Opportunity Information: Apply for PA 04 124
Apply for PA 04 124
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "STUDIES OF ENERGY BALANCE AND CANCER IN HUMANS" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.399 Cancer Control.
- This funding opportunity was created on Dec 2, 2008 and posted on Dec 2, 2008.
- Applicants must submit their applications by May 2, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education For profit organizations other than small businesses Private institutions of higher education County governments State governments.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Faith based or Community based Organizations Non domestic (non U.S.) Entities (Foreign Organizations).
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Opportunity Summary:
The National Cancer Institute (NCI), part of the National Institutes of Health, offered this funding opportunity to support investigator-initiated human research on energy balance and its connection to cancer. The central goal was to deepen understanding of what shapes energy balance in people (including inputs like diet and physical activity and outcomes like body composition) and to clarify the biological and behavioral pathways through which energy balance may influence cancer risk, cancer prognosis after diagnosis, and patient quality of life. The opportunity was designed to move beyond broad correlations by encouraging studies that can better explain mechanisms and help interpret why certain patterns of weight change, activity, or metabolic markers might relate to cancer outcomes.
A defining feature of the announcement is that it targeted projects that could build on existing human data rather than starting entirely from scratch. Applicants were required to have already collected measures from human participants on at least two of the following domains: diet, physical activity, body composition, and/or related biomarkers. Biomarkers could include specimens such as blood, urine, exfoliated cells, or tissue samples. In practice, this eligibility rule steered the program toward teams with ongoing cohorts, clinical studies, or completed trials where additional analyses, follow-up, or targeted specimen work could be added efficiently. The research supported could range from new analyses of existing datasets to additional collection of data and biological specimens within ongoing investigations, allowing investigators to extend the scientific value of established studies.
The scope of research emphasized human energy balance as it relates to cancer across the continuum: prevention (risk), outcomes after diagnosis (prognosis and survivorship), and patient-centered endpoints such as quality of life. By focusing on factors affecting energy balance and mechanisms tied to cancer, projects could include work that links behavioral measures (for example, patterns of physical activity or dietary intake) with physiologic or molecular indicators (such as metabolic, hormonal, inflammatory, or other biologic markers) and then connects those to cancer-relevant endpoints. The overall intent was that findings would strengthen the evidence base on how energy balance contributes to cancer development and progression and help refine future prevention and intervention strategies.
From an administrative standpoint, the opportunity was issued as Program Announcement PA 04-124, titled "Studies of Energy Balance and Cancer in Humans." It was categorized as a discretionary funding opportunity and listed the funding instrument type as a cooperative agreement. The activity areas fell under education and health, and it referenced CFDA numbers 93.393 (Cancer Cause and Prevention Research) and 93.399 (Cancer Control). The announcement stated there was no cost-sharing or matching requirement, reducing barriers for applicants that might not have institutional funds to contribute.
The opportunity invited both competitive supplements to existing NCI-funded grants and new applications under common NIH research mechanisms, specifically R01s and R21s. This structure meant investigators with an active NCI grant could propose an add-on project that leveraged their current infrastructure and data, while other teams could apply for standalone awards to support new analyses or expansions of existing human datasets meeting the eligibility criteria. The listed award ceiling was $200,000, indicating an emphasis on targeted, leverage-driven projects rather than large, multi-site initiatives.
Eligibility was broad and included public and state-controlled institutions of higher education, private institutions of higher education, for-profit organizations other than small businesses, county and state governments, and additional categories such as eligible federal agencies, faith-based or community-based organizations, and non-U.S. entities (foreign organizations). That broad eligibility aligned with the program's focus on human data resources, which can exist in universities, health systems, government settings, and international cohorts.
Key dates show the announcement was posted on December 2, 2008, with an original and current closing date of May 2, 2009, and an archive date of June 2, 2009. Applicants were directed to the full announcement on the NIH grants website, and contact information was provided for technical access issues through the NIH Office of Extramural Research (OER) webmaster.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is Program Announcement PA 04-124, titled "Studies of Energy Balance and Cancer in Humans."
Which agency offered this opportunity?
The opportunity was offered by the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH).
What is the main purpose of the program?
The central goal was to support investigator-initiated human research on energy balance and its connection to cancer, with an emphasis on improving understanding of what shapes energy balance in people and how energy balance may influence cancer risk, prognosis after diagnosis, and patient quality of life.
What does "energy balance" mean in the context of this announcement?
