Opportunity Information: Apply for PAR 10 074
Apply for PAR 10 074
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Technology Development for High Throughput Structural Biology Research (P01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Jan 4, 2010 and posted on Jan 4, 2010.
- Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments City or township governments State governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Independent school districts County governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH) offered this Funding Opportunity Announcement (FOA) to support the development of new technologies and methods that make high throughput structural biology more capable and more efficient, especially for proteins that are currently difficult to handle with standard pipelines. The central aim is not simply to solve more structures using existing approaches, but to invent, refine, and validate enabling technologies that remove bottlenecks in the overall workflow, from making proteins in usable form through determining their structures. The FOA highlights that strong applications would propose fresh ideas for protein production and structure determination aimed at specific classes of hard targets, with an emphasis on method development that can be generalized and scaled.
Scientifically, the opportunity is focused on the parts of structural biology where throughput drops because targets are challenging. The announcement explicitly calls out difficult proteins such as membrane proteins, small protein complexes, and proteins from humans or other higher eukaryotes, which often present problems in expression, solubility, stability, purification, crystallization, spectral quality, or conformational heterogeneity. The FOA encourages projects that advance high throughput structure determination using X ray crystallography and NMR, and it also welcomes proposals that improve other connected tasks in structural biology, including structural genomics style workflows. In practice, this means applicants could propose innovations that improve cloning and expression systems, stabilize proteins or complexes, streamline purification, enhance crystallization or sample preparation, accelerate data collection and interpretation, or otherwise make it feasible to process classes of proteins that are not currently amenable to high throughput approaches.
The funding mechanism is a P01 program project grant, which is designed for coordinated, interdependent research projects that gain a clear advantage by being funded together rather than as separate standalone grants. In a P01, multiple projects are expected to fit together around a shared scientific theme, with synergy across the components and a coherent plan showing why the integrated program is more powerful than a set of unrelated projects. This FOA also notes that it runs in parallel with a companion opportunity of the same scientific scope under the R01 mechanism (PAR 10 073), which is more appropriate for single-project efforts that do not require the multi-project program structure.
On funding levels and award counts, the FOA does not set a fixed budget total, a fixed number of awards, or a standard project size. Instead, NIGMS indicates that awards will depend on the scientific merit of applications and the availability of funds within the institute's general funding pool. Because proposed programs can vary widely in scope and complexity, both the size and duration of awards were expected to vary as well. In other words, the portfolio would be shaped by the number, quality, proposed timelines, and costs of the submissions received.
In terms of eligibility, the opportunity was broadly open to many types of applicants, reflecting NIH's general approach to institutional eligibility for research grants. Eligible applicants included public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for profit organizations (including small businesses and other than small businesses), and a wide range of government entities (state, county, city/township, special district governments, independent school districts, and certain public housing authorities/Indian housing authorities). The FOA also identified additional eligible groups such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, faith based or community based organizations, regional organizations, U.S. territories or possessions, certain tribal organizations and governments, and eligible federal agencies. The listing signals that NIGMS was primarily interested in supporting strong method-development programs regardless of organizational type, as long as the applicant could assemble the expertise and infrastructure needed for a coordinated high throughput structural biology technology effort.
Administratively, this was a discretionary grant opportunity in the health area, tied to CFDA 93.859 (Biomedical Research and Research Training), and it did not require cost sharing or matching. The FOA was posted January 4, 2010, with an original and current closing date of May 7, 2013, and it was archived June 7, 2013. The official funding opportunity number is PAR 10 074, and the sponsoring agency is NIH (specifically NIGMS). The full announcement was hosted through the NIH grants guide, and the NIH Office of Extramural Research provided technical contact information for access or linking issues.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is an NIH/NIGMS Funding Opportunity Announcement (FOA) to support the development of new technologies and methods that improve high throughput structural biology, especially for proteins that are difficult to process using standard pipelines.
What is the official FOA number?
The funding opportunity number is PAR-10-074.
Which NIH institute is sponsoring this FOA?
