Opportunity Information: Apply for PA 10 085
Apply for PA 10 085
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "The Role of Cellular Organelles in Alcohol Induced Tissue Injury (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.701 Trans NIH Recovery Act Research Support.
- This funding opportunity was created on Mar 17, 2010 and posted on Mar 17, 2010.
- Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Independent school districts Public and State controlled institutions of higher education City or township governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH National Institute on Alcohol Abuse and Alcoholism (NIAAA) released this Funding Opportunity Announcement (FOA), PA-10-085, to support Research Project Grant (R01) studies focused on how cellular organelles contribute to alcohol-induced tissue injury. The central idea is that heavy or prolonged alcohol use can damage multiple organs, including the liver, heart, pancreas, brain, and lungs, but the underlying biological mechanisms are still not fully mapped. This FOA frames cellular organelles as a major missing piece in that puzzle, emphasizing that organelles are not just passive cell parts but active drivers of cellular function and stress responses, and therefore likely key to understanding how alcohol exposure translates into tissue damage.
The scientific scope is built around three main goals. First, the FOA encourages projects that explain how acute or chronic alcohol consumption changes the structure and function of organelles, and then directly links those organelle changes to the development of tissue injury. In practice, that could include work on how alcohol alters organelle integrity, trafficking, energy production, calcium handling, oxidative stress responses, or protein quality control, and how those disturbances push cells toward inflammation, cell death, fibrosis, or impaired repair. Second, the FOA prioritizes research on why people respond differently to alcohol exposure, particularly through variation in organelle-associated proteins and their regulation. That includes studying changes in organelle protein composition, post-translational regulation, and relevant signaling pathways that modify organelle behavior, with the aim of connecting these molecular differences to susceptibility or resilience to alcohol-related damage. Third, the FOA explicitly promotes translational outputs: identifying biomarkers that could help with prognosis or diagnosis of alcohol-related tissue injury, and pinpointing new therapeutic targets that could be used to prevent, slow, or treat organ damage driven by alcohol.
A notable feature of the announcement is its push for innovative experimental designs and newer technologies that can reveal organelle-level mechanisms with more precision than traditional approaches. The FOA specifically highlights emerging and data-rich methods such as genomics, proteomics, metabolomics, and bioinformatics, along with advanced microscopy and imaging approaches that can visualize organelle function in intact cells and tissues. The intent is to generate deeper mechanistic insight, not only describing that injury occurs but clarifying the step-by-step pathways that connect alcohol exposure to organelle dysfunction and then to tissue pathology, ideally producing findings that can translate into clinical insight.
In terms of funding mechanism and structure, this opportunity uses the NIH R01 mechanism, meaning it is designed for full-scale, hypothesis-driven research projects with a level of depth and duration typical of R01 awards. It is paired with a parallel announcement of the same scientific scope under an R21 mechanism (PA-10-086), which is generally used for earlier-stage, exploratory, or higher-risk ideas. The FOA does not set a fixed total budget or number of awards; instead, NIAAA indicates that award numbers and amounts will depend on application quality, project duration, and requested costs, and that funding is contingent on the availability of funds.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants listed include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (other than small businesses, which are addressed separately), small businesses, federal agencies, state and local governments, tribal governments and tribal organizations, U.S. territories or possessions, and a wide range of mission-based institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities. Faith-based and community-based organizations are also included among eligible entities. The FOA states there is no cost-sharing or matching requirement.
Key administrative details from the listing include that it falls under the NIH/health activity category (CFDA 93.701) and was posted on March 17, 2010, with an original and final closing date of May 7, 2013, and an archive date of June 7, 2013. The sponsoring agency is the National Institutes of Health, with NIAAA leading the scientific area. For applicants or institutions needing help accessing the announcement or encountering technical issues, the notice directs users to the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs)
1) What is this funding opportunity (FOA) and who is sponsoring it?
This is NIH Funding Opportunity Announcement (FOA) PA-10-085 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It supports Research Project Grant (R01) studies focused on how cellular organelles contribute to alcohol-induced tissue injury.
2) What is the main scientific focus of PA-10-085?
The FOA focuses on understanding how changes in cellular organelles help drive tissue injury caused by heavy or prolonged alcohol use. It emphasizes that organelles are active regulators of cellular function and stress responses and may be a key missing link between alcohol exposure and organ damage.
