Opportunity Information: Apply for PA 09 148
Apply for PA 09 148
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Studies of Energy Balance and Cancer in Humans (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research.
- This funding opportunity was created on Apr 8, 2009 and posted on Apr 8, 2009.
- Applicants must submit their applications by May 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments County governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses Private institutions of higher education Independent school districts City or township governments.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations U.S. Territory or Possession.
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Opportunity Summary:
The Studies of Energy Balance and Cancer in Humans (R01) opportunity (Funding Opportunity Number PA-09-148) is a National Cancer Institute (NCI) Funding Opportunity Announcement under the National Institutes of Health (NIH) that supports human-focused research on how energy balance relates to cancer. The central aim is to identify and clarify the factors that shape energy balance and to spell out the biological and behavioral mechanisms through which energy balance can influence cancer risk (whether someone develops cancer), prognosis (how cancer progresses and outcomes after diagnosis), and quality of life (how people feel and function during and after cancer). In practical terms, the announcement is looking for studies that help explain the connections among body weight, physical activity, diet and nutrition, metabolism, and related physiologic pathways, and how those connections translate into measurable cancer outcomes in humans.
The FOA is intentionally broad about the kinds of studies it will support, as long as they meaningfully advance understanding of energy balance in relation to cancer. Proposed work can include new analyses of existing datasets (for example, reanalyzing cohort or clinical study data to test new energy balance hypotheses), as well as research that adds new data collection or new biospecimen collection to ongoing investigations. That means an applicant might build on an established cohort or clinical study by adding more detailed measures of diet, activity, adiposity, metabolic biomarkers, or other relevant exposures, and then linking those measures to cancer incidence, recurrence, survival, treatment response, or patient-reported outcomes. The expectation stated in the announcement is that the findings will contribute concrete, usable knowledge that improves the field’s ability to explain why energy balance matters for cancer and how those pathways might be targeted for prevention or improved survivorship.
Funding is provided through the NIH R01 mechanism, which is the standard research project grant used for mature, hypothesis-driven projects with well-developed aims, strong preliminary rationale, and an approach that can be carried out over multiple years. NIH notes that this R01 announcement runs in parallel with another FOA of the same scientific scope using the R21 mechanism (PA-09-149), which is typically meant for earlier-stage, exploratory, or developmental work. In other words, applicants with a more fully developed project suited to a larger, longer effort would generally look to the R01, while applicants proposing high-risk or early proof-of-concept work might consider the companion R21 announcement.
This is a discretionary grant opportunity, categorized under health and education-related funding activities, and it aligns with NIH cancer research program areas including Cancer Cause and Prevention Research (CFDA 93.393) and Cancer Biology Research (CFDA 93.396). The announcement explicitly states there is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of the award. As with most NIH announcements, the number of awards and the total funds available are not guaranteed; awards depend on the availability of appropriated funds and on the volume and quality of applications received, with an emphasis on funding meritorious proposals.
Eligibility is expansive and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofits with and without 501(c)(3) status (including those other than universities), small businesses, for-profit organizations (other than small businesses), and a wide range of government entities such as state governments, counties, cities or townships, special district governments, and independent school districts. The FOA also indicates additional eligible groups such as eligible federal agencies, faith-based or community-based organizations, Hispanic-serving institutions, foreign organizations (non-U.S. entities), regional organizations, and U.S. territories or possessions. This broad eligibility reflects NIH’s typical approach of allowing applications from many organizational settings as long as the proposed research team and environment are capable of carrying out rigorous human research relevant to cancer and energy balance.
Key administrative details shown in the source listing include a posted and creation date of April 8, 2009, with an original and current closing date of May 7, 2012, and an archive date of June 7, 2012, indicating the announcement is historical rather than currently open. For full technical details, NIH referenced the official posting on the NIH Grants Guide (http://grants.nih.gov/grants/guide/pa-files/PA-09-148.html) and provided NIH Office of Extramural Research (OER) webmaster contact information for access or linking problems.
Frequently Asked Questions (FAQs): Studies of Energy Balance and Cancer in Humans (R01) - PA-09-148
What is the Studies of Energy Balance and Cancer in Humans (R01) opportunity?
It is a National Cancer Institute (NCI) Funding Opportunity Announcement (FOA) under the National Institutes of Health (NIH) that supports human-focused research examining how energy balance relates to cancer. The FOA is identified as PA-09-148 and uses the NIH R01 grant mechanism.
Which agency is offering this funding opportunity?
The FOA is offered by the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH).
What is the central aim of this FOA?
The central aim is to identify and clarify factors that shape energy balance and to describe the biological and behavioral mechanisms through which energy balance can influence cancer risk, cancer prognosis, and quality of life in humans.
