Opportunity Information: Apply for RFA RM 11 013
Apply for RFA RM 11 013
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Studies to evaluate cellular heterogeneity using transcriptional profiling of single cells (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Nov 23, 2011 and posted on Nov 23, 2011.
- Applicants must submit their applications by Jan 23, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Eligible applicants include: County governments City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Special district governments Independent school districts Native American tribal governments (Federally recognized) State governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This NIH funding opportunity (RFA-RM-11-013) supports cooperative agreement (U01) projects focused on understanding cellular heterogeneity by measuring gene expression at the single-cell level in human samples. The core scientific goal is to capture transcriptional signatures from individual cells and use those data to define and distinguish cell types and/or cell states within a mixed population. In practical terms, the program is aimed at advancing single-cell transcriptional profiling as a way to move beyond bulk measurements that average signals across many cells, which can hide rare subpopulations, transitional states, or functionally important differences among apparently similar cells.
A central requirement of the opportunity is that funded projects must explicitly address "noise" in single-cell transcriptional data and develop approaches to detect, quantify, analyze, and interpret it. The FOA recognizes that variability in single-cell datasets can come from technical sources (such as cell capture efficiency, RNA loss, amplification bias, sequencing depth, batch effects, or other processing artifacts) as well as biological sources (such as cell cycle stage, stochastic gene expression, activation status, microenvironmental influences, or genuine subpopulation structure). Applicants are expected not only to characterize these noise sources, but also to devise and test methods that minimize artifactual or technical noise without erasing meaningful biological variation. Just as importantly, projects should explore what the observed heterogeneity means biologically, rather than treating all variability as error.
Administratively, this is a discretionary health research opportunity administered by the National Institutes of Health under CFDA 93.310 (Trans-NIH Research Support). The total estimated funding level is $4,000,000. Because it uses a U01 cooperative agreement mechanism, awardees should expect substantial programmatic involvement from NIH compared to a standard research grant, typically including coordination, shared milestones, and collaborative expectations that align individual projects with broader program goals.
Eligibility is broad and includes many organization types: public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), small businesses, for-profit organizations (including those other than small businesses), and multiple levels of government (state, county, city/township, special districts, and independent school districts), as well as public housing authorities. It also explicitly includes tribal governments and tribal organizations, Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) entities. The announcement states there is no cost sharing or matching requirement.
In terms of timing, the opportunity was posted on November 23, 2011, with an original and current closing date of January 23, 2012, and an archive date of February 23, 2012. Additional details and the full announcement were provided through the NIH grants guide link included in the notice. For access or linking issues, the contact listed is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the funding opportunity number and sponsor?
This opportunity is NIH RFA-RM-11-013, administered by the National Institutes of Health (NIH).
What is the primary scientific focus of this opportunity?
The focus is understanding cellular heterogeneity by measuring gene expression at the single-cell level in human samples. Projects are expected to capture transcriptional signatures from individual cells and use those data to define and distinguish cell types and/or cell states within mixed cell populations.
Why does the FOA emphasize single-cell transcriptional profiling instead of bulk measurements?
Single-cell transcriptional profiling is intended to move beyond bulk measurements that average signals across many cells. Bulk averaging can mask rare subpopulations, transitional states, and functionally important differences among cells that may appear similar when measured in aggregate.
What kind of samples are expected for the research?
The FOA states the work is focused on human samples, with gene expression measured at the single-cell level.
What is the central requirement related to "noise" in single-cell data?
Funded projects must explicitly address noise in single-cell transcriptional data and develop approaches to detect, quantify, analyze, and interpret that noise.
What sources of variability ("noise") does the FOA recognize?
The FOA recognizes both technical and biological sources of variability. Technical sources may include cell capture efficiency, RNA loss, amplification bias, sequencing depth, batch effects, and other processing artifacts. Biological sources may include cell cycle stage, stochastic gene expression, activation status, microenvironmental influences, and genuine subpopulation structure.
Is the goal to remove all variability from single-cell datasets?
No. Applicants are expected to minimize artifactual or technical noise without erasing meaningful biological variation. Projects should also explore what observed heterogeneity means biologically, rather than treating all variability as error.
What award mechanism is used for this funding opportunity?
The mechanism is a cooperative agreement (U01).
What does it mean that this is a U01 cooperative agreement?
A U01 cooperative agreement typically involves substantial programmatic involvement from NIH compared to a standard research grant. The FOA indicates this may include coordination, shared milestones, and collaborative expectations to align individual projects with broader program goals.
How much total funding is estimated for this program?
The total estimated funding level is $4,000,000.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.310 (Trans-NIH Research Support).
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad. It includes public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), small businesses, for-profit organizations (including those other than small businesses), and multiple levels of government (state, county, city/township, special districts, and independent school districts), as well as public housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly includes tribal governments and tribal organizations.
Are minority-serving institutions included in eligibility?
Yes. The FOA explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, and Tribally Controlled Colleges and Universities.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations.
Are U.S. territories eligible to apply?
Yes. The FOA explicitly includes U.S. territories or possessions.
Are non-U.S. (foreign) entities eligible to apply?
Yes. The FOA explicitly states that non-U.S. (foreign) entities are included.
When was this opportunity posted?
The opportunity was posted on November 23, 2011.
What were the closing dates for submission?
The original and current closing date listed is January 23, 2012.
When was the opportunity archived?
The archive date is February 23, 2012.
Where can applicants find the full announcement?
The notice indicates that additional details and the full announcement were available via the NIH grants guide link included in the posting.
Who should be contacted for access or linking issues?
For access or linking issues, the contact listed is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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