Opportunity Information: Apply for PAR 10 073
Apply for PAR 10 073
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Technology Development for High Throughput Structural Biology Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Jan 4, 2010 and posted on Jan 4, 2010.
- Applicants must submit their applications by Jan 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Native American tribal governments (Federally recognized) County governments For profit organizations other than small businesses State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH National Institute of General Medical Sciences (NIGMS) funding opportunity PAR-10-073 supports R01 research projects aimed at creating and improving technologies that make high throughput structural biology possible, especially in areas where current pipelines struggle. The main idea is to push beyond incremental optimization and instead develop genuinely useful methods and tools that can speed up and broaden the ability to determine protein structures at scale. While the announcement sits within the broader umbrella of structural biology, its emphasis is clearly on technology and methodology development rather than routine structure determination. The expectation is that successful projects will remove bottlenecks and expand what types of proteins can be handled in a high throughput manner.
Scientifically, the FOA is interested in new ideas across the structural biology workflow, from protein production all the way through structure determination. It explicitly highlights high throughput X-ray crystallography and NMR as core areas, but it is not limited to those techniques. Work that addresses related component tasks in structural biology, including structural genomics efforts and other enabling steps that feed into structure determination, is also considered relevant. In practice, this means applications could target problems like improving expression systems, stabilizing proteins for purification, developing better crystallization strategies, advancing sample preparation, automating data collection or analysis, or creating new experimental and computational methods that increase throughput and success rates.
A defining feature of this opportunity is its focus on "challenging proteins" that are not currently well served by high throughput approaches. The announcement calls out difficult classes such as membrane proteins, small protein complexes, and proteins from humans and other higher eukaryotes, while also leaving room for other hard targets. The intent is to encourage applicants to tackle the types of molecules that routinely fail in standard pipelines due to issues like instability, low expression, heterogeneity, conformational flexibility, or difficulty obtaining well-behaved samples. Proposals are expected to concentrate on methods development that makes these targets more tractable, rather than simply applying existing methods to solve a set of structures.
In terms of funding mechanism and program structure, this FOA uses the NIH R01 grant mechanism, meaning it is designed for discrete, investigator-driven research projects. It runs in parallel with a companion announcement of the same scientific scope that uses a different mechanism (P01, PAR-10-074), which is typically more suited to multi-project program grants. Award decisions are contingent on available funds and on the quality and number of applications received, so there is no guaranteed number of awards stated beyond that condition.
Eligibility is broad and includes many types of organizations. Eligible applicants include public and private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses, for-profit organizations other than small businesses, state and local governments (including counties, cities, townships, special district governments), independent school districts, and public housing authorities/Indian housing authorities. The announcement also lists a range of additional eligible entities, including federally recognized and other tribal governments and organizations, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, Hispanic-serving institutions, historically black colleges and universities (HBCUs), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and non-U.S. (foreign) organizations. There is no cost sharing or matching requirement.
Administratively, this is a discretionary grant opportunity in the health funding category, listed under CFDA 93.859 (Biomedical Research and Research Training). The opportunity was posted on January 4, 2010, with an original and final closing date of January 7, 2013, and it was archived on February 7, 2013. The full announcement was hosted by NIH at the grants guide page referenced in the listing, and NIH Office of Extramural Research (OER) web support contact information is provided for access or linking issues.
Frequently Asked Questions (FAQs)
What is the funding opportunity PAR-10-073?
PAR-10-073 is a National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) funding opportunity announcement that supports R01 research projects focused on developing and improving technologies that enable high throughput structural biology, especially where existing pipelines struggle.
Which NIH institute is sponsoring this opportunity?
This opportunity is sponsored by the NIH National Institute of General Medical Sciences (NIGMS).
What grant mechanism does this FOA use?
PAR-10-073 uses the NIH R01 mechanism, which supports discrete, investigator-driven research projects.
What is the main goal of the research supported by this FOA?
