Opportunity Information: Apply for PA 13 038
Apply for PA 13 038
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Solid Organ Transplantation Older Donors and Recipients (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.866 Aging Research.
- This funding opportunity was created on Jan 4, 2013 and posted on Dec 6, 2012.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Special district governments State governments Public housing authorities/Indian housing authorities Independent school districts Public and State controlled institutions of higher education City or township governments For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Solid Organ Transplantation Older Donors and Recipients (R21) funding opportunity (PA-13-038) was a discretionary NIH grant program issued by the National Institute on Aging (NIA) to support exploratory, early-stage research focused on solid organ transplantation (SOT) in older adults. The main purpose was to generate new evidence and insights that improve how older donors and older transplant recipients are evaluated, treated, and supported before and after transplant. The FOA emphasized that aging changes the biology of immunity and organ function, so transplant decisions and post-transplant care in older populations may require approaches that differ from those used in younger patients. Projects funded under this announcement were expected to strengthen scientific understanding of immunobiology at the intersection of aging and transplantation and to translate that knowledge into better clinical practice and policy.
The scope of supported research was broad and included basic, clinical, translational, epidemiological, and outcomes studies, reflecting an interest not only in mechanisms but also in real-world effectiveness and health system impacts. The FOA highlighted several priority areas: improving selection and evaluation of older donors and older recipients (including risk stratification and matching considerations); improving management of older transplant recipients (such as complications, comorbidity burden, frailty, functional outcomes, and long-term follow-up strategies); advancing understanding of immunology and immunosuppression specifically as it pertains to older patients (including age-related immune changes, rejection risk, infection risk, malignancy risk, and medication tolerability); and studying healthcare disparities, utilization patterns, and costs affecting transplantation in older adults. The overall goal was evidence-based guidance that could improve access to transplantation for older individuals, strengthen organ allocation and utilization decisions, increase graft survival, and improve both short- and long-term outcomes for older SOT patients.
This opportunity used the NIH R21 mechanism, which is commonly aimed at exploratory or developmental projects that can test novel hypotheses, establish feasibility, generate pilot data, or open new directions that may later be scaled into larger studies. The award ceiling listed for this FOA was $200,000, and it did not require cost sharing or matching funds, which can make it more accessible for institutions that cannot commit non-federal matching resources. As a health-focused grant, it was associated with CFDA program areas tied to Nursing Research (93.361) and Aging Research (93.866), reflecting NIA leadership and the relevance to clinical care and aging-related outcomes.
Eligibility was intentionally expansive and included many types of U.S. and non-U.S. applicants. Eligible domestic applicants included state, county, city/township, and special district governments; independent school districts; public and state-controlled universities; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; small businesses; and for-profit organizations other than small businesses. The FOA also explicitly included Tribal governments and Tribal organizations, public housing/Indian housing authorities, and a range of mission-driven institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and other minority-serving institutions (including AANAPISI). Faith-based and community-based organizations and eligible federal agencies were also included. Importantly, foreign organizations and foreign institutions were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components were allowed under NIH policy, signaling an openness to international collaboration and comparative research where appropriate.
Administratively, the FOA was posted on December 6, 2012, with a creation date of January 4, 2013. The original and current closing date listed was January 7, 2016, and the archive date was February 7, 2016, indicating that this particular announcement is no longer active but remains part of the historical NIH funding record. The sponsoring agency was the National Institutes of Health, with NIA as the issuing institute, and the full announcement was made available through the NIH grants guide. For access or technical issues, the notice directed applicants to contact the NIH Office of Extramural Research (OER) webmaster.
In practical terms, this FOA was aimed at improving transplant science and care for an aging population by encouraging studies that address the distinctive clinical risks and benefits older adults face in transplantation, the complexities of immunosuppression in later life, and the system-level barriers that can limit equitable access. The expected payoff was not only better biological understanding but also actionable findings that could influence clinical guidelines, transplant center practices, and policy decisions related to organ allocation, donor-recipient matching, and long-term management in older transplant recipients.
Frequently Asked Questions (FAQs): Solid Organ Transplantation Older Donors and Recipients (R21) (PA-13-038)
What is the Solid Organ Transplantation Older Donors and Recipients (R21) funding opportunity (PA-13-038)?
PA-13-038 was a discretionary NIH grant funding opportunity issued by the National Institute on Aging (NIA). It used the NIH R21 mechanism to support exploratory, early-stage research focused on solid organ transplantation (SOT) in older donors and older transplant recipients.
What was the main purpose of this FOA?
The purpose was to generate new evidence and insights that improve how older donors and older transplant recipients are evaluated, treated, and supported before and after transplant. The FOA emphasized that aging alters immunity and organ function, so clinical decisions and post-transplant management in older adults may need approaches that differ from those used in younger patients.
Which NIH institute issued this announcement?
The issuing institute was the National Institute on Aging (NIA), under the National Institutes of Health (NIH).
Is this funding opportunity still active?
No. The listed closing date was January 7, 2016, and the archive date was February 7, 2016, indicating the announcement is no longer active and remains as part of the historical NIH funding record.
