Opportunity Information: Apply for PA 09 149
Apply for PA 09 149
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Studies of Energy Balance and Cancer in Humans (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research.
- This funding opportunity was created on Apr 8, 2009 and posted on Apr 8, 2009.
- Applicants must submit their applications by May 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Independent school districts City or township governments Private institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses Special district governments.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations U.S. Territory or Possession.
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Opportunity Summary:
The Studies of Energy Balance and Cancer in Humans (R21) opportunity (Funding Opportunity Number PA-09-149) was a National Cancer Institute (NCI) funding announcement under the National Institutes of Health (NIH) designed to support exploratory, developmental research on how energy balance relates to cancer. The central goal was to encourage studies that identify the factors that shape energy balance (for example, behaviors and exposures that influence body weight, metabolism, physical activity, diet, or related physiologic processes) and to clarify the biological or behavioral mechanisms by which these factors may affect cancer risk, cancer outcomes after diagnosis (prognosis), and cancer-related quality of life. The announcement emphasized building knowledge that strengthens understanding of the links among energy balance, cancer development, and survivorship outcomes.
The FOA used the NIH R21 mechanism, which is typically aimed at early-stage, high-impact ideas, pilot studies, and proof-of-concept work that can generate data needed for larger projects later. In practical terms, applicants could propose a wide range of human-focused research approaches, including new analyses of existing datasets as well as projects that add new data collection or collect additional biological specimens within ongoing studies. This flexibility was meant to make it possible to pursue promising hypotheses quickly, leverage existing cohorts or trials, and expand current investigations with targeted new measurements when needed.
This R21 announcement ran in parallel with a companion FOA of the same scientific scope that supported the R01 mechanism (PA-09-148). The pairing signaled that NIH wanted to support both smaller, exploratory efforts (R21) and larger, more definitive research projects (R01) in the same topic area, allowing investigators to match the mechanism to the maturity and scale of their proposed work.
Funding levels and the number of awards were not fixed because NIH expected applications to vary widely in scope, duration, and cost. The total amount awarded and the number of funded projects were to depend on the mix of applications received, their scientific quality, their requested budgets, and their project timelines. The listed award ceiling for this opportunity was $200,000. No cost sharing or matching was required.
Eligibility was broad and included many organization types across the public, private, and nonprofit sectors. Eligible applicants included public and state-controlled institutions of higher education and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (other than higher education institutions), for-profit organizations (including but not limited to small businesses), and multiple levels of government such as state, county, city or township, special district governments, and independent school districts. The FOA also explicitly allowed additional categories such as eligible federal agencies, faith-based or community-based organizations, Hispanic-serving institutions, U.S. territories or possessions, regional organizations, and non-U.S. (foreign) entities.
Administratively, the opportunity was categorized as a discretionary grant focused in the health and education domain, aligned with CFDA program areas 93.393 (Cancer Cause and Prevention Research) and 93.396 (Cancer Biology Research). It was posted on April 8, 2009, and had an original and final closing date of May 7, 2012, with an archive date of June 7, 2012. The full announcement was made available through the NIH grants guide, and NIH provided technical contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
Frequently Asked Questions (FAQs)
What is the Studies of Energy Balance and Cancer in Humans (R21) opportunity?
It is a National Cancer Institute (NCI) funding announcement under the National Institutes of Health (NIH) designed to support exploratory and developmental human research on how energy balance relates to cancer. The opportunity is identified as Funding Opportunity Number (FON) PA-09-149 and uses the NIH R21 grant mechanism.
Which NIH institute sponsored this funding opportunity?
The opportunity was issued by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).
What is the main scientific focus of the FOA?
The focus is on energy balance and cancer in humans, including identifying factors that shape energy balance and clarifying biological or behavioral mechanisms linking those factors to cancer risk, outcomes after diagnosis (prognosis), and cancer-related quality of life.
What does "energy balance" mean in the context of this FOA?
Within this announcement, energy balance refers to factors and processes related to body weight, metabolism, physical activity, diet, and other related physiologic processes, as well as behaviors and exposures that influence these outcomes.
