Opportunity Information: Apply for RFA HG 11 015
Apply for RFA HG 11 015
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Technology Development for High Throughput Functional Genomics (R43/44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on May 23, 2011 and posted on May 23, 2011.
- Applicants must submit their applications by Aug 2, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $750,000.00 to eligible and selected applicants.
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), issued this funding opportunity to support the creation of new and improved technologies that can rapidly and comprehensively find, confirm, and describe functional elements in eukaryotic genomes. The focus is on sequence-based functional elements, meaning DNA or RNA features whose roles can be inferred, tested, or measured directly from genomic sequence and related assays. In practical terms, the opportunity targets technology that makes it easier to identify and characterize things like regulatory DNA (enhancers, promoters, insulators), transcription factor binding sites, noncoding RNAs, chromatin-associated features, and other genomic elements that influence gene activity and cellular function. A major emphasis is high throughput and efficiency, so proposals are expected to push beyond small-scale, low-throughput approaches and instead enable comprehensive, scalable functional genomics workflows.
This announcement uses the SBIR R43/R44 mechanism, which is designed specifically for small businesses developing innovative technologies with strong potential for commercialization and broad research impact. Under the SBIR structure, Phase I (R43) typically supports early feasibility and proof-of-concept work, while Phase II (R44) supports more advanced research and development aimed at producing a more mature, validated technology. The eligible applicant pool is therefore limited to small businesses, and there is no cost sharing or matching requirement. The overall goal is to move functional genomics technology forward in ways that are practical, adoptable by the research community, and positioned to become robust products, platforms, or services.
Scientifically, the solicitation is framed as part of a larger coordinated effort. It shares the same scientific scope as companion announcements aimed at different applicant types and project styles: an R01 version for full research project grants (RFA-HG-11-013) and an R21 version for exploratory/developmental projects (RFA-HG-11-014). Together, these related opportunities were meant to stimulate a pipeline of innovation across academia and industry, with the SBIR track emphasizing small business-led development and translation. The announcement also explicitly connects to the technology development push that began in 2003 within the ENCODE project, reflecting NHGRI's long-term interest in building the tools needed to map functional DNA elements across the genome in a systematic, data-rich way.
Administratively, the opportunity is a discretionary NIH grant in the health funding category under CFDA 93.172 (Human Genome Research). The funding opportunity number is RFA-HG-11-015, titled "Technology Development for High Throughput Functional Genomics (R43/44)." It was posted on May 23, 2011, with an application closing date of August 2, 2011, and an archive date of September 2, 2011. The estimated total funding listed for the announcement is $750,000. Additional details and the full official text were made available through the NIH grants guide page linked in the notice, and NIH Office of Extramural Research webmaster contacts were provided for access or linking problems.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is an NIH/NHGRI funding opportunity to support the creation of new and improved technologies for high throughput functional genomics in eukaryotic genomes. The funding opportunity number is RFA-HG-11-015, titled "Technology Development for High Throughput Functional Genomics (R43/44)."
Which NIH institute is offering the grant?
The opportunity was issued by the National Human Genome Research Institute (NHGRI), which is part of the National Institutes of Health (NIH).
What is the overall scientific goal?
The goal is to advance technologies that can rapidly and comprehensively find, confirm, and describe functional elements in eukaryotic genomes, with an emphasis on scalable, efficient, high throughput approaches.
What kinds of genomic features are considered "functional elements" under this opportunity?
The focus is on sequence-based functional elements (DNA or RNA features) whose roles can be inferred, tested, or measured directly from genomic sequence and related assays. Examples listed include regulatory DNA (enhancers, promoters, insulators), transcription factor binding sites, noncoding RNAs, chromatin-associated features, and other elements that influence gene activity and cellular function.
What does "sequence-based functional elements" mean in practical terms?
It refers to DNA or RNA features where function can be evaluated using genomic sequence information and assays tied to sequence, enabling identification and characterization directly from sequence and related measurements rather than relying on indirect or purely observational approaches.
What is meant by "high throughput" in this announcement?
The announcement emphasizes technologies that move beyond small-scale, low-throughput methods and instead enable comprehensive, scalable functional genomics workflows that can be applied broadly and efficiently.
What grant mechanism is being used?
This announcement uses the SBIR R43/R44 mechanism.
Who is eligible to apply?
The eligible applicant pool is limited to small businesses, consistent with the SBIR program structure described in the announcement.
What is the difference between Phase I and Phase II under this SBIR structure?
Phase I (R43) typically supports early feasibility and proof-of-concept work. Phase II (R44) typically supports more advanced research and development to produce a more mature, validated technology.
Is cost sharing or matching required?
No. The opportunity specifies there is no cost sharing or matching requirement.
What kinds of outcomes are expected from funded projects?
The announcement highlights outcomes that are practical and adoptable by the research community, and positioned to become robust products, platforms, or services with strong commercialization potential and broad research impact.
How does this SBIR opportunity relate to other NIH opportunities mentioned?
It shares the same scientific scope as companion announcements aimed at other applicant types and project styles: an R01 version (RFA-HG-11-013) and an R21 version (RFA-HG-11-014). The SBIR track emphasizes small business-led development and translation.
Does this opportunity connect to any larger coordinated efforts?
Yes. The solicitation is framed as part of a broader, coordinated effort to stimulate innovation across academia and industry, and it explicitly connects to the technology development push that began in 2003 within the ENCODE project.
What is the funding opportunity title and number?
The title is "Technology Development for High Throughput Functional Genomics (R43/44)" and the funding opportunity number is RFA-HG-11-015.
What is the CFDA number and program area?
The CFDA is 93.172, listed as Human Genome Research.
What type of grant is this described as administratively?
It is described as a discretionary NIH grant in the health funding category.
How much total funding was estimated for this announcement?
The estimated total funding listed for the announcement is $750,000.
When was the opportunity posted?
It was posted on May 23, 2011.
What was the application closing date?
The application closing date was August 2, 2011.
When was the archive date?
The archive date was September 2, 2011.
Where could applicants find the full official text and additional details?
The notice states that additional details and the full official text were available through the NIH grants guide page linked in the notice.
Who was listed for technical help if there were access or linking problems?
NIH Office of Extramural Research webmaster contacts were provided for access or linking problems.
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