The sponsoring agency is the National Institutes of Health (NIH), specifically the National Institute of General Medical Sciences (NIGMS).
What is the main goal of the FOA?
The central goal is to invent, refine, and validate enabling technologies that remove bottlenecks across the structural biology workflow, from producing proteins in usable form through determining their structures. The focus is not simply to solve more structures using existing approaches, but to create methods that make high throughput structural biology more capable and more efficient.
What kinds of projects are considered a good fit?
Strong applications would propose fresh ideas for protein production and structure determination aimed at specific classes of hard targets, with an emphasis on method development that can be generalized and scaled for broader use.
What parts of the structural biology pipeline does the FOA aim to improve?
The FOA is focused on areas where throughput drops because targets are challenging. It highlights bottlenecks that can occur during expression, solubility, stability, purification, crystallization, spectral quality, and issues like conformational heterogeneity, as well as downstream structure determination steps.
Which protein targets are explicitly described as challenging?
The FOA explicitly calls out difficult proteins such as membrane proteins, small protein complexes, and proteins from humans or other higher eukaryotes.
Which structure determination methods are emphasized?
The FOA encourages projects that advance high throughput structure determination using X-ray crystallography and NMR.
Does the FOA allow improvements to related structural biology tasks beyond X-ray and NMR?
Yes. It also welcomes proposals that improve other connected tasks in structural biology, including structural genomics-style workflows.
What types of technology or method innovations could be proposed under this FOA?
Based on the FOA description, applicants could propose innovations that improve cloning and expression systems, stabilize proteins or complexes, streamline purification, enhance crystallization or sample preparation, accelerate data collection and interpretation, or otherwise enable processing of protein classes not currently amenable to high throughput approaches.
What is the funding mechanism for this opportunity?
The mechanism is a P01 Program Project Grant.
What does it mean that this is a P01 program project grant?
A P01 is intended for coordinated, interdependent research projects that gain a clear advantage by being funded together rather than as separate standalone grants. Projects are expected to fit around a shared scientific theme, show synergy across components, and explain why the integrated program is stronger than unrelated projects funded separately.
Is there a related opportunity for single-project applications?
Yes. The FOA notes it runs in parallel with a companion opportunity of the same scientific scope under the R01 mechanism, identified as PAR-10-073, which is more appropriate for single-project efforts that do not require a multi-project program structure.
Does the FOA specify a fixed total budget, a standard award size, or a fixed number of awards?
No. The FOA does not set a fixed budget total, a fixed number of awards, or a standard project size.
How are award amounts and the number of awards determined?
NIGMS indicates that awards depend on the scientific merit of applications and the availability of funds in the institute's general funding pool. Because programs can vary widely in scope and complexity, both award size and duration were expected to vary based on the submissions received.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
What is the CFDA number associated with this opportunity?
The opportunity is tied to CFDA 93.859 (Biomedical Research and Research Training).
What type of grant opportunity is this categorized as?
It is described as a discretionary grant opportunity in the health area.
Who is eligible to apply?
Eligibility is broadly open to many applicant types. Eligible applicants include public and private institutions of higher education; nonprofits (with and without 501(c)(3) status); for-profit organizations (including small businesses and other than small businesses); and multiple types of government entities (state, county, city/township, special district governments, independent school districts, and certain public housing authorities/Indian housing authorities).
Are minority-serving institutions and certain community-based organizations included in the eligible applicant list?
Yes. The FOA identifies additional eligible groups such as HBCUs, Hispanic Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, certain tribal organizations and governments, and eligible federal agencies.
When was the FOA posted, and what were the closing dates?
The FOA was posted on January 4, 2010. The original and current closing date listed is May 7, 2013.
Is this FOA still active?
No. The FOA was archived on June 7, 2013.
Where was the full announcement hosted?
The full announcement was hosted through the NIH Grants Guide.
Who provided technical contact information for access or linking issues?
The NIH Office of Extramural Research provided technical contact information for access or linking issues.
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