Opportunity Information: Apply for PA 13 037
Apply for PA 13 037
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Solid Organ Transplantation Older Donors and Recipients (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Dec 6, 2012 and posted on Dec 6, 2012.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts County governments City or township governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education For profit organizations other than small businesses State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Solid Organ Transplantation Older Donors and Recipients (R03) opportunity (Funding Opportunity Number PA-13-037) is a discretionary NIH grant program run by the National Institute on Aging (NIA). It supports small, focused research projects that improve understanding of solid organ transplantation (SOT) in older adults, with the broader goal of generating practical evidence that can strengthen clinical decision-making and policy in an area where age-related biology and real-world transplant outcomes intersect. The announcement emphasizes that aging changes immune function, physiology, and risk profiles in ways that can affect donor organ quality, recipient selection, immunosuppression tolerance, complication rates, and both short- and long-term graft and patient outcomes. Projects funded through this initiative are intended to build knowledge around the immunobiology of aging in the transplant setting and to translate that knowledge into better access, allocation, utilization, and outcomes for older transplant candidates and recipients.
The FOA invites a wide range of research approaches, including basic science, clinical studies, translational work, epidemiology, and outcomes research. In practical terms, that means applications could range from mechanistic studies of how immune aging influences rejection or infection risk, to analyses of registry or claims data that identify outcome patterns and cost drivers, to pragmatic clinical strategies aimed at tailoring care for older recipients. While the scope is broad, the announcement highlights several priority themes. One major focus is the appropriate selection of older donors and older recipients, which can include developing or validating selection criteria, risk stratification tools, biomarkers, or clinical algorithms that better predict which older patients will benefit from transplantation and which older organs can be used safely and effectively. Another major theme is improving management of older SOT recipients, including perioperative care, geriatric-relevant complications, medication management, frailty and functional outcomes, post-transplant surveillance, and strategies to reduce hospitalizations, adverse events, and loss of independence.
A third emphasized area is immunology and immunosuppression specifically as it pertains to older transplant patients. Because older adults may have different immune responsiveness and different vulnerability to immunosuppression-related harms (such as infections, malignancy, metabolic complications, kidney injury, and drug toxicities), the FOA encourages work that clarifies how immune aging changes rejection risk and how immunosuppressive regimens might be optimized for older recipients. This can include studies on immune phenotypes in aging, immune monitoring approaches, dose minimization strategies, or balancing rejection prevention against complication avoidance in older populations. The fourth highlighted theme addresses healthcare disparities, utilization, and costs of SOT in older patients, which can include inequities in referral, listing, access to organs, transplant center practices, geographic variability, insurance-related barriers, differential outcomes across populations, and economic analyses of transplant versus alternative therapies in later life.
As an R03 mechanism, this opportunity is designed for smaller-scale projects, pilot studies, secondary data analyses, or early-stage work that can produce targeted insights or generate preliminary data for larger follow-on studies. The award ceiling listed is $100,000, and the program does not require cost sharing or matching. The activity category is health, and it falls under CFDA 93.866 (Aging Research). The FOA was posted on December 6, 2012, with an original and final closing date of January 7, 2016, and an archive date of February 7, 2016, meaning it is a historical listing rather than an open competition today; however, it still provides a clear picture of the research priorities NIA was seeking to advance in this area.
Eligibility is broad and includes many common applicant types such as public and private institutions of higher education, nonprofit organizations (including 501(c)(3) entities and certain non-501(c)(3) nonprofits), small businesses, for-profit organizations (other than small businesses), and a wide range of government entities (state, county, city/township, special district). The FOA also explicitly includes tribal governments (federally recognized and other than federally recognized) and tribally controlled colleges and universities, as well as public housing authorities/Indian housing authorities and independent school districts. Additional eligible applicant categories include various minority-serving institutions (such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs), faith-based and community-based organizations, eligible federal agencies, U.S. territories or possessions, and regional organizations. Notably, non-U.S. entities are allowed to apply: foreign organizations and foreign institutions are eligible, non-U.S. components of U.S. organizations may apply, and foreign components are permitted consistent with NIH policy.
In summary, PA-13-037 targeted research that addresses the growing clinical and policy challenge of transplantation in an aging population. It aimed to fund projects that clarify how aging affects donor organ use and recipient outcomes, improve clinical management and immunosuppression strategies for older recipients, and address disparities and cost/utilization issues that shape real-world access and success. The expected end result of funded work was stronger, evidence-based guidance that improves organ allocation and utilization decisions, enhances graft survival, and advances both short- and long-term outcomes for older adults involved in solid organ transplantation.
FAQs: Solid Organ Transplantation Older Donors and Recipients (R03) - PA-13-037
What is the PA-13-037 grant opportunity?
