Opportunity Information: Apply for PAS 11 280
Apply for PAS 11 280
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "T1 Translational Research Novel interventions for prevention and treatment of age related conditions (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jul 25, 2011 and posted on Jul 25, 2011.
- Applicants must submit their applications by Sep 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses City or township governments State governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Native American tribal governments (Federally recognized) Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.
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Opportunity Summary:
The NIH funding opportunity PAS-11-280, titled "T1 Translational Research Novel interventions for prevention and treatment of age related conditions (R21)," is a discretionary grant program aimed at speeding up early-stage translational work that can lead to new ways to prevent or treat diseases and functional problems that disproportionately affect older adults. It uses the R21 exploratory/developmental mechanism, meaning it is intended for high-impact, early proof-of-concept studies rather than large, fully matured research programs. The central focus is on T1 translational research in aging, defined here as taking findings from basic biology and clinical biomedical research and actively pushing them toward practical strategies that could become therapies or interventions for real-world age-related conditions.
The projects this announcement seeks are those that move beyond purely descriptive aging biology and instead directly support the development of interventions. The FOA explicitly welcomes a wide range of therapeutic approaches, including biologics (such as proteins, antibodies, or other biologically derived therapeutics), pharmacological approaches (small molecules and other drug-like candidates), and non-pharmacological approaches (which could include behavioral, lifestyle, device-based, rehabilitative, or other non-drug interventions). The intent is to accelerate development, so proposed studies should be framed around translational steps that de-risk a candidate intervention, clarify feasibility, establish preliminary efficacy signals, define mechanism relevant to disease, identify biomarkers or endpoints, or otherwise help move an intervention closer to clinical application for older populations.
A key requirement is that the application clearly ties the proposed work to a clinically meaningful aging-related pathology or condition. If the research includes basic studies in animal models, the proposal must plainly state how the work has potential to treat or prevent a specific clinical age-related disease or condition, not just illuminate aging processes in general. The FOA emphasizes that the direct relevance of the data to a clinical aging condition must be established and stated clearly, which signals that reviewers are expected to prioritize projects with a credible line of sight from experimental results to human health impact in aging.
Administratively, this opportunity was posted July 25, 2011, with an original and final closing date of September 7, 2014, and it was archived October 8, 2014. The award ceiling listed is $200,000, and there is no cost sharing or matching requirement. It is cataloged under CFDA 93.866 (Aging Research) and is sponsored by the National Institutes of Health.
Eligibility is broad and includes many common NIH applicant types across academia, government, nonprofit, and industry. Eligible applicants include public and private institutions of higher education, 501(c)(3) and non-501(c)(3) nonprofits (including faith-based and community-based organizations), small businesses and other for-profit organizations (with small businesses explicitly called out), and a range of government entities such as state, county, city or township governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities. The FOA also includes Native American tribal governments (federally recognized and other than federally recognized) and Native American tribal organizations, as well as tribally controlled colleges and universities (TCCUs). In addition, it explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), regional organizations, US territories or possessions, and notably allows non-US entities (foreign institutions) to apply, along with non-domestic components of US organizations and eligible federal agencies.
For reference and official details, the full announcement was available via the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PAS-11-280.html. The listed point of contact for access or technical issues is the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV), including help if there are problems accessing the announcement or linking to it.
FAQs: NIH PAS-11-280 (R21) - T1 Translational Research Novel Interventions for Prevention and Treatment of Age Related Conditions
1) What is PAS-11-280?
PAS-11-280 is a National Institutes of Health (NIH) funding opportunity announcement titled "T1 Translational Research Novel interventions for prevention and treatment of age related conditions (R21)." It is a discretionary grant program intended to speed up early-stage translational research that could lead to new ways to prevent or treat diseases and functional problems that disproportionately affect older adults.
2) What does "T1 translational research" mean in this funding opportunity?
In this announcement, T1 translational research is described as work that takes findings from basic biology and clinical biomedical research and actively pushes them toward practical strategies that could become therapies or interventions for real-world age-related conditions. The emphasis is on moving toward application, not only generating descriptive knowledge.
3) What funding mechanism does this opportunity use?
This opportunity uses the NIH R21 exploratory/developmental research mechanism. That means it is intended for high-impact, early proof-of-concept studies rather than large, fully mature research programs.
4) What is the main purpose of the R21 projects under PAS-11-280?
The purpose is to accelerate early-stage translational steps that can move a candidate intervention closer to clinical application for older populations. Projects should move beyond descriptive aging biology and instead support intervention development.
5) What types of interventions are encouraged?
The FOA welcomes a wide range of therapeutic approaches, including:
- Biologics (for example, proteins, antibodies, or other biologically derived therapeutics)
- Pharmacological approaches (for example, small molecules and other drug-like candidates)
- Non-pharmacological approaches (for example, behavioral, lifestyle, device-based, rehabilitative, or other non-drug interventions)
6) What kinds of research activities fit the "accelerate development" intent?
Proposed studies should be framed around translational steps that help move an intervention toward clinical use. Examples described in the opportunity include work to:
- De-risk a candidate intervention
- Clarify feasibility
- Establish preliminary efficacy signals
- Define mechanism relevant to disease
- Identify biomarkers or endpoints
- Otherwise advance an intervention closer to clinical application for older adults
7) Is purely descriptive aging biology a fit for this FOA?
No. The central focus is on moving beyond purely descriptive studies of aging biology and instead directly supporting development of interventions aimed at prevention or treatment of age-related conditions.
8) What is the requirement regarding clinical relevance to aging-related conditions?