The main goal is to move beyond incremental optimization and create genuinely useful methods and tools that speed up and broaden the ability to determine protein structures at scale. Projects are expected to remove bottlenecks and expand the range of proteins that can be handled in a high throughput manner.
Is this FOA focused on routine structure determination?
No. Although it sits under the broader umbrella of structural biology, the emphasis is on technology and methodology development rather than routine structure determination.
What parts of the structural biology pipeline are in scope?
The FOA is interested in new ideas across the full workflow, from protein production through structure determination, including related enabling steps that feed into structure determination.
Which structural biology techniques are explicitly highlighted?
High throughput X-ray crystallography and NMR are explicitly highlighted as core areas, but the opportunity is not limited to those techniques.
What kinds of project topics are considered relevant?
Examples of relevant targets include improving expression systems, stabilizing proteins for purification, developing better crystallization strategies, advancing sample preparation, automating data collection or analysis, and creating new experimental and computational methods that increase throughput and success rates.
Does the FOA support work connected to structural genomics?
Yes. Component tasks in structural biology, including structural genomics efforts and other enabling steps that feed into structure determination, are described as relevant.
What does the FOA mean by focusing on "challenging proteins"?
A defining feature of the opportunity is its focus on difficult protein targets that are not currently well served by high throughput approaches, encouraging methods development that makes these targets more tractable.
Which protein classes are specifically called out as challenging?
The announcement specifically calls out membrane proteins, small protein complexes, and proteins from humans and other higher eukaryotes, while leaving room for other difficult targets.
What types of problems make proteins "challenging" for high throughput pipelines?
The FOA describes issues such as instability, low expression, heterogeneity, conformational flexibility, and difficulty obtaining well-behaved samples as factors that cause targets to fail in standard pipelines.
Are proposals expected to simply apply existing methods to solve a set of structures?
No. Proposals are expected to concentrate on methods development that makes challenging targets more tractable, rather than primarily applying existing methods to determine a collection of structures.
Is there a related opportunity using a different grant mechanism?
Yes. This FOA runs in parallel with a companion announcement of the same scientific scope that uses a P01 mechanism (PAR-10-074), which is typically suited to multi-project program grants.
How are award decisions made?
Award decisions are contingent on the availability of funds and on the quality and number of applications received. The announcement does not state a guaranteed number of awards beyond those conditions.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofits with or without 501(c)(3) status, small businesses, for-profit organizations other than small businesses, and a wide range of government and other entity types as listed in the announcement.
Are state and local government entities eligible?
Yes. Eligible applicants include state and local governments, including counties, cities, townships, and special district governments.
Are school districts eligible?
Yes. Independent school districts are listed among eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed among eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. The announcement includes federally recognized and other tribal governments and organizations, as well as tribally controlled colleges and universities (TCCUs).
Are minority-serving institutions eligible?
Yes. The announcement lists Alaska Native and Native Hawaiian serving institutions, Hispanic-serving institutions, and historically black colleges and universities (HBCUs), among other eligible entities.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are included in the eligible entity types listed.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed as eligible.
Are non-U.S. (foreign) organizations eligible?
Yes. Non-U.S. (foreign) organizations are explicitly listed as eligible applicants.
Are eligible federal agencies able to apply?
Yes. Eligible federal agencies are included in the list of eligible entities.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
What is the funding category for this opportunity?
This is a discretionary grant opportunity in the health funding category.
What CFDA number is associated with this opportunity?
The opportunity is listed under CFDA 93.859 (Biomedical Research and Research Training).
When was this opportunity posted?
The opportunity was posted on January 4, 2010.
What were the closing dates for the opportunity?
The original and final closing date listed for the opportunity is January 7, 2013.
Is this opportunity still open?
No. It was archived on February 7, 2013.
Where was the full announcement hosted?
The full announcement was hosted by NIH on the grants guide page referenced in the listing.
Who is listed as a contact for access or linking issues?
NIH Office of Extramural Research (OER) web support contact information is provided for access or linking issues.
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