PA-13-037 is a discretionary NIH grant opportunity titled "Solid Organ Transplantation Older Donors and Recipients (R03)." It was run by the National Institute on Aging (NIA) and designed to support small, focused research projects that improve understanding of solid organ transplantation (SOT) in older adults.
Which NIH institute runs this program?
This opportunity is run by the National Institute on Aging (NIA), which is part of the National Institutes of Health (NIH).
What is the main purpose of this funding opportunity?
The program supports research that clarifies how aging affects transplant-related biology and real-world outcomes, with the goal of producing practical evidence to improve clinical decision-making and policy for older donors, older transplant candidates, and older recipients.
What does "R03" mean in this context?
R03 refers to an NIH grant mechanism intended for smaller-scale projects. In this FOA, that includes pilot studies, secondary data analyses, or early-stage work that can generate targeted insights or preliminary data for larger follow-on studies.
How much funding is available per award?
The listed award ceiling is $100,000.
Is cost sharing or matching required?
No. The program does not require cost sharing or matching.
What research areas and approaches are invited?
The FOA invites a wide range of approaches, including basic science, clinical studies, translational research, epidemiology, and outcomes research. Examples described include mechanistic studies related to immune aging, analyses using registry or claims data, and pragmatic strategies aimed at tailoring care for older recipients.
Why is aging a key focus in solid organ transplantation research?
The announcement emphasizes that aging changes immune function, physiology, and risk profiles. These changes can influence donor organ quality, recipient selection, tolerance of immunosuppression, complication rates, and both short- and long-term graft and patient outcomes.
What are the priority themes highlighted in the FOA?
The FOA highlights four major themes: (1) selection of older donors and older recipients, (2) management of older SOT recipients, (3) immunology and immunosuppression in older transplant patients, and (4) healthcare disparities, utilization, and costs affecting older SOT patients.
What kinds of projects fit the "older donor and older recipient selection" theme?
Projects may include developing or validating selection criteria, risk stratification tools, biomarkers, or clinical algorithms that better predict which older patients are likely to benefit from transplantation and which older donor organs can be used safely and effectively.
What does the FOA prioritize for improving management of older transplant recipients?
Highlighted areas include perioperative care, geriatric-relevant complications, medication management, frailty and functional outcomes, post-transplant surveillance, and strategies to reduce hospitalizations, adverse events, and loss of independence.
What immunology and immunosuppression topics are emphasized for older recipients?
The FOA encourages research on how immune aging changes rejection risk and how immunosuppressive regimens might be optimized for older adults. Examples include studies of immune phenotypes in aging, immune monitoring approaches, dose minimization strategies, and balancing rejection prevention against complication avoidance in older populations.
What types of immunosuppression-related harms are noted as concerns for older adults?
The FOA notes that older adults may be more vulnerable to harms such as infections, malignancy, metabolic complications, kidney injury, and drug toxicities.
What disparities, utilization, and cost issues does the FOA call out?
Topics can include inequities in referral, listing, and access to organs; transplant center practices; geographic variability; insurance-related barriers; differential outcomes across populations; and economic analyses comparing transplantation versus alternative therapies in later life.
What is the broader expected impact of projects funded under PA-13-037?
The FOA aims to generate evidence that strengthens guidance on organ allocation and utilization decisions, enhances graft survival, and advances short- and long-term outcomes for older adults involved in solid organ transplantation.
What is the activity category and CFDA number associated with this opportunity?
The activity category is health, and the listing falls under CFDA 93.866 (Aging Research).
Is this funding opportunity currently open?
No. The FOA was posted on December 6, 2012, with an original and final closing date of January 7, 2016, and an archive date of February 7, 2016. This indicates it is a historical listing rather than an open competition today.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (including 501(c)(3) entities and certain non-501(c)(3) nonprofits); small businesses; for-profit organizations (other than small businesses); and many government entities (state, county, city/township, and special districts).
Are tribal entities and tribal colleges eligible?
Yes. The FOA explicitly includes tribal governments (federally recognized and other than federally recognized) and tribally controlled colleges and universities. It also includes public housing authorities/Indian housing authorities.
Are minority-serving institutions eligible?
Yes. The FOA includes multiple minority-serving institution categories such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs.
Are faith-based and community-based organizations eligible?
Yes. The FOA lists faith-based and community-based organizations among eligible applicant types.
Can foreign organizations apply?
Yes. The FOA states that foreign organizations and foreign institutions are eligible, non-U.S. components of U.S. organizations may apply, and foreign components are permitted consistent with NIH policy.
Does the FOA allow U.S. territories or regional organizations to apply?
Yes. The eligibility list includes U.S. territories or possessions and regional organizations.
What types of results are these R03 projects expected to produce?
Because this is an R03 mechanism, projects are intended to produce targeted insights or preliminary data that can inform clinical and policy decisions and potentially support larger follow-on studies.
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