What does "energy balance" mean in the context of this announcement?
Based on the FOA description, energy balance is considered through interconnected factors such as body weight, physical activity, diet and nutrition, metabolism, and related physiologic pathways, and how these factors connect to measurable cancer outcomes in humans.
What kinds of cancer-related outcomes does the FOA care about?
The FOA highlights outcomes related to cancer risk (whether someone develops cancer), prognosis (how cancer progresses and outcomes after diagnosis), and quality of life (how people feel and function during and after cancer). It also mentions linking energy-balance-related measures to outcomes such as cancer incidence, recurrence, survival, treatment response, and patient-reported outcomes.
Does the FOA focus on human studies or animal/lab studies?
The FOA is explicitly described as supporting human-focused research on energy balance and cancer.
How broad is the scope of research that can be proposed?
The announcement is intentionally broad about the kinds of studies it will support, as long as the proposed work meaningfully advances understanding of energy balance in relation to cancer.
Are applicants allowed to use existing datasets?
Yes. The FOA specifically notes that proposed work can include new analyses of existing datasets, such as reanalyzing cohort or clinical study data to test new energy balance hypotheses.
Can applicants add new data or biospecimen collection to ongoing studies?
Yes. The FOA indicates that research may add new data collection or new biospecimen collection to ongoing investigations, such as building on an established cohort or clinical study.
What types of measures or exposures might be added to an ongoing cohort or clinical study?
Examples described include adding more detailed measures of diet, activity, adiposity, metabolic biomarkers, or other relevant exposures, and then linking those measures to cancer-related endpoints.
What is the expectation for the contribution of the research findings?
The FOA states an expectation that findings will contribute concrete, usable knowledge that improves the field's ability to explain why energy balance matters for cancer and how those pathways might be targeted for prevention or improved survivorship.
What funding mechanism is used for this FOA?
Funding is provided through the NIH R01 mechanism, described as the standard research project grant used for mature, hypothesis-driven projects with well-developed aims, strong preliminary rationale, and an approach that can be carried out over multiple years.
Is there a related FOA for smaller or more exploratory projects?
Yes. NIH notes this R01 FOA runs in parallel with a companion FOA of the same scientific scope using the R21 mechanism (PA-09-149), which is typically intended for earlier-stage, exploratory, or developmental work.
How should an applicant decide between the R01 (PA-09-148) and the companion R21 (PA-09-149)?
Based on the description, projects that are more fully developed and suited to a larger, longer effort would generally align with the R01, while high-risk or early proof-of-concept work might be better suited to the companion R21.
Is cost sharing or matching required?
No. The announcement explicitly states there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award.
Are the number of awards or total funds guaranteed?
No. As described, the number of awards and the total funds available are not guaranteed. Awards depend on the availability of appropriated funds and on the volume and quality of applications received, with an emphasis on funding meritorious proposals.
How is this grant opportunity categorized?
It is described as a discretionary grant opportunity categorized under health and education-related funding activities.
Which NIH cancer research program areas does this FOA align with?
The FOA aligns with NIH cancer research program areas including Cancer Cause and Prevention Research (CFDA 93.393) and Cancer Biology Research (CFDA 93.396).
Who is eligible to apply?
Eligibility is described as expansive and includes many types of domestic and non-domestic organizations, including public and private institutions of higher education; nonprofits with and without 501(c)(3) status; small businesses; for-profit organizations (other than small businesses); and government entities such as states, counties, cities or townships, special district governments, and independent school districts.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA indicates that foreign organizations (non-U.S. entities) are eligible.
Are faith-based or community-based organizations eligible to apply?
Yes. The FOA explicitly includes faith-based or community-based organizations among eligible applicants.
Are U.S. territories or possessions eligible?
Yes. The FOA includes U.S. territories or possessions in its stated eligibility.
Are federal agencies eligible to apply?
Yes. The FOA indicates that eligible federal agencies are among eligible applicant groups.
Is this FOA currently open for applications?
No. The administrative details provided indicate it is historical: it was posted and created on April 8, 2009, had an original and current closing date of May 7, 2012, and was archived on June 7, 2012.
Where can someone find the official FOA text and technical details?
NIH referenced the official posting on the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-09-148.html.
Who is listed as a contact for access or linking problems?
The NIH Office of Extramural Research (OER) webmaster contact is referenced for access or linking problems in connection with the official posting.
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| Centers of Cancer Nanotechnology Excellence (CCNEs)(U54) Apply for RFA CA 09 012 Funding Number: RFA CA 09 012 Agency: National Institutes of Health Category: Education Health Funding Amount: $3,200,000 |
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