Opportunity Information: Apply for SP 16 006

  • The HHS-SAMHS in the health sector is offering a public funding opportunity titled "Strategic Prevention Framework for Prescription Drugs (SPF Rx)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.243.
  • This funding opportunity was created on Mar 29, 2016 and posted on Mar 29, 2016.
  • Applicants must submit their applications by May 31, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $371,616.00 in funding.
  • The number of recipients for this funding is limited to 25 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for SP 16 006

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:

Opportunity Summary:

The Strategic Prevention Framework for Prescription Drugs (SPF Rx) is a SAMHSA discretionary cooperative agreement (HHS-SAMHSA, CFDA 93.243) aimed at helping jurisdictions that have already completed a Strategic Prevention Framework State Incentive Grant (SPF SIG) take the next step by focusing specifically on prescription drug misuse, with a strong emphasis on opioid-related harms. The opportunity is targeted to states, U.S. territories, and pacific jurisdictions (collectively referred to as states in the notice), as well as eligible tribal entities, and it is built around the idea that communities can reduce misuse and overdoses by pairing evidence-based prevention strategies with stronger data use and closer coordination with healthcare and pharmacy partners.

At its core, SPF Rx is designed to change both knowledge and behavior around prescription medications. A major theme is public awareness about the danger of sharing medications, which is a common pathway for nonmedical use, especially among adolescents and young adults. Alongside community messaging, the program also prioritizes engagement with the medical and pharmaceutical communities to address overprescribing risks, particularly for young adults, by encouraging safer prescribing practices and better clinical decision-making. Prevention is not limited to one setting; the grant emphasizes delivering education and prevention activities across schools and broader community environments, and reaching multiple audiences, including parents, prescribers, and patients.

A defining feature of the program is its reliance on Prescription Drug Monitoring Program (PDMP) data as both a tool and a marker of successful implementation. PDMPs are state-run databases that track the prescribing and dispensing of controlled substances and are intended to help identify patterns that may indicate misuse, diversion, or unsafe prescribing. By giving prescribers and pharmacists visibility into a patient's controlled-substance history, PDMPs can support safer care and reduce opportunities for inappropriate access to medications. For SPF Rx, SAMHSA signals that it will look for PDMP data to be incorporated into local needs assessments and strategic plans, reinforcing that prevention planning should be data-driven rather than purely anecdotal.

Eligibility and readiness requirements reflect that data emphasis. State applicants must already have a fully operational PDMP in place to apply, since the program expects PDMP information to be actively used to guide strategy selection, targeting, and monitoring. Tribal entities are also included, but the notice makes clear that tribes must coordinate with state-run PDMPs to identify collaboration opportunities that can help limit overprescribing and related harms in tribal communities, recognizing that PDMP infrastructure is generally managed at the state level.

From a performance and accountability standpoint, SAMHSA indicates it will track reductions in opioid overdoses as a key indicator of program success, along with the practical integration of PDMP data into prevention planning. In other words, the program is not only about distributing educational materials; it is structured to demonstrate measurable community-level impact and improved use of surveillance and prescribing data in prevention frameworks.

Administratively, this funding opportunity (Funding Opportunity Number SP 16 006) was posted March 29, 2016, with an application closing date of May 31, 2016. SAMHSA expected to make about 25 awards, with an award ceiling of $371,616. The cooperative agreement structure also signals that awardees should expect substantial federal involvement beyond simple pass-through funding, often including ongoing collaboration, guidance, and reporting expectations aligned with the program's prevention and data objectives.

Strategic Prevention Framework for Prescription Drugs (SPF Rx) - FAQs

What is the Strategic Prevention Framework for Prescription Drugs (SPF Rx)?

SPF Rx is a SAMHSA discretionary cooperative agreement (HHS-SAMHSA, CFDA 93.243) focused on preventing prescription drug misuse, with a strong emphasis on opioid-related harms. It is designed for jurisdictions that have already completed a Strategic Prevention Framework State Incentive Grant (SPF SIG) and are ready to take the next step by concentrating specifically on prescription medications.

What is the main goal of SPF Rx?

The main goal is to reduce prescription drug misuse and related harms (especially opioid harms) by combining evidence-based prevention strategies with stronger use of data and closer coordination with healthcare and pharmacy partners.

Who is the funding intended for?

The opportunity is targeted to states, U.S. territories, and pacific jurisdictions (referred to collectively as states in the notice), as well as eligible tribal entities.

Is SPF Rx only for jurisdictions that previously completed SPF SIG?

Yes. The program is described as supporting jurisdictions that have already completed a Strategic Prevention Framework State Incentive Grant (SPF SIG) and are prepared to focus specifically on prescription drug misuse.

What substances or harms does SPF Rx emphasize?

