Opportunity Information: Apply for RFA DA 13 011
Apply for RFA DA 13 011
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "The Interplay of Substance Abuse and HIV 1 Infection on Glial Cell Function (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Aug 24, 2012 and posted on Aug 24, 2012.
- Applicants must submit their applications by Nov 19, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Private institutions of higher education State governments Public housing authorities/Indian housing authorities Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "The Interplay of Substance Abuse and HIV-1 Infection on Glial Cell Function (R21)" (Funding Opportunity Number RFA-DA-13-011) is a National Institutes of Health program issued by the National Institute on Drug Abuse (NIDA). It calls for basic and preclinical research projects focused on how substance abuse and HIV-1 infection work together, or interact, to change glial cell biology in the central nervous system. The central idea behind the announcement is that glial cells are not just passive support cells in the brain; they have neurotransmitter receptors, transporters, and other molecular targets that respond to drugs of abuse, and they are also affected by HIV-related viral factors and the body’s immune response to infection. Because both substance use and HIV can independently disrupt glial function, NIDA is specifically encouraging studies that look at the combined or synergistic effects, aiming to clarify the molecular and cellular consequences of these dual exposures within the CNS.
This funding opportunity uses the NIH R21 mechanism, which is typically intended for exploratory, early-stage projects that can test new ideas, generate proof-of-concept data, or open up a novel line of investigation. In that spirit, the FOA is geared toward research that can illuminate mechanisms at the cellular and molecular level rather than large-scale clinical trials. Applicants are expected to propose studies that directly address how drugs of abuse and HIV-1 infection alter glial cell function, and how those alterations may contribute to broader CNS dysfunction. While the text does not list specific required experimental systems, the emphasis on basic and preclinical work points toward approaches such as cell culture models, animal models, molecular biology and virology methods, neuroimmune signaling assays, or other mechanistic strategies that can disentangle how HIV-related processes and substance-related processes converge on glial biology.
Key administrative details include an award ceiling of $200,000 and no cost sharing or matching requirement. The opportunity was posted on August 24, 2012, with an original and current closing date of November 19, 2012, and it was archived on December 20, 2012. The activity falls under the health and education category and is associated with CFDA number 93.279 (Drug Abuse and Addiction Research Programs). Even though the dates indicate this specific announcement is historical, the summary remains useful as a description of the kind of science NIDA was prioritizing: mechanistic, CNS-focused research on the intersection of HIV neuropathogenesis and the neurobiology of substance abuse, centered specifically on glial cells.
Eligibility for this FOA was broad and included many types of organizations. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses), and multiple levels of government such as state, county, city/township governments, special district governments, and independent school districts. It also explicitly included tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a wide range of mission-driven institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs). Importantly, foreign institutions were eligible to apply, and non-U.S. components of U.S. organizations could participate, with foreign components allowed as defined in NIH policy. This reflects NIH’s general interest in attracting strong mechanistic science regardless of geography, as long as the proposed work meets NIH requirements and is well-justified.
For applicants needing the full announcement details, the FOA pointed to the NIH Grants Guide webpage (http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-13-011.html). For access or linking problems, the listed point of contact was the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "The Interplay of Substance Abuse and HIV-1 Infection on Glial Cell Function (R21)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DA-13-011.
Which agency and institute issued this funding opportunity?
This is a National Institutes of Health (NIH) program issued by the National Institute on Drug Abuse (NIDA).
What is the main scientific focus of this FOA?
The FOA calls for basic and preclinical research on how substance abuse and HIV-1 infection interact (including combined or synergistic effects) to alter glial cell biology in the central nervous system (CNS).
Why are glial cells a central focus of the announcement?
The FOA emphasizes that glial cells are not just passive support cells. They have neurotransmitter receptors, transporters, and other molecular targets that respond to drugs of abuse, and they are also affected by HIV-related viral factors and the immune response to infection. Because substance use and HIV can each disrupt glial function on their own, the FOA prioritizes research on what happens when both exposures occur together.
What types of research projects does this FOA encourage?
It encourages mechanistic studies at the cellular and molecular level that directly address how drugs of abuse and HIV-1 infection alter glial cell function, and how those alterations may contribute to broader CNS dysfunction.
Is this opportunity intended for clinical trials?
The FOA is geared toward basic and preclinical work and emphasizes mechanism-focused studies rather than large-scale clinical trials.
What grant mechanism does this opportunity use?
This opportunity uses the NIH R21 mechanism.
What does the R21 mechanism imply about project stage and scope?
R21 awards are typically intended for exploratory, early-stage projects that test new ideas, generate proof-of-concept data, or open a novel line of investigation.
Does the FOA specify required experimental models or systems?
No specific experimental systems are listed as required in the provided summary. However, because the FOA emphasizes basic and preclinical mechanistic work, it points toward approaches such as cell culture models, animal models, molecular biology and virology methods, and neuroimmune signaling assays, or other strategies that can disentangle how HIV-related and substance-related processes converge on glial biology.
What is the maximum award amount (award ceiling)?
The award ceiling is $200,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
When was this opportunity posted?
It was posted on August 24, 2012.
What was the application closing date?
The original and current closing date was November 19, 2012.
Is this FOA still active?
No. It was archived on December 20, 2012, indicating it is a historical announcement.
Even if it is archived, what is this FOA useful for?
The summary is still useful as a description of the type of science NIDA was prioritizing: mechanistic, CNS-focused research on the intersection of HIV neuropathogenesis and the neurobiology of substance abuse, centered on glial cells.
What category is this funding opportunity associated with?
The activity falls under the health and education category.
What CFDA number is associated with this opportunity?
The associated CFDA number is 93.279 (Drug Abuse and Addiction Research Programs).
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses); and multiple levels of government such as state, county, and city/township governments, special district governments, and independent school districts.
Are tribal entities eligible to apply?
Yes. The FOA explicitly includes tribal governments and tribal organizations, as well as public housing authorities/Indian housing authorities.
Are minority-serving institutions and similar mission-driven institutions included in eligibility?
Yes. The FOA explicitly includes organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are foreign institutions eligible?
Yes. Foreign institutions were eligible to apply. The FOA also states that non-U.S. components of U.S. organizations could participate, and foreign components were allowed as defined in NIH policy.
Where can applicants find the full FOA text?
The FOA directs users to the NIH Grants Guide webpage at http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-13-011.html.
Who should be contacted if there are problems accessing or linking to the FOA webpage?
The listed point of contact for access or linking problems is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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