What type of grant mechanism did this opportunity use?
This opportunity used the NIH R21 mechanism, which is generally intended for exploratory or developmental research. R21 projects commonly test novel hypotheses, establish feasibility, generate pilot data, or open new lines of investigation that may later be expanded into larger studies.
What was the maximum award amount (award ceiling) under this FOA?
The award ceiling listed for this FOA was $200,000.
Did the FOA require cost sharing or matching funds?
No. The FOA stated that cost sharing or matching funds were not required.
What research areas were within scope?
The scope was broad and included basic, clinical, translational, epidemiological, and outcomes research related to solid organ transplantation in older adults. The FOA reflected interest in mechanisms, real-world effectiveness, and health system impacts.
What priority topics did the FOA highlight?
Highlighted priorities included: improving selection and evaluation of older donors and older recipients (including risk stratification and matching); improving management of older recipients (complications, comorbidity burden, frailty, functional outcomes, and long-term follow-up); advancing understanding of immunology and immunosuppression in older patients (age-related immune changes and associated risks such as rejection, infection, malignancy, and medication tolerability); and studying healthcare disparities, utilization patterns, and costs affecting transplantation in older adults.
What outcomes or impacts was NIH hoping to achieve through funded projects?
The FOA aimed to produce evidence-based guidance to improve access to transplantation for older individuals, strengthen organ allocation and utilization decisions, increase graft survival, and improve short- and long-term outcomes for older SOT patients. It also emphasized producing knowledge that could influence clinical practice and policy.
Why did the FOA emphasize aging-related biology?
The FOA emphasized that aging changes the biology of immunity and organ function. Because of these changes, transplant evaluation, decision-making, immunosuppression, and post-transplant care may need to be tailored for older donors and older recipients rather than simply applying approaches developed for younger populations.
Did the FOA focus only on laboratory research?
No. While immunobiology was an important focus, the FOA also explicitly supported clinical, translational, epidemiological, and outcomes studies, including real-world effectiveness and health system impacts.
What is meant by "solid organ transplantation (SOT)" in this FOA?
The FOA focused on solid organ transplantation as a field of research and care. The announcement did not restrict the scope to a single organ in the provided description; instead, it emphasized improving transplantation science and clinical management for older donors and recipients across SOT.
Who was eligible to apply (in general terms)?
Eligibility was expansive and included a wide range of U.S. and non-U.S. applicants, spanning government entities, academic institutions, nonprofits, and for-profit organizations, among others.
Which U.S. government entities were eligible?
Eligible domestic government applicants included state governments, county governments, city or township governments, special district governments, and independent school districts.
Were colleges and universities eligible?
Yes. Eligible applicants included public and state-controlled institutions of higher education and private institutions of higher education.
Were nonprofit organizations eligible?
Yes. The FOA included nonprofit organizations with or without 501(c)(3) status.
Were for-profit organizations eligible?
Yes. Eligibility included small businesses and for-profit organizations other than small businesses.
Were Tribal governments and Tribal organizations eligible?
Yes. The FOA explicitly included Tribal governments and Tribal organizations, as well as public housing/Indian housing authorities.
Did the FOA encourage participation by minority-serving institutions?
The FOA explicitly listed multiple categories of mission-driven and minority-serving institutions as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and other minority-serving institutions (including AANAPISI).
Were faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations were listed among eligible applicants.
Could federal agencies apply?
Yes. Eligible federal agencies were included as eligible applicants.
Were foreign organizations eligible to apply?
Yes. The FOA stated that foreign organizations and foreign institutions were eligible to apply.
Were foreign components allowed on applications?
Yes. The FOA indicated that non-U.S. components of U.S. organizations were eligible and that foreign components were allowed under NIH policy, supporting international collaboration or comparative work when appropriate.
Which CFDA program areas were associated with this opportunity?
The FOA was associated with CFDA program areas tied to Nursing Research (93.361) and Aging Research (93.866).
When was the FOA posted and what were the key dates?
The FOA was posted on December 6, 2012, with a creation date of January 4, 2013. The listed closing date was January 7, 2016, and the archive date was February 7, 2016.
Where was the full announcement made available?
The full announcement was made available through the NIH grants guide.
Who was listed as the contact for access or technical issues?
For access or technical issues, the FOA directed applicants to contact the NIH Office of Extramural Research (OER) webmaster.
What kinds of practical changes could research funded under this FOA support?
Based on the FOA description, funded research was expected to generate actionable findings that could inform clinical guidelines, transplant center practices, and policy decisions, including organ allocation, donor-recipient matching, and long-term management strategies for older transplant recipients.
Did the FOA address disparities and costs in transplantation for older adults?
Yes. The FOA highlighted interest in healthcare disparities, utilization patterns, and costs affecting transplantation in older adults.
Did the FOA emphasize outcomes beyond graft survival?
Yes. In addition to graft survival, the FOA highlighted outcomes relevant to older recipients such as complications, comorbidity burden, frailty, functional outcomes, and long-term follow-up considerations.
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