Opportunity Information: Apply for PA 15 049
Apply for PA 15 049
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Underactive Bladder in Aging (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Nov 24, 2014 and posted on Nov 24, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) For profit organizations other than small businesses Public and State controlled institutions of higher education Independent school districts Public housing authorities/Indian housing authorities Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Underactive Bladder in Aging (R01) opportunity (Funding Opportunity Number PA 15 049) was a National Institutes of Health discretionary grant program designed to support research on underactive bladder (UAB) specifically as it relates to aging and older adults. The program invited R01 applications proposing basic, clinical, or translational studies that deepen understanding of UAB, clarify how it develops or worsens with age, and generate evidence that can improve real-world diagnosis, evaluation, and treatment decisions for older people. In practical terms, the FOA was aimed at moving the field beyond general descriptions of urinary symptoms and toward clearer biological mechanisms, better clinical definitions and diagnostic approaches, and more effective prevention and management strategies tailored to aging populations.
The FOA highlighted four broad, priority research directions. First, it encouraged work on the biology, etiology, and pathophysiology of UAB, including studies in animal models and/or in older adult populations, to identify the underlying mechanisms responsible for impaired bladder emptying in later life. Second, it emphasized translation, meaning projects that take findings from basic science or clinical research and move them closer to clinical practice and health decision-making, such as developing clinically meaningful biomarkers, decision tools, or pathways that clinicians can use. Third, it sought studies addressing diagnosis, prevention, management, and clinical outcomes of UAB in older adults, reflecting interest in how UAB is identified, how it can be prevented or mitigated, what treatments or care strategies work best, and what outcomes matter most to patients and health systems (for example, symptom burden, functional status, complications, and quality of life). Fourth, it called for epidemiology and risk-factor research focused on how UAB emerges with advancing age, including population-level estimates, predictors, and potentially modifiable contributors that could inform prevention or earlier identification.
From a funding mechanics standpoint, this was an NIH R01 grant mechanism, which typically supports hypothesis-driven, investigator-initiated projects of substantial scope. The announcement listed no cost sharing or matching requirement. The activity categories referenced were health-related, with CFDA numbers 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) and 93.866 (Aging Research), signaling relevance to both kidney/urologic health research and aging-focused research priorities.
Eligibility was broad and included many types of U.S.-based and non-U.S. organizations. Eligible applicants included state and local governments (such as counties, cities, townships, special districts, and independent school districts), public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), public housing authorities/Indian housing authorities, and tribal governments and organizations. The eligibility section also explicitly included a range of mission-focused institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and foreign organizations (non-U.S. entities), as well as eligible federal agencies.
Administratively, the opportunity was posted on November 24, 2014, with an original and current closing date listed as January 7, 2018, and an archive date of February 7, 2018, meaning the FOA is no longer active for new submissions under that specific announcement. The full announcement was hosted through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-15-049.html, and the NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues.
Overall, the intent of PA 15 049 was to build a stronger, evidence-based foundation for understanding and treating underactive bladder in older adults by supporting studies that range from mechanism-focused biology to clinically actionable diagnostic and management approaches, while also improving the epidemiologic picture of who is affected and why risk increases with age.
Frequently Asked Questions (FAQs): Underactive Bladder in Aging (R01) - PA-15-049
What is the "Underactive Bladder in Aging (R01)" funding opportunity?
It is a National Institutes of Health (NIH) discretionary grant opportunity that supported research on underactive bladder (UAB) specifically as it relates to aging and older adults. The Funding Opportunity Number (FOA) is PA-15-049.
What grant mechanism did this opportunity use?
This opportunity used the NIH R01 grant mechanism, which generally supports hypothesis-driven, investigator-initiated research projects of substantial scope.
What was the overall purpose of PA-15-049?
The intent was to strengthen the evidence base for understanding and treating underactive bladder in older adults by funding studies ranging from basic biological mechanisms to clinically actionable diagnostic and management approaches, as well as epidemiology and risk-factor research focused on aging populations.
What kinds of research projects were encouraged under this FOA?
