Opportunity Information: Apply for PA 14 127
Apply for PA 14 127
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Targeted Basic Behavioral and Social Science and Intervention Development for HIV Prevention and Care (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Feb 28, 2014 and posted on Feb 28, 2014.
- Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments For profit organizations other than small businesses Public housing authorities/Indian housing authorities City or township governments Small businesses County governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Targeted Basic Behavioral and Social Science and Intervention Development for HIV Prevention and Care (R01) funding opportunity (PA 14-127) is a National Institutes of Health (NIH) research grant program designed to spur new, targeted work that can reduce new HIV infections and improve health outcomes for people living with HIV. The announcement lays out priority directions for innovative behavioral and social science research, along with intervention development efforts that build directly on that foundational research. In practice, the program is meant to strengthen the pipeline from basic behavioral and social science discovery through to practical, testable interventions for HIV prevention and HIV care.
A central emphasis of the opportunity is supporting studies that generate the behavioral and social science knowledge needed to make prevention and care interventions more effective. This includes research that clarifies how individual behavior, relationships, social networks, communities, culture, stigma, socioeconomic conditions, and other structural factors shape HIV risk, testing, prevention uptake, treatment engagement, and long-term viral suppression. The goal is not basic research in the abstract, but basic research that directly informs intervention design by identifying mechanisms and leverage points that can be translated into strategies that actually change outcomes in real-world settings.
The FOA also encourages applicants to move beyond discovery and actively translate findings into intervention development. That translation piece includes operationalizing key constructs from basic research into intervention components, designing programs or strategies that address identified barriers and facilitators, and then assessing feasibility. Feasibility work can include questions like whether an intervention is acceptable to intended users, whether it can be delivered with fidelity, how it fits into specific service settings, and what practical constraints may affect adoption or scale. The intent is to make sure the science is not only theoretically strong, but also usable and deliverable.
A third major focus area is testing the efficacy of HIV prevention and care interventions. In other words, the program supports rigorous evaluations of whether newly developed or refined interventions actually work under controlled or well-defined conditions. This positions the R01 mechanism as appropriate for substantial projects that can include strong designs and meaningful outcome measures, with the broader aim of producing evidence that can eventually inform best practices and future implementation efforts.
From an administrative standpoint, this is a discretionary NIH grant using the R01 research project grant mechanism, falling under health-related activity categories. The opportunity is associated with CFDA numbers 93.242 (Mental Health Research Grants), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research), signaling the cross-cutting relevance of HIV work to mental health, behavioral science, and infectious disease research portfolios. The announcement specifies that cost sharing or matching is not required, which generally lowers barriers for applicants who may not have non-federal funds to contribute.
Eligibility is broad and includes many types of U.S.-based and non-U.S.-based organizations. Eligible applicants include state, county, city/township, and special district governments; public housing authorities/Indian housing authorities; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits (both 501(c)(3) and certain non-501(c)(3) entities, excluding higher education where specified); and for-profit organizations, including small businesses. The eligibility language also explicitly includes a range of mission-focused institutions and community-rooted entities such as faith-based and community-based organizations, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs). Tribal governments (federally recognized and other than federally recognized), U.S. territories or possessions, and federal agencies are also listed among eligible applicants.
Importantly, the FOA allows international participation. Non-domestic (non-U.S.) entities and foreign institutions are eligible to apply, non-domestic components of U.S. organizations are eligible, and foreign components (as defined by the NIH Grants Policy Statement) are allowed. This reflects the reality that HIV prevention and care challenges are global, and that impactful behavioral and social science advances and intervention development can come from diverse geographic and cultural contexts.
In terms of timing, the FOA was posted and created on February 28, 2014, with an original and current closing date of January 7, 2017, and an archive date of February 7, 2017. That means the announcement itself is no longer active for new submissions under that specific FOA as written, but it remains a useful reference point for the types of HIV behavioral and social science and intervention development research NIH sought to fund during that period, and it can help prospective applicants understand how NIH frames the pathway from basic behavioral/social science to feasible interventions to efficacy testing.
For applicants or institutions looking for the full details, NIH provided an additional information link to the archived program announcement page (http://grants.nih.gov/grants/guide/pa-files/PA-14-127.html). For technical difficulties accessing the announcement online or linking issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the Targeted Basic Behavioral and Social Science and Intervention Development for HIV Prevention and Care (R01) opportunity (PA 14-127)?
PA 14-127 is a National Institutes of Health (NIH) research grant opportunity that uses the R01 research project grant mechanism to support targeted behavioral and social science research and HIV intervention development. The program is designed to spur new work that can reduce new HIV infections and improve health outcomes for people living with HIV by strengthening the pathway from foundational behavioral/social science findings to practical, testable interventions.
What is the overall goal of this funding opportunity?
The overall goal is to build a stronger pipeline from basic behavioral and social science discovery to intervention development and then to efficacy testing for HIV prevention and HIV care. The emphasis is on research that directly informs intervention design and produces evidence that can improve real-world outcomes.
What kinds of research are prioritized under this announcement?
