Opportunity Information: Apply for PA 15 051
Apply for PA 15 051
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Underactive Bladder in Aging (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Nov 24, 2014 and posted on Nov 24, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) County governments For profit organizations other than small businesses Special district governments Small businesses State governments Public and State controlled institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities City or township governments Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity titled "Underactive Bladder in Aging (R21)" (Funding Opportunity Number PA-15-051) supports exploratory, early-stage research aimed at improving what is known about underactive bladder (UAB) as it relates to aging. The FOA is geared toward basic, clinical, and translational studies that can clarify why UAB occurs more often or becomes more consequential in older adults, and how those impacts ripple into health, function, and quality of life. The overall intent is to build a stronger evidence base that ultimately informs better diagnosis, evaluation, and treatment approaches for older people affected by UAB.
The scientific scope is broad, but it is organized around four major emphasis areas. First, NIH is looking for projects that investigate the biology, etiology, and pathophysiology of UAB, using animal models and/or studies in older adult populations. This includes mechanistic work that can explain age-related changes in bladder muscle function, neural control of voiding, sensory signaling, and other physiological systems that may contribute to incomplete emptying or impaired bladder contraction. Second, the FOA encourages translation of basic and clinical findings into clinical practice and health decision-making, meaning applicants can focus on bridging the gap between discovery and real-world care, such as identifying clinically meaningful biomarkers, developing practical assessment tools, or generating data that could shape guidelines and care pathways.
Third, NIH highlights the need for research that improves the diagnosis, prevention, management, and understanding of clinical outcomes of UAB in older adults. Projects in this category might explore improved diagnostic strategies, better ways to distinguish UAB from other lower urinary tract conditions that are common in later life, approaches to preventing complications, or studies of how different management options affect outcomes that matter to patients, such as urinary retention episodes, infections, sleep disruption, falls risk, catheter use, or overall functional status. Fourth, the FOA invites epidemiology and risk factor research focused on how UAB develops with advancing age, including population-level studies that estimate prevalence and incidence, identify high-risk subgroups, and clarify contributing factors such as comorbidities, medications, neurologic conditions, frailty, or prior pelvic interventions.
This opportunity uses the NIH R21 grant mechanism, which is specifically designed for exploratory and developmental projects. In practice, that means NIH is encouraging novel ideas and early proof-of-concept work that may not yet have the level of preliminary evidence expected for larger, more definitive grant mechanisms. The aim is to help investigators generate foundational data, test innovative hypotheses, or develop new methods that can later support more extensive research programs. The award ceiling listed for this FOA is $200,000, and the opportunity does not require cost sharing or matching funds.
The FOA falls under the Health funding activity category and is associated with CFDA number 93.866 (Aging Research). It was posted on November 24, 2014, with an original and current closing date of January 7, 2018, and an archive date of February 7, 2018, indicating the announcement is no longer active for new submissions under those dates. The sponsoring agency is NIH, and the full announcement was made available through the NIH grants guide (link provided in the source data).
Eligibility is expansive and includes many organization types that commonly participate in federally funded research. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, state and local governments (including county and city/township governments), special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. Additional eligible entities called out include federally eligible agencies, faith-based or community-based organizations, historically underrepresented and capacity-building institutions (such as HBCUs, Hispanic-serving institutions, AANAPISIS, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities), U.S. territories or possessions, and non-U.S. entities (foreign organizations), as well as regional organizations.
For access issues with the online announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV), which is intended for technical problems reaching or linking to the FOA rather than scientific questions about project fit.
Frequently Asked Questions (FAQs): Underactive Bladder in Aging (R21) - NIH (PA-15-051)
1) What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Underactive Bladder in Aging (R21)". The Funding Opportunity Number (FOA) is PA-15-051.
2) What is the overall purpose of this funding opportunity?
This FOA supports exploratory, early-stage research to improve what is known about underactive bladder (UAB) as it relates to aging. It aims to strengthen the evidence base so that, over time, research findings can inform better diagnosis, evaluation, and treatment approaches for older adults affected by UAB.
3) What types of research does this FOA support?
The FOA supports a broad range of basic, clinical, and translational research focused on UAB in the context of aging, including studies that clarify why UAB occurs more often or becomes more consequential in older adults and how those impacts affect health, function, and quality of life.
4) What grant mechanism is used for this opportunity?
This opportunity uses the NIH R21 mechanism, which is designed for exploratory and developmental projects.
5) What does an NIH R21 mechanism typically emphasize in this FOA?
