Opportunity Information: Apply for PA 15 058
Apply for PA 15 058
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Dec 8, 2014 and posted on Dec 8, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses County governments Public and State controlled institutions of higher education Independent school districts Native American tribal governments (Federally recognized) Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses City or township governments State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity PA 15 058, titled "Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R01)," is a discretionary National Institutes of Health (NIH) research grant solicitation aimed at expanding what is known about how the body processes ethanol and how those processing steps contribute to alcohol-related illness. Rather than focusing only on the well-known, classical pathways of alcohol metabolism, this FOA is centered on integrated and innovative projects that investigate novel or overlooked roles of ethanol-metabolizing enzymes, the metabolites produced during ethanol breakdown, and the cofactors that enable or modulate these reactions. A key theme is how these ethanol-related pathways interact with other biological systems that may amplify injury, change disease trajectories, or create vulnerabilities in specific tissues and patient populations.
The core scientific goal is to support research that can reveal cellular and molecular mechanisms linking excessive or long-term alcohol exposure to end-organ injuries and a broad spectrum of alcohol-induced diseases. The FOA emphasizes uncovering "key components" involved not just in the onset of pathology, but also in the progression and long-term maintenance of alcohol-related disorders. In practical terms, NIH is looking for studies that go beyond describing association and instead generate mechanistic insights and high-value data that could lead to real breakthroughs in understanding why alcohol damages particular organs, which pathways are driving that damage, and where the most promising points of intervention might be.
The public health motivation is explicit: alcohol misuse contributes to diverse, serious medical conditions, and the FOA frames this work as essential for improving diagnosis, treatment, and clinical management, especially for vulnerable patient groups who experience disproportionate harm from alcohol-induced pathologies. By clarifying the biochemical and molecular underpinnings of ethanol metabolism in disease contexts, the program aims to lay groundwork for better clinical tools, including potential biomarkers for risk or early disease detection, and for therapeutic strategies that target relevant enzymes, metabolites, or cofactor-dependent processes. The ultimate intended impact is improved disease outcomes and, by extension, broader improvements in public health.
This opportunity uses the NIH R01 mechanism, indicating support for substantial, hypothesis-driven research projects that may combine multiple approaches or disciplines as needed to address complex biological questions. The funding instrument type is a grant, and the activity category is health, listed under CFDA number 93.273 (Alcohol Research Programs). There is no cost sharing or matching requirement, which generally means applicants are not expected to contribute non-federal funds as a condition of the award.
Eligibility is broad and includes many organization types, reflecting NIH's intent to attract the strongest ideas from a wide research ecosystem. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations other than small businesses, and small businesses. Government entities at multiple levels are eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also highlights eligibility for tribal governments and tribal organizations, including federally recognized Native American tribal governments, other tribal entities, and tribally controlled colleges and universities.
In addition, the eligibility language explicitly includes a range of mission-focused and community-linked institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies. Importantly, the announcement allows participation by non-U.S. entities: non-domestic (non-U.S.) organizations and foreign institutions are eligible to apply, non-domestic components of U.S. organizations are eligible, and foreign components (as defined by the NIH Grants Policy Statement) are allowed. This signals openness to international expertise and collaborations where they strengthen the science.
Key dates show that the opportunity was posted and created on December 8, 2014, with an original and current closing date of January 7, 2018, and an archive date of February 7, 2018, meaning the FOA is no longer active for new submissions under that solicitation as written. The administering agency is NIH, and the primary reference link provided is the NIH Grants Guide page for PA 15 058 at http://grants.nih.gov/grants/guide/pa-files/PA-15-058.html. For access or technical issues with the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: PA-15-058 - Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R01)
What is PA-15-058?
PA-15-058 is a National Institutes of Health (NIH) research funding opportunity titled "Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R01)." It solicits research projects that expand understanding of how ethanol is processed in the body and how those processes contribute to alcohol-related illnesses.
What kind of research is this opportunity trying to support?
