Opportunity Information: Apply for PA 14 125
Apply for PA 14 125
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Strengthening Adherence to Antiretroviral Based HIV Treatment and Prevention (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Feb 28, 2014 and posted on Feb 28, 2014.
- Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Special district governments State governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Small businesses Independent school districts Private institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) grant opportunity titled "Strengthening Adherence to Antiretroviral Based HIV Treatment and Prevention (R21)" (Funding Opportunity Number PA-14-125) was a discretionary research grant program aimed at improving how well people start and stay on antiretroviral (ARV) medications used for both HIV treatment and HIV prevention. The scientific focus centered on two closely related areas: antiretroviral therapy (ART) for people living with HIV and pre-exposure prophylaxis (PrEP) for people at risk of acquiring HIV. The core idea behind the announcement was that ARV medications are highly effective when taken as prescribed, but real-world adherence challenges can weaken outcomes, so the NIH sought research that would identify what drives adherence problems and, importantly, test practical ways to improve and sustain adherence over time.
A major emphasis of the FOA was intervention development that is feasible and can be implemented quickly in real settings. Rather than funding purely theoretical or highly specialized approaches that would be difficult to deploy outside of research environments, the announcement highlighted the need for strategies that could be translated into routine practice in clinical care, community-based programs, and even policy contexts. In practical terms, this means the program was looking for studies that not only explain adherence behavior but also produce interventions that health systems, community organizations, or public health programs could realistically adopt without extensive new infrastructure. The goal was to directly strengthen HIV treatment and prevention outcomes by improving consistent medication use, which is central to viral suppression for ART and to preventive protection for PrEP.
This was an R21 mechanism, which typically supports exploratory or early-stage projects that can generate proof-of-concept evidence, refine intervention models, or establish preliminary data needed for larger trials. The listed award ceiling was $200,000, and the opportunity did not require cost sharing or matching. The FOA was posted on February 28, 2014, and the application closing date shown was January 7, 2017, with an archive date of February 7, 2017, meaning it is no longer active but remains available for reference.
Eligibility under this announcement was broad and included many types of domestic U.S. organizations and governments, such as state and local governments (including counties, cities or townships, and special district governments), federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, independent school districts, public and private institutions of higher education, and nonprofit organizations both with and without 501(c)(3) status. It also allowed for-profit organizations and small businesses. Beyond those standard categories, the FOA explicitly included a wide range of additional eligible applicants, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISISs), as well as faith-based and community-based organizations and eligible federal agencies.
Notably, the opportunity permitted international participation. Non-U.S. entities (foreign organizations and foreign institutions) were eligible to apply, and non-U.S. components of U.S. organizations could participate. Foreign components, as defined by the NIH Grants Policy Statement, were allowed. This design choice aligns with the global nature of HIV prevention and treatment needs and suggests NIH interest in adherence research that could be relevant across different health systems, cultural contexts, and epidemic settings.
From an administrative standpoint, the opportunity was categorized under Health as the funding activity area and referenced CFDA numbers 93.242 (Mental Health Research Grants) and 93.856 (Microbiology and Infectious Diseases Research). The sponsoring agency was the National Institutes of Health. The full announcement was hosted on the NIH grants website (the FOA page listed under the NIH Guide for Grants and Contracts), and the posted contact for access or technical issues was the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV, specifically for difficulties accessing the announcement or linking to it online.
In summary, PA-14-125 supported early, actionable research to understand and improve adherence to ART and PrEP, with a strong push toward interventions that are practical, sustainable, and ready to move into clinical, community, and policy environments. The overall public health intent was straightforward: better adherence translates to better HIV treatment outcomes for individuals, reduced transmission at the population level, and stronger prevention effectiveness for people using PrEP.
Frequently Asked Questions (FAQs)
What is the NIH funding opportunity PA-14-125 about?
PA-14-125, titled "Strengthening Adherence to Antiretroviral Based HIV Treatment and Prevention (R21)," is an NIH research grant opportunity focused on improving how well people start and continue taking antiretroviral (ARV) medications used for HIV treatment and HIV prevention.
What is the main public health goal of this opportunity?
The goal is to improve real-world outcomes by strengthening consistent medication use. Better adherence supports viral suppression for people on antiretroviral therapy (ART) and improves preventive protection for people using pre-exposure prophylaxis (PrEP), which can reduce HIV transmission at the population level.
Which medication-use areas does this FOA focus on?
The scientific focus includes two closely related areas: ART for people living with HIV and PrEP for people at risk of acquiring HIV.
Why does NIH emphasize adherence in this announcement?
The announcement highlights that ARV medications are highly effective when taken as prescribed, but adherence challenges in real-world settings can weaken outcomes. NIH sought research that identifies what drives adherence problems and tests practical ways to improve and sustain adherence over time.
What kinds of research projects were encouraged under PA-14-125?
The FOA emphasized research that both explains adherence behavior and develops or tests interventions to improve adherence. A major priority was intervention development that can be implemented quickly and realistically in real settings.
What does "intervention development that is feasible and can be implemented quickly" mean here?
It means the FOA favored strategies that could be translated into routine practice rather than approaches that are purely theoretical or too specialized to deploy outside research environments. The intent was to produce interventions that health systems, community organizations, or public health programs could adopt without extensive new infrastructure.
In what settings were interventions expected to be usable?
The FOA highlighted translation into routine practice across clinical care settings, community-based programs, and policy contexts.
What grant mechanism does this opportunity use?
This funding opportunity uses the NIH R21 mechanism, which typically supports exploratory or early-stage research designed to generate proof-of-concept evidence, refine intervention models, or establish preliminary data that can support larger trials later.
What is the funding limit (award ceiling) for this R21?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The opportunity stated that cost sharing or matching is not required.
Is PA-14-125 currently open for applications?
No. The FOA is no longer active. It was posted on February 28, 2014, had an application closing date of January 7, 2017, and an archive date of February 7, 2017. It remains available for reference.
Who is eligible to apply within the United States?
Eligibility was broad and included many types of U.S. organizations and governments, including state and local governments (such as counties, cities or townships, and special district governments), federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, independent school districts, public and private institutions of higher education, and nonprofit organizations with or without 501(c)(3) status.
Are for-profit organizations or small businesses eligible?
Yes. The FOA allowed for-profit organizations and small businesses to apply.
Are minority-serving institutions specifically included in eligibility?
Yes. The FOA explicitly included a wide range of additional eligible applicants, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISISs).
Are faith-based and community-based organizations eligible?
Yes. The FOA explicitly included faith-based and community-based organizations among eligible applicants.
Can federal agencies apply?
Yes. The FOA included eligible federal agencies among the eligible applicant types.
Does the opportunity allow international (non-U.S.) applicants?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) were eligible to apply, and non-U.S. components of U.S. organizations could participate.
Are foreign components allowed under this announcement?
Yes. Foreign components, as defined by the NIH Grants Policy Statement, were allowed.
What is the NIH funding activity area for this FOA?
The funding activity area is categorized under Health.
What CFDA numbers are referenced for this opportunity?
The FOA referenced CFDA numbers 93.242 (Mental Health Research Grants) and 93.856 (Microbiology and Infectious Diseases Research).
Which agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants website, with the FOA page listed under the NIH Guide for Grants and Contracts.
Who should be contacted for access or technical issues viewing the announcement online?
The posted contact for difficulties accessing the announcement or linking to it online is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall research intent of PA-14-125 in plain terms?
The intent is to support early, actionable research that identifies why adherence problems happen and tests practical, sustainable solutions that can move into real clinical, community, and policy environments to strengthen HIV treatment and prevention outcomes.
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