In this FOA, the R21 mechanism emphasizes novel ideas, early proof-of-concept work, and exploratory studies that may not yet have the level of preliminary evidence expected for larger grant mechanisms. The intent is to help investigators generate foundational data, test innovative hypotheses, or develop new methods that can support future, more extensive research programs.
6) How much funding is available (award ceiling) under this FOA?
The listed award ceiling for this FOA is $200,000.
7) Is cost sharing or matching required?
No. The FOA states that it does not require cost sharing or matching funds.
8) What scientific areas does NIH emphasize in this FOA?
The FOA is organized around four major emphasis areas: (1) biology/etiology/pathophysiology of UAB in aging, (2) translation of findings into clinical practice and health decision-making, (3) improving diagnosis/prevention/management and understanding clinical outcomes in older adults, and (4) epidemiology and risk factor research related to UAB development with advancing age.
9) What kinds of projects fall under the biology, etiology, and pathophysiology emphasis area?
This area includes mechanistic studies using animal models and/or older adult populations to explain age-related changes relevant to UAB, such as changes in bladder muscle function, neural control of voiding, sensory signaling, and other physiological systems that may contribute to incomplete bladder emptying or impaired bladder contraction.
10) What does the FOA mean by translating findings into clinical practice and decision-making?
The FOA encourages work that bridges discovery and real-world care, such as identifying clinically meaningful biomarkers, developing practical assessment tools, or generating data that could help shape guidelines and care pathways.
11) What diagnosis and management topics does NIH highlight for older adults with UAB?
The FOA highlights research intended to improve diagnosis, prevention, management, and understanding of clinical outcomes of UAB in older adults. Examples include improved diagnostic strategies, better approaches to distinguish UAB from other lower urinary tract conditions common in later life, prevention of complications, and evaluation of management options based on outcomes that matter to patients.
12) What patient-relevant outcomes are explicitly mentioned in the FOA?
The FOA mentions outcomes such as urinary retention episodes, infections, sleep disruption, falls risk, catheter use, and overall functional status.
13) What epidemiology and risk factor research is encouraged?
The FOA invites population-level studies to estimate prevalence and incidence, identify high-risk subgroups, and clarify contributing factors to UAB with age, including factors such as comorbidities, medications, neurologic conditions, frailty, or prior pelvic interventions.
14) What is the funding activity category and CFDA number associated with this opportunity?
The funding activity category is Health. The FOA is associated with CFDA 93.866 (Aging Research).
15) When was this FOA posted, and what were the closing and archive dates?
The FOA was posted on November 24, 2014. The original and current closing date listed is January 7, 2018. The archive date is February 7, 2018.
16) Is this funding opportunity currently active?
No. Based on the provided dates (closing date of January 7, 2018 and archive date of February 7, 2018), this announcement is no longer active for new submissions under those dates.
17) Who is the sponsoring agency for this FOA?
The sponsoring agency is the National Institutes of Health (NIH).
18) Where was the full announcement made available?
The full announcement was made available through the NIH grants guide (a link was provided in the source data).
19) What types of organizations are eligible to apply?
Eligibility is broad and includes: public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status); for-profit organizations other than small businesses; small businesses; state and local governments (including county and city/township governments); special district governments; independent school districts; public housing authorities/Indian housing authorities; tribal governments and tribal organizations; federally eligible agencies; faith-based or community-based organizations; U.S. territories or possessions; regional organizations; and non-U.S. entities (foreign organizations).
20) Which historically underrepresented or capacity-building institutions are explicitly included as eligible?
The FOA explicitly includes institutions such as HBCUs, Hispanic-serving institutions, AANAPISIS, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities.
21) Are foreign (non-U.S.) organizations eligible to apply?
Yes. The eligibility list includes non-U.S. entities (foreign organizations).
22) Who should be contacted for technical problems accessing the online announcement?
For access issues with the online announcement (such as trouble reaching or linking to the FOA), the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
23) Is the listed contact intended for scientific questions about whether a project fits the FOA?
No. The provided contact is intended for technical problems accessing or linking to the FOA, rather than scientific questions about project fit.
24) What age group is the primary focus of the research supported by this FOA?
The FOA centers on UAB in older adults and how aging influences the development, severity, consequences, and clinical outcomes of UAB.
25) Does the FOA allow both animal model studies and human population studies?
Yes. The FOA explicitly references research using animal models and/or studies in older adult populations, and it also encourages epidemiology and risk factor research at the population level.
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