Opportunity Information: Apply for RFA AA 12 007
Apply for RFA AA 12 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Translational Research in Alcoholic Hepatitis (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Nov 23, 2011 and posted on Nov 23, 2011.
- Applicants must submit their applications by Feb 15, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments County governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments Native American tribal governments (Federally recognized) Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Translational Research in Alcoholic Hepatitis (U01) funding opportunity (RFA-AA-12-007) was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, to support cooperative agreement projects focused specifically on Alcoholic Hepatitis (AH). The central purpose of the program is to speed up "bench-to-bedside" progress by moving promising scientific findings toward practical clinical applications that can improve outcomes for people with AH. In other words, NIAAA is looking for research that does more than describe disease biology; it should actively push emerging insights toward testable, treatment-relevant strategies, including the development of new therapies or improved use of existing ones.
A defining feature of this opportunity is its emphasis on tight collaboration between basic scientists and clinicians. The announcement highlights that advancing treatment in AH depends on teams that can connect mechanistic understanding (for example, pathways of liver injury, inflammation, immune dysfunction, or other biologic drivers relevant to AH) with clinical realities such as patient heterogeneity, disease severity, and practical considerations in designing and implementing therapeutic approaches. Because it is offered as a U01 cooperative agreement, awardees should expect a more interactive relationship with NIAAA than under a typical research project grant, with programmatic involvement intended to help keep projects aligned with translational goals and milestones.
The scope is intentionally narrow: it is directed at Alcoholic Hepatitis and not at alcoholic fibrosis/cirrhosis or the complications of portal hypertension. This boundary matters because it signals that applications should keep AH as the primary clinical and biological focus rather than drifting into broader alcohol-related liver disease topics. Projects that primarily address long-term fibrotic progression, established cirrhosis management, or portal hypertension complications would likely be considered out of scope unless they are clearly tied to AH mechanisms or near-term therapeutic translation in AH.
From an administrative standpoint, this was a discretionary health-related funding opportunity under CFDA 93.273 (Alcohol Research Programs). It did not require cost sharing or matching. The opportunity was posted and created on November 23, 2011, with an original and final application closing date of February 15, 2012, and it was archived on March 17, 2012. NIAAA estimated total funding at about $4,000,000, with an award ceiling of $2,000,000, implying the program could support one or more sizable projects depending on final awards and budgets.
Eligibility was broad and included many organization types. Eligible applicants included nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses), public and private institutions of higher education, and multiple levels of government (state, county, city/township, special district, independent school districts, and U.S. territories or possessions). The eligibility list also explicitly included tribal governments and tribally controlled institutions, public housing authorities/Indian housing authorities, and a range of mission- or population-focused organizations and institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations. Notably, the announcement also allowed non-U.S. entities (foreign organizations) and regional organizations, indicating NIAAA was open to strong AH translational proposals regardless of geography, as long as they met NIH requirements and the program goals.
For applicants seeking the full details, the announcement referenced an NIH guide link (http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-12-007.html). For technical access issues, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the Translational Research in Alcoholic Hepatitis (U01) funding opportunity?
It is a National Institutes of Health (NIH) funding opportunity issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to support cooperative agreement (U01) projects focused specifically on Alcoholic Hepatitis (AH). The opportunity number is RFA-AA-12-007.
What is the main goal of this program?
The central goal is to accelerate "bench-to-bedside" progress in Alcoholic Hepatitis by moving promising scientific findings toward practical clinical applications that can improve outcomes for people with AH. The program is intended to support work that pushes emerging insights toward testable, treatment-relevant strategies, including developing new therapies or improving the use of existing ones.
Does the program support basic research, clinical research, or both?
Based on the description, the program emphasizes translational research that connects mechanistic understanding (basic science) with clinical realities and practical therapeutic development. A defining feature is tight collaboration between basic scientists and clinicians, indicating that projects are expected to bridge both domains rather than staying purely descriptive or disconnected from clinical application.
