Opportunity Information: Apply for RFA HD 15 005
Apply for RFA HD 15 005
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R41)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Sep 9, 2014 and posted on Aug 22, 2014.
- Applicants must submit their applications by Dec 17, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the following 1. Is organized for profit, with a place of business located in the United States, which operates primarily within the United States or which makes a significant contribution to the United States economy through payment of taxes or use of American products, materials or labor 2. Is in the legal form of an individual proprietorship, partnership, limited liability company, corporation, joint venture, association, trust or cooperative, except that where the form is a joint venture, there must be less than 50 percent participation by foreign business entities in the joint venture 3. (i) SBIR and STTR. Be a concern which is more than 50 directly owned and controlled by one or more individuals (who are citizens or permanent resident aliens of the United States), other business concerns (each of which is more than 50 directly owned and controlled by individuals who are citizens or permanent resident aliens of the United States), or any combination of these OR (ii) SBIR only. Be a concern which is more than 50 owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these. No single venture capital operating company, hedge fund, or private equity firm may own more than 50 of the concern OR (iii) SBIR and STTR. Be a joint venture in which each entity to the joint venture must meet the requirements set forth in paragraph 3 (i) or 3 (ii) of this section. A joint venture that includes one or more concerns that meet the requirements of paragraph (ii) of this section must comply with 121.705(b) concerning registration and proposal requirements. 4. Has, including its affiliates, not more than 500 employees.
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Opportunity Summary:
Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R41) is a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) funding opportunity focused on creating practical, technology-driven solutions that can better detect, monitor, and address neurologic problems that arise during pregnancy, around delivery, or in early infancy. The central aim is to support the development of new tools and technologies that improve diagnosis and enable timely intervention, with the larger goal of improving outcomes for fetuses and newborns who either already have a known neurologic condition or are considered high risk for neurologic complications. In plain terms, the program is designed to move beyond basic research and push toward innovations that can be used in real clinical settings to inform decisions and reduce the burden of neurologic injury and disability in the perinatal period.
This opportunity is offered as a discretionary grant under the health-related funding activity area and is tied to the NICHD (Eunice Kennedy Shriver National Institute of Child Health and Human Development) extramural research program (CFDA 93.865). It uses the R41 mechanism, which is the Phase I SBIR award type. Phase I typically supports early feasibility and proof-of-concept work, meaning the expectation is that applicants will propose a well-defined, testable development plan that demonstrates technical merit and a credible path toward a product or clinical tool, rather than an open-ended research project. The emphasis on "tools and technology" signals that applicants should be thinking in terms of devices, software, diagnostics, monitoring systems, biomarkers, clinical decision support, or other applied solutions that can directly support clinicians and caregivers during pregnancy and the neonatal period.
The program’s scope centers on perinatal neurologic health, which includes neurologic disease identified in utero, neurologic complications related to pregnancy and birth, and early-life risks that can lead to long-term developmental or neurologic impairment. While the announcement text provided does not list specific topic examples, the intent is clear: fund innovations that help with assessment (better measurement and detection), and improvement (intervention or management approaches that can change outcomes). That can include technologies that identify neurologic compromise earlier, stratify risk more accurately, monitor neurologic status in ways that are usable in real time, or guide interventions during critical windows when the developing brain is most vulnerable. The overall theme is translation: moving from an unmet clinical need to a tool that can be validated and ultimately deployed.
Eligibility is limited to small businesses, consistent with the SBIR program. To qualify, an applicant must be a for-profit U.S. small business with a place of business in the United States and operations primarily in the United States (or otherwise make a significant contribution to the U.S. economy through taxes or use of American products, materials, or labor). The business must fit an acceptable legal structure (such as an LLC, corporation, partnership, sole proprietorship, joint venture, association, trust, or cooperative), and if it is a joint venture, foreign participation must be under 50 percent. Ownership and control rules follow SBIR requirements, including pathways for firms owned by U.S. citizens or permanent residents, as well as SBIR-only provisions allowing majority ownership by multiple venture capital operating companies, hedge funds, or private equity firms, as long as no single such entity owns more than 50 percent. The company (including affiliates) must have no more than 500 employees. There is no cost sharing or matching requirement, so applicants are not required to provide non-federal matching funds as a condition of the award.
From a funding standpoint, the announcement lists an estimated total program funding level of $1,000,000 and an award ceiling of $150,000, reflecting a relatively small, early-stage development award typical of SBIR Phase I budgets. The opportunity was posted on August 22, 2014, created on September 9, 2014, and had an original and current closing date of December 17, 2014. It was archived on January 17, 2015, meaning it is no longer active for submission, but it still serves as a reference point for the type of projects NIH has sought to support in this area and for organizations tracking prior NIH solicitations.
