Opportunity Information: Apply for RFA DA 13 010
Apply for RFA DA 13 010
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "The Interplay of Substance Abuse and HIV 1 Infection on Glial Cell Function (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Aug 24, 2012 and posted on Aug 24, 2012.
- Applicants must submit their applications by Nov 19, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Independent school districts City or township governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education State governments Special district governments Private institutions of higher education Small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "The Interplay of Substance Abuse and HIV-1 Infection on Glial Cell Function (R01)" (Funding Opportunity Number RFA-DA-13-010) is a National Institutes of Health (NIH) research funding announcement issued by the National Institute on Drug Abuse (NIDA). It is aimed at supporting basic and preclinical studies that dig into how substance abuse and HIV-1 infection jointly affect the biology of glial cells in the central nervous system (CNS). The central idea behind the announcement is that glial cells are not just passive support cells; they actively shape brain signaling and immune responses, and they carry many of the molecular targets that drugs of abuse interact with. At the same time, HIV-1 infection, along with the body’s immune response to the virus, can disrupt normal glial function. This FOA is therefore focused on the overlap between these two forces and the possibility that substance use and HIV-related processes may amplify or modify each other’s effects on glia, leading to changes in CNS function and potentially contributing to neurological complications.
From a scientific perspective, the opportunity encourages projects that clarify the molecular and cellular consequences of (1) substance abuse alone, (2) HIV-1 infection alone, and (3) the interaction between substance abuse and HIV-1 infection, specifically as these influences play out in glial cells. The announcement highlights that glial cells express neurotransmitter receptors, transporters, and other molecular components that can be directly affected by abused substances, which can alter glial signaling, inflammatory responses, and support functions for neurons. In parallel, HIV-1-related viral factors and host inflammatory responses can hijack or distort glial cell pathways. The intent is to fund research that can map out these mechanisms in detail, with an emphasis on understanding how combined exposures reshape glial behavior within the CNS environment. Because the FOA is framed as basic and preclinical, it is oriented toward mechanistic work and foundational discoveries that can later inform therapeutic strategies, rather than toward clinical trials.
Administratively, this is a discretionary grant opportunity using the NIH R01 mechanism, which typically supports substantial, hypothesis-driven research projects. The activity category is listed under Education and Health, and it falls under CFDA 93.279 (Drug Abuse and Addiction Research Programs). The posted and creation date for the opportunity is August 24, 2012, with an original and current closing date of November 19, 2012, and an archive date of December 20, 2012. The listed award ceiling is $500,000, and there is no cost-sharing or matching requirement, meaning applicants are not required to contribute a specified amount of non-federal funds to be eligible.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, with distinctions noted for institutions of higher education), for-profit organizations (other than small businesses), small businesses, state and local governments (including county, city/township, special district governments), public housing authorities/Indian housing authorities, independent school districts, and various tribal entities including federally recognized tribal governments and other Native American tribal organizations. The FOA also explicitly includes a wide range of mission-focused institutions and community-based entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Importantly, foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined in the NIH Grants Policy Statement. This wide eligibility reflects the global relevance of HIV and substance use disorders and the value of drawing from diverse research settings and expertise.
For applicants looking for official details, the announcement provides an additional information link hosted on the NIH grants site: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-13-010.html. The contact information included in the source data points to the NIH Office of Extramural Research (OER) webmaster emails for technical issues accessing or linking to the full announcement.
Frequently Asked Questions (FAQ)
What is the title of this grant opportunity?
The opportunity is titled "The Interplay of Substance Abuse and HIV-1 Infection on Glial Cell Function (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DA-13-010.
Which agency and institute are sponsoring this funding announcement?
This is a National Institutes of Health (NIH) funding announcement issued by the National Institute on Drug Abuse (NIDA).
What is the main purpose of this FOA?
The FOA supports basic and preclinical research to understand how substance abuse and HIV-1 infection jointly affect the biology and function of glial cells in the central nervous system (CNS), including how these combined influences may contribute to changes in CNS function and neurological complications.
Why are glial cells a focus of this opportunity?
The FOA emphasizes that glial cells actively shape brain signaling and immune responses, and that they contain many of the molecular targets that drugs of abuse interact with. The announcement also notes that HIV-1 infection and the body's immune response to the virus can disrupt normal glial function, making glia a key intersection point for these processes.
What kinds of studies does the FOA encourage?
The FOA encourages projects that clarify molecular and cellular consequences in glial cells of: (1) substance abuse alone, (2) HIV-1 infection alone, and (3) the interaction between substance abuse and HIV-1 infection, with an emphasis on detailed mechanism mapping within the CNS environment.
Is this opportunity focused on clinical trials?
No. The announcement is framed as basic and preclinical, with an emphasis on mechanistic and foundational discoveries that can later inform therapeutic strategies, rather than clinical trials.
What is the grant mechanism used for this opportunity?
This opportunity uses the NIH R01 research project grant mechanism, which is typically used for substantial, hypothesis-driven research projects.
What is the CFDA number associated with this program?
The CFDA number listed is 93.279 (Drug Abuse and Addiction Research Programs).
What activity category is this opportunity listed under?
The activity category is listed under Education and Health.
What are the key dates for this FOA?
The opportunity was posted/created on August 24, 2012. The original and current closing date is November 19, 2012. The archive date is December 20, 2012.
What is the award ceiling for this opportunity?
The listed award ceiling is $500,000.
Is cost sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement, so applicants are not required to contribute a specified amount of non-federal funds to be eligible.
Who is eligible to apply?
Eligibility is broad and includes many U.S. and non-U.S. organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, with distinctions noted for institutions of higher education), for-profit organizations (other than small businesses), small businesses, and a range of government and community-based entities.
Are state and local government entities eligible?
Yes. The FOA includes state governments and local governments, including county governments, city or township governments, and special district governments.
Are tribal organizations eligible?
Yes. The FOA includes federally recognized tribal governments and other Native American tribal organizations.
Are public housing authorities eligible to apply?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are included in the eligibility list.
Are minority-serving institutions specifically included?
Yes. The FOA explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based and community-based organizations among eligible applicants.
Are regional organizations eligible?
Yes. Regional organizations are listed as eligible.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among eligible applicants.
Can foreign institutions apply?
Yes. The FOA states that foreign institutions are eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
Yes. The FOA states that non-U.S. components of U.S. organizations are eligible.
Are foreign components allowed under this FOA?
Yes. Foreign components are allowed as defined in the NIH Grants Policy Statement.
Where can applicants find the official FOA text and full details?
The announcement provides an NIH link for additional information: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-13-010.html.
What scientific theme ties the proposed research together?
The FOA is centered on the overlap between substance abuse-related effects on glial molecular targets (such as neurotransmitter receptors and transporters) and HIV-1-related viral and inflammatory processes that can disrupt glial pathways, with the goal of clarifying how combined exposures reshape glial behavior in the CNS.
What kinds of glial changes are mentioned as being relevant?
The FOA highlights changes to glial signaling, inflammatory responses, and glial support functions for neurons, and how these may be altered by drugs of abuse, HIV-1-related factors, and the host immune response.
Who is listed as a contact for technical issues accessing or linking to the full announcement?
The source data points to NIH Office of Extramural Research (OER) webmaster emails for technical issues related to accessing or linking to the full announcement.
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