Opportunity Information: Apply for RFA ES 12 007
Apply for RFA ES 12 007
- The National Institutes of Health in the environment health sector is offering a public funding opportunity titled "Transgenerational Inheritance in Mammals After Environmental Exposure (TIME) (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health.
- This funding opportunity was created on Aug 22, 2012 and posted on Aug 22, 2012.
- Applicants must submit their applications by Dec 18, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Special district governments Small businesses State governments Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities County governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Transgenerational Inheritance in Mammals After Environmental Exposure (TIME) (R21) opportunity (Funding Opportunity Number RFA-ES-12-007) was a National Institutes of Health grant funding announcement issued by the National Institute of Environmental Health Sciences (NIEHS) to stimulate exploratory research on whether environmental toxicant exposures can cause harmful biological or health-related traits that persist across generations. The central scientific focus is transgenerational inheritance in mammals, specifically testing the idea that an exposure in one generation could lead to adverse phenotypic outcomes in later generations that were not directly exposed. The FOA explicitly emphasizes the use of mouse or rat models as the experimental systems for investigating these multigenerational effects, reflecting a push for controlled, mechanistic, and reproducible studies in well-established mammalian models.
Mechanistically, the program intent is aimed at projects that can rigorously evaluate whether an environmental exposure produces effects that are passed down beyond the immediately exposed individuals, and to do so in a way that can separate direct exposure effects from inherited effects. In practical terms, that typically means designing animal studies that track outcomes across multiple generations, with careful definition of which generations are directly exposed versus which are considered unexposed descendants, and then measuring phenotypes that could include developmental, reproductive, metabolic, neurologic, immune, or other health-relevant endpoints. Because it uses the NIH R21 mechanism, the opportunity is positioned for early-stage, high-impact, hypothesis-generating work rather than large-scale definitive trials, supporting creative approaches that can open up new lines of investigation in environmental health and inheritance biology.
From an administrative and funding standpoint, this was a discretionary grant program with an estimated total funding level of $1,000,000. The award ceiling was listed as $200,000, and there was no cost sharing or matching requirement. The announcement was posted and created on August 22, 2012, with an original and current closing date of December 18, 2012, and it was archived on January 18, 2013. The associated CFDA number was 93.113 (Environmental Health), which ties it to NIEHS-supported environmental health research activities.
Eligibility was broad across U.S.-based organizations and included public and private institutions of higher education, public/state-controlled institutions, nonprofit organizations with and without 501(c)(3) status, small businesses, and certain for-profit organizations (other than small businesses), as well as a wide range of governmental entities such as state, county, city/township, special district governments, public housing authorities/Indian housing authorities, and school districts. The FOA also explicitly called out additional eligible applicants including historically underrepresented and mission-focused organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, among others, as well as U.S. territories or possessions and regional organizations. At the same time, foreign institutions were not eligible to apply, and non-U.S. components of U.S. organizations were not eligible; however, foreign components as defined by the NIH Grants Policy Statement were allowed, meaning a U.S. applicant could potentially include certain foreign elements in the project when justified and compliant with NIH policy.
Overall, the TIME (R21) FOA was designed to catalyze focused mammalian research that addresses a major question in environmental health: whether toxicant exposures can leave biological "echoes" that manifest as disease or dysfunction in later, unexposed generations. By supporting exploratory studies using rodents, NIEHS sought to advance evidence and methods that could clarify if, when, and how environmentally induced effects are inherited across generations, with implications for risk assessment, public health protection, and understanding long-term consequences of environmental exposures.
FAQs: Transgenerational Inheritance in Mammals After Environmental Exposure (TIME) (R21) - RFA-ES-12-007
What is the TIME (R21) funding opportunity?
TIME (Transgenerational Inheritance in Mammals After Environmental Exposure) was a National Institutes of Health (NIH) grant funding announcement issued by the National Institute of Environmental Health Sciences (NIEHS). It used the NIH R21 mechanism to stimulate exploratory research on whether environmental toxicant exposures can cause harmful biological or health-related traits that persist across generations.
What is the scientific question this FOA is trying to answer?
The central question is whether an environmental exposure in one generation can lead to adverse phenotypic outcomes in later generations that were not directly exposed. The focus is specifically on transgenerational inheritance in mammals.
What does "transgenerational inheritance" mean in the context of this opportunity?
