinary nature of transplant research in older adults. There is no cost sharing or matching requirement, which means applicants are not required to provide non-federal funds to receive an award.
Eligibility is broad and includes many types of domestic U.S. organizations such as public and private institutions of higher education, nonprofits (including 501(c)(3) and other nonprofit structures), for-profit organizations (including small businesses), state and local governments, tribal governments and tribal organizations, public housing authorities, independent school districts, and special district governments. The announcement also explicitly allows a wide set of additional eligible applicants, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISI institutions, faith-based or community-based organizations, and eligible federal agencies. Importantly, foreign participation is allowed: non-U.S. entities (foreign organizations and foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined by the NIH Grants Policy Statement are permitted.
Key dates indicate that the FOA was posted on December 6, 2012, created on January 4, 2013, and had a closing date of January 7, 2016, with an archive date of February 7, 2016. The sponsoring agency is NIH, specifically NIA, and the full announcement was available via the NIH Grants Guide at the provided link. For technical access issues related to the electronic announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs): Solid Organ Transplantation Older Donors and Recipients (R01) - PA-13-030
What is this funding opportunity?
This is a National Institutes of Health (NIH) grant announcement titled Solid Organ Transplantation Older Donors and Recipients (R01), funding opportunity number PA-13-030. It supports research on solid organ transplantation involving older donors and/or older recipients, with the goal of improving both scientific understanding and real-world clinical practice.
Which NIH institute leads this opportunity?
The opportunity is led by the National Institute on Aging (NIA), part of NIH.
What is the main goal of the program?
The central goal is to improve understanding and practice of transplantation in an aging population, including better evidence to guide who should receive transplants, how older recipients should be managed, and how organs from older donors can be used safely and effectively.
What type of grant mechanism is used?
This opportunity uses the NIH R01 mechanism, which typically supports discrete, hypothesis-driven research projects of significant scope under a traditional research grant structure.
What research areas does the FOA support?
The scientific scope is intentionally broad. Supported study types can include basic science, clinical research, translational work, epidemiology, and outcomes research, as long as the central focus is transplantation involving older donors and/or recipients.
What priority topics does the FOA highlight?
The FOA highlights several priority areas, including:
- Selection of older donors and recipients (for example: risk stratification, frailty and comorbidity assessment, donor organ quality metrics, decision tools to predict suitability and outcomes)
- Management of older transplant recipients (for example: perioperative care, long-term monitoring, rehabilitation, medication management, strategies to reduce complications)
- Immunology and immunosuppression in aging (for example: immunosenescence effects on rejection, infection risk, cancer risk, drug response; tailoring regimens for older recipients)
- Healthcare disparities, utilization, and costs (for example: unequal access to evaluation or listing, variation in allocation/acceptance practices, outcome differences by demographic or socioeconomic factors, economic impact of care)
Does the FOA require projects to be basic science or clinical?
No. The FOA allows a wide range of study designs and disciplines (basic, translational, clinical, epidemiology, outcomes), as long as the work is centered on improving understanding or practice of solid organ transplantation involving older adults.
What kinds of practical outcomes is NIA looking for?
The FOA is intended to generate evidence that can improve clinical decisions and policies affecting older transplant candidates and recipients. Examples of practical impact described include improving access to transplantation for older adults, informing organ allocation and utilization decisions (including for organs from older donors), and improving graft survival and patient outcomes over both short and long time horizons.
Does the FOA address immunosuppression specifically in older recipients?
Yes. A key emphasis is the effect of aging on immune function (immunosenescence) and how that influences rejection risk, infection susceptibility, cancer risk, and drug responses, as well as how immunosuppressive regimens might be tailored for older recipients to balance graft protection with safety.
Are healthcare disparities and access issues within scope?
Yes. The FOA explicitly calls attention to disparities, utilization, and costs, including unequal access to evaluation or listing, variation in allocation or organ acceptance practices, differences in outcomes by demographic or socioeconomic factors, and the economic impact of transplant care in older populations.
Is there a cost sharing or matching requirement?
No. The opportunity states there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal funds as a condition of receiving an award.
Who is eligible to apply within the United States?
Eligibility is broad and includes many types of domestic U.S. organizations, including:
- Public and private institutions of higher education
- Nonprofits (including 501(c)(3) and other nonprofit structures)
- For-profit organizations (including small businesses)
- State and local governments
- Tribal governments and tribal organizations
- Public housing authorities
- Independent school districts
- Special district governments
Are minority-serving institutions and community-based organizations eligible?
Yes. The FOA explicitly allows additional eligible applicants including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISI institutions, and faith-based or community-based organizations.
Is foreign participation allowed?
Yes. Foreign participation is allowed, including:
- Non-U.S. entities (foreign organizations and foreign institutions) may apply
- Non-U.S. components of U.S. organizations are eligible
- Foreign components (as defined by the NIH Grants Policy Statement) are permitted
What are the relevant CFDA listings mentioned?
The FOA lists CFDA programs including Aging Research (93.866) and Nursing Research (93.361), reflecting the multidisciplinary nature of transplantation research involving older adults.
When was this FOA posted and when did it close?
Key dates provided are:
- Posted date: December 6, 2012
- Created date: January 4, 2013
- Closing date: January 7, 2016
- Archive date: February 7, 2016
Is this funding opportunity still open?
No. Based on the provided dates, the FOA had a closing date of January 7, 2016 and an archive date of February 7, 2016.
Where was the full announcement made available?
The full announcement was made available via the NIH Grants Guide at the link referenced in the opportunity description.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH), specifically the National Institute on Aging (NIA).
Who should be contacted for technical access issues related to the electronic announcement?
For technical access issues related to the electronic announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What does the FOA say about the intended impact of funded work?
The FOA describes intended impact on both science and practice, including strengthening knowledge of the immunobiology of aging in transplantation and producing evidence-based guidance that improves access, informs utilization and allocation decisions (including older donor organs), and improves graft survival and patient outcomes.
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