Opportunity Information: Apply for PA 10 243
Apply for PA 10 243
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Structural Interventions, Alcohol Use, and Risk of HIV/AIDS (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Aug 2, 2010 and posted on Aug 2, 2010.
- Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses City or township governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses County governments Public housing authorities/Indian housing authorities State governments Private institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity titled "Structural Interventions, Alcohol Use, and Risk of HIV/AIDS (R21)" (Funding Opportunity Number PA-10-243) is a National Institutes of Health grant announcement led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Its central focus is on supporting research that tests whether structural interventions can lower the risk of HIV/AIDS transmission by changing the broader environment in which alcohol is used. In this context, "structural" generally means interventions that operate at the level of settings, systems, policies, institutions, or community environments rather than only targeting individual behavior. The announcement highlights a key gap it aims to address: while structural and environmental strategies have been used successfully to reduce many alcohol-related harms, comparatively little research has directly extended these approaches into HIV/AIDS prevention and risk reduction, especially where alcohol use contributes to increased exposure or vulnerability.
This FOA uses the NIH Exploratory/Developmental Grant mechanism (R21), which is typically intended for early-stage, innovative, or pilot-style projects that can generate preliminary data, test feasibility, or explore promising new directions. The announcement notes that this R21 FOA runs in parallel with another NIH announcement of the same scientific scope that uses the R01 mechanism (PA-10-242), which is generally more appropriate for larger, more fully developed research programs. In practical terms, the R21 pathway is meant to help investigators explore novel ideas and build an evidence base that could later support a larger-scale trial or broader implementation research.
The opportunity is categorized as a discretionary grant in the health area (CFDA 93.273, Alcohol Research Programs) and does not require cost sharing or matching funds. The listed award ceiling is $275,000, which aligns with the typical scale of an R21 budget limit. The FOA also makes clear that the exact size and duration of awards can vary because proposed projects may differ widely in design, setting, and scope. Likewise, the number of awards and total dollars ultimately funded depend on the volume and quality of applications received and on the requested budgets and project durations.
Eligibility is broad and includes many types of organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations other than small businesses, small businesses, and a wide range of government entities such as city or township governments, county governments, state governments, special district governments, and public housing authorities or Indian housing authorities. The FOA also explicitly includes eligibility for organizations and institutions serving specific populations and communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. In addition, non-U.S. entities (foreign organizations), regional organizations, eligible federal agencies, and U.S. territories or possessions are included, reflecting NIH's common practice of allowing diverse organizational participation when scientifically justified.
From an applicant's perspective, the research theme centers on the intersection of alcohol use environments and HIV/AIDS risk. The intent is to move beyond interventions that only counsel individuals and instead evaluate changes to the conditions that shape risk, such as the physical and social context of drinking, availability and access dynamics, venue-level practices, or other environmental levers that could reduce alcohol-related sexual risk behaviors, reduce exposure to high-risk situations, or otherwise lower the likelihood of HIV transmission. The FOA is positioned for studies that can credibly assess effectiveness, meaning applicants would typically be expected to propose a research design capable of generating useful evidence, even if exploratory in scale, and to connect the structural change clearly to measurable HIV risk-related outcomes.
Key administrative dates included a posted and creation date of August 2, 2010, with an original and current closing date of May 7, 2013, and an archive date of June 7, 2013, indicating that the announcement is now archived rather than active for new submissions. For reference and details, the FOA provided an official NIH link (http://grants.nih.gov/grants/guide/pa-files/PA-10-243.html). For technical issues accessing the announcement or linking problems, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Structural Interventions, Alcohol Use, and Risk of HIV/AIDS (R21)" and the Funding Opportunity Number is PA-10-243.
Which agency and institute are responsible for this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What is the main purpose of this funding opportunity?
The central purpose is to support research that tests whether structural interventions can lower the risk of HIV/AIDS transmission by changing the broader environment in which alcohol is used, especially in ways that reduce alcohol-related HIV risk.
What does "structural intervention" mean in this announcement?
In this context, "structural" generally refers to interventions that operate at the level of settings, systems, policies, institutions, or community environments, rather than interventions focused only on changing individual behavior.
Why does this FOA focus on structural interventions related to alcohol and HIV risk?
The announcement highlights a gap in the evidence base: structural and environmental strategies have successfully reduced many alcohol-related harms, but comparatively little research has directly applied these approaches to HIV/AIDS prevention and risk reduction where alcohol use increases exposure or vulnerability.
What grant mechanism does this FOA use?
This FOA uses the NIH Exploratory/Developmental Grant mechanism (R21), which is commonly used for early-stage, innovative, or pilot-style research.
What kinds of projects are a good fit for an R21 under this FOA?
Projects that are exploratory in scale and can generate preliminary data, test feasibility, or explore innovative directions related to structural interventions, alcohol use environments, and HIV/AIDS risk reduction are a good fit.
Is there a related funding opportunity with a different grant mechanism?
Yes. This R21 FOA (PA-10-243) runs in parallel with another NIH announcement of the same scientific scope that uses the R01 mechanism (PA-10-242), which is generally intended for larger and more fully developed research programs.
How is the R21 pathway described in relation to future research?
The R21 pathway is described as a way to explore novel ideas and build an evidence base that could later support a larger-scale trial or broader implementation research.
What is the program area and CFDA number associated with this opportunity?
The opportunity is categorized as a discretionary grant in the health area under CFDA 93.273 (Alcohol Research Programs).
Is cost sharing or matching required?
No. The announcement states that cost sharing or matching funds are not required.
What is the award ceiling for this FOA?
The listed award ceiling is $275,000, which aligns with the typical R21 budget limit.
Are award size, number of awards, and project duration fixed?
No. The FOA indicates that award size and duration can vary because projects may differ widely in design, setting, and scope. The number of awards and total funding depend on the volume and quality of applications received and on the requested budgets and project durations.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3)); for-profit organizations other than small businesses; small businesses; and a range of government entities (city or township governments, county governments, state governments, special district governments, and public housing authorities or Indian housing authorities).
Are community-serving and minority-serving institutions eligible?
Yes. The FOA explicitly includes organizations and institutions serving specific populations and communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA includes non-U.S. entities (foreign organizations), regional organizations, eligible federal agencies, and U.S. territories or possessions, consistent with NIH practice when scientifically justified.
What types of research topics does this FOA encourage?
The research theme centers on the intersection of alcohol use environments and HIV/AIDS risk, encouraging studies that move beyond individual counseling approaches and evaluate changes to conditions that shape risk (for example, the physical and social context of drinking, availability and access dynamics, and venue-level practices).
What kinds of outcomes should projects connect to structural changes?
The FOA emphasizes connecting the structural change to measurable HIV risk-related outcomes, such as reductions in alcohol-related sexual risk behaviors, reduced exposure to high-risk situations, or other measurable reductions in the likelihood of HIV transmission.
Does the FOA require a specific study design?
The FOA does not specify a single required design in the provided information, but it is positioned for studies that can credibly assess effectiveness, even if exploratory in scale, and clearly link the structural intervention to measurable HIV risk-related outcomes.
What are the key dates for this opportunity?
The posted and creation date is August 2, 2010. The original and current closing date is May 7, 2013. The archive date is June 7, 2013.
Is this funding opportunity currently active?
No. Because the archive date is June 7, 2013 and the closing date is May 7, 2013, the announcement is archived rather than active for new submissions.
Where can applicants find the official NIH announcement?
The FOA provided the official NIH link: http://grants.nih.gov/grants/guide/pa-files/PA-10-243.html
Who should be contacted for technical issues accessing the announcement link?
For technical issues accessing the announcement or problems with linking, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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