Opportunity Information: Apply for RFA ES 12 006
Apply for RFA ES 12 006
- The National Institutes of Health in the environment health sector is offering a public funding opportunity titled "Transgenerational Inheritance in Mammals After Environmental Exposure (TIME) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health.
- This funding opportunity was created on Aug 22, 2012 and posted on Aug 22, 2012.
- Applicants must submit their applications by Dec 18, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Independent school districts Public housing authorities/Indian housing authorities Special district governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education County governments State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Transgenerational Inheritance in Mammals After Environmental Exposure (TIME) (R01) opportunity, Funding Opportunity Number RFA-ES-12-006, is a National Institutes of Health (NIH) discretionary grant solicitation in the environmental health area (CFDA 93.113, Environmental Health). It was posted on August 22, 2012, with an application due date of December 18, 2012, and it later entered archive status on January 18, 2013. The program set out to support research that goes beyond early, suggestive observations by pushing investigators to deepen and rigorously validate already reported examples of transgenerational inheritance in mammals following exposure to environmental toxicants. A key feature of the scientific scope is its emphasis on truly transgenerational outcomes, defined here as effects persisting through the F3 generation when the initiating exposure occurs during prenatal development, which is the classic benchmark used to separate direct exposure effects from inherited effects across generations.
The central goal of the FOA is to encourage well-powered, mechanistically informed studies that build on existing evidence rather than simply initiating brand-new, high-risk exploratory work. In practice, this means applicants were expected to take "known examples" of mammalian transgenerational phenomena linked to toxicant exposure and design studies that further test, replicate, and clarify them. The focus on environmental toxicants places the work squarely in the realm of environmental health science, with implications for understanding how exposures might have lasting biological consequences not just for exposed individuals, but also for subsequent generations that were never directly exposed.
This announcement uses the NIH R01 mechanism, indicating support for mature, hypothesis-driven projects that can deliver definitive advances, typically with stronger preliminary justification and clearer experimental direction than smaller pilot mechanisms. The FOA explicitly notes that exploratory studies were to be supported under a companion announcement (RFA-ES-12-007), which effectively draws a line between projects intended to establish feasibility or generate early signals (the companion FOA) and projects intended to perform more comprehensive follow-up on already observed transgenerational effects (this R01 FOA). That distinction matters because it signals to applicants that this TIME R01 opportunity was aimed at deeper investigation: refining study designs, confirming inheritance patterns through the appropriate generation, strengthening causal inference, and advancing the field beyond initial reports.
Funding details indicate an estimated total program funding level of $2,000,000, with an award ceiling of $500,000, and no cost sharing or matching requirement. This combination suggests the agency anticipated making a limited number of relatively substantial awards, sized to support multi-year animal studies and the kinds of cross-generational designs that can be resource-intensive, including breeding, longitudinal phenotyping, and molecular or epigenetic analyses that are often essential when studying inheritance patterns.
Eligibility was broad across U.S.-based organizations and included public and private institutions of higher education, nonprofits (with and without 501(c)(3) status, excluding institutions of higher education in those categories as specified), small businesses, other for-profit organizations (beyond small businesses), and a wide range of governmental entities (state, county, city or township, special district governments, independent school districts, and public housing authorities/Indian housing authorities). Tribal governments and tribal organizations were eligible as described, and the eligibility section further highlights inclusion of institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, regional organizations, and U.S. territories or possessions. At the same time, the FOA clearly states that non-U.S. entities (foreign institutions) were not eligible to apply, and non-U.S. components of U.S. organizations were also not eligible to apply; however, foreign components as defined in the NIH Grants Policy Statement were allowed, which typically means certain collaborations or project elements involving foreign work could be permissible within NIH policy boundaries, even though the applicant organization itself needed to be U.S.-based.
For applicants trying to access the full announcement or encountering technical issues, the FOA provided an official NIH link to the full text (http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-12-006.html) and directed users to NIH Office of Extramural Research (OER) webmaster support for access or linking problems. Overall, TIME (R01) was positioned as a targeted effort to move the science of environmentally induced transgenerational inheritance in mammals from intriguing observations into more definitive, carefully tested evidence, with a specific generational standard (through F3 after prenatal exposure) and a clear division between exploratory work and more developed follow-up studies.
FAQs: Transgenerational Inheritance in Mammals After Environmental Exposure (TIME) (R01)
What is the TIME (R01) funding opportunity?
TIME (R01) is a National Institutes of Health (NIH) discretionary grant solicitation focused on environmental health research. Its full title is "Transgenerational Inheritance in Mammals After Environmental Exposure (TIME) (R01)."
