Opportunity Information: Apply for PA 15 057
Apply for PA 15 057
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Unconventional Roles of Ethanol Metabolizing Enzymes, Metabolites, and Cofactors in Health and Disease (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Dec 8, 2014 and posted on Dec 8, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: State governments City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Independent school districts Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Small businesses Private institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This NIH discretionary grant opportunity (Funding Opportunity Number PA 15-057) supports early-stage, high-impact research that looks beyond the standard, well-described pathways of alcohol metabolism and instead focuses on unconventional or underappreciated roles of ethanol-metabolizing enzymes, their downstream metabolites, required cofactors, and their cross-talk with other biological systems. The central idea is that alcohol-related disease is not explained only by classical ethanol breakdown, but also by less obvious biochemical consequences of these pathways, including how metabolic intermediates and cofactor shifts can reshape cellular signaling, stress responses, inflammation, and tissue repair. The award mechanism is an R21, which is typically used by NIH to encourage exploratory and developmental studies that may be too novel or preliminary for larger, longer-term grants, with the expectation that successful projects will produce strong pilot data that can later be expanded into more definitive research programs.
The scientific purpose is tightly centered on alcohol-induced diseases and end-organ injury, especially the cellular and molecular events that trigger disease onset, drive progression over time, and help maintain chronic pathology in people exposed to excessive or long-term alcohol use. Rather than treating ethanol metabolism as a simple detoxification sequence, the announcement emphasizes integrated and innovative work that can reveal key components and interactions that have been overlooked, such as how ethanol-metabolizing enzymes may influence non-metabolic functions, how metabolites may act as signaling molecules, or how shifts in cofactors might reprogram redox balance, gene regulation, mitochondrial function, or immune activation. The NIH frames this as a path to breakthroughs in understanding the diverse medical disorders linked to alcohol consumption, implying interest in mechanistic studies that connect biochemical changes to tangible disease processes in tissues and organs.
A major expected outcome is actionable knowledge that improves real-world clinical care for vulnerable patient populations harmed by alcohol-related pathologies. The FOA explicitly links basic and translational insight to downstream benefits in diagnosis, treatment, and disease management. In practical terms, this means the research is expected to identify or clarify molecular targets, biomarkers, or pathway interactions that could be leveraged to detect alcohol-related injury earlier, stratify risk, or guide therapeutic development. Because alcohol can damage many organ systems, the scope implicitly supports a broad range of disease contexts, as long as the proposed work is rooted in ethanol metabolizing pathways and their unconventional contributions to pathology.
From an administrative standpoint, this is a grant (FundingInstrumentType: Grant) under the health activity category, associated with CFDA 93.273 (Alcohol Research Programs). There is no cost sharing or matching requirement, which lowers the financial barrier to apply. The award ceiling is listed as $275,000, indicating a cap on the maximum support level under this announcement. The opportunity was posted and created on December 8, 2014, had an original and current closing date of January 7, 2018, and was archived February 7, 2018, meaning it is no longer open for new applications but remains useful as a reference for similar current NIH opportunities and priorities.
Eligibility is broad and includes many types of organizations: state, county, city/township, and special district governments; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; nonprofits both with and without 501(c)(3) status (with caveats noted in the full text); small businesses; and for-profit organizations other than small businesses. The announcement also highlights additional eligible applicants such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions, as well as faith-based or community-based organizations and eligible federal agencies. Importantly, non-U.S. entities are eligible: foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy. That international openness signals NIH interest in globally relevant, generalizable mechanisms of alcohol-related disease biology.
The funding agency is the National Institutes of Health, and the official full announcement was provided through the NIH grants guide (link: http://grants.nih.gov/grants/guide/pa-files/PA-15-057.html). For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV), which is primarily for troubleshooting access and linking rather than scientific program questions. Overall, the opportunity is best understood as an NIH push to seed creative, mechanistically grounded research that reframes ethanol metabolism as a network of interacting biochemical and signaling events that can drive organ injury and chronic disease, with the longer-term goal of improving clinical outcomes and public health.
Frequently Asked Questions (FAQs): NIH Grant PA-15-057 (R21)
What is the funding opportunity number for this NIH grant?
The Funding Opportunity Number (FON) is PA-15-057.
What kind of research is this opportunity meant to support?
This opportunity supports early-stage, high-impact research focused on alcohol-induced disease and end-organ injury, specifically research that looks beyond the standard, well-described pathways of alcohol metabolism. It emphasizes unconventional or underappreciated roles of ethanol-metabolizing enzymes, their downstream metabolites, required cofactors, and cross-talk with other biological systems.