SPF Rx focuses on prescription drug misuse and places a strong emphasis on opioid-related harms, including reducing opioid overdoses as a key indicator of success.

What kinds of prevention approaches does SPF Rx promote?

The grant emphasizes pairing evidence-based prevention strategies with improved data use and coordination. It supports public awareness and education, and encourages prevention activities across schools and broader community settings.

What behaviors or knowledge is SPF Rx trying to change?

SPF Rx is intended to change both knowledge and behavior around prescription medications. A major theme is increasing public awareness about the danger of sharing medications, which is identified as a common pathway for nonmedical use, particularly among adolescents and young adults.

Which audiences are expected to be reached?

The opportunity highlights reaching multiple audiences, including parents, prescribers, and patients. It also points to adolescents and young adults as populations of concern in relation to medication sharing and nonmedical use.

Does SPF Rx involve schools, or is it only a community program?

It involves both. The grant emphasizes delivering education and prevention activities across schools and broader community environments rather than limiting prevention to a single setting.

How does SPF Rx involve healthcare and pharmacy partners?

SPF Rx prioritizes engagement with medical and pharmaceutical communities to address overprescribing risks and to encourage safer prescribing practices and better clinical decision-making, particularly with attention to risks affecting young adults.

What is a Prescription Drug Monitoring Program (PDMP) in the context of this grant?

In this notice, a PDMP is described as a state-run database that tracks the prescribing and dispensing of controlled substances. PDMPs are intended to help identify patterns that may indicate misuse, diversion, or unsafe prescribing, and to give prescribers and pharmacists visibility into a patient's controlled-substance history.

Why is PDMP data so important for SPF Rx?

PDMP data is a defining feature of SPF Rx. SAMHSA signals that PDMP data should be used as both a tool and a marker of successful implementation, including incorporation into local needs assessments and strategic plans so that prevention planning is data-driven rather than anecdotal.

How is PDMP data expected to be used by awardees?

The notice indicates PDMP data should be incorporated into local needs assessments and strategic plans, and used to guide strategy selection, targeting, and monitoring as part of the prevention framework.

Is an operational PDMP required to apply?

Yes for state applicants. The notice states that state applicants must already have a fully operational PDMP in place to apply, because PDMP information is expected to be actively used to guide and monitor prevention activities.

Are tribal entities eligible, and do they need a PDMP?

Eligible tribal entities are included. The notice also explains that tribes must coordinate with state-run PDMPs to identify collaboration opportunities to help limit overprescribing and related harms in tribal communities, recognizing that PDMP infrastructure is generally managed at the state level.

How will SAMHSA measure success for SPF Rx?

SAMHSA indicates it will track reductions in opioid overdoses as a key indicator of success. It will also look for practical integration of PDMP data into prevention planning, emphasizing measurable community-level impact and improved use of surveillance and prescribing data.

Is SPF Rx mainly an education and awareness campaign?

No. While public awareness and education are emphasized (including messaging about the dangers of sharing medications), the program is framed around measurable outcomes and data-driven planning, including use of PDMP data and tracking indicators like reductions in opioid overdoses.

What is the funding opportunity number for SPF Rx?

The Funding Opportunity Number is SP 16 006.

When was the opportunity posted and when did it close?

The notice states it was posted on March 29, 2016, and the application closing date was May 31, 2016.

How many awards did SAMHSA expect to make?

SAMHSA expected to make about 25 awards.

What was the award ceiling?

The award ceiling was $371,616.

What does it mean that this is a cooperative agreement?

The cooperative agreement structure signals substantial federal involvement beyond simple pass-through funding. The notice indicates awardees should expect ongoing collaboration, guidance, and reporting expectations aligned with the program's prevention and data objectives.

What federal agency is associated with SPF Rx?

The program is a SAMHSA discretionary cooperative agreement under HHS-SAMHSA (CFDA 93.243).

Browse more opportunities from the same agency: HHS-SAMHS

Browse more opportunities from the same category: Health

Next opportunity: Innovative Coordinated Access and Mobility Grants Program - 2016 NOFO

Previous opportunity: Disability and Rehabilitation Research Projects (DRRP) Program: Traumatic Brain Injury (TBI) Model Systems National Data and Statistical Center.

USGrants.org Applicant Portal:

Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.

Apply for SP 16 006

 

[Watch] how do funding administrators access proposals?