In this program, energy balance includes inputs such as diet and physical activity and outcomes such as body composition, along with related biomarkers and biologic/behavioral pathways that may connect energy balance to cancer-related endpoints.
What types of research questions did the announcement encourage?
The announcement encouraged studies that move beyond broad correlations by clarifying mechanisms and helping interpret why certain patterns of weight change, physical activity, dietary intake, or metabolic markers might relate to cancer outcomes.
Is this opportunity limited to human studies?
Yes. The announcement specifically supported investigator-initiated human research on energy balance and cancer in humans.
What was a defining eligibility feature of this announcement?
A defining feature was that applicants were required to have already collected measures from human participants on at least two of the following domains: diet, physical activity, body composition, and/or related biomarkers.
Which domains had to be represented in existing participant measures?
Applicants needed existing human participant measures in at least two of these areas: diet, physical activity, body composition, and/or related biomarkers.
What counts as "related biomarkers" under this announcement?
Biomarkers could include specimens such as blood, urine, exfoliated cells, or tissue samples.
Did applicants need to start a brand-new cohort or study to apply?
No. The program specifically targeted projects that could build on existing human data rather than starting entirely from scratch.
What kinds of existing studies could be leveraged?
The eligibility approach steered the program toward teams with ongoing cohorts, clinical studies, or completed trials where additional analyses, follow-up, or targeted specimen work could be added efficiently.
What kinds of work could be supported under this announcement?
Supported work could range from new analyses of existing datasets to additional collection of data and biological specimens within ongoing investigations, as a way to extend the scientific value of established studies.
What parts of the cancer continuum were included in scope?
The scope emphasized human energy balance as it relates to cancer across prevention (risk), outcomes after diagnosis (prognosis and survivorship), and patient-centered endpoints such as quality of life.
What outcomes or endpoints were highlighted?
The announcement highlighted cancer risk, cancer prognosis after diagnosis (including survivorship), and patient quality of life as key endpoints of interest.
What kinds of measures could projects connect in their analyses?
Projects could link behavioral measures (for example, patterns of physical activity or dietary intake) with physiologic or molecular indicators (such as metabolic, hormonal, inflammatory, or other biologic markers) and connect those to cancer-relevant endpoints.
What was the intended impact of findings from funded studies?
The intent was that findings would strengthen the evidence base on how energy balance contributes to cancer development and progression and help refine future prevention and intervention strategies.
What type of funding opportunity was this categorized as?
It was categorized as a discretionary funding opportunity.
What was the listed funding instrument type?
The funding instrument type was a cooperative agreement.
Which NIH research mechanisms were mentioned?
The opportunity invited new applications under common NIH research mechanisms, specifically R01s and R21s.
Were competitive supplements allowed?
Yes. The opportunity invited competitive supplements to existing NCI-funded grants.
Who might be a good fit for a competitive supplement under this program?
Investigators with an active NCI grant could propose an add-on project that leverages their current infrastructure and existing human data that meet the eligibility criteria (at least two domains already measured).
What was the maximum award amount listed?
The listed award ceiling was $200,000.
Did the announcement require cost-sharing or matching funds?
No. The announcement stated there was no cost-sharing or matching requirement.
What activity areas were associated with this opportunity?
The activity areas fell under education and health.
Which CFDA numbers were referenced?
The announcement referenced CFDA 93.393 (Cancer Cause and Prevention Research) and 93.399 (Cancer Control).
Which organization types were eligible to apply?
Eligibility included public and state-controlled institutions of higher education, private institutions of higher education, for-profit organizations other than small businesses, county and state governments, and additional categories such as eligible federal agencies, faith-based or community-based organizations, and non-U.S. entities (foreign organizations).
Were non-U.S. (foreign) organizations eligible?
Yes. Non-U.S. entities (foreign organizations) were included in the eligible applicant categories.
Could for-profit organizations apply?
Yes. For-profit organizations other than small businesses were listed among the eligible applicants.
Could government entities apply?
Yes. County and state governments were listed as eligible, and additional categories included eligible federal agencies.
Could faith-based or community-based organizations apply?
Yes. Faith-based or community-based organizations were included in the eligible categories.
What were the key dates for the announcement?
The announcement was posted on December 2, 2008. The original closing date was May 2, 2009, and the current closing date was also May 2, 2009. The archive date was June 2, 2009.
Where were applicants directed to find the full announcement?
Applicants were directed to the full announcement on the NIH grants website.
Who was listed as a contact for technical access issues?
For technical access issues, contact information was provided for the NIH Office of Extramural Research (OER) webmaster.
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