The announcement highlights three major areas: (1) targeted basic behavioral and social science research that generates knowledge needed to improve prevention and care interventions, (2) translation of findings into intervention development and feasibility assessment, and (3) testing the efficacy of HIV prevention and care interventions under controlled or well-defined conditions.
What does "targeted basic behavioral and social science" mean in this context?
It refers to foundational behavioral and social science research that is not purely abstract, but is intentionally aimed at identifying mechanisms, leverage points, barriers, and facilitators that can be translated into intervention strategies. The expectation is that this basic research directly informs the design of interventions intended to change HIV-related outcomes.
What factors and influences does the FOA expect studies to examine?
The FOA points to influences such as individual behavior, relationships, social networks, communities, culture, stigma, socioeconomic conditions, and other structural factors. These influences are framed as shaping HIV risk, testing, prevention uptake, treatment engagement, and long-term viral suppression.
Which parts of the HIV prevention and care continuum are relevant to this opportunity?
Based on the description, relevant topics include HIV risk, HIV testing, uptake of prevention approaches, engagement in HIV treatment and care, and sustaining long-term viral suppression for people living with HIV.
Does the program support intervention development as well as basic research?
Yes. A central emphasis is moving beyond discovery to translate basic behavioral and social science findings into intervention development. This includes turning key constructs into intervention components, designing strategies that address identified barriers and facilitators, and assessing feasibility.
What does "translation" from basic research to intervention development involve?
Translation includes operationalizing key constructs from basic research into concrete intervention components, designing programs or strategies around identified mechanisms, and conducting feasibility work to determine whether the intervention is usable, deliverable, and suited to the intended service settings.
What kinds of feasibility questions are mentioned in the announcement?
The FOA notes feasibility questions such as whether an intervention is acceptable to intended users, whether it can be delivered with fidelity, how it fits into specific service settings, and what practical constraints could affect adoption or scale.
Does this opportunity support efficacy testing of interventions?
Yes. A third major focus is testing the efficacy of HIV prevention and care interventions through rigorous evaluations that determine whether newly developed or refined interventions work under controlled or well-defined conditions.
Why is the R01 mechanism highlighted, and what does that imply about project scope?
The opportunity uses the NIH R01 research project grant mechanism and is positioned as appropriate for substantial projects. The description notes that projects can include strong study designs and meaningful outcome measures, consistent with rigorous efficacy evaluations and robust intervention development work.
Is cost sharing or matching required?
No. The announcement specifies that cost sharing or matching is not required.
Which NIH-related activity categories or research areas does this opportunity fall under?
Administratively, it is described as a discretionary NIH grant under health-related activity categories, reflecting cross-cutting relevance across behavioral science, mental health, and infectious disease research portfolios.
What CFDA numbers are associated with this opportunity, and what do they indicate?
The opportunity is associated with CFDA 93.242 (Mental Health Research Grants), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research). These CFDA numbers signal the cross-cutting nature of HIV-related behavioral, social science, and infectious disease research.
Who is eligible to apply?
Eligibility is broad. The FOA lists many types of applicants, including various U.S. government entities (state, county, city/township, special districts), public housing authorities/Indian housing authorities, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities, excluding higher education where specified), and for-profit organizations including small businesses.
Are community-based or mission-focused organizations explicitly included as eligible applicants?
Yes. The eligibility language explicitly includes faith-based and community-based organizations and a range of institutions that are often community-rooted or mission-focused.
Are minority-serving institutions explicitly included?
Yes. The FOA explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs).
Are tribal governments eligible to apply?
Yes. Tribal governments (federally recognized and other than federally recognized) are listed among eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included in the eligibility list.
Are federal agencies eligible?
Yes. Federal agencies are listed among eligible applicants.
Can non-U.S. (international) organizations apply?
Yes. The FOA allows international participation. Non-domestic (non-U.S.) entities and foreign institutions are eligible to apply.
Can a U.S. organization include non-U.S. components in its application?
Yes. The FOA states that non-domestic components of U.S. organizations are eligible.
Are foreign components allowed under NIH policy definitions?
Yes. The FOA indicates that foreign components (as defined by the NIH Grants Policy Statement) are allowed.
When was this FOA posted, and what are the key dates?
The FOA was posted and created on February 28, 2014. The original and current closing date is listed as January 7, 2017, and the archive date is February 7, 2017.
Is PA 14-127 still open for new submissions?
No. Based on the listed closing and archive dates, the announcement is no longer active for new submissions under that specific FOA as written.
If the FOA is archived, why is it still useful?
The archived announcement can still be a useful reference for understanding the types of HIV behavioral and social science research, intervention development, feasibility assessment, and efficacy testing that NIH sought to support during that period, as well as how NIH framed the pathway from discovery to usable interventions.
Where can applicants find the full archived announcement?
NIH provided an archived program announcement page at: http://grants.nih.gov/grants/guide/pa-files/PA-14-127.html
Who should be contacted for technical issues accessing the announcement link?
For technical difficulties accessing the announcement online or link-related issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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