3) What types of alcohol-related tissue injury are in scope?
The announcement frames alcohol-induced injury as affecting multiple organs, including the liver, heart, pancreas, brain, and lungs. Projects are expected to connect alcohol exposure to organelle dysfunction and then to tissue pathology in one or more relevant tissues.
4) What are the three main goals or priorities described in the FOA?
The FOA is organized around three priorities: (1) explaining how acute or chronic alcohol consumption changes organelle structure and function and linking those changes to tissue injury; (2) understanding why people respond differently to alcohol exposure, especially through variation in organelle-associated proteins and their regulation; and (3) producing translational outputs, including biomarkers and therapeutic targets for alcohol-related tissue injury.
5) What kinds of organelle changes does the FOA encourage applicants to study?
The FOA highlights research that examines alcohol-related changes in organelle integrity, trafficking, energy production, calcium handling, oxidative stress responses, and protein quality control, and then ties those disturbances to outcomes such as inflammation, cell death, fibrosis, or impaired repair.
6) Does the FOA require applicants to link organelle dysfunction to tissue injury mechanisms?
Yes. A central emphasis is moving beyond describing injury and instead clarifying step-by-step pathways that connect alcohol exposure to organelle dysfunction and then to tissue pathology.
7) What does the FOA say about individual differences in response to alcohol?
The FOA prioritizes research on variability in susceptibility or resilience to alcohol-related tissue damage, with a particular focus on variation in organelle-associated proteins and how they are regulated.
8) What molecular or regulatory factors are specifically mentioned for studying differential responses?
The FOA specifically points to studying changes in organelle protein composition, post-translational regulation, and relevant signaling pathways that modify organelle behavior, with the goal of connecting these differences to risk or protection from alcohol-related injury.
9) Are biomarkers and therapeutic targets within scope?
Yes. The FOA explicitly promotes translational outcomes, including identifying biomarkers that may help with diagnosis or prognosis of alcohol-related tissue injury and pinpointing therapeutic targets to prevent, slow, or treat alcohol-driven organ damage.
10) What kinds of methods and technologies does the FOA encourage?
The FOA encourages innovative and data-rich approaches that can reveal organelle-level mechanisms with high precision. Methods specifically highlighted include genomics, proteomics, metabolomics, and bioinformatics, as well as advanced microscopy and imaging approaches that can visualize organelle function in intact cells and tissues.
11) Is this opportunity intended for exploratory ideas or full-scale projects?
PA-10-085 uses the NIH R01 mechanism, which is intended for full-scale, hypothesis-driven research projects with the depth and duration typical of R01 awards.
12) Is there a related funding opportunity for smaller or more exploratory studies?
Yes. The announcement notes a parallel FOA with the same scientific scope under the R21 mechanism (PA-10-086), which is generally used for earlier-stage, exploratory, or higher-risk ideas.
13) Does the FOA specify a fixed budget or a set number of awards?
No. NIAAA indicates that the number of awards and award amounts depend on application quality, project duration, and requested costs, and that funding is contingent on the availability of funds.
14) Is cost sharing or a matching contribution required?
No. The FOA states there is no cost-sharing or matching requirement.
15) Who is eligible to apply?
Eligibility is broad and includes many U.S. and non-U.S. organizations. Eligible applicants include public and private institutions of higher education; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses, which are addressed separately); small businesses; federal agencies; state and local governments; tribal governments and tribal organizations; U.S. territories or possessions; and mission-based institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities. Faith-based and community-based organizations are also included.
16) Does the FOA allow applications from non-U.S. organizations?
Yes. The eligibility description states that eligible applicants include U.S. and non-U.S. organizations.
17) Which federal agency and institute are associated with this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), with the National Institute on Alcohol Abuse and Alcoholism (NIAAA) leading the scientific area.
18) What is the activity category and CFDA number listed for this opportunity?
The listing places the opportunity under the NIH/health activity category and identifies CFDA 93.701.
19) When was the FOA posted, and what are the closing and archive dates?
The FOA was posted on March 17, 2010. The original and final closing date is May 7, 2013, and the archive date is June 7, 2013.
20) Where can applicants get help if they have trouble accessing the announcement or run into technical issues?
The notice directs users to contact the NIH Office of Extramural Research (OER) webmaster for assistance with accessing the announcement or resolving technical problems.
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