In this FOA, transgenerational inheritance refers to effects that appear in descendant generations that were not directly exposed to the environmental toxicant, suggesting that the exposure may have produced inheritable biological changes rather than only direct exposure effects.
What types of experimental models are emphasized?
The FOA explicitly emphasizes the use of mouse or rat models as the experimental systems for investigating multigenerational effects. This reflects an intent to support controlled, mechanistic, and reproducible studies in well-established mammalian models.
Are non-rodent models supported?
Based on the information provided, the FOA explicitly emphasizes mouse or rat models. No other model systems are described in the provided summary.
What kinds of study designs fit the program intent?
The program intent is aimed at projects that can rigorously evaluate whether an environmental exposure produces effects that are passed down beyond immediately exposed individuals. Practical implications include animal study designs that track outcomes across multiple generations and clearly distinguish directly exposed generations from unexposed descendants.
Why does the FOA stress separating direct exposure effects from inherited effects?
A core goal is to determine whether observed outcomes are due to direct toxicant exposure or are truly inherited. That typically requires careful identification of which generations had direct exposure and which are considered unexposed descendants, along with systematic phenotyping across generations.
What types of health or biological outcomes (phenotypes) are relevant?
Phenotypes could include developmental, reproductive, metabolic, neurologic, immune, or other health-relevant endpoints. The FOA is oriented toward adverse phenotypic outcomes that matter for biology and health.
What is the funding mechanism, and what does it imply about project scope?
This opportunity used the NIH R21 mechanism. R21 awards are positioned for early-stage, high-impact, hypothesis-generating work rather than large-scale definitive trials, supporting creative exploratory studies that can open new lines of investigation.
Which NIH institute issued this announcement?
The announcement was issued by the National Institute of Environmental Health Sciences (NIEHS), part of NIH.
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is RFA-ES-12-007.
What was the estimated total funding level for the program?
The estimated total funding level was $1,000,000.
What was the award ceiling?
The award ceiling was listed as $200,000.
Was cost sharing or matching required?
No. The opportunity stated there was no cost sharing or matching requirement.
When was the announcement posted and created?
The announcement was posted and created on August 22, 2012.
What was the closing date for applications?
The original and current closing date was December 18, 2012.
Is this funding opportunity still active?
No. It was archived on January 18, 2013, and the closing date was in 2012.
What CFDA number is associated with this opportunity?
The associated CFDA number was 93.113 (Environmental Health), which ties it to NIEHS-supported environmental health research activities.
Who was eligible to apply?
Eligibility was broad across U.S.-based organizations and included public and private institutions of higher education, public/state-controlled institutions, nonprofit organizations with and without 501(c)(3) status, small businesses, certain for-profit organizations (other than small businesses), and many governmental entities (for example state, county, city/township, special district governments, public housing authorities/Indian housing authorities, and school districts).
Were minority-serving or mission-focused organizations specifically included as eligible applicants?
Yes. The FOA explicitly called out additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, among others.
Were U.S. territories or regional organizations eligible?
Yes. The eligibility list included U.S. territories or possessions and regional organizations.
Are foreign institutions eligible to apply directly?
No. Foreign institutions were not eligible to apply based on the information provided.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations were not eligible, as stated in the provided summary.
Can a U.S. applicant include any foreign work in the project?
Yes, foreign components (as defined by the NIH Grants Policy Statement) were allowed. This means a U.S. applicant could potentially include certain foreign elements in the project when justified and compliant with NIH policy, even though foreign institutions could not apply directly.
What is meant by "discretionary grant program" in this summary?
The summary describes the program as discretionary, meaning NIEHS issued the opportunity to stimulate research in a specific area of interest (transgenerational inheritance after environmental exposure) under the NIH grant framework, rather than it being an entitlement or formula-based program.
What is the broader significance of the TIME research area?
The FOA was designed to address whether toxicant exposures can leave biological effects that manifest as disease or dysfunction in later, unexposed generations. The summary notes implications for risk assessment, public health protection, and understanding long-term consequences of environmental exposures.
What types of projects was NIEHS trying to catalyze through this FOA?
NIEHS sought focused mammalian research using rodents that could advance evidence and methods to clarify if, when, and how environmentally induced effects are inherited across generations, using mechanistic and reproducible approaches suited to exploratory R21 studies.
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