Opportunity Information: Apply for RFA CA 10 006
Apply for RFA CA 10 006
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Transdisciplinary Research in Energetics and Cancer (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.399 Cancer Control.
- This funding opportunity was created on Nov 24, 2009 and posted on Nov 24, 2009.
- Applicants must submit their applications by Feb 26, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $15,000,000.00 to eligible and selected applicants.
- Eligible applicants include: State governments Small businesses Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Units of Local Governments
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Opportunity Summary:
The Transdisciplinary Research in Energetics and Cancer (TREC) (U54) funding opportunity (RFA-CA-10-006) is a National Cancer Institute (NCI) initiative that supports the creation of specialized research centers focused on how energetics, meaning nutrition, physical activity, energy balance, body weight, and obesity, influence cancer risk and outcomes. The central idea is that the most important questions in this area cannot be answered well within a single field, so applicants are expected to build genuinely transdisciplinary teams that span basic biology and mechanistic science (including genetics and genomics) as well as behavioral science, social and cultural factors, and broader environmental and policy influences. The program is open to qualified applicants whether or not they were involved in earlier versions of TREC, and it is designed to push collaboration across disciplines rather than fund isolated projects working in parallel.
The FOA emphasizes two major goals. First, it aims to deepen scientific understanding of the mechanisms linking energy balance to carcinogenesis and cancer across the continuum, from causation and prevention through other stages where relevant. This includes research ranging from cellular and animal models to human studies, and it explicitly includes genomic and genetic approaches that can clarify biological pathways connecting obesity, diet, and physical activity with cancer development and progression. Second, it seeks to improve and integrate understanding of obesity-related behaviors by drawing on health behavior theories and studying how those behaviors are shaped by social environments, built environments, culture, and policy. In practical terms, the centers are expected not only to investigate why obesity and related behaviors occur, but also to generate insights with broad population impact, including prevention and control strategies that can operate at community or policy levels rather than only at the individual level.
Within those broad goals, the announcement encourages particular attention to populations where the stakes and opportunities are high: children, groups at elevated risk for obesity, and cancer survivors. This reflects the reality that early-life patterns of diet and activity can set long-term trajectories for cancer risk, that obesity risk is unevenly distributed across communities, and that survivorship brings its own set of metabolic, behavioral, and clinical challenges that can affect recurrence risk, secondary cancers, and overall health.
From a funding and administrative standpoint, the mechanism is an NIH Cooperative Agreement Specialized Center grant (U54). A cooperative agreement signals that, compared with a standard research grant, NCI anticipates substantial scientific or programmatic involvement during the project period, which often means closer coordination with the agency and across the funded centers. The FOA also notes a companion, separate limited-competition U01 announcement (RFA-CA-10-501) for renewing a TREC Coordination Center, indicating that the network is intended to function as a connected consortium with centralized coordination supporting collaboration, data sharing, and cross-center activities.
NCI projected a significant investment: $15 million in total costs for fiscal year 2010 and $75 million in total costs over five years, with an expectation of about six awards. There is no cost sharing or matching requirement. The opportunity was posted November 24, 2009, with an application due date of February 26, 2010, and it was later archived March 29, 2010. Eligible applicants were broad and included state governments, local government units, federal agencies, public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations, and small businesses, reflecting an intent to draw strong center applications from a wide range of organizational settings capable of supporting complex, multi-project research.
In short, this FOA funded multidisciplinary centers meant to tackle the cancer-energetics connection from molecules to communities, pairing mechanistic and genomic research with behavioral, environmental, and policy-level studies, and doing so through a coordinated, cooperative network designed to accelerate progress beyond what individual labs or single-discipline teams could achieve alone.
Frequently Asked Questions (FAQs): Transdisciplinary Research in Energetics and Cancer (TREC) (U54) - RFA-CA-10-006
What is the TREC (U54) funding opportunity (RFA-CA-10-006)?
RFA-CA-10-006 is a National Cancer Institute (NCI) initiative that funded the creation of specialized research centers focused on how energetics influence cancer risk and outcomes. In this program, "energetics" includes nutrition, physical activity, energy balance, body weight, and obesity.
What is the purpose of creating TREC research centers?
The program was designed to support center-based, transdisciplinary research that tackles major questions about the links between energy balance and cancer that cannot be answered well within a single field or by isolated projects.
What does "transdisciplinary" mean in this FOA?
In this FOA, "transdisciplinary" means teams are expected to integrate expertise across multiple domains, including basic biology and mechanistic science (including genetics and genomics), behavioral science, social and cultural factors, and environmental and policy influences, in a way that goes beyond parallel workstreams.
What scientific areas and disciplines are expected to be included in an application?