What is the Funding Opportunity Number for this program?
The Funding Opportunity Number is RFA-ES-12-006.
Which NIH grant mechanism does this announcement use?
This announcement uses the NIH R01 mechanism, which is typically intended for mature, hypothesis-driven research projects designed to produce definitive advances.
What is the scientific focus of the TIME (R01) FOA?
The FOA supports research on transgenerational inheritance in mammals following exposure to environmental toxicants, with an emphasis on deepening and rigorously validating already reported examples rather than launching brand-new, high-risk exploratory projects.
What does the FOA mean by "truly transgenerational outcomes"?
In this FOA, "truly transgenerational outcomes" are defined as effects that persist through the F3 generation when the initiating exposure occurs during prenatal development. This F3 benchmark is described as the classic standard used to distinguish direct exposure effects from inherited effects across generations.
Why does the FOA emphasize the F3 generation for prenatal exposures?
The FOA highlights the F3 generation after prenatal exposure as the key benchmark for separating effects attributable to direct exposure from effects that reflect inheritance across generations.
Is this opportunity intended for exploratory or early-stage studies?
No. This R01 FOA is positioned to support well-powered, mechanistically informed studies that build on existing evidence and reported examples. Exploratory studies were explicitly directed to a companion announcement.
Is there a companion funding announcement for exploratory work?
Yes. The FOA notes that exploratory studies were to be supported under a companion announcement, RFA-ES-12-007.
What types of projects were applicants expected to propose under this R01?
Applicants were expected to take known examples of mammalian transgenerational phenomena linked to toxicant exposure and design studies that further test, replicate, and clarify them, including refining study designs, confirming inheritance patterns through the appropriate generation, strengthening causal inference, and advancing mechanistic understanding.
How does this FOA relate to environmental health research?
The FOA is centered on environmental toxicants and their potential to produce biological consequences that may extend beyond the exposed individual to later generations that were never directly exposed, placing the work within environmental health science.
What is the CFDA number associated with this opportunity?
The CFDA listing provided is 93.113, Environmental Health.
When was this funding opportunity posted?
It was posted on August 22, 2012.
What was the application due date?
The application due date was December 18, 2012.
Is this FOA still active?
No. The opportunity later entered archive status on January 18, 2013.
What was the estimated total program funding level?
The estimated total program funding level was $2,000,000.
What was the award ceiling?
The award ceiling listed is $500,000.
Was cost sharing or matching required?
No. The FOA states there was no cost sharing or matching requirement.
What kinds of study designs does this FOA imply may be needed?
Because the FOA targets multi-generation outcomes and emphasizes rigorous validation, it anticipates resource-intensive designs such as breeding across generations, longitudinal phenotyping, and molecular or epigenetic analyses that are often central to studying inheritance patterns.
Which organizations were eligible to apply?
Eligibility was broad for U.S.-based organizations and included public and private institutions of higher education; nonprofits (with and without 501(c)(3) status, as specified); small businesses; other for-profit organizations; and many governmental entities such as state, county, city or township, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Were tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations were described as eligible in the FOA.
Does the eligibility language specifically include certain institution types (like HBCUs or HSIs)?
Yes. The FOA highlights inclusion of organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, regional organizations, and U.S. territories or possessions.
Are non-U.S. (foreign) institutions eligible to apply as the applicant organization?
No. The FOA states that non-U.S. entities (foreign institutions) were not eligible to apply.
Are non-U.S. components of U.S. organizations eligible to apply?
No. The FOA states that non-U.S. components of U.S. organizations were also not eligible to apply.
Are foreign components allowed at all under this FOA?
Yes. The FOA notes that foreign components (as defined in the NIH Grants Policy Statement) were allowed, meaning certain collaborations or project elements involving foreign work could be permissible under NIH policy boundaries, even though the applicant organization needed to be U.S.-based.
Where can applicants find the full text of the FOA?
The FOA provided the official NIH link: http://grants.nih.gov/grants/guide/rfa-files/RFA-ES-12-006.html.
Who should be contacted for technical problems accessing or linking to the FOA?
The FOA directed users to NIH Office of Extramural Research (OER) webmaster support for access or linking problems.
What is the overall purpose of the TIME (R01) initiative as described?
The initiative was positioned to move the science of environmentally induced transgenerational inheritance in mammals from early, suggestive observations to more definitive evidence, using rigorous designs, mechanistic insight, and a clear generational standard (through F3 after prenatal exposure).
