Opportunity Information: Apply for RFA HG 10 009
Apply for RFA HG 10 009
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "The Electronic Medical Records and Genomics (eMERGE) Network, Phase II Study Investigators (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Jul 21, 2010 and posted on Jul 15, 2010.
- Applicants must submit their applications by Nov 17, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $22,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The Electronic Medical Records and Genomics (eMERGE) Network, Phase II Study Investigators (U01) funding opportunity (RFA-HG-10-009) is an NIH discretionary grant designed to expand and strengthen the eMERGE network by moving proven methods from Phase I into broader, real-world use. The core aim is to support the strongest existing Phase I eMERGE sites as well as bring in new sites that already have two key assets in place: established biorepositories and genome-wide genotyping data. In Phase II, awardees are expected to incorporate state-of-the-art approaches developed during Phase I into both clinical research and the workflow of ongoing clinical care, with a strong emphasis on using electronic medical records (EMRs) as a platform for linking genomic data to phenotypes and healthcare outcomes.
This opportunity uses the U01 Cooperative Agreement mechanism, which typically means NIH expects to be more actively involved than in a standard research project grant. In practice, a cooperative agreement structure usually fits networked science where multiple institutions must follow shared standards, coordinate data elements, and contribute to common goals. For eMERGE Phase II, this implies funded sites are not operating as isolated projects; they are part of a coordinated program where harmonization of methods, data practices, and collaborative deliverables is central to the work.
Funding is planned at approximately $22,000,000 total across a four-year project period, with an anticipated maximum of up to eight awards. The listed award ceiling is $500,000. Cost sharing or matching is not required, which reduces barriers for applicants that may not have discretionary funds to commit alongside federal support.
The announcement is associated with CFDA number 93.172 (Human Genome Research) and is administered under the National Institutes of Health. It was posted July 15, 2010, created July 21, 2010, and had an original and current closing date of November 17, 2010, with an archive date of December 18, 2010. These dates place it clearly as a time-limited solicitation from that period, aimed at accelerating a second phase of development and dissemination after the initial eMERGE groundwork.
Eligibility is broad and includes many common NIH-eligible organization types. Applicants may include nonprofits with or without 501(c)(3) status, public and state-controlled institutions of higher education, private institutions of higher education, state governments, small businesses, and for-profit organizations other than small businesses, along with additional eligible groups specified in the announcement. The eligibility language also explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, and faith-based or community-based organizations, reflecting an intent to enable participation from a wide range of institutions and communities.
Overall, the opportunity is best understood as an NIH-supported expansion of a national research network operating at the intersection of genomics and clinical data systems. Phase II funding is meant to help capable sites take validated Phase I methods and apply them more broadly in clinical research settings and within clinical care processes, leveraging EMR-linked biorepositories and genome-wide genotype datasets to produce scalable, clinically relevant genomic insights. For applicants, the underlying expectation is readiness: having the biorepository and genotyping foundation already in place, plus the capacity to adopt network methods and contribute to coordinated, multi-site deliverables under NIH’s cooperative agreement model.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Electronic Medical Records and Genomics (eMERGE) Network, Phase II Study Investigators (U01) and is identified as RFA-HG-10-009.
Which federal agency is offering this grant?
This is an NIH (National Institutes of Health) discretionary grant opportunity.
What is the main purpose of eMERGE Phase II funding?
The purpose is to expand and strengthen the eMERGE network by moving methods proven in Phase I into broader, real-world use. Phase II is intended to help capable sites apply validated Phase I approaches more widely in clinical research settings and within clinical care workflows.
What is eMERGE Phase II trying to accomplish with electronic medical records (EMRs)?
Phase II emphasizes using EMRs as a platform for linking genomic data to phenotypes and healthcare outcomes. Awardees are expected to incorporate state-of-the-art approaches into clinical research and into the workflow of ongoing clinical care.
What grant mechanism is being used?
This opportunity uses the U01 Cooperative Agreement mechanism.
What does a U01 Cooperative Agreement imply for how the project will operate?
A cooperative agreement typically means NIH expects to be more actively involved than with a standard research project grant. It also typically reflects networked science where multiple institutions coordinate closely, follow shared standards, harmonize data elements and practices, and contribute to common goals and collaborative deliverables.
Are funded sites expected to work independently or as part of a coordinated network?
Funded sites are expected to operate as part of a coordinated program, not as isolated projects. Harmonization of methods, data practices, and collaborative deliverables is described as central to the work in eMERGE Phase II.
Who is this opportunity designed to support?
It is designed to support (1) the strongest existing Phase I eMERGE sites and (2) new sites that already have key capabilities in place.
What key assets should new sites already have in place to be competitive for Phase II?
The announcement highlights two key assets for new sites: established biorepositories and genome-wide genotyping data.
What is the expected focus of work during Phase II?
Phase II expects awardees to incorporate advanced approaches developed in Phase I into both clinical research and ongoing clinical care workflows, using EMR-linked genomic and phenotype data to generate clinically relevant insights at scale.
How much total funding is planned for this opportunity?
The planned total funding level is approximately $22,000,000 across a four-year project period.
How many awards does NIH anticipate making?
The opportunity anticipates a maximum of up to eight awards.
What is the award ceiling listed in the announcement?
The listed award ceiling is $500,000.
Is cost sharing or matching required?
No. The announcement states that cost sharing or matching is not required.
What is the CFDA number associated with this program?
The opportunity is associated with CFDA 93.172, listed as Human Genome Research.
When was this opportunity posted and when did it close?
It was posted July 15, 2010, created July 21, 2010, and the original and current closing date is listed as November 17, 2010. The archive date is December 18, 2010.
Is this a current, open funding opportunity?
Based on the provided dates (closing date November 17, 2010 and archive date December 18, 2010), this appears to be a time-limited solicitation from that period, rather than an open opportunity today.
What types of organizations are eligible to apply?
Eligibility is described as broad and includes: nonprofits with or without 501(c)(3) status; public and state-controlled institutions of higher education; private institutions of higher education; state governments; small businesses; and for-profit organizations other than small businesses, along with additional eligible groups specified in the announcement.
Does the eligibility language include minority-serving and community-based institutions?
Yes. The eligibility language explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), as well as faith-based or community-based organizations.
Are federal agencies eligible to apply?
Yes. The eligibility language explicitly includes eligible federal agencies.
What does NIH seem to expect from applicants in terms of readiness?
The description emphasizes readiness: having the biorepository and genome-wide genotyping foundation already in place, plus the capacity to adopt network methods and contribute to coordinated, multi-site deliverables under the cooperative agreement model.
In one sentence, how should applicants think about this opportunity?
It is an NIH-supported expansion of a national research network at the intersection of genomics and clinical data systems, designed to deploy proven Phase I methods more broadly through coordinated, multi-site work built around EMR-linked biorepositories and genome-wide genotype data.
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Previous opportunity: The Electronic Medical Records and Genomics (eMERGE) Network, Phase II Coordinating Center (U01)
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