The FOA emphasizes genuine integration spanning mechanistic and biological research (including genomic and genetic approaches) and research on behavior and the social, cultural, environmental, and policy factors that shape obesity-related behaviors.
What are the two major goals emphasized by the FOA?
The FOA emphasizes (1) deepening scientific understanding of mechanisms linking energy balance to carcinogenesis and cancer across the continuum, and (2) improving and integrating understanding of obesity-related behaviors using health behavior theories and examining how those behaviors are shaped by social environments, built environments, culture, and policy.
What kinds of research approaches are included under the first major goal?
The first goal includes research ranging from cellular and animal models to human studies. It explicitly includes genetic and genomic approaches to clarify biological pathways linking obesity, diet, and physical activity with cancer development and progression.
What kinds of research approaches are included under the second major goal?
The second goal focuses on obesity-related behaviors and how they can be understood through health behavior theories, including how behaviors are shaped by social environments, built environments, culture, and policy.
Does the FOA emphasize population impact beyond individual-level interventions?
Yes. The FOA highlights generating insights with broad population impact, including prevention and control strategies that can operate at community or policy levels, not only at the individual level.
Which populations are specifically encouraged for attention in this FOA?
The FOA encourages particular attention to children, groups at elevated risk for obesity, and cancer survivors.
Why are children highlighted in this opportunity?
The FOA reflects that early-life patterns of diet and physical activity can set long-term trajectories for cancer risk.
Why are groups at elevated risk for obesity highlighted?
The FOA notes that obesity risk is unevenly distributed across communities, making higher-risk groups an important focus for research and potential impact.
Why are cancer survivors highlighted?
The FOA notes that survivorship brings metabolic, behavioral, and clinical challenges that can affect recurrence risk, secondary cancers, and overall health.
What grant mechanism is used for this opportunity?
The mechanism is an NIH Cooperative Agreement Specialized Center grant (U54).
What does a cooperative agreement (U54) imply for how the project is managed?
A cooperative agreement indicates that NCI anticipated substantial scientific or programmatic involvement during the project period, which often means closer coordination with the agency and across funded centers than would be typical for a standard research grant.
Is this FOA intended to fund independent projects that run in parallel?
No. The FOA is designed to push collaboration across disciplines rather than fund isolated projects working in parallel.
Is the program open to applicants who were not involved in earlier versions of TREC?
Yes. The FOA states the program is open to qualified applicants whether or not they were involved in earlier versions of TREC.
How is cross-center collaboration supported in this program?
The FOA describes the network as a connected consortium and notes a companion, separate limited-competition U01 announcement (RFA-CA-10-501) for renewing a TREC Coordination Center, supporting collaboration, data sharing, and cross-center activities.
What is the companion U01 announcement referenced in the FOA?
The FOA references a separate limited-competition U01 (RFA-CA-10-501) intended for renewing a TREC Coordination Center.
How much funding did NCI project for this initiative?
NCI projected $15 million in total costs for fiscal year 2010 and $75 million in total costs over five years.
How many awards were expected under this FOA?
The FOA projected about six awards.
Is there a cost sharing or matching requirement?
No. The FOA states there is no cost sharing or matching requirement.
When was this funding opportunity posted?
The opportunity was posted on November 24, 2009.
What was the application due date?
The application due date was February 26, 2010.
What does it mean that the FOA was archived?
The FOA was later archived on March 29, 2010, indicating the opportunity is no longer active as an open solicitation.
Who was eligible to apply?
Eligible applicants included state governments, local government units, federal agencies, public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations, and small businesses.
Does the FOA limit applications to universities or nonprofit research institutions?
No. The FOA lists a broad range of eligible applicants, including government entities, nonprofits, for-profit organizations, and small businesses.
What is the overall research theme of the TREC centers?
The overall theme is understanding and addressing the cancer-energetics connection, spanning research "from molecules to communities" by pairing mechanistic and genomic research with behavioral, environmental, and policy-level studies.
Does the FOA include research across the cancer continuum?
Yes. The FOA references mechanisms linking energy balance to carcinogenesis and cancer "across the continuum," including causation and prevention through other relevant stages.
Are genomic and genetic approaches explicitly encouraged?
Yes. The FOA explicitly includes genomic and genetic approaches to clarify biological pathways connecting obesity, diet, and physical activity with cancer development and progression.
What is meant by "energetics" in this FOA?
In this FOA, energetics refers to nutrition, physical activity, energy balance, body weight, and obesity and how these factors influence cancer risk and outcomes.
What is the key design feature that distinguishes this initiative from single-lab or single-discipline efforts?
The key distinguishing feature is the expectation of truly transdisciplinary center teams and a coordinated, cooperative network intended to accelerate progress beyond what individual labs or single-discipline teams could achieve alone.
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