The solicitation is focused on integrated and innovative studies that investigate novel or overlooked roles of ethanol-metabolizing enzymes, the metabolites produced during ethanol breakdown, and the cofactors that enable or modulate these reactions, particularly in ways that interact with other biological systems and influence disease.
How is this different from studies of "classic" alcohol metabolism pathways?
Rather than concentrating only on well-known, classical pathways of ethanol metabolism, this opportunity emphasizes unconventional roles and underexplored mechanisms, including how ethanol-related enzymes, metabolites, and cofactors affect (or are affected by) other biological pathways that may amplify injury or alter disease trajectories.
What is the core scientific goal of the FOA?
The core goal is to reveal cellular and molecular mechanisms that connect excessive or long-term alcohol exposure to end-organ injury and a wide range of alcohol-induced diseases, including identifying key components involved in disease onset, progression, and long-term maintenance.
Is NIH looking for descriptive studies or mechanistic studies?
Based on the description provided, NIH is prioritizing research that goes beyond association and produces mechanistic insights and high-value data that can help explain why alcohol damages specific organs, which pathways drive that damage, and where promising intervention points may exist.
What health conditions or impacts are being targeted?
The opportunity is framed around alcohol misuse and its contribution to diverse, serious medical conditions. The emphasis is on alcohol-related end-organ injuries and alcohol-induced diseases, including mechanisms that shape disease onset, progression, and persistence.
Why is this research considered important for public health?
The public health motivation is explicit: alcohol misuse contributes to serious medical conditions, and clarifying the biochemical and molecular underpinnings of ethanol metabolism in disease contexts is intended to support improvements in diagnosis, treatment, and clinical management, especially for vulnerable patient groups disproportionately harmed by alcohol-induced pathologies.
What types of outcomes or downstream applications does the program aim to enable?
The program aims to lay groundwork for better clinical tools, including potential biomarkers for risk or early detection, and therapeutic strategies that target relevant enzymes, metabolites, or cofactor-dependent processes, with the intended impact of improving disease outcomes and broader public health.
What funding mechanism does PA-15-058 use?
This opportunity uses the NIH R01 mechanism, which is intended to support substantial, hypothesis-driven research projects that may combine multiple approaches or disciplines as needed to address complex biological questions.
Is this a grant or a contract?
The funding instrument type is a grant.
What is the activity category associated with this opportunity?
The activity category is health.
What CFDA number is associated with this program?
The listing cites CFDA number 93.273 (Alcohol Research Programs).
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement, meaning applicants are generally not expected to provide non-federal funds as a condition of the award.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status, other than institutions of higher education); for-profit organizations other than small businesses; and small businesses.
Are government entities eligible to apply?
Yes. Eligible government entities include state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The opportunity highlights eligibility for federally recognized Native American tribal governments, other tribal entities, tribal organizations, and tribally controlled colleges and universities.
Does the FOA encourage or include specific institution types such as HBCUs or HSIs?
Yes. The eligibility language explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations.
Are federal agencies eligible?
Yes. The eligibility language includes eligible federal agencies.
Can non-U.S. organizations apply?
Yes. The announcement allows participation by non-domestic (non-U.S.) organizations and foreign institutions, and it also allows non-domestic components of U.S. organizations to apply.
Are foreign components or international collaborations allowed?
Yes. Foreign components (as defined by the NIH Grants Policy Statement) are allowed, indicating that international expertise and collaborations are permissible where they strengthen the science.
What are the key dates for this opportunity?
The opportunity was posted and created on December 8, 2014. The original and current closing date is January 7, 2018, and the archive date is February 7, 2018.
Is this funding opportunity currently open for new submissions?
No. The archive date (February 7, 2018) and the closing date (January 7, 2018) indicate the FOA is no longer active for new submissions under that solicitation as written.
Which agency administers this opportunity?
The administering agency is the National Institutes of Health (NIH).
Where can I find the official NIH page for PA-15-058?
The primary reference link provided is: http://grants.nih.gov/grants/guide/pa-files/PA-15-058.html
Who is the contact for access or technical issues with the announcement?
For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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