Applicants also applied for:

Applicants who have applied for this opportunity (SP 16 006) also looked into and applied for these:

Funding Opportunity
Grants to Prevent Prescription Drug/Opioid Overdose-Related Deaths (PDO) Apply for SP 16 005

Funding Number: SP 16 005
Agency: HHS-SAMHS
Category: Health
Funding Amount: $11,000,000
Partnerships for Countermeasures against Select Pathogens (R01) Apply for RFA AI 16 034

Funding Number: RFA AI 16 034
Agency: HHS-NIH11
Category: Health
Funding Amount: Case Dependent
HPV Roundtable: Creating a National Network of Partners to Promote Cancer Prevention through Human Papillomavirus Vaccination- Financed in Part by 2016 Prevention and Public Health Funds Apply for CDC RFA IP16 1602PPHF16

Funding Number: CDC RFA IP16 1602PPHF16
Agency: HHS-CDC-NCIRD
Category: Health
Funding Amount: $500,000
New Technologies for the Glycosciences (R41/R42) Apply for PA 16 158

Funding Number: PA 16 158
Agency: HHS-NIH11
Category: Health
Funding Amount: Case Dependent
Cooperative Agreements for Tribal Behavioral Health Apply for SM 16 010

Funding Number: SM 16 010
Agency: HHS-SAMHS
Category: Health
Funding Amount: $200,000
New Technologies for the Glycosciences (R43/R44) Apply for PA 16 157

Funding Number: PA 16 157
Agency: HHS-NIH11
Category: Health
Funding Amount: Case Dependent
Adult Maturational Changes and Dysfunctions in Emotion Regulation (R21) Apply for RFA MH 17 400

Funding Number: RFA MH 17 400
Agency: HHS-NIH11
Category: Health
Funding Amount: $200,000
Dental Faculty Development and Loan Repayment Program Apply for HRSA 16 182

Funding Number: HRSA 16 182
Agency: HHS-HRSA
Category: Health
Funding Amount: Case Dependent
Advancing National Public Health Institutes Globally Apply for CDC RFA GH14 141903CONT16

Funding Number: CDC RFA GH14 141903CONT16
Agency: HHS-CDC
Category: Health
Funding Amount: Case Dependent
Support for Public Health Drinking Water Programs to Improve Efficiency & Effectiveness for Controlling Drinking Water Exposures Apply for CDC RFA EH15 150702CONT16

Funding Number: CDC RFA EH15 150702CONT16
Agency: HHS-CDC
Category: Health
Funding Amount: Case Dependent
Tribal Public Health Capacity Building and Quality Improvement Apply for CDC RFA OT13 130304CONT16

Funding Number: CDC RFA OT13 130304CONT16
Agency: HHS-CDC
Category: Health
Funding Amount: Case Dependent
NIH Director's Transformative Research Awards (R01) Apply for RFA RM 16 007

Funding Number: RFA RM 16 007
Agency: HHS-NIH11
Category: Health
Funding Amount: Case Dependent
NIH Director's New Innovator Award Program (DP2) Apply for RFA RM 16 004

Funding Number: RFA RM 16 004
Agency: HHS-NIH11
Category: Health
Funding Amount: $1,500,000
NIH Pioneer Award Program (DP1) Apply for RFA RM 16 005

Funding Number: RFA RM 16 005
Agency: HHS-NIH11
Category: Health
Funding Amount: $700,000
Comprehensive Health Services Delivery (CHSD) Apply for RFA 621 16 000012

Funding Number: RFA 621 16 000012
Agency: USAID-TAN
Category: Health
Funding Amount: $325,211,110
Capacity building for ecological surveillance of viral hemorrhagic fevers in Sierra Leone Apply for CDC RFA CK16 1605

Funding Number: CDC RFA CK16 1605
Agency: HHS-CDC-NCEZID
Category: Health
Funding Amount: Case Dependent
Program Supplements for Violence Intervention to Enhance Lives (Short Title: VITEL) Apply for TI 16 010

Funding Number: TI 16 010
Agency: HHS-SAMHS
Category: Health
Funding Amount: $70,000
Indo-U.S. Vaccine Action Program (VAP) Small Research Grant Program (R03) Apply for PA 16 163

Funding Number: PA 16 163
Agency: HHS-NIH11
Category: Health
Funding Amount: $100,000
Emerging Infections Programs Apply for CDC RFA CK17 1701

Funding Number: CDC RFA CK17 1701
Agency: HHS-CDC-NCEZID
Category: Health
Funding Amount: Case Dependent
CDC’s Collaboration with Academia to Strengthen Public Health Workforce Capacity Apply for CDC RFA OE12 120105CONT16

Funding Number: CDC RFA OE12 120105CONT16
Agency: HHS-CDC-CSELS
Category: Health
Funding Amount: Case Dependent

 

Grant application guides and resources

It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!

Apply for Grants

 

USGrants.org applicant portal membership

 

Premium leads for funding administrators, grant writers, and loan issuers

Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.

If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.

Subscribe to Leads

 

Request more information:

Would you like to learn more about this funding opportunity, similar opportunities to "SP 16 006", eligibility, application service, and/or application tips? Submit an inquiry below:

Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.