The FOA invited R01 applications proposing basic, clinical, or translational studies that (1) deepen understanding of UAB, (2) clarify how UAB develops or worsens with age, and (3) generate evidence that can improve real-world diagnosis, evaluation, and treatment decisions for older people.
What does the FOA mean by moving beyond "general descriptions of urinary symptoms"?
In practical terms, the FOA aimed to move the field toward clearer biological mechanisms, better clinical definitions and diagnostic approaches, and more effective prevention and management strategies tailored to older adults, rather than focusing only on broad symptom descriptions.
What were the priority research directions highlighted in the FOA?
The FOA described four broad priority directions: (1) biology, etiology, and pathophysiology of UAB; (2) translation of findings toward clinically useful tools and pathways; (3) diagnosis, prevention, management, and clinical outcomes in older adults; and (4) epidemiology and risk-factor research focused on UAB as it emerges with advancing age.
What types of studies fit under the "biology, etiology, and pathophysiology" priority?
This priority included research in animal models and/or in older adult populations to identify underlying mechanisms responsible for impaired bladder emptying in later life.
What did the FOA mean by "translation" in this context?
Translation referred to projects that move findings from basic science or clinical research closer to clinical practice and health decision-making, such as developing clinically meaningful biomarkers, decision tools, or clinical pathways that clinicians can use.
What topics were included under diagnosis, prevention, management, and clinical outcomes?
This area reflected interest in how UAB is identified, how it can be prevented or mitigated, what treatments or care strategies work best for older adults, and which outcomes matter to patients and health systems (for example, symptom burden, functional status, complications, and quality of life).
What kinds of epidemiology and risk-factor research were encouraged?
The FOA called for research focused on how UAB emerges with advancing age, including population-level estimates, predictors, and potentially modifiable contributors that could inform prevention or earlier identification.
Was this opportunity limited to clinical research only?
No. The FOA explicitly invited basic, clinical, and translational studies, including mechanistic work in animal models and studies conducted in older adult populations.
Did the FOA require cost sharing or matching funds?
No. The announcement listed no cost sharing or matching requirement.
What activity categories or program areas were referenced?
The activity categories referenced were health-related. The FOA listed CFDA numbers 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) and 93.866 (Aging Research), indicating relevance to both kidney/urologic health research and aging research priorities.
Who was eligible to apply?
Eligibility was broad and included many types of U.S.-based and non-U.S. organizations. Eligible applicants included state and local governments, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), and for-profit organizations (including small businesses and other for-profits).
Were tribal governments and tribal organizations eligible?
Yes. The eligibility list included tribal governments and tribal organizations, and it also referenced Tribal Colleges and Universities (TCCUs).
Were public housing authorities eligible to apply?
Yes. Public housing authorities and Indian housing authorities were listed as eligible applicants.
Were U.S. territories or possessions included in eligibility?
Yes. The eligibility section explicitly included U.S. territories or possessions.
Were foreign (non-U.S.) organizations eligible?
Yes. The eligibility section explicitly included foreign organizations (non-U.S. entities).
Were mission-focused or minority-serving institutions explicitly included?
Yes. The eligibility section explicitly referenced Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Were faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations were explicitly included.
Were federal agencies eligible to apply?
Yes. The eligibility section included eligible federal agencies.
When was this FOA posted?
The opportunity was posted on November 24, 2014.
What were the closing dates for submissions under this announcement?
The announcement listed an original and current closing date of January 7, 2018.
Is PA-15-049 still active?
No. The archive date was February 7, 2018, which indicates the FOA is no longer active for new submissions under that specific announcement.
Where could applicants find the full announcement text?
The full announcement was hosted through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-15-049.html.
Who was listed as a contact for access or linking issues?
The NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues related to the announcement page.
What populations were the main focus of this funding opportunity?
The FOA focused on aging and older adults, emphasizing how underactive bladder develops, worsens, and can be more effectively diagnosed and managed in later life.
What real-world impacts was the FOA trying to support?
The FOA aimed to support research that leads to evidence improving real-world diagnosis, evaluation, and treatment decisions for older people, including clinically useful tools (like biomarkers or decision tools) and better prevention and management strategies.
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