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA ES 12 006) also looked into and applied for these:
| Funding Opportunity |
|---|
| Transgenerational Inheritance in Mammals After Environmental Exposure (TIME) (R21) Apply for RFA ES 12 007 Funding Number: RFA ES 12 007 Agency: National Institutes of Health Category: Environment Health Funding Amount: $200,000 |
| Environmental Influences on the Microbiome (R21) Apply for RFA ES 12 009 Funding Number: RFA ES 12 009 Agency: National Institutes of Health Category: Environment Health Funding Amount: $200,000 |
| Novel Assays for Screening the Effects of Chemical Toxicants on Cell Differentiation (SBIR R43) Apply for RFA ES 13 003 Funding Number: RFA ES 13 003 Agency: National Institutes of Health Category: Environment Health Funding Amount: $225,000 |
| Environmental Health Sciences (EHS) Core Centers (P30) Apply for RFA ES 13 002 Funding Number: RFA ES 13 002 Agency: National Institutes of Health Category: Environment Health Funding Amount: $100,000 |
| Land Use Change and Disease Emergence Apply for RFI 486 13 00002 Funding Number: RFI 486 13 00002 Agency: Thailand USAID Bangkok Category: Environment Health Funding Amount: Case Dependent |
| Mechanism for Time Sensitive Research Opportunities in Environmental Health Sciences (R21) Apply for PAR 13 136 Funding Number: PAR 13 136 Agency: National Institutes of Health Category: Environment Health Funding Amount: $200,000 |
| Twin Cities Clean Cities Initiative in the Mississippi National River and Recreation Area (MISS) NOI Not a Request for Proposals Apply for P13AP00046 Funding Number: P13AP00046 Agency: National Park Service Category: Environment Health Funding Amount: $128,000 |
| Notice of Intent Apply for F13AS00238 Funding Number: F13AS00238 Agency: Fish and Wildlife Service Category: Environment Health Funding Amount: $150,000 |
| Research Linking Environmental Exposure to Alzheimers Disease (R01) Apply for RFA ES 13 006 Funding Number: RFA ES 13 006 Agency: National Institutes of Health Category: Environment Health Funding Amount: $350,000 |
| Research Linking Environmental Exposure to Neurodegenerative Disease (R21) Apply for RFA ES 13 007 Funding Number: RFA ES 13 007 Agency: National Institutes of Health Category: Environment Health Funding Amount: $200,000 |
| Novel Methods for Obtaining Molecular Information from Archived Tissue Samples (SBIR R43/R44) Apply for RFA ES 13 009 Funding Number: RFA ES 13 009 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| The Role of Environmental Exposures in the Development of Autoimmune Disease (R21) Apply for RFA ES 13 011 Funding Number: RFA ES 13 011 Agency: National Institutes of Health Category: Environment Health Funding Amount: $200,000 |
| Validation and Demonstration of Devices for Environmental Exposure Assessment (R21/R33) Apply for RFA ES 13 013 Funding Number: RFA ES 13 013 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| Outstanding New Environmental Scientist (ONES) Award (R01) Apply for RFA ES 13 014 Funding Number: RFA ES 13 014 Agency: National Institutes of Health Category: Environment Health Funding Amount: $250,000 |
| Environmental Health Sciences Core Centers (EHS CC) (P30) Apply for RFA ES 13 012 Funding Number: RFA ES 13 012 Agency: National Institutes of Health Category: Environment Health Funding Amount: $1,300,000 |
| NIH Revision Awards for Creating Virtual Consortium for Translational/Transdisciplinary Environmental Research (ViCTER)(R01) Apply for PAR 14 050 Funding Number: PAR 14 050 Agency: National Institutes of Health Category: Environment Health Funding Amount: $250,000 |
| Developing Mercury Inventories for Artisanal and Small scale Gold Mining Sectors in Southeast Asia Apply for OES OMM 14 001 Funding Number: OES OMM 14 001 Agency: Ocean and International Environmental Scientific Category: Environment Health Funding Amount: $200,000 |
| Novel Technologies for Rapid and Sensitive Biomonitoring in Humans (R43/R44) Apply for RFA ES 14 005 Funding Number: RFA ES 14 005 Agency: National Institutes of Health Category: Environment Health Funding Amount: Case Dependent |
| SBIR E learning for HAZMAT and Emergency Response (R43/R44) Apply for RFA ES 14 003 Funding Number: RFA ES 14 003 Agency: National Institutes of Health Category: Environment Health Funding Amount: $100,000 |
| Undergraduate Research Education Program (UP) to Enhance Diversity in the Environmental Health Sciences (R25) Apply for RFA ES 14 004 Funding Number: RFA ES 14 004 Agency: National Institutes of Health Category: Environment Health Funding Amount: $100,000 |
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