Opportunity Information: Apply for PA 15 180

  • The Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "Understanding and Improving Diagnostic Safety in Ambulatory Care Incidence and Contributing Factors (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes.
  • This funding opportunity was created on Apr 8, 2015 and posted on Apr 8, 2015.
  • Applicants must submit their applications by Nov 5, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $350,000.00 in funding.
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Private institutions of higher education State governments City or township governments Native American tribal governments (Federally recognized) County governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Tribally Controlled Colleges and Universities (TCCUs) Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply.
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Opportunity Summary:

The grant opportunity titled "Understanding and Improving Diagnostic Safety in Ambulatory Care: Incidence and Contributing Factors (R01)" (Funding Opportunity Number PA 15-180) is a discretionary research grant offered by the Agency for Healthcare Research and Quality (AHRQ). It is focused on diagnostic safety in outpatient and ambulatory care settings, where many initial evaluations, test ordering decisions, follow-up actions, referrals, and treatment starts happen. The core problem the announcement is trying to address is that, even though diagnostic safety has become a major topic and there have been important recent advances, the field still lacks solid, high-confidence evidence about how often diagnostic failures occur, what forms they take, and what their real-world consequences are for patients and the healthcare system.

This FOA solicits R01 Health Services Research Projects that examine diagnostic failure in a rigorous, measurable way. In practical terms, it invites research teams to produce stronger estimates of the incidence and complexity of diagnostic failure and to clarify the contributing factors that lead to breakdowns in the diagnostic process. The emphasis is not just on identifying that errors happen, but on building a clearer picture of patterns and mechanisms: what types of diagnostic failures occur in ambulatory care, how frequently they occur across conditions or care contexts, and what system, workflow, communication, information management, or care coordination factors may be involved. AHRQ also highlights the need to quantify associated costs, harms, and impacts, which can include clinical harm to patients as well as downstream utilization and spending associated with delayed or incorrect diagnoses.

The opportunity is structured as a grant (Funding Instrument Type: Grant) under the health-focused activity category, with the CFDA number 93.226 (Research on Healthcare Costs, Quality and Outcomes). The listed award ceiling is $350,000, and there is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of the award. The announcement was posted on April 8, 2015, with an original and final closing date of November 5, 2018, and it was archived on December 6, 2018, indicating it is no longer open for new submissions under that specific posting.

Eligibility is broad across U.S.-based organizations involved in research and public service. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and multiple levels of government (state, county, city or township, and special district governments). The FOA also explicitly includes eligibility pathways for organizations serving specific populations and minority-serving institutions, such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Federally recognized tribal governments and certain other tribal organizations are also listed as eligible. At the same time, the opportunity clearly states that non-U.S. entities (foreign institutions) are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible, which narrows participation to domestic applicants and domestically located components.

Overall, this FOA is aimed at strengthening the evidence base around diagnostic safety in outpatient care by funding studies that can move the field from general concern and anecdotal recognition to well-supported estimates and explanations. The intended result is research that helps the healthcare system better understand where and why diagnostic failures happen in ambulatory settings, how often they occur, and what kinds of harm and costs they generate, creating a foundation for future interventions, measurement approaches, and safety improvements. For full details, AHRQ directed applicants to the complete announcement hosted through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-15-180.html, with technical access assistance available via the NIH Office of Extramural Research (OER) webmaster contact listed in the notice.

Frequently Asked Questions (FAQs)

What is the name of this grant opportunity?

The opportunity is titled "Understanding and Improving Diagnostic Safety in Ambulatory Care: Incidence and Contributing Factors (R01)".

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number is PA-15-180.

Which federal agency is offering this grant?

This is a discretionary research grant offered by the Agency for Healthcare Research and Quality (AHRQ).

What type of funding mechanism is this?

The funding instrument type is a Grant, and the FOA solicits R01 Health Services Research Projects.

What is the main focus area of the FOA?

The FOA focuses on diagnostic safety in outpatient and ambulatory care settings, where many key diagnostic activities occur (initial evaluations, test ordering decisions, follow-up actions, referrals, and the start of treatment).

What problem is this FOA trying to address?

Although diagnostic safety has gained attention and the field has made advances, the FOA highlights a continued lack of solid, high-confidence evidence on:

  • How often diagnostic failures occur
  • What forms diagnostic failures take
  • What real-world consequences they have for patients and the healthcare system

What types of projects is AHRQ seeking to fund?

AHRQ is seeking projects that examine diagnostic failure in a rigorous, measurable way, including studies designed to produce stronger estimates of diagnostic failure incidence and complexity and to clarify the contributing factors involved in breakdowns of the diagnostic process.

Does the FOA only want projects that identify errors, or also projects that explain why they happen?

The emphasis is not just on identifying that diagnostic errors happen. The FOA calls for research that builds a clearer picture of patterns and mechanisms, such as what types of diagnostic failures occur, how frequently they occur, and what factors contribute to them.

In what care settings is the research expected to focus?

The FOA targets outpatient and ambulatory care settings.

What kinds of contributing factors does the FOA highlight?

The FOA highlights contributing factors that may include system, workflow, communication, information management, or care coordination issues that can lead to breakdowns in the diagnostic process.

Is the FOA interested in measuring impacts like harm and costs?

Yes. AHRQ highlights the need to quantify associated costs, harms, and impacts, including:

  • Clinical harm to patients
  • Downstream utilization and spending linked to delayed or incorrect diagnoses

What is the CFDA number associated with this opportunity?

The CFDA number listed is 93.226 (Research on Healthcare Costs, Quality and Outcomes).

What is the award ceiling for this grant?

The listed award ceiling is $350,000.

Is cost sharing or matching required?

No. The FOA states there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award.

When was this opportunity posted?

The announcement was posted on April 8, 2015.

What were the closing dates for submission?

The FOA lists an original and final closing date of November 5, 2018.

Is this funding opportunity still open?

No. The FOA was archived on December 6, 2018, which indicates it is no longer open for new submissions under that specific posting.

Who is eligible to apply?

Eligibility is broad across U.S.-based organizations involved in research and public service. Eligible applicants include:

  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Federally recognized tribal governments
  • Certain other tribal organizations (as listed in the FOA)

Are minority-serving institutions specifically included as eligible applicants?

Yes. The FOA explicitly includes eligibility pathways for organizations serving specific populations and minority-serving institutions, including:

  • Historically Black Colleges and Universities (HBCUs)
  • Hispanic Serving Institutions
  • Tribally Controlled Colleges and Universities (TCCUs)
  • Alaska Native and Native Hawaiian Serving Institutions
  • Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Are foreign (non-U.S.) entities eligible to apply?

No. The FOA states that non-U.S. entities (foreign institutions) are not eligible to apply.

Can a non-U.S. component of a U.S. organization apply?

No. The FOA specifies that non-U.S. components of U.S. organizations are also not eligible.

What is the intended outcome of research funded by this FOA?

The FOA aims to strengthen the evidence base around diagnostic safety in outpatient care by supporting research that moves the field from general concern and anecdotal recognition to well-supported estimates and explanations of where diagnostic failures happen, how often they occur, and what harm and costs they generate. This evidence is intended to help create a foundation for future interventions, measurement approaches, and safety improvements.

Where can applicants find the full FOA announcement?

AHRQ directs applicants to the complete announcement in the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-15-180.html

Where is technical access help available for the FOA webpage?

The notice states that technical access assistance is available via the NIH Office of Extramural Research (OER) webmaster contact listed in the announcement.

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