The funding opportunity number is RFA-HD-15-005, and the full announcement was hosted through the NIH Grants Guide. Applicants or interested parties who had trouble accessing the announcement were directed to contact the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV, which is the provided contact channel for access and linking issues rather than scientific or programmatic questions.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R41).
What is the funding opportunity number?
The funding opportunity number is RFA-HD-15-005.
Which federal agency is offering this opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
Which NIH institute is tied to this program?
The opportunity is tied to the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) extramural research program.
What type of funding mechanism is this?
This opportunity uses the R41 mechanism, which is the Small Business Innovation Research (SBIR) Phase I award type.
What is the central aim of the program?
The central aim is to support development of practical, technology-driven tools that can better detect, monitor, and address neurologic problems arising during pregnancy, around delivery, or in early infancy, with the larger goal of improving outcomes for fetuses and newborns.
What kinds of health issues or conditions does this opportunity focus on?
The focus is on perinatal neurologic health, including neurologic disease identified in utero, neurologic complications related to pregnancy and birth, and early-life risks that can contribute to long-term developmental or neurologic impairment.
What does "perinatal" mean in the context of this opportunity?
Based on the description provided, "perinatal" here covers the period during pregnancy, around delivery, and early infancy, especially as it relates to neurologic outcomes for fetuses and newborns.
What is meant by "tools for assessment and improvement"?
"Assessment" refers to better measurement, detection, or monitoring of neurologic status or risk. "Improvement" refers to tools or approaches that help enable timely intervention or management to change outcomes during critical windows of vulnerability in early brain development.
Is this opportunity focused on basic research or on applied development?
The emphasis is on moving beyond basic research toward innovations that can be used in real clinical settings. Phase I SBIR typically supports early feasibility and proof-of-concept work with a defined development plan and a credible path toward a product or clinical tool.
What kinds of technologies or solutions are encouraged?
The description points to applied solutions such as devices, software, diagnostics, monitoring systems, biomarkers, and clinical decision support, or other tools that directly support clinicians and caregivers during pregnancy and the neonatal period.
Does the announcement list specific topic examples?
No specific topic examples are included in the text provided. However, the stated intent is to fund innovations that improve diagnosis and enable timely intervention for perinatal neurologic risks and conditions.
Who is eligible to apply?
Eligibility is limited to small businesses, consistent with the NIH SBIR program.
What type of business entity is required?
The applicant must be a for-profit U.S. small business and may be structured as an LLC, corporation, partnership, sole proprietorship, joint venture, association, trust, or cooperative, as described in the provided information.
Are there U.S. location or operations requirements?
Yes. The small business must have a place of business in the United States and have operations primarily in the United States, or otherwise make a significant contribution to the U.S. economy through taxes or the use of American products, materials, or labor.
Is there an employee size limit for eligibility?
Yes. The company (including affiliates) must have no more than 500 employees.
Are joint ventures allowed, and are there limits on foreign participation?
Joint ventures are included among acceptable legal structures. If the applicant is a joint venture, foreign participation must be under 50 percent.
What ownership and control rules apply?
Ownership and control follow SBIR requirements, including eligibility pathways for firms owned by U.S. citizens or permanent residents, and SBIR-only provisions allowing majority ownership by multiple venture capital operating companies, hedge funds, or private equity firms, provided that no single such entity owns more than 50 percent.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of the award.
How much total funding was estimated for the program?
The estimated total program funding level listed is $1,000,000.
What is the maximum award amount?
The award ceiling listed is $150,000, consistent with a relatively small, early-stage SBIR Phase I budget.
What is the CFDA number associated with this opportunity?
The opportunity is tied to the NICHD extramural research program and references CFDA 93.865.
When was the opportunity posted and when did it close?
It was posted on August 22, 2014, created on September 9, 2014, and had an original and current closing date of December 17, 2014.
Is this opportunity still open for submissions?
No. It was archived on January 17, 2015, which indicates it is no longer active for submission.
Where was the full announcement hosted?
The full announcement was hosted through the NIH Grants Guide.
Who should be contacted if there are problems accessing the announcement link?
The provided contact for access and linking issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Is the provided contact intended for scientific or programmatic questions?
No. The description specifies that this contact channel is for access and linking issues, not for scientific or programmatic questions.
What is the overall emphasis or theme of the projects this program sought to support?
The overall theme is translation: moving from an unmet clinical need to a tool that can be validated and ultimately deployed to inform clinical decisions and reduce neurologic injury and disability in the perinatal period.
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