What is the main scientific idea behind this FOA?
The central idea is that alcohol-related disease is not explained only by the classical ethanol breakdown pathway. Instead, less obvious biochemical consequences of ethanol-metabolizing pathways (including metabolic intermediates and cofactor shifts) may reshape cellular signaling, stress responses, inflammation, and tissue repair, contributing to disease onset, progression, and chronic pathology.
What does NIH mean by looking beyond the "standard" pathways of alcohol metabolism?
Based on the FOA description provided, it means prioritizing integrated and innovative studies that investigate overlooked components and interactions, such as non-metabolic functions of ethanol-metabolizing enzymes, signaling roles of metabolites, and how shifts in cofactors may reprogram redox balance, gene regulation, mitochondrial function, or immune activation.
What award mechanism is used for this opportunity?
The award mechanism is an NIH R21.
What is an R21 intended to fund in the context of this announcement?
Here, the R21 mechanism is presented as a way to encourage exploratory and developmental studies that may be too novel or preliminary for larger, longer-term grants. The expectation is that successful projects will produce strong pilot data that can later be expanded into more definitive research programs.
What disease areas or biological topics are emphasized?
The scientific purpose is centered on alcohol-induced diseases and end-organ injury, with emphasis on cellular and molecular events that trigger disease onset, drive progression over time, and maintain chronic pathology in people exposed to excessive or long-term alcohol use.
Does the FOA support research across multiple organ systems?
Yes. The description notes that alcohol can damage many organ systems and indicates a broad scope across disease contexts, as long as the proposed work is rooted in ethanol-metabolizing pathways and their unconventional contributions to pathology.
What types of mechanistic questions appear to be of interest?
The FOA description highlights interest in mechanism-focused work that connects biochemical changes to tangible disease processes in tissues and organs. Examples mentioned include: ethanol-metabolizing enzymes influencing non-metabolic functions, metabolites acting as signaling molecules, and cofactor-driven changes affecting redox balance, gene regulation, mitochondrial function, or immune activation.
What kinds of outcomes does NIH expect from studies funded under this FOA?
A major expected outcome is actionable knowledge that can improve real-world clinical care for patient populations harmed by alcohol-related pathologies. The FOA explicitly links basic and translational insights to downstream benefits in diagnosis, treatment, and disease management, such as identifying molecular targets, biomarkers, or pathway interactions to support earlier detection, risk stratification, or therapeutic development.
Is this opportunity focused only on basic science, or also translational impact?
Based on the information provided, it emphasizes both. It seeks mechanistic understanding while also pointing to downstream clinical benefits such as improved diagnosis, treatment, and management of alcohol-related injury.
What is the funding instrument type?
The FundingInstrumentType is a Grant.
Which agency is offering this funding opportunity?
The funding agency is the National Institutes of Health (NIH).
What is the activity category associated with this opportunity?
It is under the health activity category.
What CFDA program is this associated with?
This opportunity is associated with CFDA 93.273 (Alcohol Research Programs).
Is cost sharing or matching required?
No. The information provided states there is no cost sharing or matching requirement.
What is the maximum award amount mentioned for this opportunity?
The award ceiling is listed as $275,000, indicating a cap on the maximum support level under this announcement.
When was this opportunity posted and created?
It was posted and created on December 8, 2014.
What was the closing date for applications?
The original and current closing date listed is January 7, 2018.
Is this funding opportunity still open?
No. It was archived on February 7, 2018, and is no longer open for new applications.
Why might this archived FOA still be useful?
Even though it is closed, the description indicates it can remain useful as a reference for similar, current NIH opportunities and priorities, especially around innovative approaches to ethanol metabolism and alcohol-related disease mechanisms.
What types of organizations are eligible to apply?
Eligibility is broad and includes: state, county, city/township, and special district governments; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; nonprofits with and without 501(c)(3) status (with caveats noted in the full text); small businesses; and for-profit organizations other than small businesses.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The announcement highlights eligibility for HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISI institutions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included among eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are mentioned as eligible applicants.
Can non-U.S. entities apply for this opportunity?
Yes. The information provided states that foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy.
What does the inclusion of foreign applicants suggest about NIH priorities here?
Based on the description provided, it signals interest in globally relevant and generalizable mechanisms of alcohol-related disease biology, not limited to U.S.-only research settings.
Where can the full official announcement be found?
The full announcement is available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-15-057.html.
Who is the listed contact for access or technical issues?
The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Is the listed contact intended for scientific or programmatic questions?
The information provided indicates the listed contact is primarily for troubleshooting access and linking, rather than scientific program questions.
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