What makes this a "translational" opportunity rather than a general research program?
The program is described as looking for research that does more than describe disease biology. It is intended to actively push emerging scientific insights toward testable, treatment-relevant strategies in AH, including therapy development or improved therapeutic use, with a focus on near-term clinical application.
What does "U01 cooperative agreement" mean for applicants?
This opportunity uses the U01 cooperative agreement mechanism, which implies a more interactive relationship with NIAAA than a typical research project grant. Awardees should expect programmatic involvement from NIAAA intended to help keep projects aligned with translational goals and milestones.
How important is collaboration between basic scientists and clinicians?
Collaboration is highlighted as a defining feature of this opportunity. The announcement emphasizes that advancing treatment in AH depends on teams that can connect mechanistic understanding (such as pathways of liver injury, inflammation, and immune dysfunction) with clinical realities like patient heterogeneity, disease severity, and practical considerations in designing and implementing therapeutic approaches.
What disease area is the opportunity focused on?
The scope is intentionally narrow and directed at Alcoholic Hepatitis (AH). Applications are expected to keep AH as the primary clinical and biological focus.
Are projects on alcoholic fibrosis or cirrhosis within scope?
The announcement indicates the opportunity is not directed at alcoholic fibrosis/cirrhosis. Projects that primarily address long-term fibrotic progression or established cirrhosis management would likely be considered out of scope unless they are clearly tied to AH mechanisms or near-term therapeutic translation in AH.
Are projects on portal hypertension complications within scope?
The opportunity is described as not being directed at the complications of portal hypertension. Work centered on portal hypertension complications would likely be out of scope unless clearly tied to AH mechanisms or near-term therapeutic translation in AH.
What kinds of biological or mechanistic topics are mentioned as relevant to AH?
The description gives examples such as pathways of liver injury, inflammation, immune dysfunction, and other biologic drivers relevant to Alcoholic Hepatitis, particularly when those insights are connected to clinically meaningful therapeutic approaches.
Is this a discretionary health-related funding opportunity?
Yes. Administratively, it is described as a discretionary health-related funding opportunity.
What CFDA program is associated with this opportunity?
The opportunity is associated with CFDA 93.273 (Alcohol Research Programs).
Is cost sharing or matching required?
No. The information provided states that cost sharing or matching was not required.
When was the opportunity posted and created?
It was posted and created on November 23, 2011.
What were the application due dates?
The original and final application closing date was February 15, 2012.
Is this funding opportunity still open?
No. It was archived on March 17, 2012, and the final closing date listed was February 15, 2012.
How much funding was NIAAA expecting to provide in total?
NIAAA estimated total funding at about $4,000,000 for the program.
What was the maximum award amount (award ceiling)?
The award ceiling listed was $2,000,000.
Does the total funding amount imply multiple awards?
The information notes that a total estimate of about $4,000,000 and an award ceiling of $2,000,000 implies the program could support one or more sizable projects depending on final awards and budgets.
Who was eligible to apply?
Eligibility was broad. Eligible applicants included nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses), public and private institutions of higher education, and multiple levels of government (including state, county, city/township, special district, independent school districts, and U.S. territories or possessions).
Were tribal governments and tribally controlled institutions eligible?
Yes. The eligibility list explicitly included tribal governments and tribally controlled institutions.
Were public housing authorities eligible?
Yes. The eligibility list included public housing authorities/Indian housing authorities.
Were HBCUs and other mission- or population-focused institutions eligible?
Yes. The eligibility list explicitly included Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations.
Could foreign (non-U.S.) organizations apply?
Yes. The announcement allowed non-U.S. entities (foreign organizations) and regional organizations, indicating NIAAA was open to strong AH translational proposals regardless of geography, as long as they met NIH requirements and the program goals.
Where can applicants find the full funding announcement?
The information references the NIH guide link for the full details: http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-12-007.html
Who should be contacted for technical access issues related to the announcement?
For technical access issues, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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