What kinds of cancer-related endpoints were encouraged?
The announcement emphasized research that could inform understanding of cancer risk, cancer outcomes after diagnosis (prognosis), and cancer-related quality of life, all in relation to energy balance factors and mechanisms.
What is the central goal of the R21 announcement?
The central goal was to encourage studies that (1) identify factors shaping energy balance and (2) clarify biological or behavioral mechanisms through which those factors may affect cancer development and survivorship outcomes.
What is the NIH R21 mechanism, and why was it used here?
The NIH R21 mechanism is typically intended for exploratory, developmental research such as early-stage, high-impact ideas, pilot studies, and proof-of-concept projects. In this FOA, it was used to help investigators pursue promising hypotheses quickly and generate data that could support larger projects later.
What types of research approaches were allowed under this R21?
The FOA allowed a wide range of human-focused research approaches. Examples mentioned include new analyses of existing datasets and projects that add new data collection or collect additional biological specimens within ongoing studies.
Could applicants leverage existing cohorts, trials, or ongoing studies?
Yes. The announcement highlighted flexibility to leverage existing cohorts or trials and to expand current investigations with targeted new measurements when needed.
Was there a related funding opportunity for larger projects?
Yes. This R21 announcement ran in parallel with a companion FOA with the same scientific scope that supported the NIH R01 mechanism (PA-09-148), allowing applicants to align the mechanism with the maturity and scale of the proposed research.
How much funding was available, and how many awards were expected?
Funding levels and the number of awards were not fixed. NIH expected applications to vary widely in scope, duration, and cost, so totals depended on the mix of applications received, their scientific quality, requested budgets, and project timelines.
What was the award ceiling for this opportunity?
The listed award ceiling was $200,000.
Was cost sharing or matching required?
No. The announcement stated that no cost sharing or matching was required.
Who was eligible to apply?
Eligibility was broad and included public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (other than higher education institutions), for-profit organizations (including but not limited to small businesses), and multiple levels of government (state, county, city or township, special district governments, and independent school districts).
Were faith-based and community-based organizations eligible?
Yes. The FOA explicitly allowed faith-based or community-based organizations as eligible applicants.
Were Hispanic-serving institutions eligible?
Yes. The FOA explicitly listed Hispanic-serving institutions among eligible categories.
Were U.S. territories or possessions eligible to apply?
Yes. The FOA explicitly included U.S. territories or possessions among eligible categories.
Were regional organizations eligible?
Yes. Regional organizations were explicitly included among eligible categories.
Were non-U.S. (foreign) entities eligible to apply?
Yes. The FOA explicitly allowed non-U.S. (foreign) entities.
Were federal agencies eligible to apply?
Yes. The FOA listed eligible federal agencies among the additional eligible categories.
How was the opportunity categorized administratively?
It was categorized as a discretionary grant focused in the health and education domain.
Which CFDA program areas did this FOA align with?
The FOA was aligned with CFDA 93.393 (Cancer Cause and Prevention Research) and 93.396 (Cancer Biology Research).
When was the opportunity posted?
It was posted on April 8, 2009.
What were the closing dates for the opportunity?
The original and final closing date was May 7, 2012.
When was the opportunity archived?
The archive date was June 7, 2012.
Where could applicants find the full announcement?
The full announcement was made available through the NIH grants guide.
Who provided technical support for access or linking issues?
NIH provided technical contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
What makes this FOA different from the companion R01 FOA?
This FOA used the R21 mechanism for exploratory, developmental work, while the companion FOA (PA-09-148) supported the R01 mechanism for larger, more definitive research projects, even though both had the same scientific scope.
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| Centers of Cancer Nanotechnology Excellence (CCNEs)(U54) Apply for RFA CA 09 012 Funding Number: RFA CA 09 012 Agency: National Institutes of Health Category: Education Health Funding Amount: $3,200,000 |
| Cancer Nanotechnology Platform Partnerships (U01) Apply for RFA CA 09 013 Funding Number: RFA CA 09 013 Agency: National Institutes of Health Category: Education Health Funding Amount: $400,000 |
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