A key requirement is that the application clearly ties the proposed work to a clinically meaningful aging-related pathology or condition. The FOA emphasizes that direct relevance of the proposed data to a clinical aging condition must be established and stated clearly.
9) If my project includes animal model studies, what does the FOA require?
If the research includes basic studies in animal models, the proposal must plainly state how the work has potential to treat or prevent a specific clinical age-related disease or condition, not just illuminate aging processes in general.
10) What are reviewers likely to prioritize based on the FOA language?
The FOA signals that reviewers are expected to prioritize projects with a credible line of sight from experimental results to human health impact in aging, meaning the proposal should clearly articulate how the work supports development of a practical intervention for a defined age-related condition.
11) What is the maximum award amount listed for this opportunity?
The listed award ceiling is $200,000.
12) Is cost sharing or matching required?
No. The opportunity specifies that there is no cost sharing or matching requirement.
13) When was PAS-11-280 posted, and what were the closing dates?
The opportunity was posted on July 25, 2011. It had an original and final closing date of September 7, 2014.
14) Is this funding opportunity still open?
No. It was archived on October 8, 2014, and the final closing date was September 7, 2014.
15) Which agency sponsors this funding opportunity?
The sponsor is the National Institutes of Health (NIH).
16) What is the CFDA number associated with this opportunity?
The opportunity is cataloged under CFDA 93.866, Aging Research.
17) What types of organizations are eligible to apply?
Eligibility is broad and includes many common NIH applicant types across academia, government, nonprofit, and industry. Eligible applicants include:
- Public and private institutions of higher education
- Nonprofits (501(c)(3) and non-501(c)(3), including faith-based and community-based organizations)
- For-profit organizations, including small businesses (small businesses are explicitly called out)
- Government entities (state, county, city or township governments; independent school districts; special district governments; public housing authorities/Indian housing authorities)
- Native American tribal governments (federally recognized and other than federally recognized)
- Native American tribal organizations
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Regional organizations
- U.S. territories or possessions
- Non-U.S. entities (foreign institutions), including non-domestic components of U.S. organizations
- Eligible federal agencies
18) Are foreign institutions allowed to apply?
Yes. The FOA notably allows non-U.S. entities (foreign institutions) to apply, as well as non-domestic components of U.S. organizations.
19) Where can applicants find the official announcement text?
The full announcement was available via the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PAS-11-280.html
20) Who is the listed point of contact for access or technical issues?
The listed point of contact for access or technical issues is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV, including help if there are problems accessing the announcement or linking to it.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAS 11 280) also looked into and applied for these:
| Funding Opportunity |
|---|
| T2 Translational Research Research leading to new health care practices, community programs and policies affecting older persons (R21) Apply for PAS 11 281 Funding Number: PAS 11 281 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Bridges to the Doctorate Program (R25) Apply for PAR 11 279 Funding Number: PAR 11 279 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Advancing the Impact of Effective HIV/AIDS Prevention and Treatment Interventions (R01) Apply for PA 11 271 Funding Number: PA 11 271 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Advancing the Impact of Effective HIV/AIDS Prevention and Treatment Interventions (R21) Apply for PA 11 273 Funding Number: PA 11 273 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Advancing the Impact of Effective HIV/AIDS Prevention and Treatment Interventions (R34) Apply for PAR 11 274 Funding Number: PAR 11 274 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Advancing the Impact of Effective HIV/AIDS Prevention and Treatment Interventions (R03) Apply for PA 11 272 Funding Number: PA 11 272 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| International Research Collaboration on Alcohol and Alcoholism (U01) Apply for PAR 11 282 Funding Number: PAR 11 282 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Consumer Operated and Oriented Plan Apply for OO COO 11 001 Funding Number: OO COO 11 001 Agency: CMS Consumer Information Insurance Oversight Category: Health Funding Amount: Case Dependent |
| Frontier Community Health Integration Demonstration Apply for HRSA 11 202 Funding Number: HRSA 11 202 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Frontier Extended Stay Clinic Cooperative Agreement Apply for HRSA 11 139 Funding Number: HRSA 11 139 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Planning Grants for Clinical Trials of High Relevance to the NIGMS Mission (R34) Apply for PAR 11 287 Funding Number: PAR 11 287 Agency: National Institutes of Health Category: Health Funding Amount: $100,000 |
| Functional Restoration of Salivary Glands (R21) Apply for RFA DE 12 005 Funding Number: RFA DE 12 005 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Functional Restoration of Salivary Glands (R01) Apply for RFA DE 12 004 Funding Number: RFA DE 12 004 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Paul B. Beeson Clinical Scientist Development Award in Aging (K08) Apply for RFA AG 12 003 Funding Number: RFA AG 12 003 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Paul B. Beeson Patient Oriented Research Career Development Award in Aging (K23) Apply for RFA AG 12 004 Funding Number: RFA AG 12 004 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Bridges to the Baccalaureate Program (R25) Apply for PAR 11 285 Funding Number: PAR 11 285 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIDCR Institutional Career Development Award for Enhancing Research Capacity in Temporomandibular Joint Disorders and Orofacial Pain (K12) Apply for PAR 11 289 Funding Number: PAR 11 289 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIDCD Phase I/II Preliminary Clinical Trials in Communication Disorders (R01) Apply for PAR 11 290 Funding Number: PAR 11 290 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Aging Research Dissertation Awards to Increase Diversity (R36) Apply for PAR 11 291 Funding Number: PAR 11 291 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Secondary Analyses and Archiving of Social and Behavioral Datasets in Aging (R03) Apply for RFA AG 12 005 Funding Number: RFA AG 12 005 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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